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Ovarian hormones and binge eating: exploring associations in community samples

  • K. L. Klump (a1), P. K. Keel (a2), K. M. Culbert (a1) and C. Edler (a2)
Abstract
Background

Significant associations between changes in ovarian hormones and binge eating are present across the menstrual cycle in women with bulimia nervosa. However, no study has examined these relationships in a non-clinical sample, despite the need for these data for designing risk-factor studies.

Method

In study 1, we modified several continuous measures of binge eating and identified those that were most sensitive to menstrual-cycle fluctuations in a non-clinical sample of 10 women who completed measures for 35 days. In study 2, we explored associations between ovarian hormones and binge-eating scores in nine women who completed these same measures for 65 days and provided daily saliva samples for assays of estradiol and progesterone concentrations.

Results

In study 1, the Emotional Eating subscale of the Dutch Eating Behavior Questionnaire exhibited superior reliability and was most sensitive to predicted menstrual-cycle changes in binge eating (i.e. increased scores in the mid-luteal/premenstrual compared with follicular/ovulatory phases). In study 2, this scale showed predicted inverse associations with estradiol and positive associations with progesterone across the menstrual cycle that could not be accounted for by changes in negative affect.

Conclusion

Associations between ovarian hormones and binge eating are robust and present in clinical and non-clinical samples. Findings support the ability to examine the role of ovarian hormones as risk factors for binge eating in large-scale prospective studies and twin studies.

Copyright
Corresponding author
*Address for correspondence: K. L. Klump, Ph.D., Department of Psychology, Michigan State University, 107B Psychology Building, East Lansing, MI 48824-1116, USA. (Email: klump@msu.edu)
Linked references
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L Asarian , N Geary (2006). Modulation of appetite by gonadal steroid hormones. Philosophical Transactions of the Royal Society – Biological Science 361, 12511263.

DM Garner , MP Olmsted , J Polivy (1983). Development and validation of a multidimensional eating disorder inventory for anorexia nervosa and bulimia. International Journal of Eating Disorders 2, 1534.

G Jasienska , A Ziomkiewicz , PT Ellison , SF Lipson , I Thune (2004). Large breasts and narrow waist indicate high reproductive potential in women. Proceedings of the Royal Society of London Series B 271, 12131217.

A Kassam , JW Overstreet , C Snow-Harter , MJ De Souza , EB Gold , BL Lasley (1996). Identification of anovulation and transient luteal function using a urinary pregnanediol-3-glucuronide ration algorithm. Environmental Health Perspectives 104, 408413.

KL Klump , SA Burt , M McGue , WG Iacono (2007 a). Changes in genetic and environmental influences on disordered eating across adolescence: a longitudinal twin study. Archives of General Psychiatry 64, 14091415.

KL Klump , KM Culbert (2007). Molecular genetic studies of eating disorders: current status and future directions. Current Directions in Psychological Science 16, 3741.

KL Klump , M McGue , WG Iacono (2003). Differential heritability of eating attitudes and behaviors in prepubertal versus pubertal twins. International Journal of Eating Disorders 33, 287292.

AB Loucks , EM Heath (1994). Dietary restriction reduces luteinizing hormone (LH) pulse frequency during waking hours and increases LH pulse amplitude during sleep in young menstruating women. Journal of Clinical Endocrinology and Metabolism 78, 910915.

H Ostlund , E Keller , YL Hurd (2003). Estrogen receptor gene expression in relation to neuropsychiatric disorders. Annals of the New York Academy of Sciences 1007, 5463.

KM Pirke , U Schweiger , W Lemmel , JC Krieg , M Berger (1985). The influence of dieting on the menstrual cycle of healthy young women. Journal of Clinical Endocrinology and Metabolism 60, 11741179.

S Roberts , NJ Kenney , DG Mook (1972). Overeating induced by progesterone in the ovariectomized, adrenalectomized rat. Hormones and Behavior 3, 267276.

WA Price , MS Torem , LR DiMarzio (1987). Premenstrual exacerbation of bulimia. Psychosomatics 28, 378379.

EA Shirtcliff , DA Granger , EB Schwartz , MJ Curran , A Booth , WH Overman (2000). Assessing estradiol in biobehavioral studies using saliva and blood spots: simple radioimmunoassay protocols, reliability, and comparative validity. Hormones and Behavior 38, 137147.

AJ Stunkard , S Messick (1985). The three-factor eating questionnaire to measure dietary restraint, disinhibition, and hunger. Journal of Psychosomatic Research 29, 671680.

T Van Strien , JE Frijters , GP Bergers , PB Defares (1986). The Dutch Eating Behavior Questionnaire (DEBQ) for assessment of restrained, emotional, and external eating behavior. International Journal of Eating Disorders 5, 295315.

M Varma , JK Chai , MM Meguid , A Laviano , JR Gleason , ZJ Yang , V Blaha (1999). Effect of estradiol and progesterone on daily rhythm in food intake and feeding patterns in Fischer rats. Physiology and Behavior 68, 99107.

GN Wade (1975). Some effects of ovarian hormones on food intake and body weight in female rats. Journal of Comparative and Physiological Psychology 88, 183193.

K Waller , SH Swan , GC Windham , L Fenster , EP Elkin , BL Lasley (1998). Use of urine biomarkers to evaluate menstrual function in healthy premenopausal women. American Journal of Epidemiology 147, 10711080.

J Wardle (1987). Eating style: a validation study of the Dutch Eating Behaviour Questionnaire in normal subjects and women with eating disorders. Journal of Psychosomatic Research 31, 161169.

D Watson , LA Clark , A Tellegen (1988). Development and validation of brief measures of positive and negative affect: the PANAS scales. Journal of Personality and Social Psychology 54, 10631070.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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