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The Sheffield Experiment on the Vitamin C Requirement of Human Adults*

  • H. A. Krebs (a1)
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Abstract
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This is a summary of the main aspects of the trial conducted by the Vitamin C Subcommittee of the Accessory Food Factors Committee of the Medical Research Council. Members of the Committee were R. A. Peters (Chairman), K. H. Coward, H. A. Krebs, L. W. Mapson, L. G. Parsons, B. S. Platt, J. C. Spence, J. R. P. O'Brien (Secretary). Others taking part were A. E. Barnes, W. Bartley, I. M. Frankau, G. A. Higgins, E. M. Hume, J. Pemberton, G. L. Roberts, H. Scarborough, H. R. Vickers, J. Waterlow and W. J. W. Ferguson. A full account of the trial is published by H.M. Stationery Office (Bartley, Krebs & O'Brien, I953). This Report includes reproductions of colour photographs of the pathological conditions seen during the trial. (See also Medical Research Council: Vitamin C Subcommittee of the Accessory Food Factors Committee, 1948.)

The colour plates I to VI illustrate some of the clinical findings made during the trial.

The author is indebted to the Controller of H.M. Stationery Office for permission to produce this summary and for the use of illustrations taken from the Report.

Footnotes
References
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Bartley, W., Krebs, H. A. & O'Brien, J. R. P. (1953). Spec. Rep. Sev. wed. Res. Coztn., Lond., no. 280.
Butler, A. M. & Cushman, M. (1940). J. clin. Invest 19, 459.
Gothlin, G. F. (1931). Skand. Arch. Physiol. 61, 225.
Hess, A. F. (1920). Scurvy, Past and Present. Philadelphia: Lippincott.
Hume, E. M. & Krebs, H. A. (1949). Spec. Rep. Ser. med. Res. Colin., Lond., no. 264.
League of Nations Health Organization: Technical Commission on Nutrition (1938). Bull. Hlth Org. L.O.N. 7, 460.
Lind, J. (1757). A Treutise of the Scuruy, 2nd ed. London: Millar.
Medical Research Council: Vitamin C Subcommittee of the Accessory Food Factors Committee (1948). Lancet, 254, 853.
National Research Council: Food and Nutrition Board (1943). Repr. nut. Res. Colin., Wash., No. 115.
Thysell, T. (1939). Acta paediatr., Stockh., 26, 481.
Zilva, S. S. (1941). Biochem. J. 35, 1240.
Zilva, S. S. (1944). Brit. med. Bull. 2, 217.
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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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