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Brainstem volumetric alterations in children with autism

  • R. J. Jou (a1), N. J. Minshew (a2), N. M. Melhem (a2), M. S. Keshavan (a3) and A. Y. Hardan (a4)...

Although several studies have examined brainstem volume in autism, results have been mixed and no investigation has specifically measured gray- and white-matter structures. The aim of this investigation was to assess gray- and white-matter volumes in children with autism.


Subjects included 22 right-handed, non-mentally retarded boys with autism and 22 gender- and age-matched controls. Magnetic resonance imaging (MRI) scans were obtained using a 1.5-T scanner and volumetric measurements were performed using the BRAINS2 software package. Gray- and white-matter volumes were measured using a semi-automated segmentation process.


There were no significant differences in age and total brain volume (TBV) between the two groups but full-scale IQ was higher in controls. A decrease in brainstem gray-matter volume was observed in the autism group before and after controlling for TBV. No significant differences were observed in white-matter volume. A significant relationship was observed between brainstem gray-matter volume and oral sensory sensitivity as measured by the Sensory Profile Questionnaire (SPQ).


Findings from this study are suggestive of brainstem abnormalities in autism involving gray-matter structures with evidence supporting the existence of a relationship between these alterations and sensory deficits. These results are consistent with previous investigations and support the existence of disturbances in brainstem circuitry thought to be implicated in the sensory dysfunction observed in autism.

Corresponding author
*Address for correspondence: A. Y. Hardan, M.D., Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA. (Email:
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A Bailey , P Luthert , A Dean , B Harding , I Janota , M Montgomery , M Rutter , P Lantos (1998). A clinicopathological study of autism. Brain 121, 889905.

JM Bandim , LO Ventura , MT Miller , HC Almeida , AE Costa (2003). Autism and Möbius sequence: an exploratory study of children in northeastern Brazil. Arquivos de Neuro-psiquiatria 61, 181185.

M Bauman , TL Kemper (1985). Histoanatomic observations of the brain in early infantile autism. Neurology 35, 866874.

KT Ciesielski , RJ Harris , BL Hart , HF Pabst (1997). Cerebellar hypoplasia and frontal lobe cognitive deficits in disorders of early childhood. Neuropsychologia 35, 643655.

H Cody , K Pelphrey , J Piven (2002). Structural and functional magnetic resonance imaging of autism. International Journal of Developmental Neuroscience 20, 421438.

M Elia , R Ferri , SA Musumeci , S Panerai , M Bottitta , C Scuderi (2000). Clinical correlates of brain morphometric features of subjects with low-functioning autistic disorder. Journal of Child Neurology 15, 504508.

GR Gaffney , S Kuperman , LY Tsai , S Minchin (1988). Morphological evidence for brainstem involvement in infantile autism. Biological Psychiatry 24, 578586.

FG Happe (1994). Wechsler IQ profile and theory of mind in autism: a research note. Journal of Child Psychology and Psychiatry 35, 14611471.

AY Hardan , NJ Minshew , K Harenski , MS Keshavan (2001). Posterior fossa magnetic resonance imaging in autism. Journal of the American Academy of Child and Adolescent Psychiatry 40, 666672.

T Hashimoto , M Tayama , K Murakawa , T Yoshimoto , M Miyazaki , M Harada , Y Kuroda (1995). Development of the brainstem and cerebellum in autistic patients. Journal of Autism and Developmental Disorders 25, 118.

MR Herbert , DA Ziegler , CK Deutsch , LM O'Brien , N Lange , A Bakardjiev , J Hodgson , KT Adrien , S Steele , N Makris , D Kennedy , GJ Harris , VS Caviness (2003). Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain 126, 11821192.

RP Hobson (1991). Methodological issues for experiments on autistic individuals' perception and understanding of emotion. Journal of Child Psychology and Psychiatry 32, 11351158.

M Hsu , R Yeung-Courchesne , E Courchesne , GA Press (1991). Absence of magnetic resonance imaging evidence of pontine abnormality in infantile autism. Archives of Neurology 48, 11601163.

C Jarrold , J Brock (2004). To match or not to match? Methodological issues in autism-related research. Journal of Autism and Developmental Disorders 34, 8186.

RM Joseph , H Tager-Flusberg , C Lord (2002). Cognitive profiles and social-communicative functioning in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry 43, 807821.

J Kaufman , B Birmaher , D Brent , U Rao , C Flynn , P Moreci , D Williamson , N Ryan (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry 36, 980988.

MD Kleiman , S Neff , NP Rosman (1992). The brain in infantile autism: are posterior fossa structures abnormal? Neurology 42, 753760.

A Klin (1993). Auditory brainstem responses in autism: brainstem dysfunction or peripheral hearing loss? Journal of Autism and Developmental Disorders 23, 1535.

C Lord , M Rutter , S Goode , J Heemsbergen , H Jordan , L Mawhood , E Schopler (1989). Autism Diagnostic Observation Schedule: a standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders 19, 185212.

C Lord , M Rutter , A LeCouteur (1994). Autism Diagnostic Interview – Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders 24, 659685.

VA Magnotta , G Harris , NC Andreasen , DS O'Leary , WT Yuh , D Heckel (2002). Structural MR image processing using the BRAINS2 toolbox. Computerized Medical Imaging and Graphics 26, 251264.

EM Ornitz (1983). The functional neuroanatomy of infantile autism. International Journal of Neuroscience 19, 85124.

J Pickett , E London (2005). The neuropathology of autism: a review. Journal of Neuropathology and Experimental Neurology 64, 925935.

J Piven , E Nehme , J Simon , P Barta , G Pearlson , SE Folstein (1992). Magnetic resonance imaging in autism: measurement of the cerebellum, pons, and fourth ventricle. Biological Psychiatry 31, 491504.

PM Rodier , JL Ingram , B Tisdale , S Nelson , J Romano (1996). Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei. Journal of Comparative Neurology 370, 247261.

LL Sears , PR Finn , JE Steinmetz (1994). Abnormal classical eye-blink conditioning in autism. Journal of Autism and Developmental Disorders 24, 737751.

JR Skoyles (2002). Is autism due to cerebral–cerebellum disconnection? Medical Hypotheses 58, 332336.

K Stromland , V Nordin , M Miller , B Akerstrom , C Gillberg (1994). Autism in thalidomide embryopathy: a population study. Developmental Medicine and Child Neurology 36, 351356.

FR Volkmar , DJ Cohen , R Paul , A Klin (2005). Handbook of Autism and Pervasive Developmental Disorders. John Wiley & Sons: Hoboken, NJ.

T White , NC Andreasen , P Nopoulos , V Magnotta (2003). Gyrification abnormalities in childhood- and adolescent-onset schizophrenia. Biological Psychiatry 54, 418426.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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