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Age of onset and course of major depressive disorder: associations with psychosocial functioning outcomes in adulthood

Published online by Cambridge University Press:  10 July 2014

S. Wilson ,
B. M. Hicks ,
K. T. Foster ,
M. McGue  and
W. G. Iacono
S. Wilson*
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
B. M. Hicks
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
K. T. Foster
Affiliation:
Departments of Psychiatry and Psychology, University of Michigan, Ann Arbor, MI, USA
M. McGue
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
W. G. Iacono
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
*
*Address for correspondence: S. Wilson, Ph.D., Department of Psychology, University of Minnesota, 75 East River Rd, Minneapolis, MN 55455, USA. (Email: syliaw@umn.edu)
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Abstract

Background

Major depressive disorder (MDD) that onsets by adolescence is associated with various deficits in psychosocial functioning. However, adolescent-onset MDD often follows a recurrent course that may drive its associated impairment.

Method

To tease apart these two clinical features, we examined the relative associations of age of onset (adolescent versus adult) and course (recurrent versus single episodes) of MDD with a broad range of psychosocial functioning outcomes assessed in early adulthood. Participants comprised a large, population-based sample of male and female twins from the Minnesota Twin Family Study (MTFS; n = 1252) assessed prospectively from ages 17 to 29 years.

Results

A recurrent course of MDD predicted impairment in several psychosocial domains in adulthood, regardless of whether the onset was in adolescence or adulthood. By contrast, adolescent-onset MDD showed less evidence of impairment in adulthood after accounting for recurrence. Individuals with both an adolescent onset and recurrent episodes of MDD represented a particularly severe group with pervasive psychosocial impairment in adulthood.

Conclusions

The negative implications of adolescent-onset MDD for psychosocial functioning in adulthood seem to be due primarily to its frequently recurrent course, rather than its early onset, per se. The results highlight the importance of considering both age of onset and course for understanding MDD and its implications for functioning, and also in guiding targeted intervention efforts.

Keywords

Adolescenceage of onsetmajor depressive disorderpsychosocial functioningrecurrence
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 3 , February 2015 , pp. 505 - 514
Copyright
Copyright © Cambridge University Press 2014 

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References

Beevers, CG, Rohde, P, Stice, E, Nolen-Hoeksema, S (2007). Recovery from major depressive disorder among female adolescents: a prospective test of the scar hypothesis. Journal of Consulting and Clinical Psychology 75, 888–900.CrossRefGoogle ScholarPubMed
Bemmels, HR, Burt, SA, Legrand, LN, Iacono, WG, McGue, M (2008). The heritability of life events: an adolescent twin and adoption study. Twin Research and Human Genetics 11, 257–265.CrossRefGoogle ScholarPubMed
Billig, JP, Hershberger, SL, Iacono, WG, McGue, M (1996). Life events and personality in late adolescence: genetic and environmental relations. Behavior Genetics 26, 543–554.CrossRefGoogle ScholarPubMed
Bland, RC, Newman, SC, Orn, H (1986). Recurrent and nonrecurrent depression. A family study. Archives of General Psychiatry 43, 1085–1089.CrossRefGoogle ScholarPubMed
Bulloch, AG, Williams, JV, Lavorato, DH, Patten, SB (2009). The relationship between major depression and marital disruption is bidirectional. Depression and Anxiety 26, 1172–1177.CrossRefGoogle ScholarPubMed
Cohen, J (1988). Statistical Power Analysis for the Behavioral Sciences. Erlbaum: Hillsdale, NJ.Google Scholar
Costello, EJ, Erkanli, A, Angold, A (2006). Is there an epidemic of child or adolescent depression? Journal of Child Psychology and Psychiatry 47, 1263–1271.CrossRefGoogle Scholar
Costello, EJ, Mustillo, S, Erkanli, A, Keeler, G, Angold, A (2003). Prevalence and development of psychiatric disorders in childhood and adolescence. Archives of General Psychiatry 60, 837–877.CrossRefGoogle ScholarPubMed
Hammen, C, Brennan, PA, Keenan-Miller, D, Herr, NR (2008). Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates. Journal of Child Psychology and Psychiatry 49, 433–440.CrossRefGoogle ScholarPubMed
Iacono, WG, McGue, M (2002). Minnesota Twin Family Study. Twin Research 5, 482–487.CrossRefGoogle ScholarPubMed
Jaffee, SR, Moffitt, TE, Caspi, A, Fombonne, E, Poulton, R, Martin, J (2002). Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Archives of General Psychiatry 58, 215–222.CrossRefGoogle Scholar
Johnson, W, Hicks, BM, McGue, M, Iacono, WG (2007). Most of the girls are alright, but some aren't: personality trajectory groups from ages 14 to 24 and some associations with outcomes. Journal of Personality and Social Psychology 93, 266–284.CrossRefGoogle ScholarPubMed
Kessler, RC, Berglund, P, Demler, O, Jin, R, Merikangas, KR, Walters, EE (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry 62, 593–602.CrossRefGoogle ScholarPubMed
Klein, DN, Kotov, R, Bufferd, SJ (2011). Personality and depression: explanatory models and review of the evidence. Annual Review of Clinical Psychology 7, 269–295.CrossRefGoogle ScholarPubMed
Lewinsohn, PM, Hops, H, Roberts, RE, Seeley, JR, Andrews, JA (1993). Adolescent psychopathology: I. Prevalence and incidence of depression and other DSM-III-R disorders in high school students. Journal of Abnormal Psychology 102, 133–144.CrossRefGoogle ScholarPubMed
Lewinsohn, PM, Rohde, P, Klein, DN, Seeley, JR (1999). Natural course of adolescent major depressive disorder: I. Continuity into young adulthood. Journal of the American Academy of Child and Adolescent Psychiatry 38, 56–63.CrossRefGoogle ScholarPubMed
Lewinsohn, PM, Rohde, P, Seeley, JR, Klein, DN, Gotlib, IH (2003). Psychosocial functioning of young adults who have experienced and recovered from major depressive disorder during adolescence. Journal of Abnormal Psychology 112, 353–363.CrossRefGoogle ScholarPubMed
Marmorstein, NR, Iacono, WG, Legrand, L (2014). Obesity and depression in adolescence and beyond: reciprocal risks. International Journal of Obesity. Published online: 31 January 2014 . doi:10.1038/ijo.2014.19.CrossRefGoogle ScholarPubMed
McGuffin, P, Katz, R, Watkins, S, Rutherford, J (1996). A hospital-based twin register of the heritability of DSM-IV unipolar depression. Archives of General Psychiatry 53, 129–136.CrossRefGoogle ScholarPubMed
Ormel, J, Oldehinkel, AJ, Nolen, WA, Vollebergh, W (2004 a). Psychosocial disability before, during, and after a major depressive episode: a 3-wave population-based study of state, scar, and trait effects. Archives of General Psychiatry 61, 387–392.CrossRefGoogle Scholar
Ormel, J, Oldehinkel, AJ, Vollebergh, W (2004 b). Vulnerability before, during, and after a major depressive episode: a 3-wave population-based study. Archives of General Psychiatry 61, 990–996.CrossRefGoogle Scholar
Pettit, JW, Hartley, C, Lewinsohn, PM, Seeley, JR, Klein, DN (2013). Is liability to recurrent major depressive disorder present before first episode onset in adolescence or acquired after the initial episode? Journal of Abnormal Psychology 122, 353–358.CrossRefGoogle ScholarPubMed
Peugh, JL, Enders, CK (2005). Using the SPSS mixed procedure to fit cross-sectional and longitudinal multilevel models. Educational and Psychological Measurement 65, 717–741.CrossRefGoogle Scholar
Reich, W, Welner, Z (1988). Revised version of the Diagnostic Interview for Children and Adolescents (DICA-R). Department of Psychiatry, Washington University School of Medicine: St Louis, MO.Google Scholar
Robins, LM, Baber, T, Cottler, LB (1987). Composite International Diagnostic Interview: Expanded Subtance Abuse Module. Department of Psychiatry, Washington University: St Louis, MO.Google Scholar
Robins, LM, Wing, J, Wittchen, HU, Helzer, JE, Babor, TF, Burke, J, Farmer, A, Jablenski, A, Pickens, R, Regier, DA, Sartorius, N, Towle, LH (1988). The Composite International Diagnostic Interview: an epidemiologic instrument suitable for use in conjunction with different diagnostic systems in different cultures. Archives of General Psychiatry 45, 1069–1077.CrossRefGoogle ScholarPubMed
Rohde, P, Lewinsohn, PM, Klein, DN, Seeley, JR, Gau, JM (2013). Key characteristics of major depressive disorder occurring in childhood, adolescence, emerging adulthood, and adulthood. Clinical Psychological Science 1, 41–53.CrossRefGoogle ScholarPubMed
Rohde, P, Lewinsohn, PM, Seeley, JR (1994). Are adolescents changed by an episode of major depression? Journal of the American Academy of Child and Adolescent Psychiatry 33, 1289–1298.CrossRefGoogle ScholarPubMed
Solomon, DA, Keller, MB, Leon, AC, Mueller, TI, Lavori, PW, Shea, T, Coryell, W, Warshaw, M, Turvey, C, Maser, JD, Endicott, J (2000). Multiple recurrences of major depressive disorder. American Journal of Psychiatry 157, 229–233.CrossRefGoogle ScholarPubMed
Spanier, GB (1976). Measuring dyadic adjustment: new scales for assessing the quality of marriage and similar dyads. Journal of Marriage and the Family 38, 15–28.CrossRefGoogle Scholar
Spitzer, RL, Endicott, J, Robins, E (1978). Research Diagnostic Criteria: rationale and reliability. Archives of General Psychiatry 35, 773–782.CrossRefGoogle ScholarPubMed
Spitzer, RL, Williams, JBW, Gibbon, M, First, MB (1987). Structured Clinical Interview for DSM-III-R (SCID). Biometrics Research Division, New York State Psychiatric Institute: New York, NY.Google Scholar
Tellegen, A, Waller, NG (2008). Exploring personality through test construction: development of the Multidimensional Personality Questionnaire. In Handbook of Personality Theory and Testing: Vol. II. Personality Measurement and Assessment (ed. Boyle, G. J., Matthews, G. and Saklofske, D. H.), pp. 261–292. Sage: Thousand Oaks, CA.CrossRefGoogle Scholar
Weissman, MM, Wolk, S, Goldstein, RB, Moreau, D, Adams, P, Greenwald, S, Klier, CM, Ryan, ND, Dahl, RE, Wickramaratne, P (1999). Depressed adolescents grown up. Journal of the American Medical Association 281, 1707–1713.CrossRefGoogle ScholarPubMed
Wilson, S, DiRago, AC, Iacono, WG (2014). Prospective inter-relationships between late adolescent personality and major depressive disorder in early adulthood. Psychological Medicine 44, 567–577.CrossRefGoogle ScholarPubMed
Zisook, S, Lesser, I, Stewart, JW, Wisniewski, SR, Balasubramani, GK, Fava, M, Gilmber, WS (2007). Effect of age at onset on the course of major depressive disorder. American Journal of Psychiatry 164, 1539–1546.CrossRefGoogle ScholarPubMed