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    Prostek, Adam Gajewska, Małgorzata Kamola, Dariusz and Bałasińska, Bożena 2014. The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation. Lipids in Health and Disease, Vol. 13, Issue. 1, p. 3.


    Yadav, Binod K. and Joyner, J. Jerish 2014. Functional Foods and Dietary Supplements.


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Regulation of adipokine secretion by n-3 fatty acids

  • María J. Moreno-Aliaga (a1), Silvia Lorente-Cebrián (a1) and J. Alfredo Martínez (a1)
  • DOI: http://dx.doi.org/10.1017/S0029665110001801
  • Published online: 14 June 2010
Abstract

Obesity leads to several chronic morbidities including type 2 diabetes, dyslipidaemia, atherosclerosis and hypertension, which are major components of the metabolic syndrome. White adipose tissue (WAT) metabolism and WAT-derived factors (fatty acids and adipokines) play an important role in the development of these metabolic disturbances. In fact, dysregulated adipokine secretion from the expanded WAT of obese individuals contributes to the development of systemic low-grade inflammation, insulin resistance and metabolic syndrome. The n-3 PUFA EPA and DHA have been widely reported to have protective effects in a range of chronic inflammatory conditions including obesity. In fact, n-3 PUFA have been shown to ameliorate low-grade inflammation in adipose tissue associated with obesity and up-regulate mitochondrial biogenesis and induce beta-oxidation in WAT in mice. Moreover, the ability of n-3 PUFA to regulate adipokine gene expression and secretion has been observed both in vitro and in vivo in rodents and human subjects. The present article reviews: (1) the physiological role of adiponectin, leptin and pre-B cell colony-enhancer factor/visfatin, three adipokines with immune-modulatory properties involved in the regulation of metabolism and insulin sensitivity and (2) the actions of n-3 PUFA on these adipokines focusing on the underlying mechanisms and the potential relationship with the beneficial effects of these fatty acids on obesity-associated metabolic disorders. It can be concluded that the ability of n-3 PUFA to improve obesity and insulin resistance conditions partially results from the modulation of WAT metabolism and the secretion of bioactive adipokines including leptin, adiponectin and visfatin.

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*Corresponding author: Dr María J. Moreno-Aliaga, fax + 34 948 42 56 49, email mjmoreno@unav.es
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1.JK Sethi & AJ Vidal-Puig (2007) Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res 48, 12531262.

2.T Gurevich-Panigrahi , S Panigrahi , E Wiechec (2009) Obesity: pathophysiology and clinical management. Curr Med Chem 16, 506521.

3.A Marti , A Marcos & JA Martinez (2001) Obesity and immune function relationships. Obes Rev 2, 131140.

4.PE Scherer (2006) Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 55, 15371545.

5.P Trayhurn (2005) Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand 184, 285293.

6.PJ Havel (2004) Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 53, Suppl. 1, S143S151.

7.J Boucher , B Masri , D Daviaud (2005) Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 146, 17641771.

8.CM de Souza Batista , RZ Yang , MJ Lee (2007) Omentin plasma levels and gene expression are decreased in obesity. Diabetes 56, 16551661.

9.P Trayhurn & IS Wood (2005) Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33, 10781081.

10.UN Das (2001) Is obesity an inflammatory condition? Nutrition 17, 953966.

11.DB Jump & SD Clarke (1999) Regulation of gene expression by dietary fat. Annu Rev Nutr 19, 6390.

13.EW Kraegen , PW Clark , AB Jenkins (1991) Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 40, 13971403.

14.LH Storlien , EW Kraegen , DJ Chisholm (1987) Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science 237, 885888.

15.J Ruzickova , M Rossmeisl , T Prazak (2004) Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue. Lipids 39, 11771185.

16.P Flachs , O Horakova , P Brauner (2005) Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. Diabetologia 48, 23652375.

19.N Perez-Echarri , P Perez-Matute , B Marcos-Gomez (2009) Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats. J Nutr Biochem 20, 705714.

21.M Takahashi , N Tsuboyama-Kasaoka , T Nakatani (2002) Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production. Am J Physiol Gastrointest Liver Physiol 282, G338–348.

22.HJ Kim , M Takahashi & O Ezaki (1999) Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs. J Biol Chem 274, 2589225898.

23.J Delarue , C LeFoll , C Corporeau (2004) N-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity? Reprod Nutr Dev 44, 289299.

24.E Peyron-Caso , S Fluteau-Nadler , M Kabir (2002) Regulation of glucose transport and transporter 4 (GLUT-4) in muscle and adipocytes of sucrose-fed rats: effects of N-3 poly- and monounsaturated fatty acids. Horm Metab Res 34, 360366.

25.C Ruggiero , F Lattanzio , F Lauretani (2009) Omega-3 polyunsaturated fatty acids and immune-mediated diseases: inflammatory bowel disease and rheumatoid arthritis. Curr Pharm Des 15, 41354148.

26.PJ White & A Marette (2006) Is omega-3 key to unlocking inflammation in obesity? Diabetologia 49, 19992001.

28.CN Serhan , S Hong , K Gronert (2002) Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med 196, 10251037.

29.CN Serhan , N Chiang & TE Van Dyke (2008) Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 8, 349361.

30.A Gonzalez-Periz , R Horrillo , N Ferre (2009) Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB J 23, 19461957.

31.P Flachs , M Rossmeisl , M Bryhn (2009) Cellular and molecular effects of n-3 polyunsaturated fatty acids on adipose tissue biology and metabolism. Clin Sci (Lond) 116, 116.

32.J Todoric , M Loffler , J Huber (2006) Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids. Diabetologia 49, 21092119.

33.N Pérez-Echarri , P Pérez-Matute , B Marcos-Gómez (2008) Differential inflammatory status in rats susceptible or resistant to diet-induced obesity: effects of EPA ethyl ester treatment. Eur J Nutr 47, 380386.

34.P Pérez-Matute , A Marti , JA Martínez (2005) Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism. Am J Physiol Regul Integr Comp Physiol 288, R1682–1688.

35.M Itoh , T Suganami , N Satoh (2007) Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. Arterioscler Thromb Vasc Biol 27, 19181925.

37.Y Zhang , R Proenca , M Maffei (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425432.

39.PJ Havel , S Kasim-Karakas , W Mueller (1996) Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab 81, 44064413.

41.MJ Lee & SK Fried (2009) Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion. Am J Physiol Endocrinol Metab 296, E1230E1238.

43.M Rosenbaum , EM Murphy , SB Heymsfield (2002) Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 87, 23912394.

44.M Caprio , E Fabbrini , AM Isidori (2001) Leptin in reproduction. Trends Endocrinol Metab 12, 6572.

45.A La Cava & G Matarese (2004) The weight of leptin in immunity. Nat Rev Immunol 4, 371379.

46.IS Farooqi , G Matarese , GM Lord (2002) Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110, 10931103.

47.P Sarraf , RC Frederich , EM Turner (1997) Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med 185, 171175.

48.G Matarese , EH Leiter & A La Cava (2007) Leptin in autoimmunity: many questions, some answers. Tissue Antigens 70, 8795.

49.J Shen , I Sakaida , K Uchida (2005) Leptin enhances TNFalpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells. Life Sci 77, 15021515.

50.J Santos-Alvarez , R Goberna & V Sanchez-Margalet (1999) Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 194, 6–11.

51.H Zarkesh-Esfahani , AG Pockley , Z Wu (2004) Leptin indirectly activates human neutrophils via induction of TNFalpha. J Immunol 172, 18091814.

52.Y Zhao , R Sun , L You (2003) Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem Biophys Res Commun 300, 247252.

53.JK Howard , GM Lord , G Matarese (1999) Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 104, 10511059.

54.H Tilg & AR Moschen (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6, 772783.

55.M Murata , H Kaji , Y Takahashi (2000) Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro. Biochem Biophys Res Commun 270, 343348.

56.WM Mueller , FM Gregoire , KL Stanhope (1998) Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology 139, 551558.

57.MJ Moreno-Aliaga , MM Swarbrick , S Lorente-Cebrian (2007) Sp1-mediated transcription is involved in the induction of leptin by insulin-stimulated glucose metabolism. J Mol Endocrinol 38, 537546.

58.MJ Moreno-Aliaga , KL Stanhope & PJ Havel (2001) Transcriptional regulation of the leptin promoter by insulin-stimulated glucose metabolism in 3t3-L1 adipocytes. Biochem Biophys Res Commun 283, 544548.

59.PG Cammisotto , Y Gelinas , Y Deshaies (2003) Regulation of leptin secretion from white adipocytes by free fatty acids. Am J Physiol Endocrinol Metab 285, E521E526.

63.AS Rossi , YB Lombardo , JM Lacorte (2005) Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats. Am J Physiol Regul Integr Comp Physiol 289, R486R494.

64.A Ramel , D Parra , JA Martinez (2009) Effects of seafood consumption and weight loss on fasting leptin and ghrelin concentrations in overweight and obese European young adults. Eur J Nutr 48, 107114.

65.UB Pajvani , M Hawkins , TP Combs (2004) Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 279, 1215212162.

66.JM Bruun , AS Lihn , C Verdich (2003) Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in human subjects. Am J Physiol Endocrinol Metab 285, E527–533.

67.Y Qi , N Takahashi , SM Hileman (2004) Adiponectin acts in the brain to decrease body weight. Nat Med 10, 524529.

68.T Yamauchi , J Kamon , H Waki (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7, 941946.

69.M Kumada , S Kihara , S Sumitsuji (2003) Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 23, 8589.

70.N Kubota , Y Terauchi , T Yamauchi (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277, 2586325866.

71.N Maeda , I Shimomura , K Kishida (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8, 731737.

72.TP Combs , UB Pajvani , AH Berg (2004) A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 145, 367383.

73.TP Combs , JA Wagner , J Berger (2002) Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 143, 998–1007.

74.N Ouchi , S Kihara , Y Arita (2000) Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 102, 12961301.

76.AM Wolf , D Wolf , H Rumpold (2004) Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem Biophys Res Commun 323, 630635.

77.M Fasshauer , S Kralisch , M Klier (2003) Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 301, 10451050.

78.P Flachs , V Mohamed-Ali , O Horakova (2006) Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. Diabetologia 49, 394397.

79.S Neschen , K Morino , JC Rossbacher (2006) Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice. Diabetes 55, 924928.

80.S Lorente-Cebrián , P Pérez-Matute , JA Martínez (2006) Effects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytes. J Physiol Biochem 62, 6169.

81.YC Long & JR Zierath (2006) AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116, 17761783.

82.LG Fryer , A Parbu-Patel & D Carling (2002) The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 277, 2522625232.

83.AS Lihn , N Jessen , SB Pedersen (2004) AICAR stimulates adiponectin and inhibits cytokines in adipose tissue. Biochem Biophys Res Commun 316, 853858.

84.S Lorente-Cebrian , M Bustos , A Marti (2009) Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes. Clin Sci (Lond) 117, 243249.

86.A Fukuhara , M Matsuda , M Nishizawa (2005) Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307, 426430.

87.B Samal , Y Sun , G Stearns (1994) Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 14, 14311437.

88.H Tilg & AR Moschen (2008) Role of adiponectin and PBEF/visfatin as regulators of inflammation: involvement in obesity-associated diseases. Clin Sci (Lond) 114, 275288.

89.JR Revollo , AA Grimm & S Imai (2007) The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals. Curr Opin Gastroenterol 23, 164170.

90.T Luk , Z Malam & JC Marshall (2008) Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity. J Leukoc Biol 83, 804816.

91.AR Moschen , A Kaser , B Enrich (2007) Visfatin, an adipocytokine with proinflammatory and immunomodulating properties. J Immunol 178, 17481758.

92.Y Li , Y Zhang , B Dorweiler (2008) Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. J Biol Chem 283, 3483334843.

93.T Romacho , V Azcutia , M Vazquez-Bella (2009) Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity. Diabetologia 52, 24552463.

94.SW Liu , SB Qiao , JS Yuan (2009) Association of plasma visfatin levels with inflammation, atherosclerosis and acute coronary syndromes (ACS) in human subjects. Clin Endocrinol (Oxf) 71, 202207.

95.S Kralisch , J Klein , U Lossner (2005) Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes. J Endocrinol 185, R1–8.

96.S Kralisch , J Klein , U Lossner (2005) Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 289, E586–590.

97.J Hector , B Schwarzloh , J Goehring (2007) TNFalpha alters visfatin and adiponectin levels in human fat. Horm Metab Res 39, 250255.

98.N Kloting & I Kloting (2005) Visfatin: gene expression in isolated adipocytes and sequence analysis in obese WOKW rats compared with lean control rats. Biochem Biophys Res Commun 332, 10701072.

99.KC Choi , OH Ryu , KW Lee (2005) Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNFalpha in visceral fat of OLETF rats. Biochem Biophys Res Commun 336, 747753.

100.KC Choi , SY Lee , HJ Yoo (2007) Effect of PPAR-delta agonist on the expression of visfatin, adiponectin, and resistin in rat adipose tissue and 3T3-L1 adipocytes. Biochem Biophys Res Commun 357, 6267.

101.TD Filippatos , CS Derdemezis , DN Kiortsis (2007) Increased plasma levels of visfatin/pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome. J Endocrinol Invest 30, 323326.

102.DG Haider , G Holzer , G Schaller (2006) The adipokine visfatin is markedly elevated in obese children. J Pediatr Gastroenterol Nutr 43, 548549.

103.J Berndt , N Kloting , S Kralisch (2005) Plasma visfatin concentrations and fat depot-specific mRNA expression in human subjects. Diabetes 54, 29112916.

104.A Hammarstedt , J Pihlajamaki , V Rotter Sopasakis (2006) Visfatin is an adipokine, but it is not regulated by thiazolidinediones. J Clin Endocrinol Metab 91, 11811184.

105.P Wang , MM van Greevenbroek , FG Bouwman (2007) The circulating PBEF/NAMPT/visfatin level is associated with a beneficial blood lipid profile. Pflugers Arch 454, 971976.

106.C Pagano , C Pilon , M Olivieri (2006) Reduced plasma visfatin/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in human subjects. J Clin Endocrinol Metab 91, 31653170.

107.K Krzyzanowska , F Mittermayer , W Krugluger (2006) Increase in visfatin after weight loss induced by gastroplastic surgery. Obesity (Silver Spring) 14, 18861889.

108.E Garcia-Fuentes , JM Garcia-Almeida , J Garcia-Arnes (2007) Plasma visfatin concentrations in severely obese subjects are increased after intestinal bypass. Obesity (Silver Spring) 15, 23912395.

109.DG Haider , K Schindler , G Schaller (2006) Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding. J Clin Endocrinol Metab 91, 15781581.

110.M Manco , JM Fernandez-Real , F Equitani (2007) Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women. J Clin Endocrinol Metab 92, 483490.

111.MP Chen , FM Chung , DM Chang (2006) Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 91, 295299.

112.B Zahorska-Markiewicz , M Olszanecka-Glinianowicz , J Janowska (2007) Serum concentration of visfatin in obese women. Metabolism 56, 11311134.

113.A Fukuhara , M Matsuda , M Nishizawa (2007) Retraction. Science 318, 565.

115.DG Haider , F Mittermayer , G Schaller (2006) Free fatty acids normalize a rosiglitazone-induced visfatin release. Am J Physiol Endocrinol Metab 291, E885–890.

116.AH Lichtenstein , LJ Appel , M Brands (2006) Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 114, 8296.

118.JW Fetterman Jr & MM Zdanowicz (2009) Therapeutic potential of n-3 polyunsaturated fatty acids in disease. Am J Health Syst Pharm 66, 11691179.

119.K He (2009) Fish, long-chain omega-3 polyunsaturated fatty acids and prevention of cardiovascular disease – eat fish or take fish oil supplement? Prog Cardiovasc Dis 52, 95–114.

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