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Nutritional determinants of cognitive aging and dementia

  • Martha C. Morris (a1)
Abstract

The objective of this review is to provide an overview of nutritional factors involved in cognitive aging and dementia with a focus on nutrients that are also important in neurocognitive development. Several dietary components were targeted, including antioxidant nutrients, dietary fats and B-vitamins. A critical review of the literature on each nutrient group is presented, beginning with laboratory and animal studies of the underlying biological mechanisms, followed by prospective epidemiological studies and randomised clinical trials. The evidence to date is fairly strong for protective associations of vitamin E from food sources, the n-3 fatty acid, DHA, found in fish, a high ratio of polyunsaturated to saturated fats, and vitamin B12 and folate. Attention to the level of nutrient intake is crucial for interpreting the literature and the inconsistencies across studies. Most of the epidemiological studies that observe associations have sufficient numbers of individuals who have both low and adequate nutrient status. Few of the randomised clinical trials are designed to target participants who have low baseline status before randomising to vitamin supplement treatments, and this may have resulted in negative findings. Post-hoc analyses by some of the trials reveal vitamin effects in individuals with low baseline intakes. The field of diet and dementia is a relatively young area of study. Much further work needs to be done to understand dietary determinants of cognitive aging and diseases. Further, these studies must be particularly focused on the levels of nutrient intake or status that confer optimum or suboptimal brain functioning.

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Corresponding author
Corresponding author: Professor Martha Clare Morris, fax +1 708 660 2104, email Martha_C_Morris@rush.edu
References
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1. Brewer, JB, Gabrieli, JDE, Preston, AR et al. (2007) Memory. In Textbook of Clinical Neurology , 3rd ed. [Goestz, CG]. Philadelphia, PA: Saunders Elsevier.
2. Evans, DA, Funkenstein, HH, Albert, MS et al. (1989) Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA 262, 25512556.
3. Bennett, DA (2000) Part II. Clinical diagnosis and course of Alzheimer's disease. Dis Mon 46, 666686.
4. Schneider, JA, Arvanitakis, Z, Bang, W et al. (2007) Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69, 21972204.
5. Hebert, LE, Scherr, PA, Bienias, JL et al. (2003) Alzheimer disease in the US population: Prevalence estimates using the 2000 census. Arch Neurol 60, 11191122.
6. Hebert, LE, Beckett, LA, Scherr, PA et al. (2001) Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050. Alzheimer Dis Assoc Disord 15, 169173.
7. McKhann, G, Drachman, D, Folstein, M et al. (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939944.
8. Anonymous (1985) Criteria for the clinical diagnosis of Alzheimer's disease. Excerpts from the NINCDS-ADRDA Work Group report. J Am Geriatr Soc 33, 23.
9. Reitz, C, Brayne, C & Mayeux, R (2011) Epidemiology of Alzheimer disease. Nat Rev Neurol 7, 137152.
10. Davidglus, M, Bell, C, Berrettini, W et al. (2010) National Institutes of Health State-of-the-Science Conference Statement: Preventing Alzhiemer's Disease and Cognitive Decline. NIH Consensus State-of-the-Science Statements, p. 130.
11. Larson, EB, Wang, L, Bowen, JD et al. (2010) Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med 144, 7381.
12. Luchsinger, JA, Noble, JM & Scarmeas, N (2007) Diet and Alzheimer's disease. Curr Neurol Neurosci Rep 7, 366372.
13. Skoog, I, Lernfelt, B, Landahl, S et al. (1996) 15-year longitudinal study of blood pressure and dementia. Lancet 347, 11411145.
14. Kivipelto, M, Helkala, EL, Laakso, MP et al. (2002) Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Ann Intern Med 137, 149155.
15. Whitmer, RA, Gunderson, EP, Barrett-Connor, E et al. (2005) Obesity in middle age and future risk of dementia: A 27 year longitudinal population based study. Br Med J 330, 1360.
16. Luchsinger, JA, Tang, MX, Stern, Y et al. (2001) Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort. Am J Epidemiol 154, 635641.
17. Reitz, C, Brickman, AM, Luchsinger, JA et al. (2007) Frequency of subclinical heart disease in elderly persons with dementia. Am J Geriatr Cardiol 16, 183188.
18. Schneider, JA, Wilson, RS, Bienias, JL et al. (2004) Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology 62, 11481155.
19. Kalmijn, S, Foley, D, White, L et al. (2000) Metabolic cardiovascular syndrome and risk of dementia in Japanese–American elderly men. The Honolulu-Asia aging study. Arterioscler Thromb Vasc Biol 20, 22552260.
20. Yaffe, K, Weston, AL, Blackwell, T et al. (2009) The metabolic syndrome and development of cognitive impairment among older women. Arch Neurol 66, 324328.
21. Solomon, A, Kareholt, I, Ngandu, T et al. (2009) Serum total cholesterol, statins and cognition in non-demented elderly. Neurobiol Aging 30, 10061009.
22. Beydoun, MA, Beason-Held, LL, Kitner-Triolo, MH et al. (2010) Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment. J Epidemiol Community Health 65, 949957.
23. t'Veld, BA, Ruitenberg, A, Hofman, A et al. (2001) Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 345, 15151521.
24. Bekris, LM, Yu, CE, Bird, TD et al. (2010) Genetics of Alzheimer disease. J Geriatr Psychiatry Neurol 23, 213227.
25. Morris, MC, Evans, DA, Hebert, LE et al. (1999) Methodological issues in the study of cognitive decline. Am J Epidemiol 149, 789793.
26. Spector, R (2009) Nutrient transport systems in brain: 40 years of progress. J Neurochem 111, 315320.
27. Spector, R (2010) Nature and consequences of mammalian brain and CSF efflux transporters: Four decades of progress. J Neurochem 112, 1323.
28. Pardridge, WM (1998) Blood-brain barrier carrier-mediated transport and brain metabolism of amino acids. Neurochem Res 23, 635644.
29. Muller, D (1995) Vitamin E and neurological function: Lessons from patients with abetalipoproteinaemia. Redox Rep 1, 239245.
30. Muller, DP, Lloyd, JK & Wolff, OH (1983) Vitamin E and neurological function: Abetalipoproteinaemia and other disorders of fat absorption. Ciba Found Symp 101, 106121.
31. Koscik, RL, Farrell, PM, Kosorok, MR et al. (2004) Cognitive function of children with cystic fibrosis: Deleterious effect of early malnutrition. Pediatrics 113, 15491558.
32. Morris, MC & Tangney, CC (2011) A potential design flaw of randomized trials of vitamin supplements. JAMA 305, 13481349.
33. Blumberg, J, Heaney, RP, Huncharek, M et al. (2010) Evidence-based criteria in the nutritional context. Nutr Rev 68, 478484.
34. Mecocci, P, MacGarvey, U, Kaufman, AE et al. (1993) Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol 34, 609616.
35. Bishop, NA, Lu, T & Yankner, BA (2010) Neural mechanisms of ageing and cognitive decline. Nature 464, 529535.
36. Haigis, MC & Yankner, BA (2010) The aging stress response. Mol Cell 40, 333344.
37. Christen, Y (2000) Oxidative stress and Alzheimer disease. Am J Clin Nutr 71, 621S629S.
38. Jenner, P (1994) Oxidative damage in neurodegenerative disease. Lancet 344, 68.
39. Mecocci, P, MacGarvey, U & Beal, MF (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 36, 747751.
40. Beal, MF (2003) Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann N Y Acad Sci 991, 120131.
41. Sardesai, VM (1995) Role of antioxidants in health maintenance. Nutr Clin Pract 10, 1925.
42. Olanow, CW (1990) Oxidation reactions in Parkinson's disease. Neurology 40, 10 Suppl 3, S-7.
43. Koscik, RL, Lai, HJ, Laxova, A et al. (2005) Preventing early, prolonged vitamin E deficiency: An opportunity for better cognitive outcomes via early diagnosis through neonatal screening. J Pediatr 147, 3 Suppl., S51S56.
44. Luchsinger, JA, Tang, MX, Shea, S et al. (2003) Antioxidant vitamin intake and risk of Alzheimer's disease. Arch Neurol 60, 203208.
45. Engelhart, MJ, Geerlings, MI, Ruitenberg, A et al. (2002) Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 287, 32233229.
46. Ravaglia, G, Forti, P, Lucicesare, A et al. (2008) Plasma tocopherols and risk of cognitive impairment in an elderly Italian cohort. Am J Clin Nutr 87, 13061313.
47. Mangialasche, F, Kivipelto, M, Mecocci, P et al. (2010) High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. J Alzheimers Dis 20, 10291037.
48. Kang, JH & Grodstein, F (2008) Plasma carotenoids and tocopherols and cognitive function: A prospective study. Neurobiol Aging 29, 13941403.
49. Helmer, C, Peuchant, E, Letenneur, L et al. (2003) Association between antioxidant nutritional indicators and the incidence of dementia: Results from the PAQUID prospective cohort study. Eur J Clin Nutr 57, 15551561.
50. Zandi, PP, Anthony, JC, Khachaturian, AS et al. (2004) Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: The Cache County Study. Arch Neurol 61, 8288.
51. Devore, EE, Grodstein, F, van Rooij, FJ et al. (2010) Dietary antioxidants and long-term risk of dementia. Arch Neurol 67, 819825.
52. Fillenbaum, GG, Kuchibhatla, MN, Hanlon, JT et al. (2005) Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E. Ann Pharmacother 39, 20092014.
53. Laurin, D, Foley, DJ, Masaki, KH et al. (2002) Vitamin E and C supplements and risk of dementia. JAMA 288, 22662268.
54. Morris, MC, Evans, DA, Bienias, JL et al. (2002) Dietary intake of antioxidant nutrients and the risk of incident Alzheimer's disease in a biracial community study. JAMA 287, 32303237.
55. Morris, MC, Evans, DA, Bienias, JL et al. (2002) Vitamin E and cognitive decline in older persons. Arch Neurol 59, 11251132.
56. Gray, SL, Anderson, ML, Crane, PK et al. (2008) Antioxidant vitamin supplement use and risk of dementia or Alzheimer's disease in older adults. J Am Geriatr Soc 56, 291295.
57. Maxwell, CJ, Hicks, MS, Hogan, DB et al. (2005) Supplemental use of antioxidant vitamins and subsequent risk of cognitive decline and dementia. Dement Geriatr Cogn Disord 20, 4551.
58. Kang, JH, Cook, NR, Manson, JE et al. (2009) Vitamin E, vitamin C, beta carotene, and cognitive function among women with or at risk of cardiovascular disease: The Women's Antioxidant and Cardiovascular Study. Circulation 119, 27722780.
59. Grodstein, F, Kang, JH, Glynn, RJ et al. (2007) A randomized trial of beta carotene supplementation and cognitive function in men: The Physicians’ Health Study II. Arch Intern Med 167, 21842190.
60. Kang, JH, Cook, N, Manson, J et al. (2006) A randomized trial of vitamin E supplementation and cognitive function in women. Arch Intern Med 166, 24622468.
61. Petersen, RC, Thomas, RG, Grundman, M et al. (2005) Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 352, 23792388.
62. Yang, CS, Lu, G, Ju, J et al. (2010) Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols. Ann NY Acad Sci 1203, 2934.
63. Devaraj, S, Leonard, S, Traber, MG et al. (2008) Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic Biol Med 44, 12031208.
64. Linscheer, WG & Vergroesen, AJ. (1994) Lipids. In Modern Nutrition in Health and Disease , p. 4788 [Shils, M, Olson, JA & Shike, M]. Philadelphia: Lea &Febige.
65. Keys, A & Parlin, RW (1966) Serum cholesterol response to changes in dietary lipids. Am J Clin Nutr 19, 175181.
66. Brouwer, IA, Wanders, AJ & Katan, MB (2010) Effect of animal and industrial trans fatty acids on HDL and LDL cholesterol levels in humans – a quantitative review. PLoS ONE 5, e9434.
67. Mensink, RP & Katan, MB (1991) Effect of dietary fatty acids on serum lipids and lipoproteins: A meta-analysis of 27 trials. Arterioscler Thromb 12, 911912.
68. Puglielli, L, Tanzi, R & Kovacs, D (2003) Alzheimer's disease: The cholesterol connection. Nat Neurosci 6, 345351.
69. Evans, DA, Beckett, LA, Field, TS et al. (1997) Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons. JAMA 277, 822824.
70. Bennett, DA, Wilson, RS, Schneider, JA et al. (2003) Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease. Neurology 60, 246252.
71. Simons, M, Keller, P, De Strooper, B et al. (1998) Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 95, 64606464.
72. Sparks, DL, Liu, H, Gross, DR et al. (1995) Increased density of cortical apolipoprotein E immunoreactive neurons in rabbit brain after dietary administration of cholesterol. Neurosci Lett 187, 142144.
73. Walker, LC, Parker, CA, Lipinski, WJ et al. (1997) Cerebral lipid deposition in aged apolipoprotein-E-deficient mice. Am J Pathol 151, 13711377.
74. Howland, DS, Trusko, SP, Savage, MJ et al. (1998) Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol. J Biol Chem 273, 1657616582.
75. Ullrich, C, Pirchl, M & Humpel, C (2010) Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits. Mol Cell Neurosci 45, 408417.
76. Greenwood, CE & Winocur, G (1996) Cognitive impairment in rats fed high-fat diets: A specific effect of saturated fatty-acid intake. Behav Neurosci 110, 451459.
77. Pistell, PJ, Morrison, CD, Gupta, S et al. (2010) Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol 219, 2532.
78. Sparks, DL, Friedland, R, Petanceska, S et al. (2006) Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology. J Nutr Health Aging 10, 247254.
79. Streit, WJ & Sparks, DL (1997) Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits. J Mol Med 75, 130138.
80. Wong, KL, Murakami, K & Routtenberg, A (1989) Dietary cis-fatty acids that increase protein F1 phosphorylation enhance spatial memory. Brain Res 505, 302305.
81. Devore, EE, Stampfer, MJ, Breteler, MM et al. (2009) Dietary fat intake and cognitive decline in women with type 2 diabetes. Diabetes Care 32, 635640.
82. Eskelinen, MH, Ngandu, T, Helkala, EL et al. (2008) Fat intake at midlife and cognitive impairment later in life: A population-based CAIDE study. Int J Geriatr Psychiatry 23, 741747.
83. Beydoun, MA, Kaufman, JS, Satia, JA et al. (2007) Plasma n-3 fatty acids and the risk of cognitive decline in older adults: The atherosclerosis risk in communities study. Am J Clin Nutr 85, 11031111.
84. Morris, MC, Evans, DA, Bienias, JL et al. (2003) Dietary fats and the risk of incident Alzheimer's disease. Arch Neurol 60, 194200.
85. Morris, MC, Evans, DA, Bienias, JL et al. (2004) Dietary fat intake and 6-year cognitive change in an older biracial community population. Neurology 62, 15731579.
86. Heude, B, Ducimetiere, P & Berr, C (2003) Cognitive decline and fatty acid composition of erythrocyte membranes – The EVA study. Am J Clin Nutr 77, 803808.
87. Luchsinger, JA, Min-Xing, T, Shea, S et al. (2002) Caloric intake and the risk of Alzheimer disease. Arch Neurol 59, 12581263.
88. Engelhart, MJ, Geerlings, MI, Ruitenberg, A et al. (2002) Diet and risk of dementia: Does fat matter? Neurology 59, 19151921.
89. Samieri, C, Feart, C, Letenneur, L et al. (2008) Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk. Am J Clin Nutr 88, 714721.
90. Solfrizzi, V, Colacicco, AM, D'Introno, A et al. (2006) Dietary intake of unsaturated fatty acids and age-related cognitive decline: A 8·5-year follow-up of the Italian Longitudinal Study on Aging. Neurobiol Aging 27, 16941704.
91. Ferrara, A, Barrett-Connor, E & Shan, J (1997) Total, LDL, and HDL cholesterol decrease with age in older men and women. The Rancho Bernardo Study 1984–1994. Circulation 96, 3743.
92. Solomon, A, Kareholt, I, Ngandu, T et al. (2007) Serum cholesterol changes after midlife and late-life cognition: Twenty-one-year follow-up study. Neurology 68, 751756.
93. Whitmer, RA, Sidney, S, Selby, J et al. (2005) Midlife cardiovascular risk factors and risk of dementia in late life. Neurology 64, 277281.
94. Reynolds, CA, Gatz, M, Prince, JA et al. (2010) Serum lipid levels and cognitive change in late life. J Am Geriatr Soc 58, 501509.
95. Solomon, A, Kivipelto, M, Wolozin, B et al. (2009) Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later. Dement Geriatr Cogn Disord 28, 7580.
96. Mainous, AG III, Eschenbach, SL, Wells, BJ et al. (2005) Cholesterol, transferrin saturation, and the development of dementia and Alzheimer's disease: Results from an 18-year population-based cohort. Fam Med 37, 3642.
97. Notkola, IL, Sulkava, R, Pekkanen, J et al. (1998) Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. Neuroepidemiology 17, 1420.
98. Rastas, S, Pirttila, T, Mattila, K et al. (2010) Vascular risk factors and dementia in the general population aged >85 years: Prospective population-based study. Neurobiol Aging 31, 17.
99. Li, G, Shofer, JB, Kukull, WA, Peskind, ER et al. (2005) Serum cholesterol and risk of Alzheimer disease: A community-based cohort study. Neurology 65, 10451050.
100. Yaffe, K, Barrett-Connor, E, Lin, F et al. (2002) Serum lipoprotein levels, statin use, and cognitive function in older women. Arch Neurol 59, 378384.
101. Moroney, JT, Tang, MX, Berglund, L et al. (1999) Low-density lipoprotein cholesterol and the risk of dementia with stroke. JAMA 282, 254260.
102. Reitz, C, Tang, MX, Manly, J et al. (2008) Plasma lipid levels in the elderly are not associated with the risk of mild cognitive impairment. Dement Geriatr Cogn Disord 25, 232237.
103. Romas, SN, Tang, MX, Berglund, L et al. (1999) APOE genotype, plasma lipids, lipoproteins, and AD in community elderly. Neurology 53, 517521.
104. Harris, WS, Mozaffarian, D, Lefevre, M et al. (2009) Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids. J Nutr 139, 804S819S.
105. Connor, WE. Importance of n-3 fatty acids in health and disease. Am J Clin Nutr 71, 1 Suppl., 171S–1715S.
106. Carrie, I, Clement, M, de Javel, D et al. (2000) Specific phospholipid fatty acid composition of brain regions in mice. Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation. J Lipid Res 41, 465472.
107. Connor, WE, Neuringer, M & Lin, DS (1990) Dietary effects on brain fatty acid composition: The reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys. J Lipid Res 31, 237247.
108. Gamoh, S, Hashimoto, M, Sugioka, K et al. (1999) Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. Neuroscience 93, 237241.
109. Suzuki, H, Park, SJ, Tamura, M et al. (1998) Effect of the long-term feeding of dietary lipids on the learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in adult mice: A comparison of sardine oil diet with palm oil diet. Mech Ageing Dev 101, 119128.
110. Moriguchi, T, Greiner, RS & Salem, N Jr. (2000) Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. J Neurochem 75, 25632573.
111. Lim, SYSH (2000) Intakes of dietary docosahexaenoic acid ethyl ester and egg phosphatidylcholine improve maze-learning ability in young and old mice. J Nutr 130, 16291632.
112. Lim, SY & Suzuki, H (2000) Effect of dietary docosahexaenoic acid and phosphatidylcholine on maze behavior and fatty acid composition of plasma and brain lipids in mice. Int J Vitam Nutr Res 70, 251259.
113. Greiner, RS, Moriguchi, T, Hutton, A et al. (1999) Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks. Lipids 34, Suppl., 239243.
114. Minami, M, Kimura, S, Endo, T et al. (1997) Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. Pharmacol Biochem Behav 58, 11231129.
115. Jensen, MM, Skarsfeldt, T & Hoy, CE (1996) Correlation between level of (n-3) polyunsaturated fatty acids in brain phospholipids and learning ability in rats. A multiple generation study. Biochim Biophys Acta 1300, 203209.
116. Yamamoto, N, Saitoh, M, Moriuchi, A et al. (1987) Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. J Lipid Res 28, 144151.
117. Gamoh, S, Hashimoto, M, Hossain, S et al. (2001) Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats. Clin Exp Pharmacol Physiol 28, 266270.
118. Lim, S & Suzuki, H (2001) Changes in maze behavior of mice occur after sufficient accumulation of docosahexaenoic acid in brain. J Nutr 131, 319324.
119. Sugimoto, Y, Taga, C, Nishiga, M et al. (2002) Effect of docosahexaenoic acid-fortified Chlorella vulgaris strain CK22 on the radial maze performance in aged mice. Biol Pharm Bull 25, 10901092.
120. Itokazu, N, Ikegaya, Y, Nishikawa, M et al. (2000) Bidirectional actions of docosahexaenoic acid on hippocampal neurotransmissions in vivo . Brain Research 862, 211216.
121. McGahon, BM, Martin, DS, Horrobin, DF et al. (1999) Age-related changes in synaptic function: Analysis of the effect of dietary supplementation with omega-3 fatty acids. Neuroscience 94, 305314.
122. Poling, JS, Vicini, S, Rogawski, MA et al. (1996) Docosahexaenoic acid block of neuronal voltage-gated K+ channels: Subunit selective antagonism by zinc. Neuropharmacology 35, 969982.
123. Vreugdenhil, M, Bruehl, C, Voskuyl, RA et al. (1996) Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. Proc Natl Acad Sci USA 93, 1255912563.
124. Xiao, Y & Li, X (1999) Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation. Brain Res 846, 112121.
125. Young, C, Gean, PW, Chiou, LC et al. (2000) Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus. Synapse 37, 9094.
126. Chalon, S, Delion-Vancassel, S, Belzung, C et al. (1998) Dietary fish oil affects monoaminergic neurotransmission and behavior in rats. J Nutr 128, 25122519.
127. de la Presa Owens, S & Innis, SM (1999) Docosahexaenoic and arachidonic acid prevent a decrease in dopaminergic and serotoninergic neurotransmitters in frontal cortex caused by a linoleic and alpha-linolenic acid deficient diet in formula-fed piglets. J Nutr 129, 20882093.
128. Delion, S, Chalon, S, Guilloteau, D et al. (1996) alpha-Linolenic acid dietary deficiency alters age-related changes of dopaminergic and serotoninergic neurotransmission in the rat frontal cortex. J Neurochem 66, 15821591.
129. Innis, SM (2000) The role of dietary n-6 and n-3 fatty acids in the developing brain. Dev Neurosci 22, 474480.
130. Ikemoto, A, Nitta, A, Furukawa, S et al. (2000) Dietary n-3 fatty acid deficiency decreases nerve growth factor content in rat hippocampus. Neurosci Lett 285, 99–102.
131. Okada, M, Amamoto, T, Tomonaga, M et al. (1996) The chronic administration of docosahexaenoic acid reduces the spatial cognitive deficit following transient forebrain ischemia in rats. Neuroscience 71, 1725.
132. He, K, Song, Y, Daviglus, ML et al. (2004) Fish consumption and incidence of stroke: A meta-analysis of cohort studies. Stroke 35, 15381542.
133. Barberger-Gateau, P, Letenneur, L, Deschamps, V et al. (2002) Fish, meat, and risk of dementia: Cohort study. Br Med J 325, 932933.
134. Huang, TL, Zandi, PP, Tucker, KL et al. (2005) Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology 65, 14091414.
135. Kalmijn, S, Launer, LJ, Ott, A et al. (1997) Dietary fat intake and the risk of incident dementia in the Rotterdam study. Ann Neurol 42, 776782.
136. Morris, MC, Evans, DA, Bienias, JL et al. (2003) Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 60, 940946.
137. Schaefer, EJ, Bongard, V, Beiser, AS et al. (2006) Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: The Framingham Heart Study. Arch Neurol 63, 15451550.
138. Larrieu, S, Letenneur, L, Helmer, C et al. (2004) Nutritional factors and risk of incident dementia in the PAQUID longitudinal cohort. J Nutr Health Aging 8, 150154.
139. Gillum, RF, Mussolino, ME & Madans, JH (1996) The relationship between fish consumption and stroke incidence. The NHANES I Epidemiologic Follow-up Study (National Health and Nutrition Examination Survey). Arch Intern Med 156, 537542.
140. Iso, H, Rexrode, KM, Stampfer, MJ et al. (2001) Intake of fish and omega-3 fatty acids and risk of stroke in women. JAMA 285, 304312.
141. Keli, SO, Feskens, EJ & Kromhout, D (1994) Fish consumption and risk of stroke. The Zutphen Study. Stroke 25, 328332.
142. Orencia, AJ, Daviglus, ML, Dyer, AR et al. (1996) Fish consumption and stroke in men. 30-year findings of the Chicago Western Electric Study. Stroke 27, 204209.
143. Morris, MC, Evans, DA, Tangney, CC et al. (2005) Fish consumption and cognitive decline with age in a large community study. Arch Neurol 62, 18491853.
144. Devore, EE, Grodstein, F, van Rooij, FJ et al. (2009) Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. Am J Clin Nutr 90, 170176.
145. Barberger-Gateau, P, Raffaitin, C, Letenneur, L et al. (2007) Dietary patterns and risk of dementia: The Three-City cohort study. Neurology 69, 19211930.
146. Belin, RJ, Greenland, P, Martin, L et al. (2011) Fish intake and the risk of incident heart failure: The Women's Health Initiative. Circ Heart Fail 4, 404413.
147. Quinn, JF, Raman, R, Thomas, RG et al. (2010) Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: A randomized trial. JAMA 304, 19031911.
148. van de Rest, O, Geleijnse, JM, Kok, FJ et al. (2008) Effect of fish oil on cognitive performance in older subjects: A randomized, controlled trial. Neurology 71, 430438.
149. van Gelder, BM, Tijhuis, M, Kalmijn, S et al. (2007) Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: The Zutphen Elderly Study. Am J Clin Nutr 85, 11421147.
150. Whalley, LJ, Deary, IJ, Starr, JM et al. (2008) n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: An observational follow-up study in late adulthood. Am J Clin Nutr 87, 449454.
151. Hunter, D. (1998) Biochemical indicators of dietary intake. In Nutritional Epidemiology , pp. 174243 [Willett, WC]. New York: Oxford University Press.
152. Molloy, AM & Scott, JM (2001) Folates and prevention of disease. Public Health Nutr 4, 601609.
153. Quinivan, EP & Gregory, JF (2003) Effect of food fortification on folic acid intakes in the United States. Am J Clin Nutr 77, 221226.
154. Kalmbach, RD, Choumenkovitch, SF, Troen, AM et al. (2008) Circulating folic acid in plasma: Relation to folic acid fortification. Am J Clin Nutr 88, 763768.
155. Herbert, V & Das, KC. (1994) Folic Acid and Vitamin B12. In Modern Nutrition in Health and Disease , 8th ed., p. 402425 [Shils, M, Olson, JA & Shike, M]. Philadelphia: Lea & Febiger.
156. Savage, DG & Lindenbaum, J (1995) Neurological complications of acquired cobalamin deficiency: Clinical aspects. [Review] [114 refs]. Baillieres Clin Haematol 8, 657678.
157. Carmel, R (1997) Cobalamin, the stomach, and aging. Am J Clin Nutr 66, 750759.
158. Pfeiffer, CM, Caudill, SP, Gunter, EW et al. (2005) Biochemical indicators of B vitamin status in the US population after folic acid fortification: Results from the National Health and Nutrition Examination Survey 1999–2000. Am J Clin Nutr 82, 442450.
159. Seshadri, S, Beiser, A, Selhub, J et al. (2002) Plasma homocysteine as a risk factor dementia and Alzheimer's disease. N Engl J Med 346, 476483.
160. Haan, MN, Miller, JW, Aiello, AE et al. (2007) Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: Results from the Sacramento Area Latino Study on Aging. Am J Clin Nutr 85, 511517.
161. Luchsinger, JA, Tang, MX, Shea, S et al. (2004) Plasma homocysteine levels and risk of Alzheimer disease. Neurology 62, 19721976.
162. Ho, PI, Collins, SC, Dhitavat, S et al. (2001) Homocysteine potentiates beta-amyloid neurotoxicity: Role of oxidative stress. J Neurochem 78, 249253.
163. Tchantchou, F & Shea, TB (2008) Folate deprivation, the methionine cycle, and Alzheimer's disease. Vitam Horm 79, 8397.
164. Mooijaart, SP, Gussekloo, J, Frolich, M et al. (2005) Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: The Leiden 85-Plus study. Am J Clin Nutr 82, 866871.
165. Tucker, KL, Qiao, N, Scott, T et al. (2005) High homocysteine and low B vitamins predict cognitive decline in aging men: The Veterans Affairs Normative Aging Study. Am J Clin Nutr 82, 627635.
166. Kado, DM, Karlamangla, AS, Huang, MH et al. (2005) Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med 118, 161167.
167. Kim, JM, Kim, SW, Shin, IS et al. (2008) Folate, vitamin b(12), and homocysteine as risk factors for cognitive decline in the elderly. Psychiatry Invest 5, 3640.
168. Morris, MC, Evans, DA, Bienias, JL et al. (2005) Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol 62, 641645.
169. Tangney, CC, Tang, Y, Evans, DA et al. (2009) Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline. Neurology 72, 361367.
170. Clarke, R, Birks, J, Nexo, E et al. (2007) Low vitamin B-12 status and risk of cognitive decline in older adults. Am J Clin Nutr 86, 13841391.
171. Kang, JH, Irizarry, MC & Grodstein, F (2006) Prospective study of plasma folate, vitamin B12, and cognitive function and decline. Epidemiology 17, 650657.
172. Garcia, AA, Haron, Y, Evans, LR et al. (2004) Metabolic markers of cobalamin deficiency and cognitive function in normal older adults. J Am Geriatr Soc 52, 6671.
173. Teunissen, CE, Blom, AH, van Boxtel, MP et al. (2003) Homocysteine: A marker for cognitive performance? A longitudinal follow-up study. J Nutr Health Aging 7, 153159.
174. McCaddon, A, Hudson, P, Abrahamsson, L et al. (2001) Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease. Dement Geriatr Cogn Disord 12, 133137.
175. Morris, MS, Jacques, PF, Rosenberg, IH et al. (2007) Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 85, 193200.
176. Luchsinger, JA, Tang, MX, Miller, J et al. (2007) Relation of higher folate intake to lower risk of Alzheimer disease in the elderly. Arch Neurol 64, 8692.
177. Ravaglia, G, Forti, P, Maioli, F et al. (2005) Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 82, 636643.
178. Corrada, MM, Kawas, CH, Hallfrisch, J et al. (2005) Reduced risk of Alzheimer's disease with high folate intake: The Baltimore Longitudinal Study of Aging. Alzheimers Dement 1, 1118.
179. Wang, HX, Wahlin, A, Basun, H et al. (2001) Vitamin B(12) and folate in relation to the development of Alzheimer's disease. Neurology 56, 11881194.
180. Kim, JM, Stewart, R, Kim, SW et al. (2008) Changes in folate, vitamin B12 and homocysteine associated with incident dementia. J Neurol Neurosurg Psychiatry 79, 864868.
181. Morris, MC, Evans, DA, Bienias, JL et al. (2004) Dietary niacin and risk of incident Alzheimer's disease and of cognitive decline. J Neurol Neurosurg Psychiatry 75, 10931099.
182. Nelson, C, Wengreen, HJ, Munger, RG et al. (2009) Dietary folate, vitamin B-12, vitamin B-6 and incident Alzheimer's disease: The cache county memory, health and aging study. J Nutr Health Aging 13, 899905.
183. Durga, J, van Boxtel, MP, Schouten, EG et al. (2007) Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: A randomised, double blind, controlled trial. Lancet 369, 208216.
184. de Jager, CA, Oulhaj, A & Jacoby, R (2011) Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: A randomized controlled trial. Int J Geriatr Psychiatry (Epublication ahead of print version).
185. McMahon, JA, Green, TJ & Skeaff, CM (2006) A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 354, 27642772.
186. Kang, JH, Cook, N, Manson, J et al. (2008) A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Am J Clin Nutr 88, 16021610.
187. Smith, AD, Smith, SM, de Jager, CA et al. (2010) Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: A randomized controlled trial. PLoS ONE 5, e12244.
188. Chodos, RB & Ross, JF (1951) The effects of combined folic acid and liver extract therapy. Blood 6, 12131233.
189. Scarmeas, N, Stern, Y & Mayeux, R (2009) Mediterranean diet and mild cognitive impairment. Arch Neurol 66, 216225.
190. Feart, C, Samieri, C, Rondeau, V et al. (2009) Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA 302, 638648.
191. Tangney, CC, Kwasny, MJ, Li, H et al. (2011) Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population. Am J Clin Nutr 93, 601607.
192. Scarmeas, N, Stern, Y, Mayeux, R et al. (2006) Mediterranean diet, Alzheimer disease, and vascular mediation. Arch Neurol 63, 17091717.
193. Sundelof, J, Kilander, L, Helmersson, J et al. (2009) Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: A prospective population-based study. J Alzheimers Dis 18, 7178.
194. Wengreen, HJ, Munger, RG, Corcoran, CD et al. (2007) Antioxidant intake and cognitive function of elderly men and women: The Cache County Study. J Nutr Health Aging 11, 230237.
195. Morris, MC, Evans, DA, Tangney, CC et al. (2005) Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am J Clin Nutr 81, 508514.
196. Commenges, D, Scotet, V, Renaud, S et al. (2000) Intake of flavonoids and risk of dementia. Eur J Epidemiol 16, 357363.
197. Berr, C, Balansard, B, Arnaud, J et al. (2000) Cognitive decline is associated with systemic oxidative stress: The EVA study. Etude du Vieillissement Arteriel. J Am Geriatr Soc 48, 12851291.
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Proceedings of the Nutrition Society
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  • EISSN: 1475-2719
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