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The effects of antipsychotics on brain structure: what have we learnt from structural imaging of schizophrenia?: A commentary on ‘Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings’ by Navari & Dazzan (2009)

  • S. J. Borgwardt (a1) (a2) (a3), R. Smieskova (a1) (a2), P. Fusar-Poli (a3), K. Bendfeldt (a2) and A. Riecher-Rössler (a1)...
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*Address for correspondence: Dr S. J. Borgwardt, Psychiatric Outpatient Department, University Hospital Basel, Petersgraben 4, CH-4031Basel, Switzerland. (Email:
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SJ Borgwardt , PK McGuire , J Aston , U Gschwandtner , MO Pfluger , RD Stieglitz , EW Radue , A Riecher-Rossler (2008). Reductions in frontal, temporal and parietal volume associated with the onset of psychosis. Schizophrenia Research 106, 108114.

LE DeLisi (2008). Reviewing the ‘facts about schizophrenia’: a possible or impossible task? Schizophrenia Research 102, 1920.

P Fusar-Poli , J Perez , M Broome , S Borgwardt , A Placentino , E Caverzasi , M Cortesi , P Veggiotti , P Politi , F Barale , P McGuire (2007). Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 31, 465484.

DE Job , HC Whalley , EC Johnstone , SM Lawrie (2005). Grey matter changes over time in high risk subjects developing schizophrenia. Neuroimage 25, 10231030.

GT Konopaske , KA Dorph-Petersen , RA Sweet , JN Pierri , W Zhang , AR Sampson , DA Lewis (2008). Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biological Psychiatry 63, 759765.

S Navari , P Dazzan (2009). Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings. Psychological Medicine. Published online: 2 April 2009. doi:10.1017/S0033291709005315.

C Pantelis , D Velakoulis , PD McGorry , SJ Wood , J Suckling , LJ Phillips , AR Yung , ET Bullmore , W Brewer , B Soulsby , P Desmond , PK McGuire (2003). Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 361, 281288.

A Riecher-Rossler , U Gschwandtner , J Aston , S Borgwardt , M Drewe , P Fuhr , M Pfluger , W Radu , C Schindler , RD Stieglitz (2007). The Basel early-detection-of-psychosis (FEPSY) study – design and preliminary results. Acta Psychiatrica Scandinavica 115, 114125.

R Smieskova , P Fusar-Poli , P Allen , K Bendfeldt , RD Stieglitz , J Drewe , EW Radu , PK McGuire , A Riecher , SJ Borgwardt (in press). The effects of antipsychotics on the brain: What have we learnt from structural neuroimaging of schizophrenia? – a systematic review. Current Pharmaceutical Design.

SJ Wood , C Pantelis , D Velakoulis , M Yucel , A Fornito , PD McGorry (2008). Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk. Schizophrenia Bulletin 34, 322329.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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