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Clozapine-induced nocturnal enuresis: diagnostic and treatment issues

  • King Han Kho and Olaf Nielsen (a1)
Abstract
Aims and Method

To report the management of three cases of clozapine-induced enuresis, by description of these cases and literature review.

Results

Heavy sedation, generalised epilepsy and diabetes mellitus induced by clozapine are some of the mechanisms that underlie the emergence of this side-effect.

Clinical Implications

These cases illustrate several different pathophysiological mechanisms necessitating further diagnostic investigations before adequate treatment can be started. Clozapine-induced enuresis is probably under-reported owing to the embarrassing nature of this side-effect.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
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Brugman, N. J., Cohen, D. & De VRIES, R. H. (2000) Diabetes mellitus after treatment with clozapine. Nederlands Tijdschrift voor Geneeskunde, 144, 437439.
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BJPsych Bulletin
  • ISSN: 0955-6036
  • EISSN: 1472-1473
  • URL: /core/journals/bjpsych-bulletin
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Clozapine-induced nocturnal enuresis: diagnostic and treatment issues

  • King Han Kho and Olaf Nielsen (a1)
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