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Carbamazepine monitoring

  • Carol Paton (a1) and Andrew W. Procter (a1)
Extract

Background of the study

Rationale for monitoring carbamazepine levels

Carbamazepine fulfils some of the criteria required in order to render a drug suitable for serum level monitoring in that there is poor inter-individual reproducibility of the serum levels achieved with fixed dosage regimes, interbrand differences in bioavailability are known to occur and serum levels can be raised significantly by several commonly prescribed drugs; dextropropoxyphene (a constituent of coprozamol), erythromycin, isoniazid and cimetidine.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
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Brodie, M. J. & Hallworth, M. J. (1987) Therapeutic monitoring of carbamazepine. Hospital Update, Jan 87, 5763.
Chadwick, D. W. (1987) Overuse of monitoring of blood concentrations of antiepileptic drugs. British Medical Journal, 294, 723724.
Nolen, W. A., Jansen, G. S. & Broekman, M. (1988) Measuring plasma levels of carbamazepine; a pharmacokinetic study in patients with affective disorders. Pharmacopsychiatry, 21, 252254.
Pharmacokinetics and pharmacodynamics. In Tegretol-Hospital Pharmacists Guide. Geigy Pharmaceuticals, 1990.
Post, R. M. & Uhde, T. W. (1986) Anticonvulsants in non-epileptic psychosis. In Aspects of Epilepsy and Psychiatry (eds. Trimble, M. R. and Bolwig, T. G.). Chichester: John Wiley.
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BJPsych Bulletin
  • ISSN: 0955-6036
  • EISSN: 1472-1473
  • URL: /core/journals/bjpsych-bulletin
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Carbamazepine monitoring

  • Carol Paton (a1) and Andrew W. Procter (a1)
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