Belvederi Murri, Martino Prestia, Davide Mondelli, Valeria Pariante, Carmine Patti, Sara Olivieri, Benedetta Arzani, Costanza Masotti, Mattia Respino, Matteo Antonioli, Marco Vassallo, Linda Serafini, Gianluca Perna, Giampaolo Pompili, Maurizio and Amore, Mario 2016. The HPA axis in bipolar disorder: Systematic review and meta-analysis. Psychoneuroendocrinology, Vol. 63, p. 327.
Doucette, Sarah Levy, Adrian Flowerdew, Gordon Horrocks, Julie Grof, Paul Ellenbogen, Mark and Duffy, Anne 2016. Early parent-child relationships and risk of mood disorder in a Canadian sample of offspring of a parent with bipolar disorder: findings from a 16-year prospective cohort study. Early Intervention in Psychiatry, Vol. 10, Issue. 5, p. 381.
Nijjar, Rami Ellenbogen, Mark A. and Hodgins, Sheilagh 2016. Sexual Risk Behaviors in the Adolescent Offspring of Parents with Bipolar Disorder: Prospective Associations with Parents’ Personality and Externalizing Behavior in Childhood. Journal of Abnormal Child Psychology, Vol. 44, Issue. 7, p. 1347.
Schreuder, Merel M. Vinkers, Christiaan H. Mesman, Esther Claes, Stephan Nolen, Willem A. and Hillegers, Manon H.J. 2016. Childhood trauma and HPA axis functionality in offspring of bipolar parents. Psychoneuroendocrinology, Vol. 74, p. 316.
Barry, Tom J. Murray, Lynne Fearon, R.M. Pasco Moutsiana, Christina Cooper, Peter Goodyer, Ian M. Herbert, Joe and Halligan, Sarah L. 2015. Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood. Psychoneuroendocrinology, Vol. 52, p. 251.
Houtepen, L.C. Boks, M.P.M. Kahn, R.S. Joëls, M. and Vinkers, C.H. 2015. Antipsychotic use is associated with a blunted cortisol stress response: A study in euthymic bipolar disorder patients and their unaffected siblings. European Neuropsychopharmacology, Vol. 25, Issue. 1, p. 77.
Park, Min-Hyeon Chang, Kiki D. Hallmayer, Joachim Howe, Meghan E. Kim, Eunjoo Hong, Seung Chul and Singh, Manpreet K. 2015. Preliminary study of anxiety symptoms, family dysfunction, and the brain-derived neurotrophic factor (BDNF) Val66Met genotype in offspring of parents with bipolar disorder. Journal of Psychiatric Research, Vol. 61, p. 81.
Romo-Nava, Francisco Fresán-Orellana, Ana Barragán, Virginia Saracco-Álvarez, Ricardo Becerra-Palars, Claudia Osorio, Yanik Pérez, Emrys Heinze, Gerhard and Lara, Diogo R. 2015. The Affective and Emotional Composite Temperament Scale (AFECTS): Psychometric properties of the Spanish version in a community sample from Mexico City and comparison between remitted psychiatric patients. Journal of Affective Disorders, Vol. 172, p. 251.
Zandstra, Anna Roos E. Ormel, Johan Nederhof, Esther Hoekstra, Pieter J. and Hartman, Catharina A. 2015. The Role of Basal Cortisol in Predicting Change in Mental Health Problems Across the Transition to Middle School. Journal of Adolescent Health, Vol. 56, Issue. 5, p. 489.
Zandstra, Anna Roos E. Hartman, Catharina A. Nederhof, Esther van den Heuvel, Edwin R. Dietrich, Andrea Hoekstra, Pieter J. and Ormel, Johan 2015. Chronic Stress and Adolescents’ Mental Health: Modifying Effects of Basal Cortisol and Parental Psychiatric History. The TRAILS Study. Journal of Abnormal Child Psychology, Vol. 43, Issue. 6, p. 1119.
Harvey, Christopher-James Gehrman, Phil and Espie, Colin A. 2014. Who is predisposed to insomnia: A review of familial aggregation, stress-reactivity, personality and coping style. Sleep Medicine Reviews, Vol. 18, Issue. 3, p. 237.
Mamah, Daniel Owoso, Akinkunle Sheffield, Julia M. and Bayer, Chelsea 2014. The WERCAP Screen and the WERC Stress Screen: psychometrics of self-rated instruments for assessing bipolar and psychotic disorder risk and perceived stress burden. Comprehensive Psychiatry, Vol. 55, Issue. 7, p. 1757.
Nijjar, Rami Ellenbogen, Mark A. and Hodgins, Sheilagh 2014. Personality, coping, risky behavior, and mental disorders in the offspring of parents with bipolar disorder: A comprehensive psychosocial assessment. Journal of Affective Disorders, Vol. 166, p. 315.
Singh, Manpreet K Chang, Kiki D Kelley, Ryan G Saggar, Manish Reiss, Allan L and Gotlib, Ian H 2014. Early signs of anomalous neural functional connectivity in healthy offspring of parents with bipolar disorder. Bipolar Disorders, Vol. 16, Issue. 7, p. 678.
Aydin, Adem Selvi, Yavuz Besiroglu, Lutfullah Boysan, Murat Atli, Abdullah Ozdemir, Osman Kilic, Sultan and Balaharoglu, Ragıp 2013. Mood and metabolic consequences of sleep deprivation as a potential endophenotype’ in bipolar disorder. Journal of Affective Disorders, Vol. 150, Issue. 2, p. 284.
Ellenbogen, Mark A. Linnen, Anne-Marie Santo, Jonathan B. aan het Rot, Marije Hodgins, Sheilagh and Young, Simon N. 2013. Salivary cortisol and interpersonal functioning: An event-contingent recording study in the offspring of parents with bipolar disorder. Psychoneuroendocrinology, Vol. 38, Issue. 7, p. 997.
Patino, Luis R Adler, Caleb M Mills, Neil P Strakowski, Stephen M Fleck, David E Welge, Jeffrey A and DelBello, Melissa P 2013. Conflict monitoring and adaptation in individuals at familial risk for developing bipolar disorder. Bipolar Disorders, Vol. 15, Issue. 3, p. 264.
Ellenbogen, Mark A. 2012. Introduction to the special section on biopsychosocial moderators of the stress response. Anxiety, Stress & Coping, Vol. 25, Issue. 4, p. 359.
It is well known that the hypothalamic–pituitary–adrenal (HPA) axis is compromised in major depression and bipolar disorder. There is increasing evidence that subtle HPA abnormalities, such as elevated cortisol levels, precede the development of an affective disorder. Interpersonal stress is also associated with the development of affective disorders. The present study sought to determine whether interpersonal chronic and episodic stress moderated the relationship between cortisol levels in the natural environment and risk status, defined as having a parent with bipolar disorder.
Sixty-two offspring of parents with bipolar disorder (OBD) and 60 offspring with no family history of affective disorders (OFH−), aged 19.48 years (s.d.=3.38, range 14–28), completed interviews assessing mental disorders and chronic and episodic stress, and provided saliva samples over 3 days.
Regression analyses revealed that the OBD who experienced high interpersonal chronic stress displayed a larger cortisol rise following awakening than the OBD reporting low interpersonal chronic stress. The same relationship was also found for levels of non-interpersonal chronic stress. The OBD who reported experiencing severe interpersonal episodic stress exhibited higher levels of daytime cortisol than the OBD reporting interpersonal episodic stress of mild severity. Importantly, none of the above relationships were detected in the OFH−. Each of the interactions between family history of affective disorders and stress remained after controlling for age, gender and offspring lifetime affective disorders and current non-affective disorders.
A biological sensitivity to stress may underlie the susceptibility to affective disorders among the OBD.
This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.
Email your librarian or administrator to recommend adding this journal to your organisation's collection.