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Nutritional influences on epigenetics and age-related disease

  • Lara K. Park (a1) (a2), Simonetta Friso (a3) and Sang-Woon Choi (a1) (a2)
  • DOI: http://dx.doi.org/10.1017/S0029665111003302
  • Published online: 04 November 2011
Abstract

Nutritional epigenetics has emerged as a novel mechanism underlying gene–diet interactions, further elucidating the modulatory role of nutrition in aging and age-related disease development. Epigenetics is defined as a heritable modification to the DNA that regulates chromosome architecture and modulates gene expression without changes in the underlying bp sequence, ultimately determining phenotype from genotype. DNA methylation and post-translational histone modifications are classical levels of epigenetic regulation. Epigenetic phenomena are critical from embryonic development through the aging process, with aberrations in epigenetic patterns emerging as aetiological mechanisms in many age-related diseases such as cancer, CVD and neurodegenerative disorders. Nutrients can act as the source of epigenetic modifications and can regulate the placement of these modifications. Nutrients involved in one-carbon metabolism, namely folate, vitamin B12, vitamin B6, riboflavin, methionine, choline and betaine, are involved in DNA methylation by regulating levels of the universal methyl donor S-adenosylmethionine and methyltransferase inhibitor S-adenosylhomocysteine. Other nutrients and bioactive food components such as retinoic acid, resveratrol, curcumin, sulforaphane and tea polyphenols can modulate epigenetic patterns by altering the levels of S-adenosylmethionine and S-adenosylhomocysteine or directing the enzymes that catalyse DNA methylation and histone modifications. Aging and age-related diseases are associated with profound changes in epigenetic patterns, though it is not yet known whether these changes are programmatic or stochastic in nature. Future work in this field seeks to characterise the epigenetic pattern of healthy aging to ultimately identify nutritional measures to achieve this pattern.

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Corresponding author
*Corresponding author: Dr Sang-Woon Choi, fax +1 617 556 3234, email sang.choi@tufts.edu
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1.BD Juran & KN Lazaridis (2011) Genomics in the post-GWAS era. Semin Liver Dis 31, 215222.

2.VK Rakyan , TA Down , DJ Balding (2011) Epigenome-wide association studies for common human diseases. Nat Rev Genet 12, 529541.

3.JW Crott , SW Choi , JM Ordovas (2004) Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis. Carcinogenesis 25, 6976.

4.SW Choi & S Friso (2010) Epigenetics: a new bridge between nutrition and health. Adv Nutr 1, 8–16.

5.X Cheng & RM Blumenthal (2010) Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry 49, 29993008.

6.KC Kim , S Friso & SW Choi (2009) DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging. J Nutr Biochem 20, 917926.

8.AR Cyr & FE Domann (2011) The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal 15, 551589.

9.D Zilberman & S Henikoff (2007) Genome-wide analysis of DNA methylation patterns. Development 134, 39593965.

11.AS Tibbetts & DR Appling (2010) Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu Rev Nutr 30, 5781.

12.O Taban-Shomal , H Kilter , A Wagner (2009) The cardiac effects of prolonged vitamin B12 and folate deficiency in rats. Cardiovasc Toxicol 9, 95–102.

13.J-M Kim , K Hong , JH Lee (2009) Effect of folate deficiency on placental DNA methylation in hyperhomocysteinemic rats. J Nutr Biochem 20, 172176.

17.MD Niculescu , CN Craciunescu & SH Zeisel (2006) Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J 20, 4349.

18.IP Pogribny , SA Ross , C Wise (2006) Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutat Res 593, 8087.

19.IP Pogribny , SA Ross , VP Tryndyak (2006) Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Carcinogenesis 27, 11801186.

20.VP Tryndyak , SA Ross , FA Beland (2009) Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Mol Carcinog 48, 479487.

23.F Pizzolo , HJ Blom , SW Choi (2011) Folic acid effects on S-adenosylmethionine, S-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia. J Amer Coll Nutr 30, 1118.

26.J Liu , R Pickford , AP Meagher (2011) Quantitative analysis of tissue folate using ultra high-performance liquid chromatography tandem mass spectrometry. Anal Biochem 411, 210217.

28.HS Cheong , HC Lee , BL Park (2010) Epigenetic modification of retinoic acid-treated human embryonic stem cells. BMB Rep 43, 830835.

29.S Das , N Foley , K Bryan (2010) MicroRNA mediates DNA demethylation events triggered by retinoic acid during neuroblastoma cell differentiation. Cancer Res 70, 78747881.

30.SE Jackson-Rosario & WT Self (2010) Targeting selenium metabolism and selenoproteins: Novel avenues for drug discovery. Metallomics 2, 112116.

33.EO Uthus , SA Ross & CD Davis (2006) Differential effects of dietary selenium (se) and folate on methyl metabolism in liver and colon of rats. Biol Trace Elem Res 109, 201214.

34.H Zeng , L Yan , W-H Cheng (2011) Dietary selenomethionine increases exon-specific DNA methylation of the p53 gene in rat liver and colon mucosa. J Nutr 141, 14641468.

35.SA Lamprecht & M Lipkin (2003) Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat Rev Cancer 3, 601614.

36.B Stefanska , K Rudnicka , A Bednarek (2010) Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells. Eur J Pharmacol 638, 4753.

38.CD Davis & SA Ross (2007) Dietary components impact histone modifications and cancer risk. Nutr Rev 65, 8894.

39.SM Meeran , A Ahmed & TO Tollefsbol (2010) Epigenetic targets of bioactive dietary components for cancer prevention and therapy. Clin Epigenetics 1, 101116.

40.Y Zhang & H Chen (2011) Genistein, an epigenome modifier during cancer prevention. Epigenetics 6, 888891.

41.DC Dolinoy , JR Weidman , RA Waterland (2006) Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect 114, 567572.

42.N Sato , N Yamakawa , M Masuda (2011) Genome-wide DNA methylation analysis reveals phytoestrogen modification of promoter methylation patterns during embryonic stem cell differentiation. PLoS One 6, e19278.

43.MZ Fang , D Chen , Y Sun (2005) Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. Clin Cancer Res 11, 70337041.

48.M Suganuma , A Saha & H Fujiki (2011) New cancer treatment strategy using combination of green tea catechins and anticancer drugs. Cancer Sci 102, 317323.

49.WJ Lee , J-Y Shim & BT Zhu (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol Pharmacol 68, 10181030.

50.V Nandakumar , M Vaid & SK Katiyar (2011) (−)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. Carcinogenesis 32, 537544.

51.CP Wong , LP Nguyen , SK Noh (2011) Induction of regulatory T cells by green tea polyphenol EGCG. Immunol Lett 139, 7–13.

53.S Fu & R Kurzrock (2010) Development of curcumin as an epigenetic agent. Cancer 116, 46704676.

54.A King-Batoon , JM Leszczynska & CB Klein (2008) Modulation of gene methylation by genistein or lycopene in breast cancer cells. Environ Mol Mutagen 49, 3645.

55.SM Meeran , SN Patel & TO Tollefsbol (2010) Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS ONE 5, e11457.

56.M Esteller (2007) Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 8, 286298.

57.HJ Kee & H Kook (2011) Roles and targets of class I and IIa histone deacetylases in cardiac hypertrophy. J Biomed Biotechnol 2011, 928326.

58.ML North & AK Ellis (2011) The role of epigenetics in the developmental origins of allergic disease. Ann Allergy Asthma Immunol 106, 355361.

59.D Bandyopadhyay & EE Medrano (2003) The emerging role of epigenetics in cellular and organismal aging. Exp Gerontol 38, 12991307.

60.W An (2007) Histone acetylation and methylation. In Chromatin and Disease 41(III), 355374.

61.A Alvaro , R Solà , R Rosales (2008) Gene expression analysis of a human enterocyte cell line reveals downregulation of cholesterol biosynthesis in response to short-chain fatty acids. IUBMB Life 60, 757764.

62.MG Riggs , RG Whittaker , JR Neumann (1997). n-Butyrate causes histone modification in HeLa and friend erythroleukaemia cells. Nature 268, 462464.

63.JY Fang (2005) Histone deacetylase inhibitors, anticancerous mechanism and therapy for gastrointestinal cancers. J Gastroenterol Hepatol 20, 988994.

64.A Goel & BB Aggarwal (2010) Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer 62, 919930.

66.S-K Kang , S-H Cha & H-G Jeon (2006) Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells. Stem Cells Dev 15, 165174.

67.S Gravina & J Vijg (2010) Epigenetic factors in aging and longevity. Pflügers Archiv 459, 247258.

69.BI Richardson (2003) Impact of aging on DNA methylation. Ageing Res Rev 2, 245261.

70.J Golbus , TD Palella & BC Richardson (1990) Quantitative changes in T cell DNA methylation occur during differentiation and ageing. Eur J Immunol 20, 18691872.

71.RF Thompson , G Atzmon , C Gheorghe (2010) Tissue-specific dysregulation of DNA methylation in aging. Aging Cell 9, 506518.

74.K Wallace , MV Grau , AJ Levine (2010) Association between folate levels and CpG island hypermethylation in normal colorectal mucosa. Cancer Prev Res 3, 15521564.

75.AW Burgess , MC Faux , M Layton , (2011) Wnt signaling and colon tumorigenesis – a view from the periphery. Exp Cell Res (Epublication ahead of print version).

76.JP Issa , YL Ottaviano , P Celano (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 7, 536540.

78.J Feser , D Truong , C Das (2010) Elevated histone expression promotes life span extension. Mol Cell 39, 724735.

79.MC Haigis & DA Sinclair (2010) Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5, 253295.

80.A Vaquero , R Sternglanz & D Reinberg (2007) NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs. Oncogene 26, 55055520.

82.S Chung , H Yao , S Caito Regulation of SIRT1 in cellular functions: Role of polyphenols. Arch Biochem Biophys 501, 7990.

83.Z Li , C Liu , Z Xie (2011) Epigenetic dysregulation in mesenchymal stem cell aging and spontaneous differentiation. PLoS ONE 6, e20526.

85.D Stipp (2011) Linking nutrition, maturation and aging: from thrifty genes to the spendthrift phenotype. Aging 3, 8593.

86.SH Zeisel (2009) Epigenetic mechanisms for nutrition determinants of later health outcomes. Am J Clin Nutr 89, 1488S1493S.

87.AP Feinberg (2008) Epigenetics at the epicenter of modern medicine. JAMA 299, 13451350.

88.KK Sie , A Medline , J van Weel (2011) Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring. Gut (Epublication before print version).

89.A Ly , H Lee , J Chen (2011) Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring. Cancer Res 71, 988997.

90.RN Saha & K Pahan (2006) HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis. Cell Death Differ 13, 539550.

91.S Peleg , F Sananbenesi , A Zovoilis (2010) Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328, 753756.

93.N Tanji , A Ozawa , T Kikugawa , (2011) Potential of histone deacetylase inhibitors for bladder cancer treatment. Exp Rev Anticancer Ther 11, 959965.

96.JD Clarke , A Hsu , Z Yu (2011) Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res 55, 999–1009.

98.SJ Lee , C Krauthauser , V Maduskuie (2011) Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo. BMC Cancer 11, 144157.

99.J Ren , L Pulakat , A Whaley-Connell (2010) Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. J Mol Med 88, 993–1001.

100.ME Cooper & A El-Osta (2010) Epigenetics: mechanisms and implications for diabetic complications. Circ Res 107, 14031413.

102.Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (2003) Sustained effect of intensive treatment of Type 1 diabetes mellitus on development and progression of diabetic nephropathy. JAMA 290, 21592167.

103.R Teperino , K Schoonjans & J Auwerx (2010) Histone methyl transferases and demethylases; can they link metabolism and transcription? Cell Metab 12, 321327.

104.S Tonstad & J-P Després (2011) Treatment of lipid disorders in obesity. Exp Rev Cardiovasc 9, 10691080.

105.PD N'Guessan , F Riediger , K Vardarova (2009) Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. Arterioscler Thromb Vasc Biol 29, 380386.

106.FE Alkemade , P van Vliet , P Henneman (2010) Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature. Am J Pathol 176, 542548.

107.KM Aagaard-Tillery , K Grove , J Bishop (2008) Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol 41, 91–102.

108.AP Feinberg (2007) Phenotypic plasticity and the epigenetics of human disease. Nature 447, 433440.

109.MJR Heerwagen , MR Miller , LA Barbour (2010) Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol 299, R711R722.

81.W Dang , KK Steffen , R Perry (2009) Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459, 802807.

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