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A computerized magnetic resonance imaging study of corpus callosum morphology in schizophrenia

  • P. W. R. Woodruff (a1), G. D. Pearlson (a1), M. J. Geer (a1), P. E. Barta (a1) and H. D. Chilcoat (a1)...

Synopsis

The hypothesis tested was that, in schizophrenia, corpus callosum size would be reduced, particularly in the region responsible for communication between both temporal lobes. This is supported by knowledge of: (a) anatomical homotopicity and functional specialization of fibres within the corpus callosum; (b) evidence linking structural and functional deficits of the corpus callosum and left temporal lobe with schizophrenia; and (c) that temporal lobe neuronal fibres pass through the middle region of the corpus callosum. Brain area and corpus callosum areas, widths and length were measured on mid-sagittal MRI scans using a computer outlining method. Scans from 30 schizophrenics and 44 normal subjects were compared. Mid-sagittal brain area, corpus callosum area, length and anterior widths were reduced in the schizophrenic group compared with controls. A significant area difference between schizophrenics and controls was seen in the mid-corpus callosum which communicates between the temporal lobes, including the superior temporal gyri. In schizophrenics, corpus callosum area reduction was not accounted for by brain area shrinkage alone. Differences between the two groups were accounted for by comparisons between males only. These findings support the hypothesis and the possibility that localized abnormalities of bilaterally connected brain regions might have secondary effects on their homotopically distributed fibres within the corpus callosum.

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Corresponding author

1Address for correspondence: Dr P. W. R. Woodruff, Institute of Psychiatry, Dc Crespigny Park, Denmark Hill, London SE5 8AF.

References

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Andreasen, N. C. (1984). The Scale for the Assessment of Positive Symptoms (SAPS). Iowa City, Iowa: University of Iowa.
Andreasen, N. C., Nasrallah, H. A., Dunn, V., Olson, S. C., Grove, W. M., Ehrhardt, J. C., Coffman, J. A. & Crossett, J. H. W. (1986). Structural abnormalities in the frontal system in schizophrenia. Archives of General Psychiatry 43, 137144.
Andreasen, N. C., Ehrhardt, J. C., Swayze, V. W., Alliger, R. J., Yuh, W. T. C., Cohen, G. & Ziebell, S. (1990). Magnetic resonance imaging of the brain in schizophrenia: the pathophysiologic significance of structural abnormalities. Archives of General Psychiatry 47, 3544.
Barta, P. E., Pearlson, G. D., Powers, R. E., Richards, S. S. & Tune, L. E. (1990). Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. American Journal of Psychiatry 147, 14571462.
Beaumont, J. G. & Dimond, S. J. (1973). Brain disconnection and schizophrenia. British Journal of Psychiatry 123, 661662.
Bigelow, L. B.Nasrallah, H. A. & Rauscher, F. P. (1983). Corpus callosum thickness in chronic schizophrenia. British Journal of Psychiatry 142, 284287.
Brown, R., Colter, N., Corsellis, J. A. N., Crow, T. J., Frith, C. D., Jagoe, R., Johnstone, E. C. & Marsh, L. (1986). Postmortem evidence of structural brain changes in schizophrenia. Archives of General Psychiatry 43, 3642.
Byrne, W., Bleier, R. & Houston, L. (1988). Variations in human corpus callosum do not predict gender: a study using magnetic resonance imaging. Behavioral Neuroscience 102, 222227.
Casanova, M. F., Sanders, R. D., Goldberg, T. E., Bigelow, L. B., Christison, G., Torrey, E. F. & Weinberger, D. R. (1990). Morphometry of the corpus callosum in monozygotic twins discordant for schizophrenia: a magnetic resonance imaging study. Journal of Neurology, Neurosurgery and Psychiatry 53, 416421.
Chapman, L. T. & Chapman, J. P. (1987). The measurement of handedness. Brain and Cognition 6, 175183.
Coger, R. W. & Serafetinides, E. A. (1990). Schizophrenia, corpus callosum, and inter-hemispheric communication: a review. Psychiatry Research 34, 163184.
Cook, N. D. (1986). The Brain Code: Mechanisms of Information Transfer and the Role of the Corpus Callosum. Methuen: London.
Cooper, J. E., Andrews, H. & Barber, C. (1985). Stable abnormalities in the lateralisation of early cortical somatosensory evoked potentials in schizophrenic patients. British Journal of Psychiatry 146, 585593.
Dauphinais, I. D., DeLisi, L. E., Crow, T. J., Alexandropoulos, K., Colter, N., Tuma, I. & Gershon, E. S. (1990). Reduction in temporal lobe size in siblings with schizophrenia: a magnetic resonance imaging study. Psychiatry Research: Neuroimaging 35, 137147.
David, A. S. (1987). Tachistoscopic tests of colour naming and matching in schizophrenia: evidence for posterior callosal dysfunction? Psychological Medicine 17, 621630.
De Lacoste-Utamsing, C. & Holloway, R. L. (1982). Sexual dimorphism in the human corpus callosum. Science 216, 14311432.
Demeter, S., Ringo, J. L. & Doty, R. W. (1988). Morphometric analysis of the human corpus callosum and anterior commissure. Human Neurobiology 6, 219226.
Dimond, S. J., Scammell, R. E., Brouwers, E. Y. M. & Weeks, R. (1977). Functions of the centre section (trunk) of the corpus callosum in man. Brain 100, 543562.
Elliott, F. A. (1969). The corpus callosum, cingulate gyrus, septum pellucidum, septal area and fornix. In Handbook of Clinical Neurology, 2 (ed. Vinken, P. J. and Bruyn, G. W.), pp. 758775. North Holland: Amsterdam.
Fenwick, P., Brennan, D. & Philpot, M. (1983). Function of the corpus callosum in schizophrenia. British Journal of Psychiatry 143, 524.
Fish, B. & Hagin, R. (1972). Visual-motor disorders in infants at risk for schizophrenia. Archives of General Psychiatry 27, 594598.
Gazzaniga, M. S. & Freedman, H. (1973). Observations on visual processes after posterior callosal section. Neurology 23, 11261130.
Gazzaniga, M. S., Risse, G. L., Springer, S. P., Clark, E., Wilson, A. B. & Wilson, D. H. (1975). Psychological and neurologic consequences of partial and complete cerebral commissurotomy. Neurology 25, 1015.
Green, P. (1978). Defective interhemispheric transfer in schizophrenia. Journal of Abnormal Psychology 87, 472480.
Gruzelier, J., Seymour, K., Wilson, L., Jolley, A. & Hirsch, S. (1988). Impairments on neuropsychologic tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Archives of General Psychiatry 45, 623629.
Gunther, W., Petsch, R., Steinberg, R., Moser, E., Streck, P., Heller, H., Kurtz, G. & Hippins, H. (1991). Brain dysfunction during motor activation and corpus callosum alterations in schizophrenia measured by cerebral blood flow and magnetic resonance imaging. Biological Psychiatry 29, 535553.
Harvey, I., Williams, M., Toone, B. K., Lewis, S. W., Turner, S. W. & McGuffin, P. (1990). The ventricular-brain (VBR) in functional psychosis: the relationship of lateral ventricular and total intracranial area. Psychological Medicine 20, 5562.
Hatta, T., Yamamoto, M. & Kawabata, Y. (1984). Functional hemispheric differences in schizophrenia: interhemispheric transfer deficit or selective hemisphere dysfunction? Biological Psychiatry 19, 10271036.
Hauser, P., Dauphinais, D., Berrettini, W., DeLisi, L. E., Gelernter, J. & Post, R. M. (1989). Corpus callosum dimensions measured by magnetic resonance imaging in bipolar affective disorder and schizophrenia. Biological Psychiatry 26, 659668.
Hedreen, J. C. & Yin, T. C. T. (1981). Homotopic and heterotopic callosal afferents of caudal inferior parietal lobule in Macaca mulatto. Journal of Comparative Neurology 197, 605621.
Hollingshead, A. B. (1975). Four Factor Index of Social Status. Department of Sociology, Yale University: New Haven, CT.
Jacobson, S. & Marcus, E. M. (1970). The laminar distribution of the corpus callosum: a comparative study in the rat, cat, rhesus monkey and chimpanzee. Brain Research 24, 513520.
Jeeves, M. A., Simpson, D. A. & Geffen, G. (1979). Functional consequences of the transcallosal removal of intraventricular tumours. Journal of Neurology, Neurosurgery, and Psychiatry 42, 134142.
Johnstone, E. C., Owens, D. G. C., Crow, T. J., Frith, C. D., Alexandropoulis, K., Bydder, G. & Colter, N. (1989). Temporal lobe structure as determined by nuclear magnetic resonance in schizophrenia and bipolar affective disorder. Journal of Neurology, Neurosurgery and Psychiatry 52, 736741.
Jones, G. H. & Miller, J. J. (1981). Functional tests of the corpus callosum in schizophrenia. British Journal of Psychiatry 139, 553557.
Kelsoe, J. R., Cadet, J. L., Pickar, D. & Weinberger, D. R. (1988). Quantitative neuroanatomy in schizophrenia. Archives of General Psychiatry 45, 533541.
Lewis, S. W. & Mezey, C. (1985). Clinical correlates of septum pellucidum cavities: an unusual association with psychosis. Psychological Medicine 15, 112.
Lewis, S. W., Reveley, M. A., David, A. S. & Ron, M. A. (1988). Agenesis of the corpus callosum and schizophrenia: a case report. Psychological Medicine 18, 341347.
Matthew, R. J., Partain, C. L., Prakash, R., Kulkarni, M. V., Logan, T. P. & Wilson, W. H. (1985). A study of the septum pellucidum and corpus callosum in schizophrenia. Acta Psychiatrica Scandinavica 72, 414421.
Merrin, E. L., Floyd, T. C. & Fein, G. (1989). EEG coherence in unmedicated schizophrenic patients. Biological Psychiatry 25, 6066.
Murray, R. M. & Lewis, S. W. (1987). Is schizophrenia a neurodevelopmental disorder? British Medical Journal 295, 681682.
Nasrallah, H. A., Andreasen, N. C., Coffman, J. A., Olson, S. C., Dunn, V. D., Erhardt, J. C. & Chapman, S. M. (1986). A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia. Biological Psychiatry 21, 274282.
Raine, A., Harrison, G. N., Reynolds, G. P., Sheard, C., Cooper, J. E. & Medley, I. (1990). Structural and functional characteristics of the corpus callosum in schizophrenics, psychiatric controls, and normal controls. Archives of General Psychiatry 47, 10601063.
Rosenthal, R. & Bigelow, L. B. (1972). Quantitative brain measurements in chronic schizophrenia. British Journal of Psychiatry 121, 259264.
Rossi, A., Stratta, P., Gallucci, M., Passariello, R. & Casacchia, M. (1988). Brain morphology in schizophrenia by magnetic resonance imaging. Acta Psychiatrica Scandinavica 77, 741745.
Rossi, A., Stratta, P., Gallucci, M., Passariello, R. & Casacchia, M. (1989). Quantification of corpus callosum and ventricles in schizophrenia with nuclear magnetic resonance imaging: a pilot study. American Journal of Psychiatry 146, 99101.
Saykin, A. J., Gur, R. C., Gur, R. E., Mozley, P. D., Mozley, L. H., Resnick, S. M., Kester, B. & Stafiniak, P. (1991). Neuropsychological function in schizophrenia – selective impairment in memory and learning. Archives of General Psychiatry 48, 618624.
Shagass, C., Josiassen, R. C., Roemer, R. A., Straumanis, J. J. & Slepner, S. M. (1983). Failure to replicate evoked potential observations suggesting corpus callosum dysfunction in schizophrenia. British Journal of Psychiatry 142, 471476.
Shaw, J. G., Colter, N. & Resek, G. (1983). EEG coherence, lateral preference and schizophrenia. Psychological Medicine 13, 299306.
Smith, R. & Tamminga, C. A. (1985). Brain imaging in psychiatry: new developments. Psychopharmacology Bulletin 21, 588594.
Smith, R. C., Calderon, M., Ravichandran, G. K., Largen, J., Vroulis, G., Shvartsburd, A., Gordon, J. & Schoolar, J. C. (1984). Nuclear magnetic resonance in schizophrenia: a preliminary study. Psychiatry Research 12, 137147.
Smith, R. C., Baumgartner, R. & Calderon, M. (1987). Magnetic resonance imaging studies of the brains of schizophrenic patients. Psychiatry Research 20, 3346.
Sperry, R. (1982). Some effects of disconnecting the cerebral hemispheres. Science 217, 12231226.
Spitzer, R. L., Williams, J. B. W. & Gibbon, N. (1989). Structural Clinical Interview for DSM-UI-R. New York State Psychiatric Institute, Biometrics Research: New York.
Stratta, P., Rossi, A., Gallucci, M., Amicarelli, I., Passariello, R. & Casacchia, M. (1989). Hemispheric asymmetries and schizophrenia: a preliminary magnetic resonance imaging study. Biological Psychiatry 25, 275284.
Suddath, R. L., Christison, G. W., Torrey, E. F., Casanova, M. F. & Weinberger, D. R. (1990). Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New England Journal of Medicine 322, 789794.
Swayze, V. W., Andreasen, N. C., Ku, J. S. & Alliger, R. (1989). The corpus callosum in schizophrenia and mania: a controlled MRI study. Schizophrenia Research 2, 130.
Swayze, W., Andreasen, N. C., Erhardt, J. C., Yuh, W. T. C., Alliger, R. J. & Cohen, G. A. (1990). Development abnormalities of the corpus callosum in schizophrenia. Archives of Neurology 47, 805808.
Uematsu, M. & Kaiya, H. (1988). The morphology of the corpus callosum in schizophrenia: an MRI study. Schizophrenia Research 1, 391398.
Witelson, S. F. (1989). Hand and sex differences in the isthmus and genu of the human corpus callosum. Brain 112, 799833.

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