The frequency with which a given drug is prescribed (the number of doses per day) should be influenced by several factors. First, frequent prescribing is likely to be more expensive and to consume more resources. About a third of the time spent by psychiatric nurses in interaction with patients is devoted to technical activities such as drug administration (Altschul, 1972). Second, it is especially difficult to persuade psychiatric patients to take medication as prescribed whether as in-patients or as out-patients so treatment regimens should be kept as simple as possible. There is evidence that compliance is better with once or twice daily regimens than with a four times daily regimen.
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