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A longitudinal, population-based twin study of avoidant and obsessive-compulsive personality disorder traits from early to middle adulthood

Published online by Cambridge University Press:  14 August 2015

L. C. Gjerde*
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
N. Czajkowski
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway Department of Psychology, University of Oslo, Oslo, Norway
E. Røysamb
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway Department of Psychology, University of Oslo, Oslo, Norway
E. Ystrom
Affiliation:
Department of Psychology, University of Oslo, Oslo, Norway
K. Tambs
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
S. H. Aggen
Affiliation:
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA Departments of Psychiatry and Human Genetics, Virginia Commonwealth University, Richmond, VA, USA
R. E. Ørstavik
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
K. S. Kendler
Affiliation:
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA Departments of Psychiatry and Human Genetics, Virginia Commonwealth University, Richmond, VA, USA Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
T. Reichborn-Kjennerud
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway Institute of Psychiatry, University of Oslo, Oslo, Norway Department of Epidemiology, Columbia University, New York, NY, USA
G. P. Knudsen
Affiliation:
Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
*
*Address for correspondence: Dr L. C. Gjerde, Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway (Email: line.gjerde@fhi.no)

Abstract

Background.

The phenotypic stability of avoidant personality disorder (AVPD) and obsessive-compulsive personality disorder (OCPD) has previously been found to be moderate. However, little is known about the longitudinal structure of genetic and environmental factors for these disorders separately and jointly, and to what extent genetic and environmental factors contribute to their stability.

Method.

AVPD and OCPD criteria were assessed using the Structured Interview for DSM-IV Personality in 2793 young adult twins (1385 pairs, 23 singletons) from the Norwegian Institute of Public Health Twin Panel at wave 1 and 2282 (986 pairs, 310 singletons) of these on average 10 years later at wave 2. Longitudinal biometric models were fitted to AVPD and OCPD traits.

Results.

For twins who participated at both time-points, the number of endorsed sub-threshold criteria for both personality disorders (PDs) decreased 31% from wave 1 to wave 2. Phenotypic correlations between waves were 0.54 and 0.37 for AVPD and OCPD, respectively. The heritability estimates of the stable PD liabilities were 0.67 for AVPD and 0.53 for OCPD. The genetic correlations were 1.00 for AVPD and 0.72 for OCPD, while the unique environmental influences correlated 0.26 and 0.23, respectively. The correlation between the stable AVPD and OCPD liabilities was 0.39 of which 63% was attributable to genetic influences. Shared environmental factors did not significantly contribute to PD variance at either waves 1 or 2.

Conclusion.

Phenotypic stability was moderate for AVPD and OCPD traits, and genetic factors contributed more than unique environmental factors to the stability both within and across phenotypes.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 2015 

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