Cortese, Samuele 2012. The neurobiology and genetics of Attention-Deficit/Hyperactivity Disorder (ADHD): What every clinician should know. European Journal of Paediatric Neurology, Vol. 16, Issue. 5, p. 422.
Fanning, Jennifer R. Berman, Mitchell E. and Long, James M. 2014. P3 and provoked aggressive behavior. Social Neuroscience, Vol. 9, Issue. 2, p. 118.
Lenartowicz, Agatha and Loo, Sandra K. 2014. Use of EEG to Diagnose ADHD. Current Psychiatry Reports, Vol. 16, Issue. 11,
Hasler, Roland Perroud, Nader Meziane, Hadj Boumediene Herrmann, François Prada, Paco Giannakopoulos, Panteleimon and Deiber, Marie-Pierre 2016. Attention-related EEG markers in adult ADHD. Neuropsychologia, Vol. 87, p. 120.
Gatzke-Kopp, Lisa M. Willner, Cynthia J. Jetha, Michelle K. Abenavoli, Rachel M. DuPuis, David and Segalowitz, Sidney J. 2015. How does reactivity to frustrative non-reward increase risk for externalizing symptoms?. International Journal of Psychophysiology, Vol. 98, Issue. 2, p. 300.
Kropotov, J. D. Pronina, M. V. Polyakov, Ju. I. and Ponomarev, V. A. 2013. Functional biomarkers in the diagnostics of mental disorders: Cognitive event-related potentials. Human Physiology, Vol. 39, Issue. 1, p. 8.
Stroux, D. Shushakova, A. Geburek-Höfer, A.J. Ohrmann, P. Rist, F. and Pedersen, A. 2016. Deficient interference control during working memory updating in adults with ADHD: An event-related potential study. Clinical Neurophysiology, Vol. 127, Issue. 1, p. 452.
Mayer, Kerstin Wyckoff, Sarah N. Schulz, Ulrike and Strehl, Ute 2012. Neurofeedback for Adult Attention-Deficit/Hyperactivity Disorder: Investigation of Slow Cortical Potential Neurofeedback—Preliminary Results. Journal of Neurotherapy, Vol. 16, Issue. 1, p. 37.
Wiegand, Iris Hennig-Fast, Kristina Kilian, Beate Müller, Hermann J. Töllner, Thomas Möller, Hans-Jürgen Engel, Rolf R. and Finke, Kathrin 2016. EEG correlates of visual short-term memory as neuro-cognitive endophenotypes of ADHD. Neuropsychologia, Vol. 85, p. 91.
Retz, Wolfgang González-Trejo, Ernesto Römer, Konstanze D. Philipp-Wiegmann, Florence Reinert, Philip Low, Yin Fen Boureghda, Samir Rösler, Michael and Strauss, Daniel J. 2012. Assessment of post-excitatory long-interval cortical inhibition in adult attention-deficit/hyperactivity disorder. European Archives of Psychiatry and Clinical Neuroscience, Vol. 262, Issue. 6, p. 507.
Tye, Charlotte McLoughlin, Gráinne Kuntsi, Jonna and Asherson, Philip 2011. Electrophysiological markers of genetic risk for attention deficit hyperactivity disorder. Expert Reviews in Molecular Medicine, Vol. 13,
Geburek, A.J. Rist, F. Gediga, G. Stroux, D. and Pedersen, A. 2013. Electrophysiological indices of error monitoring in juvenile and adult attention deficit hyperactivity disorder (ADHD)—A meta-analytic appraisal. International Journal of Psychophysiology, Vol. 87, Issue. 3, p. 349.
Chorlian, David B. Rangaswamy, Madhavi Manz, Niklas Kamarajan, Chella Pandey, Ashwini K. Edenberg, Howard Kuperman, Samuel and Porjesz, Bernice 2015. Gender modulates the development of theta event related oscillations in adolescents and young adults. Behavioural Brain Research, Vol. 292, p. 342.
Bolduc-Teasdale, Julie Jolicoeur, Pierre and McKerral, Michelle 2012. Multiple Electrophysiological Markers of Visual-Attentional Processing in a Novel Task Directed toward Clinical Use. Journal of Ophthalmology, Vol. 2012, p. 1.
Hashimoto, Eri Riederer, Peter Franz Hesselbrock, Victor M. Hesselbrock, Michie N. Mann, Karl Ukai, Wataru Sohma, Hitoshi Thibaut, Florence Schuckit, Marc A. and Saito, Toshikazu 2013. Consensus paper of the WFSBP task force on biological markers: Biological markers for alcoholism. The World Journal of Biological Psychiatry, Vol. 14, Issue. 8, p. 549.
Kim, Soyeon Liu, Zhongxu Glizer, Daniel Tannock, Rosemary and Woltering, Steven 2014. Adult ADHD and working memory: Neural evidence of impaired encoding. Clinical Neurophysiology, Vol. 125, Issue. 8, p. 1596.
Malone, Stephen M. Vaidyanathan, Uma Basu, Saonli Miller, Michael B. MCGUE, Matt and Iacono, William G. 2014. Heritability and molecular-genetic basis of the P3 event-related brain potential: A genome-wide association study. Psychophysiology, Vol. 51, Issue. 12, p. 1246.
Heinzel, S. Dresler, T. Baehne, C. G. Heine, M. Boreatti-Hummer, A. Jacob, C. P. Renner, T. J. Reif, A. Lesch, K.-P. Fallgatter, A. J. and Ehlis, A.-C. 2013. COMT x DRD4 Epistasis Impacts Prefrontal Cortex Function Underlying Response Control. Cerebral Cortex, Vol. 23, Issue. 6, p. 1453.
Ordikhani-Seyedlar, Mehdi Lebedev, Mikhail A. Sorensen, Helge B. D. and Puthusserypady, Sadasivan 2016. Neurofeedback Therapy for Enhancing Visual Attention: State-of-the-Art and Challenges. Frontiers in Neuroscience, Vol. 10,
Sable, Jeffrey J. Knopf, Kristin L. Kyle, Marie R. Schully, Lauren T Brooks, Megan M. Parry, Kelly H. Thompson, Ivy A. Suna, Elise B. Stowe, Rachel Flink, Laura A. and Diamond, Rebecca E. 2013. Attention-deficit hyperactivity disorder reduces automatic attention in young adults. Psychophysiology, Vol. 50, Issue. 3, p. 308.
The P300 (P3) event-related potential (ERP) component, a possible endophenotype for attention deficit hyperactivity disorder (ADHD), has been widely examined in children, but received little attention in adults. Our objective was to conduct a meta-analysis of P3 studies in adults with ADHD.
We searched the Medline and PsycINFO databases for controlled studies examining both adult ADHD and matched healthy controls. Six relevant publications were identified for the meta-analysis, which had comparable data across studies with regard to the amplitude of ERP components related to target detection (P3, P3b). Pooled effect size (ES) for P3 amplitude as well as the association of the ES with age and gender were investigated using meta-regression.
Comparing the ADHD group versus controls, the pooled effect size for a decrease in P3 amplitude was in the medium range (Cohen's d=−0.55, p=0.0006). Additionally, meta-regression revealed that decrease in P3 amplitude significantly varied with the mean age of ADHD patients (p=0.0087), with a gradual increasing of the difference at higher ages. Results also showed a significant association between the ES and gender, indicating a more pronounced reduction of P3 amplitude in the ADHD group versus controls when females were predominantly represented in the sample.
To our knowledge, this is the first meta-analysis of P3 characteristics in adults with ADHD. It reveals a significantly decreased P3 amplitude during target detection. Our result that the reduction in P3 amplitude increases with age is interpreted in a neurodevelopmental context.
This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.
Email your librarian or administrator to recommend adding this journal to your organisation's collection.