Bruenig, Dagmar Lurie, Janine Morris, Charles P. Harvey, Wendy Lawford, Bruce Young, Ross McD and Voisey, Joanne 2016. A Case-Control Study and Meta-Analysis RevealBDNFVal66Met Is a Possible Risk Factor for PTSD. Neural Plasticity, Vol. 2016, p. 1.
Eiroa-Orosa, Francisco Jose Giannoni-Pastor, Anna Fidel-Kinori, Sara Guila and Argüello, José María 2016. Substance use and misuse in burn patients: Testing the classical hypotheses of the interaction between post-traumatic symptomatology and substance use. Journal of Addictive Diseases, Vol. 35, Issue. 3, p. 194.
Head, M. Goodwin, L. Debell, F. Greenberg, N. Wessely, S. and Fear, N. T. 2016. Post-traumatic stress disorder and alcohol misuse: comorbidity in UK military personnel. Social Psychiatry and Psychiatric Epidemiology, Vol. 51, Issue. 8, p. 1171.
Kochunov, Peter Thompson, Paul M. Winkler, Anderson Morrissey, Mary Fu, Mao Coyle, Thomas R. Du, Xiaoming Muellerklein, Florian Savransky, Anya Gaudiot, Christopher Sampath, Hemalatha Eskandar, George Jahanshad, Neda Patel, Binish Rowland, Laura Nichols, Thomas E. O'Connell, Jeffrey R. Shuldiner, Alan R. Mitchell, Braxton D. and Hong, L. Elliot 2016. The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects. NeuroImage, Vol. 125, p. 189.
Lind, Mackenzie J. Sawyers, Chelsea Sheerin, Christina and Amstadter, Ananda B. 2016. Comprehensive Guide to Post-Traumatic Stress Disorders.
Murphy, Eleanor 2016. African-American representation in family and twin studies of mood and anxiety disorders: A systematic review. Journal of Affective Disorders, Vol. 205, p. 311.
Palmer, Rohan H. C. Nugent, Nicole R. Brick, Leslie A. Bidwell, Cinnamon L. McGeary, John E. Keller, Matthew C. and Knopik, Valerie S. 2016. Evidence of Shared Genome-Wide Additive Genetic Effects on Interpersonal Trauma Exposure and Generalized Vulnerability to Drug Dependence in a Population of Substance Users. Journal of Traumatic Stress, Vol. 29, Issue. 3, p. 197.
Sheerin, Christina M. Lind, Mackenzie J. Bountress, Kaitlin Nugent, Nicole R. and Amstadter, Ananda B. 2016. The Genetics and Epigenetics of PTSD: Overview, Recent Advances, and Future Directions. Current Opinion in Psychology,
Young, Gerald 2016. Unifying Causality and Psychology.
Zannas, Anthony S. Binder, Elisabeth and Mehta, Divya 2016. Posttraumatic Stress Disorder.
Ashley-Koch, Allison E. Garrett, Melanie E. Gibson, Jason Liu, Yutao Dennis, Michelle F. Kimbrel, Nathan A. Beckham, Jean C. and Hauser, Michael A. 2015. Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq–Afghanistan era veterans. Journal of Affective Disorders, Vol. 184, p. 225.
Badour, Christal L. Hirsch, R. Louis Zhang, Jingmei Mandel, Howard Hamner, Mark and Wang, Zhewu 2015. Exploring the association between a cholecystokinin promoter polymorphism (rs1799923) and posttraumatic stress disorder in combat veterans. Journal of Anxiety Disorders, Vol. 36, p. 78.
Chakraborty, Nabarun Meyerhoff, James Gautam, Aarti Muhie, Seid Jibitu, Meskerem De Lima, Thereza C.M. Hammamieh, Rasha and Jett, Marti 2015. Gene and stress history interplay in emergence of PTSD-like features. Behavioural Brain Research, Vol. 292, p. 266.
Duan, Zhaoxia He, Mei Zhang, Jieyuan Chen, Kuijun Li, Bingcang and Wang, Jianmin 2015. Assessment of functional tag single nucleotide polymorphisms within the DRD2 gene as risk factors for post-traumatic stress disorder in the Han Chinese population. Journal of Affective Disorders, Vol. 188, p. 210.
Gabbay, Frances H. Choi, Kwang H. Wynn, Gary H. and Ursano, Robert J. 2015. Cannabinoids in Neurologic and Mental Disease.
Han, Song Yi Cho, Maeng Je Won, Seunghee Hong, Jin Pyo Bae, Jae Nam Cho, Seong-Jin Park, Jong-Ik Lee, Jun-Young Jeon, Hong Jin and Chang, Sung Man 2015. Sociodemographic Factors and Comorbidities Associated with Remission from Alcohol Dependence: Results from a Nationwide General Population Survey in Korea. Psychiatry Investigation, Vol. 12, Issue. 3, p. 316.
Kochunov, Peter Jahanshad, Neda Marcus, Daniel Winkler, Anderson Sprooten, Emma Nichols, Thomas E. Wright, Susan N. Hong, L. Elliot Patel, Binish Behrens, Timothy Jbabdi, Saad Andersson, Jesper Lenglet, Christophe Yacoub, Essa Moeller, Steen Auerbach, Eddie Ugurbil, Kamil Sotiropoulos, Stamatios N. Brouwer, Rachel M. Landman, Bennett Lemaitre, Hervé den Braber, Anouk Zwiers, Marcel P. Ritchie, Stuart van Hulzen, Kimm Almasy, Laura Curran, Joanne deZubicaray, Greig I. Duggirala, Ravi Fox, Peter Martin, Nicholas G. McMahon, Katie L. Mitchell, Braxton Olvera, Rene L. Peterson, Charles Starr, John Sussmann, Jessika Wardlaw, Joanna Wright, Margie Boomsma, Dorret I. Kahn, Rene de Geus, Eco J.C. Williamson, Douglas E. Hariri, Ahmad van 't Ent, Dennis Bastin, Mark E. McIntosh, Andrew Deary, Ian J. Hulshoff pol, Hilleke E. Blangero, John Thompson, Paul M. Glahn, David C. and Van Essen, David C. 2015. Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data. NeuroImage, Vol. 111, p. 300.
Logue, Mark W Amstadter, Ananda B Baker, Dewleen G Duncan, Laramie Koenen, Karestan C Liberzon, Israel Miller, Mark W Morey, Rajendra A Nievergelt, Caroline M Ressler, Kerry J Smith, Alicia K Smoller, Jordan W Stein, Murray B Sumner, Jennifer A and Uddin, Monica 2015. The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration. Neuropsychopharmacology, Vol. 40, Issue. 10, p. 2287.
Morrow, Jonathan D. Saunders, Benjamin T. Maren, Stephen and Robinson, Terry E. 2015. Sign-tracking to an appetitive cue predicts incubation of conditioned fear in rats. Behavioural Brain Research, Vol. 276, p. 59.
Munn-Chernoff, Melissa A. Grant, Julia D. Agrawal, Arpana Sartor, Carolyn E. Werner, Kimberly B. Bucholz, Kathleen K. Madden, Pamela A.F. Heath, Andrew C. and Duncan, Alexis E. 2015. Genetic overlap between alcohol use disorder and bulimic behaviors in European American and African American women. Drug and Alcohol Dependence, Vol. 153, p. 335.
The few genetically informative studies to examine post-traumatic stress disorder (PTSD) and alcohol dependence (AD), all of which are based on a male veteran sample, suggest that the co-morbidity between PTSD and AD may be attributable in part to overlapping genetic influences, but this issue has yet to be addressed in females.
Data were derived from an all-female twin sample (n=3768) ranging in age from 18 to 29 years. A trivariate genetic model that included trauma exposure as a separate phenotype was fitted to estimate genetic and environmental contributions to PTSD and the degree to which they overlap with those that contribute to AD, after accounting for potential confounding effects of heritable influences on trauma exposure.
Additive genetic influences (A) accounted for 72% of the variance in PTSD; individual-specific environmental (E) factors accounted for the remainder. An AE model also provided the best fit for AD, for which heritability was estimated to be 71%. The genetic correlation between PTSD and AD was 0.54.
The heritability estimate for PTSD in our sample is higher than estimates reported in earlier studies based almost exclusively on an all-male sample in which combat exposure was the precipitating traumatic event. However, our findings are consistent with the absence of evidence for shared environmental influences on PTSD and, most importantly, the substantial overlap in genetic influences on PTSD and AD reported in these investigations. Additional research addressing potential distinctions by gender in the relative contributions of genetic and environmental influences on PTSD is merited.
This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.
Email your librarian or administrator to recommend adding this journal to your organisation's collection.