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Working memory in schizophrenia: a meta-analysis

  • N. F. Forbes (a1), L. A. Carrick (a1), A. M. McIntosh (a1) and S. M. Lawrie (a1)
Abstract
Background

Memory impairment is being recognized increasingly as an important feature of the neuropsychology of schizophrenia. Dysfunction of working memory, a system for the short-term storage and manipulation of information, may relate to a number of core symptoms of schizophrenia. Many studies have examined working memory function in schizophrenia but a clear understanding of the nature and extent of any deficit has been elusive.

Method

A systematic review and meta-analysis of studies comparing working memory function in subjects with schizophrenia and healthy controls was performed. Following a comprehensive literature search, meta-analyses were conducted on 36 measures of phonological, visuospatial and central executive working memory functioning, encompassing 441 separate results from 187 different studies.

Results

Statistically significant effect sizes were found for all working memory measures, indicating deficits in schizophrenia groups. Some of these were robust findings in the absence of evidence of significant heterogeneity or publication bias. Meta-regression analyses showed that the working memory deficit was not simply explained by discrepancies in current IQ between schizophrenia and control groups.

Conclusions

Large deficits in working memory were demonstrated in schizophrenia groups across all three working memory domains. There were, however, no clear differences across subdomains or between particular working memory tasks. There was substantial heterogeneity across results that could only be partly explained.

Copyright
Corresponding author
*Address for correspondence: Dr S. M. Lawrie, University of Edinburgh, Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK. (Email: s.lawrie@ed.ac.uk)
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* M Albus , W Hubman , C Ehrenberg , U Forcht , F Mohr , N Sobizack , C Wahlheim , S Hecht (1996). Neuropsychological impairment in first episode and chronic schizophrenia. European Archives of Psychiatry and Clinical Neuroscience 246, 249255.

* M Albus , W Hubmann , J Scherer , B Dreikorn , S Hecht , N Sobizack , F Mohr (2002). A prospective 2-year follow-up study of neurocognitive functioning in patients with first-episode schizophrenia. European Archives of Psychiatry and Clinical Neuroscience 252, 262267.

* LL Altshuler , J Ventura , WG van Gorp , MF Green , DC Theberge , J Mintz (2004). Neurocognitive function in clinically stable men with bipolar I disorder or schizophrenia and normal control subjects. Biological Psychiatry 56, 560569.

* NC Andreasen , DS O'Leary , T Cizadlo , S Arndt , K Rezai , LL Ponto , GL Watkins , RD Hichwa (1996). Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proceedings of the National Academy of Sciences USA 93, 99859990.

* E Antonova , V Kumari , R Morris , R Halari , A Anilkumar , R Mehrotra , T Sharma (2005). The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study. Biological Psychiatry 58, 457467.

* WFC Baare , HEH Pol , R Hijman , WPT Mali , MA Viergever , RS Kahn (1999). Volumetric analysis of frontal lobe regions in schizophrenia: relation to cognitive function and symptomatology. Biological Psychiatry 45, 15971605.

* DM Bagner , MRD Melinder , DM Barch (2003). Language comprehension and working memory language comprehension and working memory deficits in patients with schizophrenia. Schizophrenia Research 60, 299309.

* T Baldeweg , A Klugman , J Gruzelier , SR Hirsch (2004). Mismatch negativity potentials and cognitive impairment in schizophrenia. Schizophrenia Research 69, 203217.

* I Barkataki , V Kumari , M Das , M Hill , R Morris , P O'Connell , P Taylor , T Sharma (2005). A neuropsychological investigation into violence and mental illness. Schizophrenia Research 74, 113.

* WW Beatty , Z Jocic , N Monson , RD Staton (1993). Memory and frontal lobe dysfunction in schizophrenia and schizoaffective disorder. Journal of Nervous and Mental Disease 181, 448453.

* AM Bollini , MC Arnold , RS Keefe (2000). Test–retest reliability of the dot test of visuospatial working memory in patients with schizophrenia and controls. Schizophrenia Research 45, 169173.

* P Brazo , RM Marié , I Halbecq , K Benali , L Segard , P Delamillieure , S Langlois-Théry , A van der Elst , F Thibaut , M Petit , S Dollfus (2002). Cognitive patterns in subtypes of schizophrenia. European Psychiatry 17, 155162.

* G Brebion , AS David , H Jones , LS Pilowsky (2004). Semantic organization and verbal memory efficiency in patients with schizophrenia. Neuropsychology 18, 378383.

* G Brebion , JM Gorman , D Malaspina , Z Sharif , X Amador (2001). Clinical and cognitive factors associated with verbal memory task performance in patients with schizophrenia. American Journal of Psychiatry 158, 758764.

* WJ Brewer , J Edwards , V Anderson , T Robinson , C Pantelis (1996). Neuropsychological, olfactory, and hygiene deficits in men with negative symptom schizophrenia. Biological Psychiatry 40, 10211031.

* PF Buckley , C Moore , H Long , C Larkin , P Thompson , F Mulvany , O Redmond , JP Stack , JT Ennis , JL Waddington (1994). 1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates. Biological Psychiatry 36, 792800.

* RW Butler , MA Jenkins , J Sprock , DL Braff (1992). Wisconsin Card Sorting Test deficits in chronic paranoid schizophrenia: evidence for a relatively discrete subgroup? Schizophrenia Research 7, 169176.

A Calev (1984). Recall and recognition in mildly disturbed schizophrenics: the use of matched tasks. Psychological Medicine 14, 425429.

* A Calev , S Edelist (1993). Affect and memory in schizophrenia: negative emotion words are forgotten less rapidly than other words by long-hospitalized schizophrenics. Psychopathology 26, 229235.

* E Cantor-Graae , S Warkentin , A Nilsson (1995). Neuropsychological assessment of schizophrenic patients during a psychotic episode: persistent cognitive deficit? Acta Psychiatrica Scandinavica 91, 283288.

LJ Chapman , JP Chapman (1973). Problems in the measurement of cognitive deficits. Psychological Bulletin 79, 380385.

LJ Chapman , JP Chapman (1978). The measurement of differential deficit. Journal of Psychiatric Research 14, 303311.

* YL Chen , YHE Chen , F Lieh-Mak (2000). Semantic verbal fluency deficit as a familial trait marker in schizophrenia. Psychiatry Research 95, 133148.

* J Chey , J Lee , YS Kim , SM Kwon , YM Shin (2002). Spatial working memory span, delayed response and executive function in schizophrenia. Psychiatry Research 110, 259271.

* L Clare , PJ McKenna , AM Mortimer , AD Baddeley (1993). Memory in schizophrenia: what is impaired and what is preserved? Neuropsychologia 31, 12251241.

* JM Cleghorn , RD Kaplan , B Szechtman , H Szechtman , GM Brown (1990). Neuroleptic drug effects on cognitive function in schizophrenia. Schizophrenia Research 3, 211219.

* HM Conklin , ME Calkins , CW Anderson , TJ Dinzeo , WG Iacono (2002). Recognition memory for faces in schizophrenia patients and their first-degree relatives. Neuropsychologia 40, 23142324.

* HM Conklin , CE Curtis , ME Calkins , WG Iacono (2005). Working memory functioning in schizophrenia patients and their first-degree relatives: cognitive functioning shedding light on etiology. Neuropsychologia 43, 930942.

* PW Corrigan , MF Green (1991). Signal detection analysis of short-term recall in schizophrenia. Journal of Nervous and Mental Disease 179, 495498.

* JM Danion , T Meulemans , F Kauffmann-Muller , H Vermaat (2001). Intact implicit learning in schizophrenia. American Journal of Psychiatry 158, 944948.

* JM Danion , L Rizzo , A Bruant (1999). Functional mechanisms underlying impaired recognition memory and conscious awareness in patients with schizophrenia. Archives of General Psychiatry 56, 639644.

* NM Docherty , SW Gordinier (1999). Immediate memory, attention and communication disturbances in schizophrenia patients and their relatives. Psychological Medicine 29, 189197.

* J Egeland , K Sundet , BR Rund , A Asbjørnsen , K Hugdahl , NI Landrø , A Lund , A Roness , KI Stordal (2003). Sensitivity and specificity of memory dysfunction in schizophrenia: a comparison with major depression. Journal of Clinical and Experimental Neuropsychology 25, 7993.

M Egger , SG Davey , M Schneider , C Minder (1997). Bias in meta-analysis detected by a simple, graphical test. British Medical Journal 315, 629634.

* R Elliott , PJ McKenna , TW Robbins , BI Sahakian (1998). Specific neuropsychological deficits in schizophrenic patients with preserved intellectual function. Cognitive Neuropsychiatry 3, 4570.

* B Elvevåg , JE Fisher , TW Weickert , DR Weinberger , TE Goldberg (2004). Lack of false recognition in schizophrenia: a consequence of poor memory? Neuropsychologia 42, 546554.

* C Exner , K Boucsein , D Degner , E Irle , G Weniger (2004). Impaired emotional learning and reduced amygdala size in schizophrenia: a 3-month follow-up. Schizophrenia Research 71, 493503.

* S Fennig , A Mottes , G Ricter-Levin , I Treves , Y Levkovitz (2002). Everyday memory and laboratory memory tests: general function predictors in schizophrenia and remitted depression. Journal of Nervous and Mental Disease 190, 677682.

* RJ Finkelstein (1983). Distractibility among paranoid and non-paranoid schizophrenics using subtests matched for discriminating power. British Journal of Clinical Psychology 22, 237244.

* P Fossati , G Amar , N Raoux , AM Ergis , JF Allilaire (1999). Executive functioning and verbal memory in young patients with unipolar depression and schizophrenia. Psychiatry Research 89, 171187.

* P Franke , M Gänsicke , S Schmitz , P Falkai , W Maier (1999). Differential memory span – abnormal lateralization pattern in schizophrenic patients and their siblings? International Journal of Psychophysiology 34, 303311.

* P Franke , W Maier , J Hardt , R Frieboes , D Lichtermann , C Hain (1993). Assessment of frontal lobe functioning in schizophrenia and unipolar major depression. Psychopathology 26, 7684.

* R Fucetola , LJ Seidman , WS Kremen , SV Faraone , JM Goldstein , MT Tsuang (2000). Age and neuropsychologic function in schizophrenia: a decline in executive abilities beyond that observed in healthy volunteers. Biological Psychiatry 48, 137146.

* DC Glahn , TD Cannon , RE Gur , JD Ragland , RC Gur (2000). Working memory constrains abstraction in schizophrenia. Biological Psychiatry 47, 3442.

* TE Goldberg , MS Aloia , ML Gourovitch , D Missar , D Pickar , DR Weinberger (1998). Cognitive substrates of thought disorder. I. The semantic system. American Journal of Psychiatry 155, 16711676.

* TE Goldberg , EF Torrey , JM Gold , LB Bigelow , RD Ragland , E Taylor , DR Weinberger (1995). Genetic risk of neuropsychological impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder. Schizophrenia Research 17, 7784.

* M Gorissen , JC Sanz , B Schmand (2005). Effort and cognition in schizophrenia patients. Schizophrenia Research 78, 199208.

* E Granholm , SK Morris , AJ Sarkin , RF Asarnaow , DV Jeste (1997). Pupillary responses index overload of working memory resources in schizophrenia. Journal of Abnormal Psychology 106, 458467.

* A Gras-Vincendon , JM Danion , D Grange , M Bilik , D Willard-Schroeder , JP Sichel , L Singer (1994). Explicit memory, repetition priming and cognitive skill learning in schizophrenia. Schizophrenia Research 13, 117126.

* M Green , E Walker (1985). Neuropsychological performance and positive and negative symptoms in schizophrenia. Journal of Abnormal Psychology 94, 460469.

MF Green , KH Nuechterlein (1999). Should schizophrenia be treated as a neurocognitive disorder? Schizophrenia Bulletin 25, 309319.

* J Gruzelier , K Seymour , L Wilson , A Jolley , S Hirsch (1988). Impairments on neuropsychologic tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Archives of General Psychiatry 45, 623629.

* JH Gruzelier , L Wilson , D Liddiard , E Peters , L Pusavat (1999). Cognitive asymmetry patterns in schizophrenia: active and withdrawn syndromes and sex differences as moderators. Schizophrenia Bulletin 25, 349362.

* RE Gur , JL Jaggi , DL Shtasel , JD Ragland , RC Gur (1994). Cerebral blood flow in schizophrenia: effects of memory processing on regional activation. Biological Psychiatry 35, 315.

* C Hagger , P Buckley , JT Kenny , L Friedman , D Ubogy , HY Meltzer (1993). Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine. Biological Psychiatry 34, 702712.

* PD Harvey , EA Earle-Boyer , JC Levinson (1988). Cognitive deficits and thought disorder: a retest study. Schizophrenia Bulletin 14, 5766.

* PD Harvey , EA Earle-Boyer , MS Wielgus , JC Levinson (1986). Encoding, memory, and thought disorder in schizophrenia and mania. Schizophrenia Bulletin 12, 252261.

* PD Harvey , M Pedley (1989). Auditory and visual distractibility in schizophrenia: clinical and medication status correlations. Schizophrenia Research 2, 295300.

L Hedges , I Olkin (1985). Statistical Methods for Meta-Analysis. Academic Press: London.

* SK Hill , SR Beers , JA Kmiec , MS Keshavan , JA Sweeney (2004). Impairment of verbal memory and learning in antipsychotic-naive patients with first-episode schizophrenia. Schizophrenia Research 68, 127136.

* SK Hill , D Schuepbach , ES Herbener , MS Keshavan , JA Sweeney (2004). Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naive patients with schizophrenia. Schizophrenia Research 68, 4963.

* AL Hoff , M Wieneke , WO Faustman , R Horon , M Sakuma , H Blankfeld , S Espinoza , LE DeLisi (1998). Sex differences in neuropsychological functioning of first-episode and chronically ill schizophrenic patients. American Journal of Psychiatry 155, 14371439.

* EA Holthausen , D Wiersma , MM Sitskoorn , PM Dingemans , AH Schene , RJ van den Bosch (2003). Long-term memory deficits in schizophrenia: primary or secondary dysfunction? Neuropsychology 17, 539547.

* MH Hsieh , K Liu , SK Liu , MJ Chiu , HG Hwu , ACN Chen (2004). Memory impairment and auditory evoked potential gating deficit in schizophrenia. Psychiatry Research: Neuroimaging 130, 161169.

* C Hughes , V Kumari , M Das , E Zachariah , U Ettinger , A Sumich , T Sharma (2005). Cognitive functioning in siblings discordant for schizophrenia. Acta Psychiatrica Scandinavica 111, 185192.

* C Hughes , V Kumari , W Soni , M Das , B Binneman , S Drozd , S O'Neil , V Mathew , T Sharma (2003). Longitudinal study of symptoms and cognitive function in chronic schizophrenia. Schizophrenia Research 59, 137146.

* B Ismail , E Cantor-Graae , TF McNeil (2000). Minor physical anomalies in schizophrenia: cognitive, neurological and other clinical correlates. Journal of Psychiatric Research 34, 4556.

* EC Johnstone , TJ Crow , CD Frith , M Stevens , L Kreel , J Husband (1978). The dementia of dementia praecox. Acta Psychiatrica Scandinavica 57, 305324.

* EM Joyce , SB Hutton , SH Mutsatsa , TRE Barnes (2005). Cognitive heterogeneity in first-episode schizophrenia. British Journal of Psychiatry 187, 516522.

SR Kay , A Fiszbein , LA Opler (1987). The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261276.

* D Kemali , M Maj , S Galderisi , MG Ariano , M Cesarelli , N Milici , A Salvati , A Valente , M Volpe (1985). Clinical and neuropsychological correlates of cerebral ventricular enlargement in schizophrenia. Journal of Psychiatric Research 19, 587596.

* D Kemali , M Maj , S Galderisi , P Monteleone , A Mucci (1987). Conditional associative learning in drug-free schizophrenic patients. Neuropsychobiology 17, 3034.

* S Keri , O Nagy , O Kelemen , CE Myers , MA Gluck (2005). Dissociation between medial temporal lobe and basal ganglia memory systems in schizophrenia. Schizophrenia Research 77, 321328.

* M Kiefer , A Apel , M Weisbrod (2002). Arithmetic fact retrieval and working memory in schizophrenia. Schizophrenia Research 53, 219227.

* J Kim , DC Glahn , KH Nuechterlein , TD Cannon (2004). Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory. Schizophrenia Research 68, 173187.

* L Krabbendam , A Honig , J Wiersma , EFPM Vuurman , PAM Hofman , MMA Derix , WA Nolen , J Jolles (2000). Cognitive dysfunctions and white matter lesions in patients with bipolar disorder in remission. Acta Psychiatrica Scandinavica 101, 274280.

* TR Kwapil , LJ Chapman , JP Chapman (1992). Monaural and binaural story recall by schizophrenic subjects. Journal of Abnormal Psychology 101, 709716.

* NI Landrø , AL Ørbeck , BR Rund (1993). Memory functioning in chronic and non-chronic schizophrenics, affectively disturbed patients and normal controls. Schizophrenia Research 10, 8592.

* RK Mahurin , DI Velligan , AL Miller (1998). Executive-frontal lobe cognitive dysfunction in schizophrenia: a symptom subtype analysis. Psychiatry Research 79, 139149.

* RG McCreadie , S Latha , R Thara , R Padmavathi , JR Ayankaran (1997). Poor memory, negative symptoms and abnormal movements in never-treated Indian patients with schizophrenia. British Journal of Psychiatry 171, 360363.

PJ McKenna , D Tamlyn , CE Lund , AM Mortimer , S Hammond , AD Baddeley (1990). Amnesic syndrome in schizophrenia. Psychological Medicine 20, 967972.

* JDC Mellers , BK Toone , WA Lishman (2000). A neuropsychological comparison of schizophrenia and schizophrenia-like psychosis of epilepsy. Psychological Medicine 30, 325335.

* R Morice (1990). Cognitive inflexibility and pre-frontal dysfunction in schizophrenia and mania. British Journal of Psychiatry 157, 5054.

* R Morice , A Delahunty (1996). Frontal/executive impairments in schizophrenia. Schizophrenia Bulletin 22, 125137.

* S Moritz , D Heeren , B Andresen , M Krausz (2001). An analysis of the specificity and the syndromal correlates of verbal memory impairments in schizophrenia. Psychiatry Research 101, 2331.

* SL Morrison-Stewart , PC Williamson , WC Corning , SP Kutcher , WG Snow , H Merskey (1992). Frontal and non-frontal lobe neuropsychological test performance and clinical symptomatology in schizophrenia. Psychological Medicine 22, 353359.

* PG Nestor , SJ Akdag , BF O'Donnell , M Niznikiewicz , S Law , ME Shenton , RW McCarley (1998). Word recall in schizophrenia: a connectionist model. American Journal of Psychiatry 155, 16851690.

* JW Newcomer , S Craft , R Fucetola , SO Moldin , G Selke , L Paras , R Miller (1999). Glucose-induced increase in memory performance in patients with schizophrenia. Schizophrenia Bulletin 25, 321335.

KH Nuechterlein , ME Dawson (1984). Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophrenia Bulletin 10, 160203.

* RE O'Carroll , C Murray , MP Austin , KP Ebmeier , GM Goodwin , J Dunan (1993). Proactive interference and the neuropsychology of schizophrenia. British Journal of Clinical Psychology 32, 353356.

TF Oltmanns (1978). Selective attention in schizophrenic and manic psychoses: the effect of distraction on information processing. Journal of Abnormal Psychology 87, 212225.

* JP Otteson , PS Holzman (1976). Cognitive controls and psychopathology. Journal of Abnormal Psychology 85, 125139.

* C Pantelis , TRE Barnes , HE Nelson , S Tanner , L Weatherley , AM Owen , TW Robbins (1997). Frontal-striatal cognitive deficits in patients with chronic schizophrenia. Brain 120, 18231843.

* C Papageorgiou , L Lykouras , B Alevizos , E Ventouras , P Mourtzouchou , N Uzunoglu , GN Christodoulou , A Rabavilas (2005). Psychophysiological differences in schizophrenics with and without delusional misidentification syndromes: a P300 study. Progress in Neuro-Psychopharmacology and Biological Psychiatry 29, 593601.

* S Park , PS Holzman (1992). Schizophrenics show spatial working memory deficits. Archives of General Psychiatry 49, 975982.

* W Perry , RK Heaton , E Potterat , T Roebuck , A Minassian , DL Braff (2001). Working memory in schizophrenia: transient ‘online’ storage versus executive functioning. Schizophrenia Bulletin 27, 157176.

* T Pirkola , A Tuulio-Henriksson , D Glahn , T Kieseppä , J Haukka , J Kaprio , J Lönnqvist , TD Cannon (2005). Spatial working memory function in twins with schizophrenia and bipolar disorder. Biological Psychiatry 58, 930936.

* AD Radant , K Claypoole , DK Wingerson , DS Cowley , PP Roy-Byrne (1997). Relationships between neuropsychological and oculomotor measures in schizophrenia patients and normal controls. Biological Psychiatry 42, 797805.

* JD Ragland , RC Gur , DC Glahn , DM Censits , RJ Smith , MG Lazarev , A Alavi , RE Gur (1998). Frontotemporal cerebral blood flow change during executive and declarative memory tasks in schizophrenia: a positron emission tomography study. Neuropsychology 12, 399413.

G Repovs , A Baddeley (2006). The multi-component model of working memory: explorations in experimental cognitive psychology. Neuroscience 139, 521.

* EM Riley , D McGovern , D Mockler , VCK Doku , S O'Ceallaigh , DG Fannon , L Tennakoon , M Santamaria , W Soni , RG Morris , T Sharma (2000). Neuropsychological functioning in first-episode psychosis: evidence of specific deficits. Schizophrenia Research 43, 4755.

* L Rizzo , JM Danion , M van der Linden , D Grangé , JG Rohmer (1996). Impairment of memory for spatial context in schizophrenia. Neuropsychology 10, 376384.

* PH Robert , V Migneco , I Chaix , L Berthet , M Kazes , JM Danion , C Baudu , G Darcourt (1997). Use of a sequencing task designed to stress the supervisory system in schizophrenic subjects. Psychological Medicine 27, 12871294.

* JM Rodríguez-Sánchez , B Crespo-Facorro , RP Iglesias , CG Bosch , M Álvarez , J Llorca , JL Vázquez-Barquero (2005). Prefrontal cognitive functions in stabilized first-episode patients with schizophrenia spectrum disorders: a dissociation between dorsolateral and orbitofrontal functioning. Schizophrenia Research 77, 279288.

* S Rosenberg , N Weber , MA Crocq , F Duval , JP Macher (1990). Random number generation by normal, alcoholic and schizophrenic subjects. Psychological Medicine 20, 953960.

* BR Rund , NI Landrø , AL Ørbeck (1997). Stability in cognitive dysfunctions in schizophrenic patients. Psychiatry Research 69, 131141.

* KA Sacco , A Termine , A Seyal , MM Dudas , JC Vessicchio , S Krishnan-Sarin , PI Jatlow , BE Wexler , TP George (2005). Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms. Archives of General Psychiatry 62, 649659.

* P Salamé , JM Danion , S Peretti , C Cuervo (1998). The state of functioning of working memory in schizophrenia. Schizophrenia Research 30, 1129.

* LJ Seidman , WS Kremen , D Koren , SV Faraone , JM Goldstein , MT Tsuang (2002). A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophrenia Research 53, 3144.

* LJ Seidman , M Lanca , WS Kremen , SV Faraone , MT Tsuang (2003). Organizational and visual memory deficits in schizophrenia and bipolar psychoses using the Rey-Osterrieth complex figure: effects of duration of illness. Journal of Clinical and Experimental Neuropsychology 25, 949964.

* M Semkovska , MA Bédard , L Godbout , F Limoge , E Stip (2004). Assessment of executive dysfunction during activities of daily living in schizophrenia. Schizophrenia Research 69, 289300.

* K Shedlack , G Lee , M Sakuma , SH Xie , M Kushner , J Pepple , DL Finer , AL Hoff , LE DeLisi (1997). Language processing and memory in ill and well siblings from multiplex families affected with schizophrenia. Schizophrenia Research 25, 4352.

* T Shinba , T Shinozaki , N Kariya , K Ebata (2000). Random number generation deficit in schizophrenia characterized by oral vs written response modes. Perceptual and Motor Skills 91, 10911105.

* MA Shoqeirat , AR Mayes (1988). Spatiotemporal memory and rate of forgetting in acute schizophrenics. Psychological Medicine 18, 843853.

* MM Sitskoorn , J Nuyen , MCM Appels , NJA van der Wee , RS Kahn (2002). Release from proactive inhibition in schizophrenia and its potential as a genotypic marker. Journal of Clinical and Experimental Neuropsychology 24, 6781.

* N Sonobe (1993). Eye movements, verbal material recall and negative symptoms in chronic schizophrenia. International Journal of Psychophysiology 15, 7378.

* SB Stefánsson , TJ Jónsdóttir (1996). Auditory event-related potentials, auditory digit span, and clinical symptoms in chronic schizophrenic men on neuroleptic medication. Biological Psychiatry 40, 1927.

* KL Traupmann (1975). Effects of categorization and imagery on recognition and recall by process and reactive schizophrenics. Journal of Abnormal Psychology 84, 307314.

* M van Beilen , M Pijnenborg , EH van Zomeren , RJ van den Bosch , FK Withaar , A Bouma (2004). What is measured by verbal fluency tests in schizophrenia? Schizophrenia Research 69, 267276.

* I van Oostrom , S Dollfus , P Brazo , P Abadie , I Halbecq , S Théry , RM Marié (2003). Verbal learning and memory in schizophrenic and Parkinson's disease patients. Psychiatry Research 117, 2534.

* A Watanabe , T Kato (2004). Cerebrovascular response to cognitive tasks in patients with schizophrenia measured by near-infrared spectroscopy. Schizophrenia Bulletin 30, 435444.

* AP Weiss , CS Dodson , DC Goff , DL Schacter , S Heckers (2002). Intact suppression of increased false recognition in schizophrenia. American Journal of Psychiatry 159, 15061513.

* FB Wood , DL Flowers (1990). Hypofrontal vs. hypo-Sylvian blood flow in schizophrenia. Schizophrenia Bulletin 16, 413424.

SW Woods (2003). Chlorpromazine equivalent doses for the newer atypical antipsychotics. Journal of Clinical Psychiatry 64, 663667.

* FMJ Woonings , MT Appelo , H Kluiter , CJ Slooff , RJ van den Bosch (2003). Learning (potential) and social functioning in schizophrenia. Schizophrenia Research 59, 287296.

* P Zuffante , CM Leonard , JM Kuldau , RM Bauer , EG Doty , RM Bilder (2001). Working memory deficits in schizophrenia are not necessarily specific or associated with MRI-based estimates of area 46 volumes. Psychiatry Research: Neuroimaging 108, 187209.

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