Katz, Martin M. Berman, Nancy Bowden, Charles L. and Frazer, Alan 2015. Evidence for Shortening the Duration of Clinical Trials of Antidepressants and a Proposed Paradigm for Such Studies. Journal of Clinical Psychopharmacology, Vol. 35, Issue. 3, p. 329.
Mulinari, Shai 2012. Monoamine Theories of Depression: Historical Impact on Biomedical Research. Journal of the History of the Neurosciences, Vol. 21, Issue. 4, p. 366.
Katz, Martin M. and Berman, Nancy 2003. The contributions of Sam Greenhouse to research on psychiatric diagnosis and psychopharmacology. Statistics in Medicine, Vol. 22, Issue. 21, p. 3291.
Swann, Alan C Katz, Martin M Bowden, Charles L Berman, Nancy G and Stokes, Peter E 1999. Psychomotor performance and monoamine function in bipolar and unipolar affective disorders. Biological Psychiatry, Vol. 45, Issue. 8, p. 979.
Casper, Regina C. Katz, Martin M. Bowden, Charles L. Davis, John M. Koslow, Stephen H. and Hanin, Israel 1994. The pattern of physical symptom changes in major depressive disorder following treatment with amitriptyline or imipramine. Journal of Affective Disorders, Vol. 31, Issue. 3, p. 151.
Maas, James W. Katz, Martin M. Koslow, Stephen H. Swann, Alan Davis, John M. Berman, Nancy Bowden, Charles L. Stokes, Peter E. and Landis, Harold 1994. Adrenomedullary function in depressed patients. Journal of Psychiatric Research, Vol. 28, Issue. 4, p. 357.
Swann, Alan C. Stokes, Peter E. Secunda, Steven K. Maas, James W. Bowden, Charles L. Berman, Nancy and Koslow, Stephen H. 1994. Depressive mania versus agitated depression: Biogenic amine and hypothalamic-pituitary-adrenocortical function. Biological Psychiatry, Vol. 35, Issue. 10, p. 803.
Hedeen, Kevin M. White, Helen L. Cooper, Barrett R. Conner, Gary W. and Norton, Ronald M. 1993. Effect of a novel monamine oxidase-a inhibitor, bw 1370U87, on urinary 3-methoxy-4-hydroxyphenylglycol in normal volunteers. Drug Development Research, Vol. 30, Issue. 1, p. 24.
Katz, Martin M. Wetzler, Scott Cloitre, Marylene Swann, Alan Secunda, Steven Mendels, Joe and Robins, Eli 1993. Expressive characteristics of anxiety in depressed men and women. Journal of Affective Disorders, Vol. 28, Issue. 4, p. 267.
Healy, D. Paykel, E. S. White, W. Whitehouse, A. M. Ashby, M. Brown, M. Theodorou, A. E. Lawrence, K. M. and Horton, R. W. 1992. Plasma noradrenaline, adrenaline and DHPG responses to clonidine in control and depressed subjects. Human Psychopharmacology: Clinical and Experimental, Vol. 7, Issue. 3, p. 167.
Katz, Martin M. Koslow, Stephen H. Maas, James W. Frazer, Alan Kocsis, James Secunda, Steven Bowden, Charles L. and Casper, Regina C. 1991. Identifying the specific clinical actions of amitriptyline: interrelationships of behaviour, affect and plasma levels in depression. Psychological Medicine, Vol. 21, Issue. 03, p. 599.
Swann, Alan C. Secunda, Steven K. Koslow, Stephen H. Katz, Martin M. Bowden, Charles L. Maas, James W. Davis, John M. and Robins, Eli 1991. Mania: Sympathoadrenal function and clinical state. Psychiatry Research, Vol. 37, Issue. 2, p. 195.
Davis, Bruce A. 1989. Biogenic amines and their metabolites in body fluids of normal, psychiatric and neurological subjects. Journal of Chromatography A, Vol. 466, p. 89.
Wetzler, Scott and Katz, Martin M. 1989. Problems with the differentiation of anxiety and depression. Journal of Psychiatric Research, Vol. 23, Issue. 1, p. 1.
Brunswick, David J. Frazer, Alan Koslow, Stephen H. Casper, Regina Stokes, Peter E. Robins, Eli and Davis, John M. 1988. Insulin-induced hypoglycaemic response and release of growth hormone in depressed patients and healthy controls. Psychological Medicine, Vol. 18, Issue. 01, p. 79.
Casper, Regina C. Kocsis, James Dysken, Maurice Stokes, Peter Croughan, Jack and Maas, James 1988. Cortisol measures in primary major depressive disorder with hypersomnia or appetite increase. Journal of Affective Disorders, Vol. 15, Issue. 2, p. 131.
Croughan, Jack L. Secunda, Steven K. Katz, Martin M. Robins, Eli Mendels, Joseph Swann, Alan and Harris-Larkin, Barbara 1988. Sociodemographic and prior clinical course characteristics associated with treatment response in depressed patients. Journal of Psychiatric Research, Vol. 22, Issue. 3, p. 227.
Bowden, Charles L. Koslow, Stephen Maas, James W. Davis, John Garver, David L. and Hanin, Israel 1987. Changes in urinary catecholamines and their metabolites in depressed patients treated with amitriptyline or imipramine. Journal of Psychiatric Research, Vol. 21, Issue. 2, p. 111.
Casper, R.C. Swann, A.C. Stokes, P.E. Chang, S. Katz, M.M. and Garver, D. 1987. Weight loss, cortisol levels, and dexamethasone suppression in major depressive disorder. Acta Psychiatrica Scandinavica, Vol. 75, Issue. 3, p. 243.
Katz, M. M. Koslow, S. H. Maas, J. W. Frazer, A. Bowden, C. L. Casper, R. Croughan, J. Kocsis, J. and Redmond, E. 1987. The timing, specificity and clinical prediction of tricyclic drug effects in depression. Psychological Medicine, Vol. 17, Issue. 02, p. 297.
There are many reports which suggest that patients with affective illness (mania and/or depression) have abnormalities in the functioning of one or more neurobiological systems. At a conference convened by the Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, these findings were reviewed and some of the factors impeding movement towards a more complete and integrated view of the functioning of neurobiological systems in patients with mania or depression were identified. As a result, a multi-research centre, collaborative approach to the study of the psychobiology of affective disorders was developed. In this collaborative programme, which has now been underway for several years, the focus has been upon: (a) the assessment of the functioning of several different types of biological systems in the same patient, both before and during treatment; (b) obtaining a reasonably large number of patients and comparison subjects; and (c) the use within and across centres of standardized diagnostic categories and behavioural rating methodologies. In this paper the history, background, and rationale for this collaborative effort are reviewed. Those biological systems chosen for study are noted, and issues such as reliability and validity of diagnoses, measurement of state variables, assessment of change with treatment, and logistical and coordinating problems are discussed.
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