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Effects of methylphenidate on executive functioning in attention-deficit/hyperactivity disorder across the lifespan: a meta-regression analysis

Published online by Cambridge University Press:  28 March 2016

H. G. H. Tamminga*
Affiliation:
Department of Radiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
L. Reneman
Affiliation:
Department of Radiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands Amsterdam Brain and Cognition Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands Brain Imaging Center, University of Amsterdam, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
H. M. Huizenga
Affiliation:
Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands Amsterdam Brain and Cognition Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands Research Priority Area Yield, University of Amsterdam, Amsterdam, The Netherlands
H. M. Geurts
Affiliation:
Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands Amsterdam Brain and Cognition Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands Research Priority Area Yield, University of Amsterdam, Amsterdam, The Netherlands
*
*Address for correspondence: H. G. H. Tamminga, Ph.D., Department of Psychology, University of Amsterdam, Weesperplein 4, 1018 XA Amsterdam, The Netherlands. (Email: g.h.tamminga@amc.nl)

Abstract

Attention-deficit/hyperactivity disorder (ADHD) in childhood and adulthood is often treated with the psychostimulant methylphenidate (MPH). However, it is unknown whether cognitive effects of MPH depend on age in individuals with ADHD, while animal studies have suggested age-related effects. In this meta-analysis, we first determined the effects of MPH on response inhibition, working memory and sustained attention, but our main goal was to examine whether these effects are moderated by age. A systematic literature search using PubMed, PsycINFO, Web of Science and MEDLINE for double-blind, placebo-controlled studies with MPH resulted in 25 studies on response inhibition (n = 775), 13 studies on working memory (n = 559) and 29 studies on sustained attention (n = 956) (mean age range 4.8–50.1 years). The effects of MPH on response inhibition [effect size (ES) = 0.40, p < 0.0001, 95% confidence interval (CI) 0.22–0.58], working memory (ES = 0.24, p = 0.053, 95% CI 0.00–0.48) and sustained attention (ES = 0.42, p < 0.0001, 95% CI 26–0.59) were small to moderate. No linear or quadratic age-dependencies were observed, indicating that effects of MPH on executive functions are independent of age in children and adults with ADHD. However, adolescent studies are lacking and needed to conclude a lack of an age-dependency across the lifespan.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2016 

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References

Agay, N, Yechiam, E, Carmel, Z, Levkovitz, Y (2010). Non-specific effects of methylphenidate (Ritalin) on cognitive ability and decision-making of ADHD and healthy adults. Psychopharmacology 210, 511519.Google Scholar
Agay, N, Yechiam, E, Carmel, Z, Levkovitz, Y (2014). Methylphenidate enhances cognitive performance with poor baseline capacities regardless of attention-deficit/hyperactivity disorder. Journal of Clinical Psychopharmacology 34, 261265.CrossRefGoogle ScholarPubMed
American Academy of Pediatrics (2001). Clinical practice guideline: treatment of the school-aged child with attention-deficit/hyperactivity disorder. Pediatrics 108, 10331044.Google Scholar
American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th edn. APA: Washington, DC.Google Scholar
Andersen, SL (2005). Stimulants and the developing brain. Trends in Pharmacological Sciences 26, 237243.Google Scholar
Aron, RA, Dowson, JH, Sahakian, BJ, Robbins, TW (2003). Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder. Biological Psychiatry 54, 14651468.Google Scholar
Barkley, RA, Fischer, M, Newby, RF, Breen, MJ (1988). Development of a multimethod clinical protocol for assessing stimulant drug response in children with attention deficit disorder. Journal of Clinical Child Psychology 17, 1424.CrossRefGoogle Scholar
Barkley, RA, Fischer, M, Smallish, L, Fletcher, K (2002). The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder. Journal of Abnormal Psychology 111, 279289.CrossRefGoogle ScholarPubMed
Barkley, RA, Murphy, KR, O'Connell, T, Connor, DF (2005). Effects of two doses of methylphenidate on simulator driving performance in adults with attention deficit hyperactivity disorder. Journal of Safety Research 36, 121131.Google Scholar
Bedard, A, Ickowicz, A, Logan, GD, Hogg-Johnson, S, Schachar, R, Tannock, R (2003). Selective inhibition in children with attention-deficit hyperactivity disorder off and on stimulant medication. Journal of Abnormal Child Psychology 31, 315327.Google Scholar
Bedard, A, Tannock, R (2008). Anxiety, methylphenidate response, and working memory in children with ADHD. Journal of Attention Disorders 11, 546557.Google Scholar
Biederman, J, Mick, E, Fried, R, Wilner, N, Spencer, TJ, Faraone, SV (2011). Are stimulants effective in the treatment of executive function deficits? Results from a randomized double blind study of OROS-methylphenidate in adults with ADHD. European Neuropsychopharmacology 21, 508515.CrossRefGoogle ScholarPubMed
Bizot, C, Chenault, N, Houzé, B, Herpin, A, David, S, Pothion, S, Trovero, F (2007). Methylphenidate reduces impulsive behaviour in juvenile Wistar rats, but not in adult Wistar, SHR and WKY rats. Psychopharmacology 193, 215223.Google Scholar
Blakemore, S, Choudhury, S (2006). Development of the adolescent brain: implications for executive function and social cognition. Journal of Child Psychology and Psychiatry 47, 296312.CrossRefGoogle ScholarPubMed
Blum, NJ, Awad, AF, Clarke, AT, Power, TJ (2011). Effect of osmotic-release oral system methylphenidate on different domains of attention and executive functioning in children with attention-deficit-hyperactivity disorder. Developmental Medicine and Child Neurology 53, 843849.CrossRefGoogle ScholarPubMed
Bolanos, CA, Glatt, SJ, Jackson, D (1998). Subsensitivity to dopaminergic drugs in periadolescent rats: a behavioural and neurochemical analysis. Developmental Brain Research 111, 2533.Google Scholar
Boonstra, AM, Kooij, JJS, Oosterlaan, J, Sergeant, JA, Buitelaar, JK (2005). Does methylphenidate improve inhibition and other cognitive abilities in adults with childhood-onset ADHD? Journal of Clinical and Experimental Neuropsychology 27, 278298.CrossRefGoogle ScholarPubMed
Borenstein, M, Hedges, LV, Higgins, JPT, Rothstein, HR (2009). Introduction to Meta-Analysis, pp. 225238. John Wiley & Sons: Chichester, UK.Google Scholar
Bouffard, R, Hechtman, L, Minde, K, Iaboni-Kassab, F (2003). The efficacy of 2 different dosages of methylphenidate in treating adults with attention-deficit hyperactivity disorder. Canadian Journal of Psychiatry 48, 546554.Google Scholar
Bron, TI, Bijlenga, D, Boonstra, AM, Breuk, M, Pardoen, WFH, Beekman, ATF, Kooij, JJS (2014). OROS-methylphenidate efficacy on specific executive functioning deficits in adults with ADHD: a randomized, placebo-controlled cross-over study. European Neuropsychopharmacology 24, 519528.CrossRefGoogle ScholarPubMed
Chamberlain, SR, Robbins, TW, Winder-Rhodes, S, Müller, U, Sahakian, BS, Blackwell, AD, Barnett, JH (2011). Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological battery. Biological Psychiatry 69, 11921203.Google Scholar
Coghill, DR, Rhodes, SM, Matthews, K (2007). The neuropsychological effects of chronic methylphenidate on drug- naïve boys with attention-deficit/hyperactivity disorder. Biological Psychiatry 62, 954962.CrossRefGoogle ScholarPubMed
Coghill, DR, Seth, S, Pedroso, S, Usala, T, Currie, J, Gagliano, A (2013). Effects of methylphenidate on cognitive functions in children and adolescents with attention-deficit/hyperactivity disorder: evidence from a systematic review and a meta-analysis. Biological Psychiatry 76, 603615.Google Scholar
Coons, HW, Klorman, R, Borgstedt, AD (1987). Effects of methylphenidate on adolescents with a childhood history of attention deficit disorder: II. Information processing. Journal of the American Academy of Child and Adolescent Psychiatry 26, 368374.CrossRefGoogle ScholarPubMed
Cortese, S, Kelly, C, Chabernaud, C, Proal, E, Di Martino, A, Milham, MP, Castellanos, FX (2012). Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies. American Journal of Psychiatry 169, 10381055.Google Scholar
Cubillo, A, Smith, AB, Barrett, N, Giampietro, V, Brammer, MJ, Simmons, A, Rubia, K (2014 a). Shared and drug-specific effects of atomoxetine and methylphenidate on inhibitory brain dysfunction in medication-naïve ADHD boys. Cerebral Cortex 24, 174185.Google Scholar
Cubillo, A, Smith, AB, Barrett, N, Giampietro, V, Brammer, MJ, Simmons, A, Rubia, K (2014 b). Drug-specific laterality effects on frontal lobe activation of atomoxetine and methylphenidate in attention deficit hyperactivity disorder boys during working memory. Psychological Medicine 44, 633646.Google Scholar
DeVito, EE, Blackwell, AD, Clark, L, Kent, L, Dezsery, AM, Turner, DC, Aitken, MRF, Sahakian, BJ (2009). Methylphenidate improves response inhibition but not reflection impulsivity in children with attention deficit hyperactivity disorder (ADHD). Psychopharmacology 202, 531539.Google Scholar
DuPaul, GJ, Barkley, RA, McMurray, MB (1994). Response of children with ADHD to methylphenidate: interaction with internalizing symptoms. Journal of the American Academy of Child and Adolescent Psychiatry 33, 894903.CrossRefGoogle ScholarPubMed
Durston, S, Tottenham, NT, Thomas, KM, Davidson, MC, Eigsti, I-M, Yang, Y, Ulug, AM, Casey, BJ (2003). Differential patterns of striatal activation in young children with and without ADHD. Biological Psychiatry 53, 871878.Google Scholar
Duval, S, Tweedie, R (2000). Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56, 455463.Google Scholar
Epstein, JN, Brinkman, WB, Froehlich, T, Langberg, JM, Narad, ME, Antonini, TN, Shiels, K, Simon, JO, Altaye, M (2011). Effects of stimulant medication, incentives, and event rate on reaction time variability in children with ADHD. Neuropsychopharmacology 36, 10601072.Google Scholar
Epstein, JN, Casey, BJ, Tonev, ST, Davidson, MC, Reiss, AL, Garrett, A, Hinshaw, SP, Greenhill, LL, Glover, G, Shafritz, KM, Vitolo, A, Kotler, LA, Jarrett, MA, Spicer, J (2007). ADHD- and medication-related brain activation effects in concordantly affected parent–child dyads with ADHD. Journal of Child Psychology and Psychiatry 48, 899913.Google Scholar
Faraone, SV, Biederman, J (2006). What is the prevalence of adult ADHD? Results of a population screen of 966 adults. Journal of Attention Disorders 9, 384391.CrossRefGoogle Scholar
Faraone, SV, Buitelaar, J (2010). Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis. European Child and Adolescent Psychiatry 19, 353364.CrossRefGoogle ScholarPubMed
Faraone, SV, Glatt, SJ (2010). A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes. Journal of Clinical Psychiatry 71, 754763.Google Scholar
Frodl, T, Skokauskas, N (2012). Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects. Acta Psychiatrica Scandinavica 125, 114126.Google Scholar
Giedd, JN (2004). Structural magnetic resonance imaging of the adolescent brain. Annals of the New York Academy of Sciences 1021, 7785.CrossRefGoogle ScholarPubMed
Gittelman, R, Manuzza, S, Shenker, R, Bonagura, N (1985). Hyperactive boys almost grown up I. Psychiatric status. Archives of General Psychiatry 42, 937947.Google Scholar
Gruber, R, Grizenko, N, Schwartz, G, Bellingham, J, Guzman, R, Joober, R (2007). Performance on the continuous performance test in children with ADHD is associated with sleep efficiency. Sleep 30, 10031009.CrossRefGoogle ScholarPubMed
Günther, T, Herpertz-Dahlmann, B, Konrad, K (2010). Sex differences in attentional performance and their modulation by methylphenidate in children with attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology 20, 179186.Google Scholar
Hanisch, C, Konrad, K, Günther, T, Herpertz-Dahlmann, B (2004). Age-dependent neuropsychological deficits and effects of methylphenidate in children with attention-deficit/hyperactivity disorder: a comparison of pre- and grade-school children. Journal of Neural Transmission 111, 865881.Google Scholar
Hart, H, Radua, J, Nakao, T, Mataix-Cols, D, Rubia, K (2013). Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: exploring task-specific, stimulant medication, and age effects. Archives of General Psychiatry 70, 185198.Google Scholar
Higgins JPT, Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration (www.cochrane-handbook.org).Google Scholar
Hozo, SP, Djulbegovic, B, Moore, AN (2005). Estimating the mean and variance from the median, range, and the size of a sample. BMC Medical Research Methodology 5, 13.Google Scholar
Kavale, K (1982). The efficacy of stimulant drug treatment for hyperactivity: a meta-analysis. Journal of Learning Disabilities 15, 280289.CrossRefGoogle ScholarPubMed
Klorman, R, Coons, HW, Borgstedt, AD (1987). Effects of methylphenidate on adolescents with a childhood history of attention deficit disorder: I. Clinical findings. American Academy of Child and Adolescent Psychiatry 26, 363367.Google Scholar
Koda, K, Ago, Y, Cong, Y, Takuma, K, Matsuda, T (2010). Effects of acute and chronic administration of atomoxetine and methylphenidate on extracellular levels of noradrenaline, dopamine and serotonin in the prefrontal cortex and striatum of mice. Journal of Neurochemistry 114, 259270.Google Scholar
Konrad, K, Günther, T, Hanisch, C, Herpertz-Dahlmann, B (2004). Differential effects of methylphenidate on attentional functions in children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry 43, 191198.Google Scholar
Konrad, K, Günther, T, Heinzel-Gutenbrunner, M, Herpertz-Dahlmann, B (2005). Clinical evaluation of subjective and objective changes in motor activity and attention in children with attention-deficit/hyperactivity disorder in a double-blind methylphenidate trial. Journal of Child and Adolescent Psychopharmacology 15, 180190.Google Scholar
Kuczenski, R, Segal, DS (2002) Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine. Journal of Neuroscience 22, 72647271.Google Scholar
Kuperman, S, Perry, P, Gaffney, GR, Lund, BC, Bever-Stille, KA, Arndt, S, Holman, TL, Moser, DJ, Paulsen, JS (2001). Buproprion SR vs. methylphenidate vs. placebo for attention deficit hyperactivity disorder in adults. Annals of Clinical Psychiatry 13, 129134.Google Scholar
Lebel, C, Gee, M, Camicioli, R, Wieler, M, Martin, W, Beaulieu, C (2012). Diffusion tensor imaging of white matter tract evolution over the lifespan. NeuroImage 60, 340352.Google Scholar
Lipsey, MW, Wilson, DB (2001). Practical Meta-analysis, vol. 49. Sage Publications Inc.: Thousand Oaks, CA.Google Scholar
Loo, SK, Hopfer, C, Teale, PD, Reite, ML (2004). EEG correlates of methylphenidate response in ADHD: association with cognitive and behavioral measures. Journal of Clinical Neurophysiology 21, 457464.Google Scholar
Losier, BJ, McGrath, PJ, Klein, RM (1996). Error patterns on the continuous performance test in non-medicated and medicated samples of children with and without ADHD: a meta-analytic review. Journal of Child Psychology and Psychiatry 37, 971987.Google Scholar
Luman, M, Papanikolau, A, Oosterlaan, J (2015). The unique and combined effects of reinforcement and methylphenidate on temporal information processing in attention-deficit/hyperactivity disorder. Journal of Clinical Psychopharmacology 35, 414421.Google Scholar
Manuzza, S, Gittelman Klein, R, Addalli, KA (1991). Young adult mental status of hyperactive boys and their brothers: a prospective follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry 30, 743751.Google Scholar
McInnes, A, Bedard, A, Hogg-Johnson, S, Tannock, R (2007). Preliminary evidence of beneficial effects of methylphenidate on listening comprehension in children with attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology 17, 3549.CrossRefGoogle ScholarPubMed
Mehta, MA, Goodyer, IM, Sahakian, BJ (2004). Methylphenidate improves working memory and set-shifting in AD/HD: relationships to baseline memory capacity. Journal of Child Psychology and Psychiatry 45, 293305.Google Scholar
Milich, R, Licht, BG, Murphy, DA, Pelham, WE (1989). Attention-deficit hyperactivity disordered boys’ evaluations of and attributions for task performance on medication versus placebo. Journal of Abnormal Psychology 98, 280284.CrossRefGoogle ScholarPubMed
Monden, Y, Dan, H, Nagashima, M, Dan, I, Tsuzuki, D, Kyutoku, Y, Gunji, Y, Yamagata, T, Watanabe, E, Momoi, MY (2012). Right prefrontal activation as a neuro-functional biomarker for monitoring acute effects of methylphenidate in ADHD children: an fNIRS study. NeuroImage. Clinical 1, 131140.Google Scholar
Monteiro Musten, L, Firestone, P, Pisterman, S, Bennett, S, Mercer, J (1997). Effects of methylphenidate on preschool children with ADHD: cognitive and behavioral functions. Journal of the American Academy of Child and Adolescent Psychiatry 36, 14071415.Google Scholar
Morris, SB, DeShon, RP (2002). Combining effect size estimates in meta-analysis with repeated measures and independent-groups designs. Psychological Methods 7, 105125.CrossRefGoogle ScholarPubMed
Murray, DW, Childress, A, Giblin, J, Williamson, D, Armstrong, R, Starr, L (2011). Effects of OROS methylphenidate on academic, behavioural, and cognitive tasks in children 9 to 12 years of age with attention-deficit/hyperactivity disorder. Clinical Pediatrics 50, 308320.Google Scholar
Nakao, T, Radua, J, Rubia, K, Mataix-Cols, D (2011). Matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medication. American Journal of Psychiatry 168, 11541163.Google Scholar
Niculescu, M, Ehrlich, ME, Unterwald, ME (2005). Age-specific behavioral responses to psychostimulants in mice. Pharmacological Biochemistry and Behavior 82, 280288.Google Scholar
Overtoom, CCE, Bekker, WM, van der Molen, MW, Verbaten, MN, Kooij, JJS, Buitelaar, JK, Kenemans, JL (2009). Methylphenidate restores link between stop-signal sensory impact and successful stopping in adults with attention-deficit/hyperactivity disorder. Biological Psychiatry 65, 614619.Google Scholar
Overtoom, CCE, Verbaten, MN, Kemner, C, Kenemans, JL, van Engeland, H, Buitelaar, JK, van der Molen, MW, van der Gugten, J, Westenberg, H, Maes, RAA, Koelega, HS (2003). Effects of methylphenidate, desipramine, and l-dopa on attention and inhibition in children with attention deficit hyperactivity disorder. Behavioural Brain Research 145, 715.CrossRefGoogle ScholarPubMed
Pietrzak, RH, Mollica, CM, Maruff, P, Snyder, PJ (2006). Cognitive effects of immediate-release methylphenidate in children with attention-deficit/hyperactivity disorder. Neuroscience and Biobehavioral Reviews 30, 12251245.Google Scholar
Pliszka, SR, Liotti, M, Bailey, BY, Perez, R, Glahn, D, Semrud-Clikeman, M (2007). Electrophysiological effects of stimulant treatment on inhibitory control in children with attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology 17, 356366.CrossRefGoogle ScholarPubMed
Punja, S, Zorzela, K, Hartling, L, Urichuk, L, Vohra, S (2013). Long-acting versus short-acting methylphenidate for paediatric ADHD: a systematic review and meta-analysis of comparative efficacy. BMJ Open 3, e002312.CrossRefGoogle ScholarPubMed
Ramtvedt, BE, Røinås, E, Aabech, HS, Sundet, KS (2013). Clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials. Journal of Child and Adolescent Psychopharmacology 23, 597604.Google Scholar
Rhodes, SM, Coghill, DR, Matthews, K (2004). Methylphenidate restores visual memory, but not working memory function in attention deficit-hyperkinetic disorder. Psychopharmacology 175, 319330.CrossRefGoogle Scholar
Riccio, CA, Waldrop, JJM, Reynolds, CR, Lowe, P (2001). Effects of stimulants on the Continuous Performance Test (CPT) implications for CPT use and interpretation. Journal of Neuropsychiatry and Clinical Neuroscience 13, 326335.Google Scholar
Rosenthal, R (1979). The ‘file drawer problem’ and tolerance for null results. Psychological Bulletin 85, 638641.Google Scholar
Rubia, K, Alegria, AA, Cubillo, A, Smith, AB, Brammer, MJ, Radua, J (2014). Effects of stimulants on brain function in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. Biological Psychiatry 76, 616628.Google Scholar
Rubia, K, Halari, R, Cubillo, A, Mohammad, A, Brammer, M, Taylor, E (2009). Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance task. Neuropharmacology 57, 640652.CrossRefGoogle ScholarPubMed
Rubia, K, Halari, R, Mohammad, A-M, Taylor, E, Brammer, M (2011) Methylphenidate normalizes frontocingulate underactivation during error processing in attention-deficit/hyperactivity disorder. Biological Psychiatry 70, 255262.Google Scholar
Schachar, R, Ickowicz, A, Crosbie, J, Donnelly, GAE, Reiz, JL, Miceli, PC, Harsanyi, Z, Darke, AC (2008). Cognitive and behavioral effects of multilayer-release methylphenidate in the treatment of children with attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology 18, 1124.Google Scholar
Scheres, A, Oosterlaan, J, Sergeant, JA (2006). Speed of inhibition predicts teacher-rated medication response in boys with attention deficit hyperactivity disorder. International Journal of Disability, Development and Education 53, 93109.Google Scholar
Scheres, A, Oosterlaan, J, Swanson, J, Morein-Zamir, S, Meiran, N, Schut, H, Vlasveld, L, Sergeant, JA (2003). The effect of methylphenidate on three forms of response inhibition in boys with AD/HD. Journal of Abnormal Child Psychology 31, 105120.Google Scholar
Schwartz, S, Correll, CU (2014). Efficacy and safety of atomoxetine in children and adolescents with attention-deficit/hyperactivity disorder: results from a comprehensive meta-analysis and metaregression. Journal of the American Academy of Child and Adolescent Psychiatry 53, 174187.Google Scholar
Shaw, P, Eckstrand, K, Sharp, W, Blumenthal, J, Lerch, JP, Greenstein, D, Clasen, L, Evans, A, Giedd, J, Rapoport, JL (2007). Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proceedings of the National Academy of Sciences 104, 1964919654.Google Scholar
Shaw, P, Kabani, NJ, Lerch, JP, Eckstrand, K, Lenroot, R, Gogtay, N, Greenstein, D, Clasen, L, Evans, A, Rapoport, JL, Giedd, JN, Wise, SP (2008). Neurodevelopmental trajectories of the human cerebral cortex. Journal of Neuroscience 28, 35863594.Google Scholar
Shiels, K, Hawk, LW Jr., Reynolds, B, Mazzullo, RJ, Rhodes, JD, Pelham, WE Jr., Waxmonsky, JG, Gangloff, BP (2009). Effects of methylphenidate on discounting of delayed rewards in attention deficit/hyperactivity disorder. Experimental and Clinical Psychopharmacology 17, 291301.Google Scholar
Simon, V, Czobor, P, Balint, S, Mészarós, Á, Bitter, I (2009). Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. British Journal of Psychiatry 194, 204211.Google Scholar
Solanto, M, Newcom, J, Vail, L, Gilbert, S, Ivanov, I, Lara, R (2009). Stimulant drug response in the predominantly inattentive and combined subtypes of attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology 19, 663671.Google Scholar
Solanto, MV (1984). Neuropharmacological basis of stimulant drug action in attention deficit disorder with hyperactivity: a review and synthesis. Psychological Bulletin 95, 387409.Google Scholar
Stein, MA, Blondis, TA, Schnitzler, ER, O'Brien, T, Fishkin, J, Blackwell, B, Szumowski, E, Roizen, NJ (1996). Methylphenidate dosing: twice daily versus three times daily. Pediatrics 98, 748756.Google Scholar
Sunohara, GA, Malone, MA, Rovet, J, Humphries, T, Roberts, W, Taylor, MJ (1999). Effect of methylphenidate on attention in children with attention deficit hyperactivity disorder (ADHD): ERP evidence. Neuropsychopharmacology 21, 218228.Google Scholar
Szobot, CM, Ketzer, C, Parente, MA, Biederman, J, Rohde, LA (2004). The acute effect of methylphenidate in Brazilian male children and adolescents with ADHD: a randomized clinical trial. Journal of Attention Disorders 8, 3743.Google Scholar
Tamm, L, Carlson, CL (2007). Task demands interacts with the single and combined effects of medication and contingencies on children with ADHD. Journal of Attention Disorders 10, 372380.Google Scholar
Tannock, R, Schachar, R, Logan, G (1995). Methylphenidate and cognitive flexibility: dissociated dose effects in hyperactive children. Journal of Abnormal Child Psychology 23, 235266.Google Scholar
Toplak, ME, West, RF, Stanovich, KE (2013). Practitioner review: do performance-based measures and ratings of executive function assess the same construct? Journal of Child Psychology and Psychiatry 54, 131143.Google Scholar
Tucha, O, Prell, S, Mecklinger, L, Bormann-Kischkel, C, Kübber, S, Linder, M, Walitza, S, Lange, KW (2006). Effects of methylphenidate on multiple components of attention in children with attention deficit hyperactivity disorder. Psychopharmacology 185, 315326.Google Scholar
Turner, DC, Blackwell, AD, Dowson, JH, McLean, A, Sahakian, BJ (2005). Neurocognitive effects of methylphenidate in adult attention-deficit/hyperactivity disorder. Psychopharmacology 178, 286295.Google Scholar
Van der Oord, S, Geurts, HM, Prins, PJM, Emmelkamp, PMG, Oosterlaan, J (2012). Prepotent response inhibition predicts treatment outcome in attention deficit/hyperactivity disorder. Child Neuropsychology 18, 5061.Google Scholar
Viechtbauer, W (2010). Conducting meta-analyses in R with the metafor package. Journal of Statistical Software 36 (https://www.jstatsoft.org/article/view/v036i03/v36i03.pdf). Accessed February 2016.Google Scholar
Volkow, ND, Wang, G, Tomasi, D, Kollins, SH, Wigal, TL, Newcorn, JH, Telang, FW, Fowler, JS, Logan, J, Wong, CT, Swanson, JM (2012). Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder. Journal of Neuroscience 32, 841849.Google Scholar
Westlyle, LT, Walhovd, KB, Dale, AM, Bjørnerud, A, Due-Tønnessen, P, Engvig, A, Grydeland, H, Tamnes, CK, Østby, Y, Fjell, AM (2010). Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry. Cerebral Cortex 20, 20552068.Google Scholar
Wigal, SB, Wigal, T, Schuck, S, Brams, M, Williamson, D, Armstrong, RB, Starr, L (2011). Academic, behavioral, and cognitive effects of OROS methylphenidate on older children with attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology 21, 121131.Google Scholar
Wilson, HK, Cox, DJ, Merkel, RL, Moore, M, Coghill, D (2006). Effect of extended release stimulant-based medications on neuropsychological functioning among adolescents with attention-deficit/hyperactivity disorder. Archives of Clinical Neuropsychology 21, 797807.Google Scholar
Zeiner, P (1999). Do the beneficial effects of extended methylphenidate treatment in boys with attention-deficit hyperactivity disorder dissipate rapidly during placebo treatment? Nordic Journal of Psychiatry 53, 5560.Google Scholar
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