Skip to main content
×
×
Home

Physiological regulation of NEFA availability: lipolysis pathway

  • V. Stich (a1) and M. Berlan (a2)
Abstract

Plasma NEFA are an important energy substrate and, furthermore, play a key role in the induction of insulin resistance in the body. The availability of NEFA is determined predominantly by their mobilization from adipose tissue triacylglycerol stores by the process of lipolysis. Adipose tissue lipolysis in man is regulated by a number of hormonal and paracrine and/or autocrine signals. The main hormonal signals may be represented by catecholamines, insulin, growth hormone, natriuretic peptides and some adipocytokines. The absolute levels and relative importance and contribution of these signals vary in different physiological situations, with diet and physical exercise being the main physiological variables that affect the hormonal signalling. Thus, modulations in hormonal signals induce an increase in NEFA mobilization in the post-absorptive state and during an acute bout of exercise, and suppress NEFA mobilization in the postprandial state. In addition, hormonal regulation is modified by long-term interventions in energy balance, such as dietary restriction and/or physical training, and is disturbed in some pathological states, such as obesity or diabetes. The question that remains is whether disturbances in lipolysis regulation in obese and diabetic subjects may be ‘corrected’ by the long-term interventions in diet and physical activity.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Physiological regulation of NEFA availability: lipolysis pathway
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Physiological regulation of NEFA availability: lipolysis pathway
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Physiological regulation of NEFA availability: lipolysis pathway
      Available formats
      ×
Copyright
Corresponding author
* Corresponding author: Vladimír Stich Fax: +420 2 67102263, Email: vladimir.stich@lf3.cuni.cz
References
Hide All
Arner, P, Kriegholm, E, Engfeldt, P & Bolinder, J (1990) Adrenergic regulation of lipolysis in situ at rest and during exercise. Journal of Clinical Investigation 85, 893898.
Blaak, E (2003) Lipolysis in adipose tissue and skeletal muscle: what can be learned from stable isotope? In Progress in Obesity Research, vol. 9, pp. 176179 [Medeiro-Neto, G, Halpern, A and Bouchard, C, editors]. Esher, Surrey: John Libbey Eurotext Ltd.
Brandt, JM, Djouadi, F & Kelly, DP (1998) Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. Journal of Biological Chemistry 273, 2378623792.
Crampes, F, Beauville, M, Riviere, D & Garrigues, M (1986) Effect of physical training in humans on the response of isolated fat cells to epinephrine. Journal of Applied Physiology 61, 2529.
Crampes, F, Rivière, D, Beauville, M, Marceron, M & Garrigues, M (1989) Lipolytic response of adipocytes to epinephrine in sedentary and exercise-trained subjects: sex related differences. European Journal of Applied Physiology 59, 249255.
De Glisezinski, I, Crampes, F, Harant, I, Berlan, M, Hejnova, J, Langin, D, Riviere, D & Stich, V (1998) Endurance training changes in lipolytic responsiveness of obese adipose tissue. American Journal of Physiology 275, E951E956.
Evans, K, Clark, ML & Frayn, KN (1999) Effects of an oral and intravenous fat load on adipose tissue and forearm lipid metabolism. American Journal of Physiology 276, E241E248.
Frayn, KN, Summers, LKM & Fielding, BA (1997) Regulation of plasma non-esterified fatty acid concentration in the postprandial state. Proceedings of the Nutrition Society 56, 713721.
Fruhbeck, G, Gomez-Ambrosi, J & Salvador, J (2001) Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes. FASEB Journal 15, 333340.
Hickner, RC, Racette, SB, Binder, EF, Fisher, JS & Kohrt, WM (2000) Effects of 10 days of endurance training on the suppression of whole body and regional lipolysis by insulin. Journal of Clinical Endocrinology and Metabolism 85, 1498.
Horowitz, JF, Braudy, FM, Martin, WH III & Klein, S (1999 a) Endurance exercise training does not alter lipolytic or adipose tissue blood flow sensitivity to epinephrine. American Journal of Physiology 277, E325E331.
Horowitz, JF, Coppack, SW, Paramore, D, Cryer, PE, Zhao, G & Klein, S (1999 b) Effect of short-term fasting on lipid kinetics in lean and obese women. American Journal of Physiology 276, E278E284.
Jensen, MD, Caruso, M, Heiling, VJ & Miles, JM (1989) Insulin regulation of lipolysis in non diabetic and IDDM subjects. Diabetes 38, 15951601.
Jensen, MD & Johnson, CM (1996) Contribution of leg and splanchnic free fatty acid kinetics to postabsorptive FFA flux in men and women. Metabolism 45, 662666.
Kanaley, JA, Cryer, PE & Jensen, MD (1993) Fatty acid kinetic responses to exercise: effect of obesity, body fat distribution and energy-restricted diet. Journal of Clinical Investigation 392, 255261.
Khalfallah, Y, Fages, S, Laville, M, Langin, D & Vidal, H (2000) Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue. Diabetes 49, 2531.
Klein, S, Weber, JM, Coyle, EF & Wolfe, RR (1996) Effect of endurance training on glycerol kinetics during strenuous exercise in humans. Metabolism 45, 357361.
Kurpad, A, Khan, K, Calder, AG, Coppack, S, Frayn, K & Macdonald, I (1994) Effect of noradrenaline on glycerol turnover and lipolysis in the whole body and subcutaneous adipose tissue in humans in vivo. Clinical Science 86, 177184.
Lafontan, M, Barbe, P & Galitzky, J (1997) Adrenergic regulation of adipocyte metabolism. Human Reproduction 2, 620.
Langin, D, Holm, C & Lafontan, M (1996) Adipocyte hormone-sensitive lipase: a major regulator of lipid metabolism. Proceedings of the Nutrition Society 55, 93109.
Lyngso, D, Simonsen, L & Bulow, J (2002) Interleukin-6 production in human subcutaneous abdominal adipose tissue: the effect of exercise. Journal of Physiology (London) 543, 373378.
Nielsen, S, Guo, Z, Albu, JB, Klein, S, O'Brien, PC & Jensen, MD (2003) Energy expenditure, sex and endogenous fuel availability in humans. Journal of Clinical Investigation 111, 981988.
Romijn, JA, Klein, S, Coyle, EF, Sossis, LS & Wolfe, RR (1993) Strenuous endurance training increases lipolysis and triglyceride fatty acid cycling. Journal of Applied Physiology 75, 108113.
Samra, JS, Clark, ML, Humphreys, SM, Bannister, PA, Summers, LKM, Macdonald, IA & Frayn, KN (1999) Evidence for glycerol uptake by subcutaneous adipose tissue. Proceedings of the Nutrition Society 58, 164A.
Samra, JS, Clark, ML, Humphreys, SM, McDonald, SM & Frayn, KN (1996) Regulation of lipid metabolism in adipose tissue during early starvation. American Journal of Physiology 271, E541E546.
Sengenes, C, Berlan, M De Glisezinsky, I, Lafontan, M & Galitzky, J (2000) Natriuretic peptides: a new lipolytic pathway in human adipocytes. FASEB Journal 14, 13451351.
Stallknecht, B, Lorentsen, J, Enevoldsen, LH, Bülow, J Biering-Sorensen, B, Galbo, H & Kjor, M (2001) Role of the sympathoadrenergic system in adipose tissue metabolism during exercise in humans. Journal of Physiology (London) 536, 283294.
Stallknecht, B, Simonsen, L, Bulow, J, Vinten, J & Galbo, H (1995) Effect of training on epinephrine-stimulated lipolysis determined by microdialysis in human adipose tissue. American Journal of Physiology 269, E1059E1066.
Stich, V, de Glisezinski, I, Crampes, F, Hejnova, J, Cottet-Emard, JM, Galitzky, J, Lafontan, M, Riviere, D & Berlan, M (2000) Activation of alpha(2)-adrenergic receptors impairs exercise-induced lipolysis in SCAT of obese subjects. American Journal of Physiology 279, R499R504.
Stich, V, de Glisezinski, I, Crampes, F, Suljkovicova, H, Galitzky, J, Riviere, D, Hejnova, J, Lafontan, M & Berlan, M (1999) Activation of antilipolytic alpha(2)-adrenergic receptors by epinephrine during exercise in human adipose tissue. American Journal of Physiology 277, R1076R1083.
Stich, V, Harant, I, de Glisezinski, I, et al. (1997) Adipose tissue lipolysis and hormone-sensitive lipase expression during very-low-calorie diet in obese female identical twins. Journal of Clinical Endocrinology and Metabolism 82, 739744.
Stich, V, Marion-Latard, F, Hejnova, J, Viguerie, N, Lefort, C, Suljkovicova, H, Langin, D, Lafontan, M & Berlan, M (2002) Hypocaloric diet reduces exercise-induced alpha 2-adrenergic antilipolytic effect and alpha 2-adrenergic receptor mRNA levels in adipose tissue of obese women. Journal of Clinical Endocrinology and Metabolism 87, 12741281.
Stich, V, Pelikanova, T, Wohl, P, Sengenès, C Zakaroff-Girard, A, Lafontan, M & Berlan, M (2003) Activation of alpha2-adrenergic receptors blunts epinephrine-induced lipolysis in subcutaneous adipose tissue during a hyperinsulinemic-euglycemic clamp in men. American Journal of Physiology 285, E599E607.
Van Aggel-Leijssen, DP, Saris, WH, Homan, M & Van Baak, MA (2001) The effect of exercise training on beta-adrenergic stimulation of fat metabolism in obese men. International Journal of Obesity and Related Metabolic Disorders 25, 1623.
Zierath, J, Livingston, JN, Thorne, A, Bolinder, J, Reynisdottir, S, Lonnqvist, F & Arner, P (1998) Regional differences in insulin inhibition of non-esterified fatty acids release from human adipocytes. Diabetologia 41, 13431354.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed