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Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults

Published online by Cambridge University Press:  09 July 2009

Sigrid Herold ,
R. S. J. Frackowiak ,
A. Le Couteur ,
M. Rutter  and
P. Howlin
Sigrid Herold*
Affiliation:
MRC Cyclotron Unit, Hammersmith Hospital; MRC Child Psychiatry Unit, Institute of Psychiatry, London
R. S. J. Frackowiak
Affiliation:
MRC Cyclotron Unit, Hammersmith Hospital; MRC Child Psychiatry Unit, Institute of Psychiatry, London
A. Le Couteur
Affiliation:
MRC Cyclotron Unit, Hammersmith Hospital; MRC Child Psychiatry Unit, Institute of Psychiatry, London
M. Rutter
Affiliation:
MRC Cyclotron Unit, Hammersmith Hospital; MRC Child Psychiatry Unit, Institute of Psychiatry, London
P. Howlin
Affiliation:
MRC Cyclotron Unit, Hammersmith Hospital; MRC Child Psychiatry Unit, Institute of Psychiatry, London
*
1 Address for correspondence: Dr Sigrid Herold, Maudsley Hospital, Denmark Hill, London SE5 8AZ.
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Synopsis

Regional cerebral blood flow, oxygen consumption and glucose consumption were measured by positron emission tomography in six young autistic men. No significant differences were found between patients and normal controls for any of the physiological variables. The results do not substantiate the previous finding of glucose hypermetabolism in autism; the likely reasons for the variance in findings are discussed.

Type
Research Article
Information
Psychological Medicine , Volume 18 , Issue 4 , November 1988 , pp. 823 - 831
Copyright
Copyright © Cambridge University Press 1988

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References

American Psychiatric Association (1987). DSM-III-R: Diagnostic and Statistical Manual of Mental Disorders. Disorders Usually First Evident in Infancy, Childhood or Adolescence pp. 27–95. The American Psychiatric Association: Washington DC.Google Scholar
August, G. J., Stewart, M. A. & Tsai, L. (1981). The incidence of cognitive disabilities in the siblings of autistic children. British Journal of Psychiatry 138, 416–422.CrossRefGoogle ScholarPubMed
Campbell, M., Rosenbloom, S., Perry, R., George, A. E., Kricheff, I. I., Anderson, L., Small, A. M. & Jennings, S. J. (1982). Computerised axial tomography in young autistic children. American Journal of Psychiatry 139, 510–512.Google ScholarPubMed
Carapulo, B. K., Cohen, D. J., Rothman, S. L., Young, J. G., Katz, J. D., Shaywitz, S. E. & Shaywitz, B. A. (1981). Computed tomographic brain scanning in children with developmental neuropsychiatric disorders. Journal of the American Academy of Child Psychiatry 20, 338–357.Google Scholar
Cooper, M. (1987). Personal Communication.Google Scholar
Creasey, H., Rumsey, J. M.Schwarz, M., Duara, R., Rapoport, J. L. & Rapoport, S. I. (1986). Brain morphometry in autistic men as measured by volumetric computed tomography. Archives of Neurology 43, 669–672.CrossRefGoogle ScholarPubMed
Creasey, H. & Rapoport, S. I. (1985). The aging human brain. Neurology 17, 2–10.Google ScholarPubMed
Damasio, H., Maurer, R. G., Damasio, A. R. & Chui, H. C. (1980). Computerised tomographic scan findings in patients with autistic behaviour. Archives of Neurology 37, 504–510.CrossRefGoogle Scholar
Fazekas, J. F., Ehrmantraut, W. R., Shea, J. G. & Kleh, J. (1958). Cerebral hemodynamics and metabolism in mental deficiency. Neurology 8, 558–561.CrossRefGoogle ScholarPubMed
Folstein, S. & Rutter, M. (1977). Infantile autism: a genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry 18, 297–321.CrossRefGoogle ScholarPubMed
Fox, P. T., Mintun, M. A., Raichle, M. E., Miezin, F. M., Allman, J. M. & Van Essen, D. C. (1986). Mapping human visual cortex with positron emission tomography. Nature 323, 806–809.CrossRefGoogle ScholarPubMed
Frackowiak, R. S. J., Lenzi, G. L., Jones, T. & Heather, J. D. (1980). Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure and normal values. Journal of Computer Assisted Tomography 4, 427–736.CrossRefGoogle ScholarPubMed
Garfunkel, J. M., Baird, H. W., & Ziegler, J. (1954). The relationship of oxygen consumption to cerebral functional activity. Journal of Pediatrics 44, 64–72.CrossRefGoogle ScholarPubMed
Gillberg, C. & Swendsen, P. (1983). Childhood psychosis and computed tomographic brain scan findings. Journal of Autism and Developmental Disorders 13, 19–32.CrossRefGoogle ScholarPubMed
Hauser, S. L., DeLong, G. R. & Rosman, N. P. (1975). Pneumographic findings in the infantile autism syndrome. Brain 98, 667–688.CrossRefGoogle ScholarPubMed
Herold, S. & Frackowiak, R. S. J. (1986). New methods in brain imaging. Psychological Medicine 16, 271–275.CrossRefGoogle ScholarPubMed
Hier, D. B., LeMay, M. & Rosenberg, P. B. (1979). Autism and unfavourable left-right asymmetries of the brain. Journal of Autism and Developmental Disorders 9, 153–159.CrossRefGoogle ScholarPubMed
Jacobsen, R., LeCouteur, A., Howlin, P. & Rutter, M. (1988). Selective subcortical abnormalities in autism. Psychological Medicine 18, 39–48.CrossRefGoogle Scholar
Kennedy, C. (1967). The cerebral metabolic rate in mentally retarded children. Archives of Neurology 16, 55–58.CrossRefGoogle ScholarPubMed
Lammertsma, A. A. & Jones, T. (1983). Correction for the presence of intravascular oxygen–15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 1. Description of the method. Journal of Cerebral Blood Flow and Metabolism 3, 416–424.CrossRefGoogle ScholarPubMed
Lammertsma, A. A., Wise, R. J. S., Heather, J. D., Gibbs, J. M., Leenders, K. L., Frackowiak, R. S. J., Rhodes, C. G. & Jones, T. (1983). Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 2. Results in normal subjects and brain tumour and stroke patients. Journal of Cerebral Blood Flow and Metabolism 3, 425–431.CrossRefGoogle ScholarPubMed
Lassen, N. A., Christensen, S., Hoedt-Rasmussen, K. & Stewart, B. M. (1966). Cerebral oxygen consumption in Down's syndrome. Archives of Neurology 15, 595–602.CrossRefGoogle ScholarPubMed
Phelps, M. E., Huang, S. C., Hoffman, E. J. & Kuhl, D. E. (1979). Validation of tomographic measurements of cerebral blood volume with C–11 labelled carboxyhaemoglobin. Journal of Nuclear Medicine 20, 328–334.Google Scholar
Phelps, M. E., Mazziotta, J. C. & Huang, S. C. (1982). Study of cerebral function with positron computed tomography. Journal of Cerebral Blood and Flow Metabolism 2, 113–162.CrossRefGoogle ScholarPubMed
Prior, M. R., Tress, B., Hoffman, W. L. & Boldt, O. (1984). Computed tomographic study of children with class autism. Archives of Neurology 41, 482–484.CrossRefGoogle Scholar
Prior, M. R. (1987). Biological and neuropsychiatric approaches to childhood autism. British Journal of Psychiatry 150, 8–17.CrossRefGoogle Scholar
Rhodes, C. G., Wise, R. J. S., Gibbs, J. M., Frackowiak, R. S. J., Hatazawa, J., Palmer, A. J., Thomas, D. G. T. & Jones, T. (1983). In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas. Annals of Neurology 14, 614–626.CrossRefGoogle ScholarPubMed
Ron, M. A., Acker, W., Shaw, G. K. & Lishman, W. A. (1982). Computerized tomography of the brain in chronic alcoholism. A survey and follow-up study. Brain 105, 497–514.CrossRefGoogle ScholarPubMed
Rosenbloom, S., Campbell, M., George, A. E., Kricheff, I. I., Taleporos, E., Anderson, L., Reuben, R. N. & Korein, J. (1984). High resolution CT scanning in infantile autism: a quantitative approach. Journal of the American Academy of Child Psychiatry 23 72–77.CrossRefGoogle ScholarPubMed
Rumsey, J. M., Duara, K., Grady, C., Rapoport, J. L, Margolin, R. A., Rapoport, S. I. & Cutter, N. R. (1985). Brain metabolism in autism. Resting cerebral glucose utilisation as measured with positron emission tomography. Archives of General Psychiatry 42, 448–455.CrossRefGoogle ScholarPubMed
Rutter, M. (1978). Diagnosis and definition. In Autism: A Reappraisal of Concepts and Treatment (ed. Rutter, M. and Schopler, E.), pp. 1–25. Plenum: New York.CrossRefGoogle Scholar
Rutter, M. (1988). Biological basis of autism, implications for intervention. In Preventive and Curative Intervention in Mental Retardation (ed Menolascino, F. J. and Stark, J. S.), pp. 265–294. Paul H. Brookes Publishing: Baltimore.Google Scholar
Sherman, M., Nass, R. & Shapiro, T. (1984). Regional cerebral blood flow in infantile autism. Journal of Autism and Developmental Disorders 4, 438–440.Google Scholar
Tsai, L., Jacoby, C. G., Stewart, M. A. & Beilser, J. M. (1982). Unfavourable left-right asymmetries of the brain and autism: a question of methodology. British Journal of Psychiatry 40, 312–319.CrossRefGoogle Scholar
Wallenstein, S., Zucker, C. L. & Fleiss, J. L. (1980). Some statistical methods useful in circulation research. Circulation Research 47, 1–9.CrossRefGoogle ScholarPubMed
Williams, C. W., Crabtree, M. L. & Burgiss, S. G. (1979). Design and performance characteristics of a positron emission computed axial tomograph – ECAT II. IEEE Transactions of Nuclear Science 26, 619–627.CrossRefGoogle Scholar
Wise, R. J. S., Bernardi, S., Frackowiak, R. S. J., Legg, N. J. & Jones, T. (1983). Serial observations on the pathophysiology of acute stroke: the transition from ischaemia to infarction as reflected in regional oxygen extraction. Brain 106, 197–222.CrossRefGoogle ScholarPubMed
World Health Organization, (1987). ICD-10 1986 draft. Ch V, categories F80–F99: mental, behavioural and developmental disorders. WHO: Geneva.Google Scholar