Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Home
Hostname: page-component-55597f9d44-mzfmx Total loading time: 0.957 Render date: 2022-08-17T08:50:57.806Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true } hasContentIssue true
  • English
Psychological Medicine Psychological Medicine

Article contents

Neurobiological mechanisms of social cognition treatment in high-functioning adults with autism spectrum disorder

Published online by Cambridge University Press:  25 September 2019

Gabriela Rosenblau Open the ORCID record for Gabriela Rosenblau[Opens in a new window] ,
Garret O'Connell ,
Hauke R. Heekeren Open the ORCID record for Hauke R. Heekeren[Opens in a new window]  and
Isabel Dziobek
Gabriela Rosenblau*
Affiliation:
Cluster of Excellence ‘Languages of Emotion’, Freie Universität Berlin, Berlin14195, Germany Department of Education and Psychology, Freie Universität Berlin, Berlin14195, Germany Autism and Neurodevelopmental Disorders Institute, The George Washington University and Children's National Health System, 2115 G St NW, Washington, DC20052, USA
Garret O'Connell
Affiliation:
Berlin School of Mind and Brain, Institute of Psychology, Humboldt-Universität zu Berlin, Unter den Linden 6, 10099, Berlin, Germany
Hauke R. Heekeren
Affiliation:
Cluster of Excellence ‘Languages of Emotion’, Freie Universität Berlin, Berlin14195, Germany Department of Education and Psychology, Freie Universität Berlin, Berlin14195, Germany Center for Cognitive Neuroscience Berlin, Freie Universität Berlin, Berlin, Germany
Isabel Dziobek
Affiliation:
Cluster of Excellence ‘Languages of Emotion’, Freie Universität Berlin, Berlin14195, Germany Department of Education and Psychology, Freie Universität Berlin, Berlin14195, Germany Berlin School of Mind and Brain, Institute of Psychology, Humboldt-Universität zu Berlin, Unter den Linden 6, 10099, Berlin, Germany
*
Author for correspondence: Gabriela Rosenblau, E-mail: grosenblau@gwu.edu
Get access Rights & Permissions[Opens in a new window]

Abstract

Background

The promise of precision medicine for autism spectrum disorder (ASD) hinges on developing neuroscience-informed individualized interventions. Taking an important step in this direction, we investigated neuroplasticity in response to an ecologically-valid, computer-based social-cognitive training (SCOTT).

Methods

In an active control group design, 48 adults with ASD were randomly assigned to a 3-month SCOTT or non-social computer training. Participants completed behavioral tasks, a functional and structural magnetic resonance imaging session before and after the training period.

Results

The SCOTT group showed social-cognitive improvements on close and distant generalization tasks. The improvements scaled with reductions in functional activity and increases in cortical thickness in prefrontal regions.

Conclusion

In sum, we provide evidence for the sensitivity of neuroscientific methods to reflect training-induced social-cognitive improvements in adults with ASD. These results encourage the use of neuroimaging data to describe and quantify treatment-related changes more broadly.

Keywords

Autism spectrum disorderindividualized medicineinterventionMRIneuroplasticitysocial cognition
Type
Original Articles
Information
Psychological Medicine , Volume 50 , Issue 14 , October 2020 , pp. 2374 - 2384
Check for updates
Copyright
Copyright © Cambridge University Press 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1994) Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association.Google Scholar
Amodio, DM and Frith, CD (2006) Meeting of minds: the medial frontal cortex and social cognition. Nature Reviews Neuroscience 7, 268–277.CrossRefGoogle ScholarPubMed
Beauchamp, KG, Kahn, LE and Berkman, ET (2016) Does inhibitory control training transfer? Behavioral and neural effects on an untrained emotion regulation task. Social Cognitive and Affective Neuroscience 11, 1374–1382.CrossRefGoogle Scholar
Behrens, TE, Hunt, LT, Woolrich, MW and Rushworth, MF (2008) Associative learning of social value. Nature 456, 245–249.CrossRefGoogle ScholarPubMed
Bishop-Fitzpatrick, L, Minshew, NJ and Eack, SM (2013) A systematic review of psychosocial interventions for adults with autism spectrum disorders. Journal of Autism and Developmental Disorders 43, 687–694.CrossRefGoogle ScholarPubMed
Bolte, S, Hubl, D, Feineis-Matthews, S, Prvulovic, D, Dierks, T and Poustka, F (2006) Facial affect recognition training in autism: Can we animate the fusiform gyrus? Behavioral Neuroscience 120, 211–216.CrossRefGoogle ScholarPubMed
Bolte, S, Ciaramidaro, A, Schlitt, S, Hainz, D, Kliemann, D, Beyer, A, Poustka, F, Freitag, C and Walter, H (2015) Training-induced plasticity of the social brain in autism spectrum disorder. British Journal of Psychiatry 207, 149–157.CrossRefGoogle ScholarPubMed
Bowler, DM (1992) ‘Theory of mind’ in Asperger's syndrome. Journal of Child Psychology and Psychiatry and Allied Disciplines 33, 877–893.CrossRefGoogle Scholar
Carter, CS, Barch, DM, Buchanan, RW, Bullmore, E, Krystal, JH, Cohen, J, Geyer, M, Green, M, Nuechterlein, KH, Robbins, T, Silverstein, S, Smith, EE, Strauss, M, Wykes, T and Heinssen, R (2008) Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the cognitive neuroscience treatment research to improve cognition in schizophrenia initiative. Biological Psychiatry 64, 4–10.CrossRefGoogle ScholarPubMed
Castelli, F, Frith, C, Happe, F and Frith, U (2002) Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain 125, 1839–1849.CrossRefGoogle ScholarPubMed
Dapretto, M, Davies, MS, Pfeifer, JH, Scott, AA, Sigman, M, Bookheimer, SY and Iacoboni, M (2006) Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nature Neuroscience 9, 28–30.CrossRefGoogle ScholarPubMed
Dziobek, I (2012) Comment: towards a more ecologically valid assessment of empathy. Emotion Review 4, 18–19.CrossRefGoogle Scholar
Dziobek, I, Fleck, S, Kalbe, E, Rogers, K, Hassenstab, J, Brand, M, Kessler, J, Woike, JK, Wolf, OT and Convit, A (2006) Introducing MASC: a movie for the assessment of social cognition. Journal of Autism and Developmental Disorders 36, 623–636.CrossRefGoogle ScholarPubMed
Dziobek, I, Rogers, K, Fleck, S, Bahnemann, M, Heekeren, HR, Wolf, OT and Convit, A (2008) Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET). Journal of Autism and Developmental Disorders 38, 464–473.CrossRefGoogle Scholar
Dziobek, I, Bahnemann, M, Convit, A and Heekeren, HR (2010) The role of the fusiform-amygdala system in the pathophysiology of autism. Archives of General Psychiatry 67, 397–405.CrossRefGoogle ScholarPubMed
Erickson, KI, Colcombe, SJ, Wadhwa, R, Bherer, L, Peterson, MS, Scalf, PE, Kim, JS, Alvarado, M and Kramer, AF (2007) Training-induced functional activation changes in dual-task processing: an fMRI study. Cerebral Cortex 17, 192–204.CrossRefGoogle ScholarPubMed
Ethofer, T, Anders, S, Erb, M, Herbert, C, Wiethoff, S, Kissler, J, Grodd, W and Wildgruber, D (2006) Cerebral pathways in processing of affective prosody: a dynamic causal modeling study. Neuroimage 30, 580–587.CrossRefGoogle ScholarPubMed
Filippi, M, Ceccarelli, A, Pagani, E, Gatti, R, Rossi, A, Stefanelli, L, Falini, A, Comi, G and Rocca, MA (2010) Motor learning in healthy humans is associated to gray matter changes: a tensor-based morphometry study. Ed. PA Valdes-Sosa. PLoS ONE 5, e10198.CrossRefGoogle Scholar
Frith, CD and Frith, U (2006) The neural basis of mentalizing. Neuron 50, 531–534.CrossRefGoogle ScholarPubMed
Frith, CD and Frith, U (2008) Implicit and explicit processes in social cognition. Neuron 60, 503–510.CrossRefGoogle ScholarPubMed
Garvert, MM, Moutoussis, M, Kurth-Nelson, Z, Behrens, TE and Dolan, RJ (2015) Learning-induced plasticity in medial prefrontal cortex predicts preference malleability. Neuron 85, 418–428.CrossRefGoogle ScholarPubMed
Golan, O and Baron-Cohen, S (2006) Systemizing empathy: teaching adults with Asperger syndrome or high-functioning autism to recognize complex emotions using interactive multimedia. Development and Psychopathology 18, 591–617.CrossRefGoogle ScholarPubMed
Gu, Y, Hu, X, Pan, W, Yang, C, Wang, L, Li, Y and Chen, A (2016) Neural activities underlying the feedback express salience prediction errors for appetitive and aversive stimuli. Nature Publishing Group Scientific Reports 6, 34032.CrossRefGoogle ScholarPubMed
Hadjikhani, N, Joseph, RM, Snyder, J and Tager-Flusberg, H (2006) Anatomical differences in the mirror neuron system and social cognition network in autism. Cerebral Cortex 16, 1276–1282.CrossRefGoogle ScholarPubMed
Hadwin, J, Baron-Cohen, S, Howlin, P and Hill, K (1996) Can we teach children with autism to understand emotions, belief, or pretence? Development and Psychopathology 8, 345–365.CrossRefGoogle Scholar
Hadwin, J, Baron-Cohen, S, Howlin, P and Hill, K (1997) Does teaching theory of mind have an effect on the ability to develop conversation in children with autism? Journal of Autism and Developmental Disorders 27, 519–537.CrossRefGoogle ScholarPubMed
Hall, J, Philip, RCM, Marwick, K, Whalley, HC, Romaniuk, L, McIntosh, AM, Santos, I, Sprengelmeyer, R, Johnstone, EC, Stanfield, AC, Young, AW and Lawrie, SM (2012) Social cognition, the male brain and the autism spectrum. PLoS ONE 7.CrossRefGoogle ScholarPubMed
Hampton, AN, Bossaerts, P and O'Doherty, JP (2008) Neural correlates of mentalizing-related computations during strategic interactions in humans. Proceedings of the National Academy of Sciences of the USA 105, 6741–6746.CrossRefGoogle ScholarPubMed
Joiner, J, Piva, M, Turrin, C and Chang, SWC (2017) Social learning through prediction error in the brain. npj Science of Learning 2, 8.CrossRefGoogle Scholar
Jones, JA and Callan, DE (2003) Brain activity during audiovisual speech perception: an fMRI study of the McGurk effect. Neuroreport 14, 1129–1133.CrossRefGoogle ScholarPubMed
Kelly, AMC and Garavan, H (2005) Human functional neuroimaging of brain changes associated with practice. Cerebral Cortex 15, 1089–1102.CrossRefGoogle Scholar
Kessler, D, Angstadt, M and Sripada, CS (2017) Reevaluating ‘cluster failure’ in fMRI using nonparametric control of the false discovery rate. Proceedings of the National Academy of Sciences 114, E3372–E3373.CrossRefGoogle Scholar
Kliemann, D, Rosenblau, G, Bölte, S, Heekeren, HR and Dziobek, I (2013) Face puzzle-two new video-based tasks for measuring explicit and implicit aspects of facial emotion recognition. Frontiers in Psychology 4.CrossRefGoogle ScholarPubMed
Kühn, S, Schmiedek, F, Noack, H, Wenger, E, Bodammer, NC, Lindenberger, U and Lövden, M (2013) The dynamics of change in striatal activity following updating training. Human Brain Mapping 34, 1530–1541.CrossRefGoogle ScholarPubMed
Lai, MC, Lombardo, MV, Ecker, C, Chakrabarti, B, Suckling, J, Bullmore, ET, Happé, F, Murphy, DGM and Baron-Cohen, S (2015) Neuroanatomy of individual differences in language in adult males with autism. Cerebral Cortex 25, 3613–3628.CrossRefGoogle ScholarPubMed
Lai, MC, Lombardo, MV, Pasco, G, Ruigrok, AN, Wheelwright, SJ, Sadek, SA, Chakrabarti, B and Baron-Cohen, S (2011) A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS One 6, e20835.CrossRefGoogle ScholarPubMed
Lee, H, Voss, MW, Prakash, RS, Boot, WR, Vo, LTK, Basak, C, VanPatter, M, Gratton, G, Fabiani, M and Kramer, AF (2012) Videogame training strategy-induced change in brain function during a complex visuomotor task. Behavioural Brain Research 232, 348–357.CrossRefGoogle ScholarPubMed
Leech, R and Sharp, DJ (2014) The role of the posterior cingulate cortex in cognition and disease. Brain 137, 12–32.CrossRefGoogle ScholarPubMed
Lord, C, Rutter, M, DiLavore, PC, Risi, S, Gotham, K and Bishop, S (2012) Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) Manual (Part I): Modules 1–4. Torrance, CA: Western Psychological Services.Google Scholar
Lord, C, Rutter, M and Le Couteur, A (1994) Autism Diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders 24, 659–685.CrossRefGoogle ScholarPubMed
Lord, C, Schopler, E and Revicki, D (1982) Sex differences in autism. Journal of Autism and Developmental Disorders 12, 317–330.CrossRefGoogle ScholarPubMed
Masi, A, DeMayo, MM, Glozier, N and Guastella, AJ (2017) An overview of autism spectrum disorder, heterogeneity and treatment options. Neuroscience Bulletin 33, 183–193.CrossRefGoogle ScholarPubMed
Mende-Siedlecki, P, Cai, Y and Todorov, A (2013) The neural dynamics of updating person impressions. Social Cognitive and Affective Neuroscience 8, 623–631.CrossRefGoogle ScholarPubMed
Metzler-Baddeley, C, Caeyenberghs, K, Foley, S and Jones, DK (2016) Task complexity and location specific changes of cortical thickness in executive and salience networks after working memory training. NeuroImage 130, 48–62.CrossRefGoogle ScholarPubMed
Miller, GA and Chapman, JP (2001) Misunderstanding analysis of covariance. Journal of Abnormal Psychology 110, 40–48.CrossRefGoogle ScholarPubMed
Montag, C, Ehrlich, A, Neuhaus, K, Dziobek, I, Heekeren, HR, Heinz, A and Gallinat, J (2010) Theory of mind impairments in euthymic bipolar patients. Journal of Affective Disorders 123, 264–269.CrossRefGoogle ScholarPubMed
Montag, C, Dziobek, I, Richter, IS, Neuhaus, K, Lehmann, A, Sylla, R, Heekeren, HR, Heinz, A and Gallinat, J (2011) Different aspects of theory of mind in paranoid schizophrenia: evidence from a video-based assessment. Psychiatry Research 186, 203–209.CrossRefGoogle ScholarPubMed
Monte, OD, Krueger, F, Solomon, JM, Schintu, S, Knutson, KM, Strenziok, M, Pardini, M, Leopold, A, Raymont, V and Grafman, J (2013) A voxel-based lesion study on facial emotion recognition after penetrating brain injury. Social Cognitive and Affective Neuroscience 8, 632–639.CrossRefGoogle Scholar
Mueller, S, Keeser, D, Samson, AC, Kirsch, V, Blautzik, J, Grothe, M, Erat, O, Hegenloh, M, Coates, U, Reiser, MF, Hennig-Fast, K and Meindl, T (2013) Convergent findings of altered functional and structural brain connectivity in individuals with high functioning autism: a multimodal MRI study. PLoS ONE 8, e67329.CrossRefGoogle ScholarPubMed
Nichols, T, Kriegeskorte, N, Yeo, BTT, Kriegeskorte, N, Milham, MP, Poldrack, RA, Poline, J and Proal, E (2017) Best practices in data analysis and sharing in neuroimaging using MRI best practices in data analysis and sharing in neuroimaging using MRI. Nature Neuroscience 20, 299–303.CrossRefGoogle ScholarPubMed
Ochsner, KN, Knierim, K, Ludlow, DH, Hanelin, J, Ramachandran, T, Glover, G and Mackey, SC (2004) Reflecting upon feelings: an fMRI study of neural systems supporting the attribution of emotion to self and other. Journal of Cognitive Neuroscience 16, 1746–1772.CrossRefGoogle ScholarPubMed
Pelphrey, KA and Carter, EJ (2008) Brain mechanisms for social perception: lessons from autism and typical development. Annals of the New York Academy of Sciences 1145, 283–299.CrossRefGoogle ScholarPubMed
Pike, N (2011) Using false discovery rates for multiple comparisons in ecology and evolution. Methods in Ecology and Evolution 2, 278–282.CrossRefGoogle Scholar
Preissler, S, Dziobek, I, Ritter, K, Heekeren, HR and Roepke, S (2010) Social cognition in borderline personality disorder: evidence for disturbed recognition of the emotions, thoughts, and intentions of others. Frontiers in Behavioral Neuroscience 4, 182.CrossRefGoogle ScholarPubMed
Rochon, E, Leonard, C, Burianova, H, Laird, L, Soros, P, Graham, S and Grady, C (2010) Neural changes after phonological treatment for anomia: an fMRI study. Brain and Language 114, 164–179.CrossRefGoogle Scholar
Rosenblau, G, Kliemann, D, Heekeren, HR and Dziobek, I (2015) Approximating implicit and explicit mentalizing with two naturalistic video-based tasks in typical development and autism spectrum disorder. Journal of Autism and Developmental Disorders 45, 953–965.CrossRefGoogle ScholarPubMed
Rosenblau, G, Kliemann, D, Dziobek, I and Heekeren, HR (2017) Emotional prosody processing in autism spectrum disorder. Social Cognitive and Affective Neuroscience 12, 224–239.Google ScholarPubMed
Rosenblau, G, Kliemann, D, Lemme, B, Walter, H, Heekeren, HR and Dziobek, I (2016) The role of the amygdala in naturalistic mentalising in typical development and in autism spectrum disorder. British Journal of Psychiatry 208, 556–564.CrossRefGoogle ScholarPubMed
Rosenblau, G, Korn, CW and Pelphrey, KA, Rosenblau, G, Korn, CW and Pelphrey, KA (2018). A computational account of optimizing social predictions reveals that adolescents are conservative learners in social contexts. The Journal of Neuroscience 38, 974–988.CrossRefGoogle Scholar
Sabatinelli, D, Fortune, EE, Li, Q, Siddiqui, A, Krafft, C, Oliver, WT, Beck, S and Jeffries, J (2011) Emotional perception: meta-analyses of face and natural scene processing. NeuroImage 54, 2524–2533.CrossRefGoogle ScholarPubMed
Sakia, RM (1992) The Box-Cox transformation technique: a review. The Statistician 41, 169.CrossRefGoogle Scholar
Sato, W, Kochiyama, T, Uono, S, Yoshimura, S, Kubota, Y, Sawada, R, Sakihama, M and Toichi, M (2017) Reduced gray matter volume in the social brain network in adults with autism spectrum disorder. Frontiers in Human Neuroscience 11, 395.CrossRefGoogle ScholarPubMed
Schiller, D, Freeman, JB, Mitchell, JP, Uleman, JS and Phelps, EA (2009) A neural mechanism of first impressions. Nature Neuroscience 12, 508–514.CrossRefGoogle ScholarPubMed
Seid-Fatemi, A and Tobler, PN (2015) Efficient learning mechanisms hold in the social domain and are implemented in the medial prefrontal cortex. Social Cognitive and Affective Neuroscience 10, 735–743.CrossRefGoogle ScholarPubMed
Storey, JD (2002) A direct approach to false discovery rates. Journal of the Royal Statistical Society. Series B: Statistical Methodology 64, 479–498.CrossRefGoogle Scholar
Sukhodolsky, DG, Vander Wyk, BC, Eilbott, JA, McCauley, SA, Ibrahim, K, Crowley, MJ and Pelphrey, KA (2016) Neural mechanisms of cognitive-behavioral therapy for aggression in children and adolescents: design of a randomized controlled trial within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward. Journal of Child and Adolescent Psychopharmacology 26, 38–48.CrossRefGoogle ScholarPubMed
Szycik, GR, Jansma, H and Münte, TF (2009) Audiovisual integration during speech comprehension: an fMRI study comparing ROI-based and whole brain analyses. Human Brain Mapping 30, 1990–1999.CrossRefGoogle ScholarPubMed
Takahashi, H, Yahata, N, Koeda, M, Matsuda, T, Asai, K and Okubo, Y (2004) Brain activation associated with evaluative processes of guilt and embarrassment: an fMRI study. Neuroimage 23, 967–974.CrossRefGoogle ScholarPubMed
Takeuchi, H, Taki, Y, Sassa, Y, Hashizume, H, Sekiguchi, A, Fukushima, A and Kawashima, R (2011) Working memory training using mental calculation impacts regional gray matter of the frontal and parietal regions. Ed. G Chapouthier PLoS ONE 6, e23175.CrossRefGoogle ScholarPubMed
Tavares, RM, Mendelsohn, A, Grossman, Y, Williams, CH, Shapiro, M, Trope, Y and Schiller, D (2015) A map for social navigation in the human brain. Neuron 87, 231–243.CrossRefGoogle ScholarPubMed
Tomasi, D, Ernst, T, Caparelli, EC and Chang, L (2004) Practice-induced changes of brain function during visual attention: a parametric fMRI study at 4 Tesla. NeuroImage 23, 1414–1421.CrossRefGoogle ScholarPubMed
Uono, S, Sato, W, Kochiyama, T, Sawada, R, Kubota, Y, Yoshimura, S and Toichi, M (2016). Neural substrates of the ability to recognize facial expressions: a voxel-based morphometry study. Social Cognitive and Affective Neuroscience. 12, 487–495.Google Scholar
Valkanova, V, Eguia Rodriguez, R and Ebmeier, KP (2014) Mind over matter – what do we know about neuroplasticity in adults? International Psychogeriatrics 26, 891–909.CrossRefGoogle ScholarPubMed
van Raalten, TR, Ramsey, NF, Duyn, J and Jansma, JM (2008) Practice induces function-specific changes in brain activity. Ed. J Lauwereyns. PLoS ONE 3, e3270.CrossRefGoogle ScholarPubMed
Ventola, P, Friedman, HE, Anderson, LC, Wolf, JM, Oosting, D, Foss-Feig, J, McDonald, N, Volkmar, F and Pelphrey, KA (2014) Improvements in social and adaptive functioning following short-duration PRT program: a clinical replication. Journal of Autism and Developmental Disorders 44, 2862–2870.CrossRefGoogle ScholarPubMed
Ventola, P, Yang, DY, Friedman, HE, Oosting, D, Wolf, J, Sukhodolsky, DG and Pelphrey, KA (2015) Heterogeneity of neural mechanisms of response to pivotal response treatment. Brain Imaging and Behavior 9, 74–88.CrossRefGoogle ScholarPubMed
Wallace, GL, Eisenberg, IW, Robustelli, B, Dankner, N, Kenworthy, L, Giedd, JN and Martin, A (2015) Longitudinal cortical development during adolescence and young adulthood in autism spectrum disorder: increased cortical thinning but comparable surface area changes. Journal of the American Academy of Child and Adolescent Psychiatry 54, 464–469.CrossRefGoogle Scholar
Walter, H, Adenzato, M, Ciaramidaro, A, Enrici, I, Pia, L and Bara, BG (2004) Understanding intentions in social interaction: the role of the anterior paracingulate cortex. Journal of Cognitive Neuroscience 16, 1854–1863.CrossRefGoogle ScholarPubMed
Wilson, SM, Molnar-Szakacs, I and Iacoboni, M (2008) Beyond superior temporal cortex: intersubject correlations in narrative speech comprehension. Cerebral Cortex 18, 230–242.CrossRefGoogle ScholarPubMed
Wolf, I, Dziobek, I and Heekeren, HR (2010) Neural correlates of social cognition in naturalistic settings: a model-free analysis approach. Neuroimage 49, 894–904.CrossRefGoogle ScholarPubMed
Woollett, K and Maguire, EA (2011) Acquiring ‘the knowledge’ of London's layout drives structural brain changes. Current Biology 21, 2109–2114.CrossRefGoogle Scholar
Yang, DY-J, Rosenblau, G, Keifer, C and Pelphrey, KA (2015) An integrative neural model of social perception, action observation, and theory of mind. Neuroscience and Biobehavioral Reviews 51, 263–275.CrossRefGoogle ScholarPubMed
Yang, YJD, Allen, T, Abdullahi, SM, Pelphrey, KA, Volkmar, FR and Chapman, SB (2018) Neural mechanisms of behavioral change in young adults with high-functioning autism receiving virtual reality social cognition training: a pilot study. pp. 1–13.CrossRefGoogle Scholar
Zaki, J and Ochsner, K (2009) The need for a cognitive neuroscience of naturalistic social cognition. Annals of the New York Academy of Sciences 1167, 16–30.CrossRefGoogle ScholarPubMed
Supplementary material: File

Rosenblau et al. supplementary material

Rosenblau et al. supplementary material

Download Rosenblau et al. supplementary material(File)
File 768 KB
6
Cited by

Save article to Kindle

To save this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Neurobiological mechanisms of social cognition treatment in high-functioning adults with autism spectrum disorder
Available formats
×

Save article to Dropbox

To save this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about saving content to Dropbox.

Neurobiological mechanisms of social cognition treatment in high-functioning adults with autism spectrum disorder
Available formats
×

Save article to Google Drive

To save this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about saving content to Google Drive.

Neurobiological mechanisms of social cognition treatment in high-functioning adults with autism spectrum disorder
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *