Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 44
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Diwadkar, Vaibhav A. and Keshavan, Matcheri S. 2015. Developmental Psychopathology.

    Jose, Dania Narayanaswamy, Janardhanan C. Agarwal, Sri Mahavir Kalmady, Sunil V. Venkatasubramanian, Ganesan and Reddy, Y.C. Janardhan 2015. Corpus callosum abnormalities in medication-naïve adult patients with obsessive compulsive disorder. Psychiatry Research: Neuroimaging, Vol. 231, Issue. 3, p. 341.

    Lebedeva, I. S. Sidorin, S. V. Akhadov, T. A. Barkhatova, A. N. Kaleda, V. G. and Semenova, N. A. 2014. Some Structural-Functional Characteristics of the Dorsolateral Prefrontal Cortex and the Genu of the Corpus Callosum and Auditory Information Processing (P300) in Healthy Subjects and Patients with Juvenile Schizophrenia. Neuroscience and Behavioral Physiology, Vol. 44, Issue. 1, p. 9.

    Bersani, G. Quartini, A. Paolemili, M. Clemente, R. Iannitelli, A. Di Biasi, C. and Gualdi, G. 2011. Neurological Soft Signs and Corpus Callosum morphology in schizophrenia. Neuroscience Letters, Vol. 499, Issue. 3, p. 170.

    Dutt, Anirban Shaikh, Madiha Ganguly, Taposhri Nosarti, Chiara Walshe, Muriel Arranz, Maria Rifkin, Larry McDonald, Colm Chaddock, Christopher A McGuire, Philip Murray, Robin M Bramon, Elvira and Allin, Matthew P.G. 2011. COMT gene polymorphism and corpus callosum morphometry in preterm born adults. NeuroImage, Vol. 54, Issue. 1, p. 148.

    Francis, Alan N. Bhojraj, Tejas S. Prasad, Konasale M. Kulkarni, Shreedhar Montrose, Debra M. Eack, Shaun M. and Keshavan, Matcheri S. 2011. Abnormalities of the corpus callosum in non-psychotic high-risk offspring of schizophrenia patients. Psychiatry Research: Neuroimaging, Vol. 191, Issue. 1, p. 9.

    King, Bryan H. and Lord, Catherine 2011. Is schizophrenia on the autism spectrum?. Brain Research, Vol. 1380, p. 34.

    Bersani, Giuseppe Quartini, Adele Iannitelli, Angela Paolemili, Marco Ratti, Flavia Di Biasi, Claudio and Gualdi, Gianfranco 2010. Corpus callosum abnormalities and potential age effect in men with schizophrenia: An MRI comparative study. Psychiatry Research: Neuroimaging, Vol. 183, Issue. 2, p. 119.

    Venkatasubramanian, Ganesan Jayakumar, Peruvumba N. Reddy, Varun Venkatesh Reddy, Umesh Srinivasa Gangadhar, Bangalore. N. and Keshavan, Matcheri S. 2010. Corpus callosum deficits in antipsychotic-naïve schizophrenia: Evidence for neurodevelopmental pathogenesis. Psychiatry Research: Neuroimaging, Vol. 182, Issue. 2, p. 141.

    Mehta, Mitul A. Golembo, Nicole I. Nosarti, Chiara Colvert, Emma Mota, Ashley Williams, Steven C. R. Rutter, Michael and Sonuga-Barke, Edmund J. S. 2009. Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: The English and Romanian Adoptees Study Pilot. Journal of Child Psychology and Psychiatry, Vol. 50, Issue. 8, p. 943.

    Xu, Lai Pearlson, Godfrey and Calhoun, Vince D. 2009. Joint source based morphometry identifies linked gray and white matter group differences. NeuroImage, Vol. 44, Issue. 3, p. 777.

    Arnone, D. McIntosh, A.M. Tan, G.M.Y. and Ebmeier, K.P. 2008. Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia. Schizophrenia Research, Vol. 101, Issue. 1-3, p. 124.

    Arnone, D. Mcintosh, A.M. Tan, G.M.Y. and Ebmeier, K.P. 2008. Metaanálisis de estudios sobre resonancia magnética del cuerpo calloso en la esquizofrenia. Psiquiatría Biológica, Vol. 15, Issue. 6, p. 214.

    Aydin, Kubilay Ucok, Alp and Guler, Julide 2008. Altered Metabolic Integrity of Corpus Callosum Among Individuals at Ultra High Risk of Schizophrenia and First-Episode Patients. Biological Psychiatry, Vol. 64, Issue. 9, p. 750.

    John, John P. Shakeel, Mohammed Kalathil and Jain, Sanjeev 2008. Corpus callosal area differences and gender dimorphism in neuroleptic-naïve, recent-onset schizophrenia and healthy control subjects. Schizophrenia Research, Vol. 103, Issue. 1-3, p. 11.

    Walterfang, M. Wood, A. G. Reutens, D. C. Wood, S. J. Chen, J. Velakoulis, D. McGorry, P. D. and Pantelis, C. 2008. Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness. The British Journal of Psychiatry, Vol. 192, Issue. 6, p. 429.

    Brambilla, Paolo and Tansella, Michele 2007. The role of white matter for the pathophysiology of schizophrenia. International Review of Psychiatry, Vol. 19, Issue. 4, p. 459.

    Venkatasubramanian, Ganesan Anthony, George Reddy, Umesh Srinivasa Reddy, Varun Venkatesh Jayakumar, Peruvumba N. and Benegal, Vivek 2007. Corpus callosum abnormalities associated with greater externalizing behaviors in subjects at high risk for alcohol dependence. Psychiatry Research: Neuroimaging, Vol. 156, Issue. 3, p. 209.

    Chinnasamy, Dhamodharan Rudd, Rebecca and Velakoulis, Dennis 2006. A case of schizophrenia with complete agenesis of the corpus callosum. Australasian Psychiatry, Vol. 14, Issue. 3, p. 327.

    Crippa, José Alexandre de Souza Zuardi, Antonio Waldo Busatto, Geraldo F. Sanches, Rafael Faria Santos, Antonio Carlos Araújo, David Amaro, Edson Hallak, Jaime Eduardo Cecílio Ng, Virginia and McGuire, Philip K. 2006. Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study. European Psychiatry, Vol. 21, Issue. 5, p. 291.


A computerized magnetic resonance imaging study of corpus callosum morphology in schizophrenia

  • P. W. R. Woodruff (a1), G. D. Pearlson (a1), M. J. Geer (a1), P. E. Barta (a1) and H. D. Chilcoat (a1)
  • DOI:
  • Published online: 01 July 2009

The hypothesis tested was that, in schizophrenia, corpus callosum size would be reduced, particularly in the region responsible for communication between both temporal lobes. This is supported by knowledge of: (a) anatomical homotopicity and functional specialization of fibres within the corpus callosum; (b) evidence linking structural and functional deficits of the corpus callosum and left temporal lobe with schizophrenia; and (c) that temporal lobe neuronal fibres pass through the middle region of the corpus callosum. Brain area and corpus callosum areas, widths and length were measured on mid-sagittal MRI scans using a computer outlining method. Scans from 30 schizophrenics and 44 normal subjects were compared. Mid-sagittal brain area, corpus callosum area, length and anterior widths were reduced in the schizophrenic group compared with controls. A significant area difference between schizophrenics and controls was seen in the mid-corpus callosum which communicates between the temporal lobes, including the superior temporal gyri. In schizophrenics, corpus callosum area reduction was not accounted for by brain area shrinkage alone. Differences between the two groups were accounted for by comparisons between males only. These findings support the hypothesis and the possibility that localized abnormalities of bilaterally connected brain regions might have secondary effects on their homotopically distributed fibres within the corpus callosum.

Corresponding author
1Address for correspondence: Dr P. W. R. Woodruff, Institute of Psychiatry, Dc Crespigny Park, Denmark Hill, London SE5 8AF.
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

N. C. Andreasen , H. A. Nasrallah , V. Dunn , S. C. Olson , W. M. Grove , J. C. Ehrhardt , J. A. Coffman & J. H. W. Crossett (1986). Structural abnormalities in the frontal system in schizophrenia. Archives of General Psychiatry 43, 137144.

N. C. Andreasen , J. C. Ehrhardt , V. W. Swayze , R. J. Alliger , W. T. C. Yuh , G. Cohen & S. Ziebell (1990). Magnetic resonance imaging of the brain in schizophrenia: the pathophysiologic significance of structural abnormalities. Archives of General Psychiatry 47, 3544.

J. G. Beaumont & S. J. Dimond (1973). Brain disconnection and schizophrenia. British Journal of Psychiatry 123, 661662.

L. B. Bigelow H. A. Nasrallah & F. P. Rauscher (1983). Corpus callosum thickness in chronic schizophrenia. British Journal of Psychiatry 142, 284287.

R. Brown , N. Colter , J. A. N. Corsellis , T. J. Crow , C. D. Frith , R. Jagoe , E. C. Johnstone & L. Marsh (1986). Postmortem evidence of structural brain changes in schizophrenia. Archives of General Psychiatry 43, 3642.

M. F. Casanova , R. D. Sanders , T. E. Goldberg , L. B. Bigelow , G. Christison , E. F. Torrey & D. R. Weinberger (1990). Morphometry of the corpus callosum in monozygotic twins discordant for schizophrenia: a magnetic resonance imaging study. Journal of Neurology, Neurosurgery and Psychiatry 53, 416421.

L. T. Chapman & J. P. Chapman (1987). The measurement of handedness. Brain and Cognition 6, 175183.

R. W. Coger & E. A. Serafetinides (1990). Schizophrenia, corpus callosum, and inter-hemispheric communication: a review. Psychiatry Research 34, 163184.

J. E. Cooper , H. Andrews & C. Barber (1985). Stable abnormalities in the lateralisation of early cortical somatosensory evoked potentials in schizophrenic patients. British Journal of Psychiatry 146, 585593.

I. D. Dauphinais , L. E. DeLisi , T. J. Crow , K. Alexandropoulos , N. Colter , I. Tuma & E. S. Gershon (1990). Reduction in temporal lobe size in siblings with schizophrenia: a magnetic resonance imaging study. Psychiatry Research: Neuroimaging 35, 137147.

C. De Lacoste-Utamsing & R. L. Holloway (1982). Sexual dimorphism in the human corpus callosum. Science 216, 14311432.

S. J. Dimond , R. E. Scammell , E. Y. M. Brouwers & R. Weeks (1977). Functions of the centre section (trunk) of the corpus callosum in man. Brain 100, 543562.

P. Fenwick , D. Brennan & M. Philpot (1983). Function of the corpus callosum in schizophrenia. British Journal of Psychiatry 143, 524.

B. Fish & R. Hagin (1972). Visual-motor disorders in infants at risk for schizophrenia. Archives of General Psychiatry 27, 594598.

M. S. Gazzaniga & H. Freedman (1973). Observations on visual processes after posterior callosal section. Neurology 23, 11261130.

M. S. Gazzaniga , G. L. Risse , S. P. Springer , E. Clark , A. B. Wilson & D. H. Wilson (1975). Psychological and neurologic consequences of partial and complete cerebral commissurotomy. Neurology 25, 1015.

P. Green (1978). Defective interhemispheric transfer in schizophrenia. Journal of Abnormal Psychology 87, 472480.

J. Gruzelier , K. Seymour , L. Wilson , A. Jolley & S. Hirsch (1988). Impairments on neuropsychologic tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Archives of General Psychiatry 45, 623629.

W. Gunther , R. Petsch , R. Steinberg , E. Moser , P. Streck , H. Heller , G. Kurtz & H. Hippins (1991). Brain dysfunction during motor activation and corpus callosum alterations in schizophrenia measured by cerebral blood flow and magnetic resonance imaging. Biological Psychiatry 29, 535553.

P. Hauser , D. Dauphinais , W. Berrettini , L. E. DeLisi , J. Gelernter & R. M. Post (1989). Corpus callosum dimensions measured by magnetic resonance imaging in bipolar affective disorder and schizophrenia. Biological Psychiatry 26, 659668.

J. C. Hedreen & T. C. T. Yin (1981). Homotopic and heterotopic callosal afferents of caudal inferior parietal lobule in Macaca mulatto. Journal of Comparative Neurology 197, 605621.

S. Jacobson & E. M. Marcus (1970). The laminar distribution of the corpus callosum: a comparative study in the rat, cat, rhesus monkey and chimpanzee. Brain Research 24, 513520.

M. A. Jeeves , D. A. Simpson & G. Geffen (1979). Functional consequences of the transcallosal removal of intraventricular tumours. Journal of Neurology, Neurosurgery, and Psychiatry 42, 134142.

E. C. Johnstone , D. G. C. Owens , T. J. Crow , C. D. Frith , K. Alexandropoulis , G. Bydder & N. Colter (1989). Temporal lobe structure as determined by nuclear magnetic resonance in schizophrenia and bipolar affective disorder. Journal of Neurology, Neurosurgery and Psychiatry 52, 736741.

G. H. Jones & J. J. Miller (1981). Functional tests of the corpus callosum in schizophrenia. British Journal of Psychiatry 139, 553557.

J. R. Kelsoe , J. L. Cadet , D. Pickar & D. R. Weinberger (1988). Quantitative neuroanatomy in schizophrenia. Archives of General Psychiatry 45, 533541.

R. J. Matthew , C. L. Partain , R. Prakash , M. V. Kulkarni , T. P. Logan & W. H. Wilson (1985). A study of the septum pellucidum and corpus callosum in schizophrenia. Acta Psychiatrica Scandinavica 72, 414421.

E. L. Merrin , T. C. Floyd & G. Fein (1989). EEG coherence in unmedicated schizophrenic patients. Biological Psychiatry 25, 6066.

R. M. Murray & S. W. Lewis (1987). Is schizophrenia a neurodevelopmental disorder? British Medical Journal 295, 681682.

H. A. Nasrallah , N. C. Andreasen , J. A. Coffman , S. C. Olson , V. D. Dunn , J. C. Erhardt & S. M. Chapman (1986). A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia. Biological Psychiatry 21, 274282.

A. Raine , G. N. Harrison , G. P. Reynolds , C. Sheard , J. E. Cooper & I. Medley (1990). Structural and functional characteristics of the corpus callosum in schizophrenics, psychiatric controls, and normal controls. Archives of General Psychiatry 47, 10601063.

R. Rosenthal & L. B. Bigelow (1972). Quantitative brain measurements in chronic schizophrenia. British Journal of Psychiatry 121, 259264.

A. Rossi , P. Stratta , M. Gallucci , R. Passariello & M. Casacchia (1988). Brain morphology in schizophrenia by magnetic resonance imaging. Acta Psychiatrica Scandinavica 77, 741745.

A. J. Saykin , R. C. Gur , R. E. Gur , P. D. Mozley , L. H. Mozley , S. M. Resnick , B. Kester & P. Stafiniak (1991). Neuropsychological function in schizophrenia – selective impairment in memory and learning. Archives of General Psychiatry 48, 618624.

C. Shagass , R. C. Josiassen , R. A. Roemer , J. J. Straumanis & S. M. Slepner (1983). Failure to replicate evoked potential observations suggesting corpus callosum dysfunction in schizophrenia. British Journal of Psychiatry 142, 471476.

R. C. Smith , M. Calderon , G. K. Ravichandran , J. Largen , G. Vroulis , A. Shvartsburd , J. Gordon & J. C. Schoolar (1984). Nuclear magnetic resonance in schizophrenia: a preliminary study. Psychiatry Research 12, 137147.

R. C. Smith , R. Baumgartner & M. Calderon (1987). Magnetic resonance imaging studies of the brains of schizophrenic patients. Psychiatry Research 20, 3346.

R. Sperry (1982). Some effects of disconnecting the cerebral hemispheres. Science 217, 12231226.

P. Stratta , A. Rossi , M. Gallucci , I. Amicarelli , R. Passariello & M. Casacchia (1989). Hemispheric asymmetries and schizophrenia: a preliminary magnetic resonance imaging study. Biological Psychiatry 25, 275284.

R. L. Suddath , G. W. Christison , E. F. Torrey , M. F. Casanova & D. R. Weinberger (1990). Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New England Journal of Medicine 322, 789794.

V. W. Swayze , N. C. Andreasen , J. S. Ku & R. Alliger (1989). The corpus callosum in schizophrenia and mania: a controlled MRI study. Schizophrenia Research 2, 130.

W. Swayze , N. C. Andreasen , J. C. Erhardt , W. T. C. Yuh , R. J. Alliger & G. A. Cohen (1990). Development abnormalities of the corpus callosum in schizophrenia. Archives of Neurology 47, 805808.

M. Uematsu & H. Kaiya (1988). The morphology of the corpus callosum in schizophrenia: an MRI study. Schizophrenia Research 1, 391398.

S. F. Witelson (1989). Hand and sex differences in the isthmus and genu of the human corpus callosum. Brain 112, 799833.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *