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Aspects of the psychology and epidemiology of rheumatoid disease

  • Sidney Crown (a1), June M. Crown (a1) and Anthony Fleming (a1)
  • DOI:
  • Published online: 01 July 2009

In a prospective study of rheumatoid disease (RD) clinical, serological, radiological, and biochemical factors were assessed on 102 patients and scores obtained on the Middlesex Hospital Questionnaire (MHQ). Patients with early RD had MHQ scores closely resembling those in the normal population. Using a new clinical prognostic index, patients who develop severe RD tended to have low scores at initial testing on the MHQ. Patients whose serum was positive for rheumatoid factor also tended to have low scores on the MHQ. Together these findings suggest a possible subclassification of RD into a less severe form in which psychosocial factors may be important, and a more severe form in which heredity or some other constitutional factor (or factors) may be important, rheumatoid factor acting as a ‘marker’.

Corresponding author
1 Address for correspondence and reprints: Dr. Sidney Crown, the London Hospital, Whitechapel, London El 1BB.
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