Frissen, Aleida van Os, Jim Habets, Petra Gronenschild, Ed Marcelis, Machteld and Hashimoto, Takanori 2017. No Evidence of Association between Childhood Urban Environment and Cortical Thinning in Psychotic Disorder. PLOS ONE, Vol. 12, Issue. 1, p. e0166651.
Guo, Wenbin Liu, Feng Chen, Jindong Wu, Renrong Li, Lehua Zhang, Zhikun and Zhao, Jingping 2017. Olanzapine modulation of long- and short-range functional connectivity in the resting brain in a sample of patients with schizophrenia. European Neuropsychopharmacology, Vol. 27, Issue. 1, p. 48.
Jørgensen, K. N. Nesvåg, R. Nerland, S. Mørch-Johnsen, L. Westlye, L. T. Lange, E. H. Haukvik, U. K. Hartberg, C. B. Melle, I. Andreassen, O. A. and Agartz, I. 2017. Brain volume change in first-episode psychosis: an effect of antipsychotic medication independent of BMI change. Acta Psychiatrica Scandinavica, Vol. 135, Issue. 2, p. 117.
Landin-Romero, Ramón Canales-Rodríguez, Erick J Kumfor, Fiona Moreno-Alcázar, Ana Madre, Mercè Maristany, Teresa Pomarol-Clotet, Edith and Amann, Benedikt L 2017. Surface-based brain morphometry and diffusion tensor imaging in schizoaffective disorder. Australian & New Zealand Journal of Psychiatry, Vol. 51, Issue. 1, p. 42.
Takahashi, Michio Matsui, Mie Nakashima, Mitsuhiro Takahashi, Tsutomu and Suzuki, Michio 2017. Callosal size in first-episode schizophrenia patients with illness duration of less than one year: A cross-sectional MRI study. Asian Journal of Psychiatry, Vol. 25, p. 197.
Abramovic, Lucija Boks, Marco P.M. Vreeker, Annabel Bouter, Diandra C. Kruiper, Caitlyn Verkooijen, Sanne van Bergen, Annet H. Ophoff, Roel A. Kahn, René S. and van Haren, Neeltje E.M. 2016. The association of antipsychotic medication and lithium with brain measures in patients with bipolar disorder. European Neuropsychopharmacology, Vol. 26, Issue. 11, p. 1741.
Alvarez-Jimenez, M. O’Donoghue, B. Thompson, A. Gleeson, J. F. Bendall, S. Gonzalez-Blanch, C. Killackey, E. Wunderink, L. and McGorry, P. D. 2016. Beyond Clinical Remission in First Episode Psychosis: Thoughts on Antipsychotic Maintenance vs. Guided Discontinuation in the Functional Recovery Era. CNS Drugs, Vol. 30, Issue. 5, p. 357.
Amann, B. L. Canales-Rodríguez, E. J. Madre, M. Radua, J. Monte, G. Alonso-Lana, S. Landin-Romero, R. Moreno-Alcázar, A. Bonnin, C. M. Sarró, S. Ortiz-Gil, J. Gomar, J. J. Moro, N. Fernandez-Corcuera, P. Goikolea, J. M. Blanch, J. Salvador, R. Vieta, E. McKenna, P. J. and Pomarol-Clotet, E. 2016. Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder. Acta Psychiatrica Scandinavica, Vol. 133, Issue. 1, p. 23.
Amato, Davide Beasley, Clare L. Hahn, Margaret K. and Vernon, Anthony C. 2016. Neuroadaptations to antipsychotic drugs: Insights from pre-clinical and human post-mortem studies. Neuroscience & Biobehavioral Reviews,
Azorin, Jean-Michel Simon, Nicolas Adida, Marc and Belzeaux, Raoul 2016. Pharmacological treatment of schizophrenia with comorbid substance use disorder. Expert Opinion on Pharmacotherapy, Vol. 17, Issue. 2, p. 231.
Cannon, Tyrone D. 2016. Brain Biomarkers of Vulnerability and Progression to Psychosis. Schizophrenia Bulletin, Vol. 42, Issue. suppl 1, p. S127.
Echarte, Luis E. 2016. Human Dignity of the Vulnerable in the Age of Rights.
Fraguas, David Díaz-Caneja, Covadonga M. Pina-Camacho, Laura Janssen, Joost and Arango, Celso 2016. Progressive brain changes in children and adolescents with early-onset psychosis: A meta-analysis of longitudinal MRI studies. Schizophrenia Research, Vol. 173, Issue. 3, p. 132.
Ganella, Eleni P. Bartholomeusz, Cali F. Seguin, Caio Whittle, Sarah Bousman, Chad Phassouliotis, Christina Everall, Ian Pantelis, Christos and Zalesky, Andrew 2016. Functional brain networks in treatment-resistant schizophrenia. Schizophrenia Research,
Goozee, Rhianna Reinders, Antje A.T.S. Handley, Rowena Marques, Tiago Taylor, Heather O'Daly, Owen McQueen, Grant Hubbard, Kathryn Mondelli, Valeria Pariante, Carmine and Dazzan, Paola 2016. Effects of aripiprazole and haloperidol on neural activation during the n-back in healthy individuals: A functional MRI study. Schizophrenia Research, Vol. 173, Issue. 3, p. 174.
Handley, Rowena Mondelli, Valeria Zelaya, Fernando Marques, Tiago Taylor, Heather Reinders, Antje A.T.S. Chaddock, Christopher McQueen, Grant Hubbard, Kathryn Papadopoulos, Andrew Williams, Steve McGuire, Philip Pariante, Carmine and Dazzan, Paola 2016. Effects of antipsychotics on cortisol, interleukin-6 and hippocampal perfusion in healthy volunteers. Schizophrenia Research, Vol. 174, Issue. 1-3, p. 99.
Jørgensen, Kjetil N. Nesvåg, Ragnar Gunleiksrud, Sindre Raballo, Andrea Jönsson, Erik G. and Agartz, Ingrid 2016. First- and second-generation antipsychotic drug treatment and subcortical brain morphology in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, Vol. 266, Issue. 5, p. 451.
Kandola, Aaron Hendrikse, Joshua Lucassen, Paul J. and Yücel, Murat 2016. Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment. Frontiers in Human Neuroscience, Vol. 10,
Liu, Xiaoyi Wang, Xijin Lai, Yunyao Hao, Chuanxi Chen, Lei Zhou, Zhenyu Yu, Xin and Hong, Nan 2016. Abnormalities of cingulate cortex in antipsychotic-naïve chronic schizophrenia. Brain Research, Vol. 1638, p. 105.
Lui, Su Zhou, Xiaohong Joe Sweeney, John A. and Gong, Qiyong 2016. Psychoradiology: The Frontier of Neuroimaging in Psychiatry. Radiology, Vol. 281, Issue. 2, p. 357.
The potential effects of antipsychotic drugs on brain structure represent a key factor in understanding neuroanatomical changes in psychosis. This review addresses two issues: (1) do antipsychotic medications induce changes in total or regional human brain volumes and (2) do such effects depend on antipsychotic type?
A systematic review of studies reporting structural brain magnetic resonance imaging (MRI) measures: (1) directly in association with antipsychotic use; and (2) in patients receiving lifetime treatment with antipsychotics in comparison with drug-naive patients or healthy controls. We searched Medline and EMBASE databases using the medical subject heading terms: ‘antipsychotics’ AND ‘brain’ AND (MRI NOT functional). The search included studies published up to 31 January 2007. Wherever possible, we reported the effect size of the difference observed.
Thirty-three studies met our inclusion criteria. The results suggest that antipsychotics act regionally rather than globally on the brain. These volumetric changes are of a greater magnitude in association with typical than with atypical antipsychotic use. Indeed, there is evidence of a specific effect of antipsychotic type on the basal ganglia, with typicals specifically increasing the volume of these structures. Differential effects of antipsychotic type may also be present on the thalamus and the cortex, but data on these and other brain areas are more equivocal.
Antipsychotic treatment potentially contributes to the brain structural changes observed in psychosis. Future research should take into account these potential effects, and use adequate sample sizes, to allow improved interpretation of neuroimaging findings in these disorders.
This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.
Email your librarian or administrator to recommend adding this journal to your organisation's collection.