Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 28
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Ollendick, Thomas H. Benoit, Kristy E. and Grills-Taquechel, Amie E. 2014. The Wiley Blackwell Handbook of Social Anxiety Disorder.

    Park, Subin Hong, Kang-E M Yang, Young Hui Kang, Jewook Park, Eun Jin Ha, Kyooseob Park, Mira and Yoo, Hee Jeong 2014. Neuropsychological and Behavioral Profiles in Attention-Deficit Hyperactivity Disorder Children of Parents with a History of Mood Disorders: A Pilot Study. Psychiatry Investigation, Vol. 11, Issue. 1, p. 65.

    Wei, Chiaying and Kendall, Philip C. 2014. Parental Involvement: Contribution to Childhood Anxiety and Its Treatment. Clinical Child and Family Psychology Review, Vol. 17, Issue. 4, p. 319.

    Jung, Eunju Raikes, Helen H. and Chazan-Cohen, Rachel 2013. Maternal Depressive Symptoms and Behavior Problems in Preschool Children from Low-Income Families: Comparison of Reports from Mothers and Teachers. Journal of Child and Family Studies, Vol. 22, Issue. 6, p. 757.

    Kouros, Chrystyna D. Quasem, Susanna and Garber, Judy 2013. Dynamic temporal relations between anxious and depressive symptoms across adolescence. Development and Psychopathology, Vol. 25, Issue. 03, p. 683.

    Merikangas, Kathleen Ries Burstein, Marcy and Schmitz, Anja 2013. Women and Health.

    Schosser, Alexandra Butler, Amy W. Uher, Rudolf Ng, Mandy Y. Cohen-Woods, Sarah Craddock, Nick Owen, Mike J. Korszun, Ania Gill, Michael Rice, John Hauser, Joanna Henigsberg, Neven Maier, Wolfgang Mors, Ole Placentino, Anna Rietschel, Marcella Souery, Daniel Preisig, Martin Craig, Ian W. Farmer, Anne E. Lewis, Cathryn M. and McGuffin, Peter 2013. Genome-wide association study of co-occurring anxiety in major depression. The World Journal of Biological Psychiatry, Vol. 14, Issue. 8, p. 611.

    Nauta, Maaike H Festen, Helma Reichart, Catrien G Nolen, Willem A Stant, A Dennis Bockting, Claudi LH van der Wee, Nic JA Beekman, Aartjan Doreleijers, Theo AH Hartman, Catharina A de Jong, Peter J and de Vries, Sybolt O 2012. Preventing mood and anxiety disorders in youth: a multi-centre RCT in the high risk offspring of depressed and anxious patients. BMC Psychiatry, Vol. 12, Issue. 1,

    Ollendick, Thomas H. and Benoit, Kristy E. 2012. A Parent–Child Interactional Model of Social Anxiety Disorder in Youth. Clinical Child and Family Psychology Review, Vol. 15, Issue. 1, p. 81.

    Jucksch, Viola Salbach-Andrae, Harriet Lenz, Klaus Goth, Kirstin Döpfner, Manfred Poustka, Fritz Freitag, Christine M. Lehmkuhl, Gerd Lehmkuhl, Ulrike and Holtmann, Martin 2011. Severe affective and behavioural dysregulation is associated with significant psychosocial adversity and impairment. Journal of Child Psychology and Psychiatry, Vol. 52, Issue. 6, p. 686.

    Suveg, Cynthia Shaffer, Anne Morelen, Diana and Thomassin, Kristel 2011. Links Between Maternal and Child Psychopathology Symptoms: Mediation Through Child Emotion Regulation and Moderation Through Maternal Behavior. Child Psychiatry & Human Development, Vol. 42, Issue. 5, p. 507.

    Burstein, Marcy Ginsburg, Golda S. and Tein, Jenn-Yun 2010. Parental Anxiety and Child Symptomatology: An Examinzation of Additive and Interactive Effects of Parent Psychopathology. Journal of Abnormal Child Psychology, Vol. 38, Issue. 7, p. 897.

    Burstein, Marcy Ginsburg, Golda S. Petras, Hanno and Ialongo, Nicholas 2010. Parent Psychopathology and Youth Internalizing Symptoms in an Urban Community: A Latent Growth Model Analysis. Child Psychiatry & Human Development, Vol. 41, Issue. 1, p. 61.

    Colletti, Christina J. M. Forehand, Rex Garai, Emily McKee, Laura Potts, Jennifer Haker, Kelly Champion, Jennifer and Compas, Bruce E. 2010. Associations of Parent–Child Anxious and Depressive Symptoms When a Caregiver Has a History of Depression. Journal of Child and Family Studies, Vol. 19, Issue. 6, p. 762.

    Hirshfeld-Becker, Dina R. 2010. Familial and temperamental risk factors for social anxiety disorder. New Directions for Child and Adolescent Development, Vol. 2010, Issue. 127, p. 51.

    Kovacs, Maria and Lopez-Duran, Nestor 2010. Prodromal symptoms and atypical affectivity as predictors of major depression in juveniles: implications for prevention. Journal of Child Psychology and Psychiatry, Vol. 51, Issue. 4, p. 472.

    Colletti, Christina J. M. Forehand, Rex Garai, Emily Rakow, Aaron McKee, Laura Fear, Jessica M. and Compas, Bruce E. 2009. Parent Depression and Child Anxiety: An Overview of the Literature with Clinical Implications. Child & Youth Care Forum, Vol. 38, Issue. 3, p. 151.

    Klein, Rachel G. 2009. Anxiety disorders. Journal of Child Psychology and Psychiatry, Vol. 50, Issue. 1-2, p. 153.

    Micco, Jamie A. Henin, Aude Biederman, Joseph Rosenbaum, Jerrold F. Petty, Carter Rindlaub, Laura A. Murphy, Marisa and Hirshfeld-Becker, Dina R. 2009. Executive functioning in offspring at risk for depression and anxiety. Depression and Anxiety, Vol. 26, Issue. 9, p. 780.

    Micco, Jamie A. Henin, Aude Mick, Eric Kim, Susie Hopkins, Courtney A. Biederman, Joseph and Hirshfeld-Becker, Dina R. 2009. Anxiety and depressive disorders in offspring at high risk for anxiety: A meta-analysis. Journal of Anxiety Disorders, Vol. 23, Issue. 8, p. 1158.


A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression

  • DOI:
  • Published online: 15 May 2006

Background. To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence.

Method. Over a 5-year follow-up, we compared psychiatric disorders in four groups of children: (1) offspring of parents with PD plus MD (n=136); (2) offspring of parents with PD without MD (n=27); (3) offspring of parents with MD but without PD (n=53); and (4) offspring of non-PD non-MD parents (n=103).

Results. Parental PD was significantly associated with increased risk for anxiety disorders, irrespective of parental MD. Parental MD was associated with increased risk for MD, disruptive behavior disorders, and deficits in psychosocial functioning, irrespective of parental PD.

Conclusions. These longitudinal findings confirm and extend previous cross-sectional results documenting significant associations between PD and MD in parents and patterns of psychopathology and dysfunction in their offspring.

Corresponding author
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Patient Care-YAW 6A 6900, 32 Fruit Street, Boston, MA 02114, USA. (Email:
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *