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Physical activity and resting metabolic rate

  • John R. Speakman (a1) (a2) and Colin Selman (a2)

The direct effects of physical activity interventions on energy expenditure are relatively small when placed in the context of total daily energy demands. Hence, the suggestion has been made that exercise produces energetic benefits in other components of the daily energy budget, thus generating a net effect on energy balance much greater than the direct energy cost of the exercise alone. Resting metabolic rate (RMR) is the largest component of the daily energy budget in most human societies and, therefore, any increases in RMR in response to exercise interventions are potentially of great importance. Animal studies have generally shown that single exercise events and longer-term training produce increases in RMR. This effect is observed in longer-term interventions despite parallel decreases in body mass and fat mass. Flight is an exception, as both single flights and long-term flight training induce reductions in RMR. Studies in animals that measure the effect of voluntary exercise regimens on RMR are less commonly performed and do not show the same response as that to forced exercise. In particular, they indicate that exercise does not induce elevations in RMR. Many studies of human subjects indicate a short-term elevation in RMR in response to single exercise events (generally termed the excess post-exercise O2 consumption; EPOC). This EPOC appears to have two phases, one lasting 2 h and a smaller much more prolonged effect lasting up to 48 h. Many studies have shown that long-term training increases RMR, but many other studies have failed to find such effects. Data concerning long-term effects of training are potentially confounded by some studies not leaving sufficient time after the last exercise bout for the termination of the long-term EPOC. Long-term effects of training include increases in RMR due to increases in lean muscle mass. Extreme interventions, however, may induce reductions in RMR, in spite of the increased lean tissue mass, similar to the changes observed in animals in response to flight.

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Corresponding author
*Corresponding author: Professor John Speakman, fax +44 1224 272396,
Present address: Insulin and Growth Factor Signalling Group, Department of Metabolic Medicine, Imperial College Faculty of Medicine, London W12 ONN, UK.
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TK Abdel-Hamid (2003) Exercise and diet in obesity treatment: An integrative system dynamics perspective. Medicine and Science in Sports and Exercise 35, 400414.

N Almeras , N Mimeault , O Serresse , MR Boulay & A Tremblay (1991) Non-exercise daily energy-expenditure and physicalactivity pattern in male endurance athletes. European Journal of Applied Physiology and Occupational Physiology 63, 184187.

A Astrup , S Toubro , LT Dalgaard , SA Urhammer , TI Sorensen & O Pedersen (1999) Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidation. International Journal of Obesity and Related Metabolic Disorders 23, 10301034.

R Bahr , P Hansson & OM Sejersted (1990) Triglyceride/fatty acid cycling is increased after exercise. Metabolism 39, 993999.

EJ Baker & TT Gleeson (1998) EPOC and the energetics of brief locomotor activity in. Mus domesticus. Journal of Experimental Zoology 280, 114120.

P Barbe , L Millet , D Larrouy , J Galitzky , M Berlan , J Louvet & D Langin (1998). Uncoupling protein-2 messenger ribonucleic acid expression during very-low-calorie diet in obese premenopausal women. Journal of Clinical Endocrinology and Metabolism 83, 24502453.

CS Berkey , HRH Rockett , MW Gillman , GA Colditz (2003) One-year changes in activity and in inactivity among 10-to 15-year-old boys and girls: Relationship to change in body mass index. Pediatrics 111, 836843.

CA Binzen , PD Swan & MM Manore (2001) Postexercise oxygen consumption and substrate use after resistance exercise in women. Medicine and Science in Sports and Exercise 33, 932938.

E Borsheim , S Knardahl , AT Hostmark & R Bahr (1998) Adrenergic control of post-exercise metabolism. Acta Physiologica Scandinavica 162, 313323.

C Bouchard , L Perusse , YC Chagnon , C Warden & D Ricquier (1997) Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Human Molecular Genetics 6, 18871889.

JB Brill , AC Perry , L Parker , A Robinson & K Burnett (2002) Doseresponse effect of walking exercise on weight loss. How much is enough?. International Journal of Obesity 26, 14841493.

NS Brown , A Smart , V Sharma , ML Brinkmeier , L Greenlee , SA Camper , DR Jensen , RH Eckel , W Krezel , P Chambon & BR Haugen (2000) Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse. Journal of Clinical Investigation 106, 7379.

KO Case , J Brahler & C Heiss (1997) Resting energy expenditures in Asian women measured by indirect calorimetry are lower than expenditures calculated from prediction equations. Journal of the American Dietetic Association 97, 12881292.

C Cavadini , AM Siega-Riz & BM Popkin (2000) US adolescent food intake trends from 1965 to 1996. Western Journal of Medicine 173, 378383.

DA Crawford , RW Jeffery & SA French (1999) Television viewing, physical inactivity and obesity. International Journal of Obesity 23, 437440.

S Davies , RH Dressendorfer , CX Gao , J Yanez , LS Carr & GC Timmis (1985) Preservation of lean body-mass and resting metabolic-rate during weight-reduction in obese women. Medicine and Science in Sports and Exercise 17, 243.

A De Lorenzo , A Tagliabue , A Andreoli , G Testolin , M Cornelli & P Durenberg (2001) Measured and predicted resting metabolic rate in Italian males and females, aged 18–59 y. European Journal of Clinical Nutrition 55, 208214.

BA Dennison , TA Erb & PL Jenkins (2002) Television viewing and television in bedroom associated with overweight risk among low-income preschool children. Pediatrics 109, 10281035.

BA Dolezal , JA Potteiger , DJ Jacobsen & SH Benedict (2000) Muscle damage and resting metabolic rate after acute resistance exercise with an eccentric overload. Medicine and Science in Sports and Exercise 32, 12021207.

G Dubnov , A Brzezinski & EM Berry (2003) Weight control and the management of obesity after menopause: the role of physical activity. Maturitas 44, 89101.

JC Eisenmann , RT Bartee & MQ Wang (2002) Physical activity TV viewing, and weight in US youth: 1999 youth risk behavior survey. Obesity Research 10, 379385.

MS Faith , N Berman , MS Heo , A Pietrobelli , D Gallagher , LH Epstein , MT Eiden & DB Allison (2001) Effects of contingent television on physical activity and television viewing in obese children. Pediatrics 107, 10431048.

DC Frankenfield , ER Muth & WA Rowe (1998) The Harris-Benedict studies of human basal metabolism: History and limitations. Journal of the American Dietetic Association 98, 439445.

HC Freake & JH Oppenheimer (1995) Thermogenesis and thyroid function. Annual Review of Nutrition 15, 263291.

GA Gaesser & GA Brooks (1984) Metabolic bases of excess postexercise oxygen consumption: a review. Medicine and Science in Sports and Exercise 16, 2943.

T Garland , MT Morgan , JG Swallow , JS Rhodes , I Girard , JG Belter & PA Carter (2002) Evolution of a small-muscle polymorphism in lines of house mice selected for high activity levels. Evolution 56, 12671275.

M Gilliat-Wimberly , MM Manore , K Woolfe , PD Swan & SS Carroll (2001) Effects of habitual physical activity on the resting metabolic rates and body compositions of women aged 35 to 50 years. Journal of the American Dietetic Association 101, 11811188.

CL Goodrick (1980) Effects of long-term voluntary wheel exercise on male and female Wistar rats. I. Longevity, body weight, and metabolic rate. Gerontology 26, 2233.

SL Gortmaker , K Peterson , J Wiecha , AM Sobol , S Dixit , MK Fox & N Laird (1999) Reducing obesity via a school-based interdisciplinary intervention among youth – Planet health. Archives of Pediatrics and Adolescent Medicine 153, 409418.

S Heshka , K Feld , MU Yang , DB Allison & SB Heymsfield (1993) Resting energy-expenditure in the obese – a cross-validation and comparison of prediction equations. Journal of the American Dietetic Association 93, 10311036.

JO Hill , JR Davis , AR Tagliaferro & J Stewart (1984) Dietary obesity and exercise in young rats. Physiology and Behaviour 33, 321328.

JO Holloszy (1993) Exercise increases average longevity of female rats despite increased food intake and no growth retardation. Journal of Gerontology 48, B97B100.

M Ichikawa , Y Fujita , H Ebisawa & T Ozeki (2000) Effects of longterm, light exercise under restricted feeding on age-related changes in physiological and metabolic variables in male Wistar rats. Mechanisms of Ageing and Development 113, 2335.

JM Jakicic & KI Gallagher (2003) Exercise considerations for the sedentary, overweight adult. Exercise and Sport Sciences Reviews 31, 9195.

JM Jakicic , RR Wing & C Winters-Hart (2002) Relationship of physical activity to eating behaviors and weight loss in women. Medicine and Science in Sports and Exercise 34, 16531659.

KF Janz , SM Levy , TL Burns , JC Torner , MC Willing & JJ Warren (2002) Fatness, physical activity, and television viewing in children during the adiposity rebound period: The Iowa bone development study. Preventive Medicine 35, 563571.

OJ Kemi , JP Loennechen , U Wisloff & O Ellingsen (2002) Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy. Journal of Applied Physiology 93, 13011309.

WJ Kraemer , BJ Noble , MJ Clark & BW Culver (1987) Physiologic responses to heavy-resistance exercise with very short rest periods. International Journal of Sports Medicine 8, 247252.

I Lerman , BC Harrison , K Freeman , TE Hewett , DL Allen , J Robbins & LA Leinwand (2002) Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains. Journal of Applied Physiology 92, 22452255.

JA Levine (2002) Non-exercise activity thermogenesis (NEAT). Best Practice and Research Clinical Endocrinology and Metabolism 16, 679702.

JA Levine , NL Eberhardt & MD Jensen (1999) Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 283, 212214.

R Lowry , H Wechsler , DA Galuska , JE Fulton & L Kann (2002) Television viewing and its associations with overweight, sedentary lifestyle, and insufficient consumption of fruits and vegetables among US high school students: Differences by race, ethnicity, and gender. Journal of School Health 72, 413421.

AH Mokdad , MK Serdula , WH Dietz , BA Bowman , JS Marks & JP Koplan (2000) The continuing epidemic of obesity in the United States. Journal of the American Medical Association 284, 16501651.

M Moreno , A Lombardi , L Beneduce , E Silvestri , G Pinna , F Goglia & A Lanni (2002) Are the effects of T-3 on resting metabolic rate in euthyroid rats entirely caused by T–3 itself?. Endocrinology 143, 504510.

KA Nagy , IA Girard & TK Brown (1999) Energetics of freeranging mammals, reptiles, and birds. Annual Review of Nutrition 19, 247277.

SJ Nielsen , AM Siega-Riz & BM Popkin (2002) Trends in energy intake in US between 1977 and 1996: Similar shifts seen across age groups. Obesity Research 10, 370378.

RL Nudds & DM Bryant (2002) Exercise training lowers the resting metabolic rate of zebra finches Taeniopygia guttata. Functional Ecology 15, 458464.

T Piersma , GA Gudmundsson & K Lilliendahl (1999) Rapid changes in the size of different functional organ and muscle groups during refueling in a long-distance migrating shorebird. Physiological and Biochemical Zoology 72, 405415.

ET Poehlman , CL Melby & SF Badylak (1991) Relation of age and physical exercise status on metabolic-rate in younger and older healthy-men. Journal of Gerontology 46, B54B58.

ET Poehlman , CL Melby , SF Badylak & J Calles (1989) Aerobic fitness and resting energy-expenditure in young-adult males. Metabolism 38, 8590.

RE Ricklefs , M Konarzewski & S Daan (1996) The relationship between basal metabolic rate and daily energy expenditure in birds and mammals. American Naturalist 147, 10471071.

AP Russell , G Wadley , MKC Hesselink , G Schaart , S Lo , B Leger , A Garnham , E Kornips , D Cameron-Smith , JP Giacobino , P Muzzin , R Snow & P Schrauwen (2003) UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects. European Journal of Physiology 445, 563569.

J Salmon , N Owen , A Bauman , MKH Schmitz & M Booth (2000) Leisure-time, occupational, and household physical activity among professional, skilled, and less-skilled workers and homemakers. Preventive Medicine 30, 191199.

P Schrauwen , WHM Saris & MKC Hesselink (2001) An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix. FASEB Journal 15, 24972502.

C Selman JS McLaren , AR Collins , GG Duthie & JR Speakman (2002) Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running. Archives of Biochemistry and Biophysics 401, 255261.

JR Speakman (2000) The cost of living: Field metabolic rates of small mammals. Advances in Ecological Research 30, 177297.

JR Speakman & PA Racey (1991) No cost of echolocation for bats in flight. Nature 350, 421423.

MJ Toth , CK Sites & ET Poehlman (1999) Hormonal and physiological correlates of energy expenditure and substrate oxidation in middle-aged, premenopausal women. Journal of Clinical Endocrinology and Metabolism 84, 27712775.

A Tremblay , S Coveney , JP Despres , A Nadeau & D Prud'homme (1992) Increased resting metabolic rate and lipid oxidation in exercise-trained individuals: evidence for a role of betaadrenergic stimulation. Canadian Journal of Physiology and Pharmacology 70, 13421347.

A Tremblay , JP Despres & C Bouchard (1985) The effects of exercise-training on energy-balance and adipose-tissue morphology and metabolism. Sports Medicine 2, 223233.

LA Tucker & M Bagwell (1991) Television viewing and obesity in adult females. American Journal of Public Health 81, 908911.

GE van der Ploeg , SM Gunn , RT Withers , AC Modra , JP Keeves & BE Chatterton (2001) Predicting the resting metabolic rate of young Australian males. European Journal of Clinical Nutrition 55, 145152.

GE van der Ploeg & RT Withers (2002) Predicting the resting metabolic rate of 30–60-year-old Australian males. European Journal of Clinical Nutrition 56, 701708.

LMLA Van Etten , KR Westerterp & FTJ Verstappen (1995) Effect of weight-training on energy-expenditure and substrate utilization during sleep. Medicine and Science in Sports and Exercise 27, 188193.

RE Van Pelt , PP Jones , KP Davy , CA Desouza , H Tanaka , BM Davy & DR Seals (1997) Regular exercise and the age-related decline in resting metabolic rate in women. Journal of Clinical Endocrinology and Metabolism 82, 32083212.

AJ Vidal-Puig , D Grujic , CY Zhang , T Hagen , O Boss , Y Ido , A Szczepanik , J Wade , V Mootha , R Cortright , DM Muoio & BB Lowell (2000) Energy metabolism in uncoupling protein 3 gene knockout mice. Journal of Biological Chemistry 275, 1625816266.

J Vioque , A Torres & J Quiles (2000) Time spent watching television, sleep duration and obesity in adults living in Valencia Spain. International Journal of Obesity 24, 16831688.

WC Willett & RL Leibel (2002) Dietary fat is not a major determinant of body fat. American Journal of Medicine 113, 4759.

K Zhang , M Sun , P Werner , AJ Kovera , J Albu , FX Pi-Sunyer & CN Boozer (2002) Sleeping metabolic rate in relation to body mass index and body composition. International Journal of Obesity 26, 376383.

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