Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 30
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Hunt, Jeffrey Schwarz, Charlotte M. Nye, Paul and Frazier, Elisabeth 2016. Is There a Bipolar Prodrome Among Children and Adolescents?. Current Psychiatry Reports, Vol. 18, Issue. 4,


    Gibbs, Melanie Winsper, Catherine Marwaha, Steven Gilbert, Eleanor Broome, Matthew and Singh, Swaran P. 2015. Cannabis use and mania symptoms: A systematic review and meta-analysis. Journal of Affective Disorders, Vol. 171, p. 39.


    Cosci, Fiammetta and Fava, Giovanni A. 2013. Staging of Mental Disorders: Systematic Review. Psychotherapy and Psychosomatics, Vol. 82, Issue. 1, p. 20.


    Simic, Iva Adzic, Miroslav Maric, Nadja Savic, Danka Djordjevic, Jelena Mihaljevic, Marina Mitic, Milos Pavlovic, Zorana Soldatovic, Ivan Krstic-Demonacos, Marija Jasovic-Gasic, Miroslava and Radojcic, Marija 2013. A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. Psychiatry Research, Vol. 209, Issue. 3, p. 658.


    DONOHUE, ANDREW W. 2012. Diagnosing Bipolar Disorder in the Community Setting. Journal of Psychiatric Practice, Vol. 18, Issue. 6, p. 395.


    Kaymaz, N. Drukker, M. Lieb, R. Wittchen, H.-U. Werbeloff, N. Weiser, M. Lataster, T. and van Os, J. 2012. Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results. Psychological Medicine, Vol. 42, Issue. 11, p. 2239.


    Malhi, Gin S Bargh, Danielle M Cashman, Emma Frye, Mark A and Gitlin, Michael 2012. The clinical management of bipolar disorder complexity using a stratified model. Bipolar Disorders, Vol. 14, p. 66.


    Rodríguez, Mar Rivas Nuevo, Roberto Chatterji, Somnath and Ayuso-Mateos, José Luis 2012. Definitions and factors associated with subthreshold depressive conditions: a systematic review. BMC Psychiatry, Vol. 12, Issue. 1,


    Skjelstad, Dag V. Holte, Arne and Malt, Ulrik F. 2012. Putative early manifestations of bipolar II disorder emerge later in the initial prodrome than manifestations hypothesized to be unrelated: an exploratory study. Early Intervention in Psychiatry, Vol. 6, Issue. 4, p. 460.


    Axelson, David A. Birmaher, Boris Strober, Michael A. Goldstein, Benjamin I. Ha, Wonho Gill, Mary Kay Goldstein, Tina R. Yen, Shirley Hower, Heather Hunt, Jeffrey I. Liao, Fangzi Iyengar, Satish Dickstein, Daniel Kim, Eunice Ryan, Neal D. Frankel, Erica and Keller, Martin B. 2011. Course of Subthreshold Bipolar Disorder in Youth: Diagnostic Progression From Bipolar Disorder Not Otherwise Specified. Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 50, Issue. 10, p. 1001.


    Jabben, Nienke Penninx, Brenda W.J.H. Beekman, Aartjan T.F. Smit, Johannes H. and Nolen, Willem A. 2011. Co-occurring manic symptomatology as a dimension which may help explaining heterogeneity of depression. Journal of Affective Disorders, Vol. 131, Issue. 1-3, p. 224.


    Skjelstad, Dag V. Malt, Ulrik F. and Holte, Arne 2011. Symptoms and behaviors prior to the first major affective episode of bipolar II disorder. An exploratory study. Journal of Affective Disorders, Vol. 132, Issue. 3, p. 333.


    Skjelstad, Dag V. Holte, Arne and Malt, Ulrik F. 2011. Genuine clinical predictors of bipolar II disorder: An exploration of temporal and contextual characteristics. Journal of Affective Disorders, Vol. 135, Issue. 1-3, p. 419.


    van Rossum, I. Dominguez, M.-d.-G. Lieb, R. Wittchen, H.-U. and van Os, J. 2011. Affective Dysregulation and Reality Distortion: A 10-Year Prospective Study of Their Association and Clinical Relevance. Schizophrenia Bulletin, Vol. 37, Issue. 3, p. 561.


    Vitiello, B. 2011. Prevention and treatment of child and adolescent depression: challenges and opportunities. Epidemiology and Psychiatric Sciences, Vol. 20, Issue. 01, p. 37.


    Katz, Gregory Durst, Rimona Shufman, Emi Bar-Hamburger, Rachel and Grunhaus, Leon 2010. Cannabis abuse and severity of psychotic and affective disorders in Israeli psychiatric inpatients. Comprehensive Psychiatry, Vol. 51, Issue. 1, p. 37.


    Tijssen, M. J. A. van Os, J. Wittchen, H.-U. Lieb, R. Beesdo, K. Mengelers, R. and Wichers, M. 2010. Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study. The British Journal of Psychiatry, Vol. 196, Issue. 2, p. 102.


    Tijssen, M. J. A. Van Os, J. Wittchen, H. U. Lieb, R. Beesdo, K. and Wichers, M. 2010. Risk factors predicting onset and persistence of subthreshold expression of bipolar psychopathology among youth from the community. Acta Psychiatrica Scandinavica, Vol. 122, Issue. 3, p. 255.


    Tijssen, M. J. A. van Os, J. Wittchen, H.-U. Lieb, R. Beesdo, K. Mengelers, R. Krabbendam, L. and Wichers, M. 2010. Evidence that bipolar disorder is the poor outcome fraction of a common developmental phenotype: an 8-year cohort study in young people. Psychological Medicine, Vol. 40, Issue. 02, p. 289.


    Kaymaz, Nil and Van Os, Jim 2009. Murray et al. (2004) revisited: is bipolar disorder identical to schizophrenia without developmental impairment?. Acta Psychiatrica Scandinavica, Vol. 120, Issue. 4, p. 249.


    ×

A prospective study of the transition rates of subthreshold (hypo)mania and depression in the general population

  • E. J. REGEER (a1), L. KRABBENDAM (a2), R. DE GRAAF (a3), M. TEN HAVE (a3), W. A. NOLEN (a4) and J. VAN OS (a2) (a5)
  • DOI: http://dx.doi.org/10.1017/S0033291705006823
  • Published online: 26 January 2006
Abstract

Background. Previous work suggests that subthreshold depression and subthreshold (hypo)mania are common, although little is known about the prognosis in terms of transition to clinical disorder. This paper presents data on the temporal relationship between subthreshold and clinical expression of mood phenotypes.

Method. In a random general population sample of 7076 individuals, symptoms of depression and (hypo)mania were measured with the Composite International Diagnostic Interview (CIDI) at baseline, after 1 year, and 2 years later.

Results. At baseline, the lifetime prevalences of depressive and (hypo)manic symptoms were 17·2% and 1·2% respectively. Predictive values of mood symptoms for a DSM-III-R mood disorder ranged from 14·3% to 50%. (Hypo)manic mood symptoms had much higher predictive values than unipolar manifestations, not only for bipolar disorder but also for major depression.

Conclusions. The subthreshold expressions of depression and (hypo)mania are prevalent and continuous with more severe clinical states. The cross-prediction of mood symptoms may support a continuum from depressive to (hypo)manic symptoms. The high predictive value of (hypo)manic symptoms for mood disorders suggests that the experience of (hypo)manic symptoms is a stronger indicator of vulnerability for mood dysregulation than the experience of depressive symptoms.

Copyright
Corresponding author
Altrecht GGZ, Tolsteegsingel 2A, 3582 AC Utrecht, The Netherlands. (Email: e.regeer@altrecht.nl)
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×