American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental Disorders (3rd ed). APA: Washington, DC.Google Scholar

Basset, A. S., McGillivray, B. C., Jones, B. D. & Tapio Pantzer, J. (1988). Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet i, 799–801.CrossRefGoogle Scholar

Bateson, W. & Punnet, R. G. (1908). Confirmation and extensions of Mendel's principles in other animals and plants. Report to the Evaluation Committee of the Royal Society. Saunders: London.Google Scholar

Bell, J. & Haldane, J. B. S. (1937). The linkage between the genes for colour-blindness and haemophilia in man. Proceedings of the Royal Society of London 123, 119–150.Google Scholar

Brockington, I. F., Kendell, R. E. & Leff, J. P. (1978). Definitions of schizophrenia: concordance and prediction of outcome. Psychological Medicine 8, 387–398.CrossRefGoogle ScholarPubMed

Brynjolfsson, J., Petursson, H., Sherrington, R. & Gurling, H. (1989). Clinical variation in chromosome 5 linked schizophrenia. Abstracts of First World Congress on Psychiatric Genetics, Poster 26, p. 95, Cambridge.Google Scholar

Byerley, W. F. (1989). Genetic linkage revisited. Nature 340, 340–341.CrossRefGoogle ScholarPubMed

Charron, D. (1990). Molecular basis of human linkage antigen class II disease associations. B Insulin-dependent diabetes mellitus. In Advances in Immunology, 48, (ed. Dixon, F. J.), pp. 132–143. Academic Press: London.Google Scholar

Detera-Wadleigh, S. D., Goldin, L. R., Sherrington, R., Erio, I., Berretini, C. de M. W., Gurling, H. & Gershon, E. S. (1989). Exclusion of linkage to 5q 11–13 in families with schizophrenia and other psychiatric disorders. Nature 340, 391–393.CrossRefGoogle Scholar

Edwards, J. H. (1990). The linkage detection problem. Annals of Human Genetics 54, 253–275.CrossRefGoogle ScholarPubMed

Egeland, J. A., Gerhard, D. S., Pauls, D. L., Sussex, J. N., Kidd, K. K., Allen, C. R., Hostetter, A. M. & Housman, D. E. (1987). Bipolar affective disorders linked to DNA markers on chromosome II. Nature 325, 783–787.CrossRefGoogle Scholar

Gottesman, I. I. & Shields, J. (1972). Schizophrenia and Genetics. Academic Press: New York.Google Scholar

Gurling, H., Sherrington, R. P., Brynjolfsson, J., Read, T., Curtis, D., Baljindur, J., Potter, M. & Petursson, H. (1989). Recent and future molecular genetic research into schizophrenia. Psychopharmacology Bulletin 15, 373–382.Google ScholarPubMed

Haldane, J. B. S., Sprunt, A. D. & Haldane, N. M. (1915). Reduplication in mice. Journal of Genetics 5, 133–135.CrossRefGoogle Scholar

Iacono, W. G., Basset, A. S. & Jones, B. D. (1988). Eye-tracking dysfunction is associated with partial trisomy chromosome 5 and schizophrenia. Archives of General Psychiatry 45, 1140–1141.Google ScholarPubMed

Kelsoe, J. R., Ginns, E. I., Egeland, J. E., Gerhard, D. S., Goldstein, A. M., Bale, S. J., Pauls, D. L., Long, R. T., Kidd, K. K., Conte, G., Housman, D. E. & Paul, S. M. (1989). Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Older Amish. Nature 342, 238–243.CrossRefGoogle Scholar

Kennedy, J. L., Giuffra, L. A., Moises, H. W., Cavalli-Sforza, L. L., Pakotis, A. J., Kidd, J. R., Castiglione, C. M., Sjogren, B., Wetterberg, L. & Kidd, K. K. (1988). Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature 336, 167–170.CrossRefGoogle Scholar

Lander, E. S. (1988). Splitting schizophrenia. Nature 336, 105–106.CrossRefGoogle ScholarPubMed

Mohr, J. (1954). A study of linkage in man. Opera ex domo biologiae hereditariae humanae Universitatis Hafriensis 33. Munksgaard: Copenhagen.Google Scholar

Morgan, T. H. (1912). Further experiments with mutations in eye-colour of Drosophila: the loss of the orange factor. Journal of the Academy of Natural Sciences of Philadelphia 15, 321–346.Google Scholar

Morton, N. E. (1955). Sequential tests for the detection of linkage. American Journal of Human Genetics 7, 277–318.Google ScholarPubMed

Propping, P. & Friedl, W. (1988). Genetic studies of biochemical, pathophysiological and pharmacological factors in schizophrenia. In Nosology. Epidemiology and Genetics of Schizophrenia, vol. 3 (ed. Tsuang, M. T. and Simpson, J. C.), ch. 25, pp. 579–608. In Handbook of Schizophrenia (ed. H. A. Nasrallah). Elsevier: Amsterdam.Google Scholar

Race, R. R. & Sanger, R. (1975). Blood Groups in Man (6th edn). Blackwell: Oxford.Google Scholar

Scriver, C. R., Kaufman, S., Woo, S. L. C. (1989). The hyper-phenylalaninaemias, Vol. 1. ch. 15, pp. 495–546. In The Metabolic Basis of Inherited Disease (6th edition) (ed. Scriver, C. R., Baudet, A. L., Sly, W. S., Valle, D.). McGraw Hill: New York.Google Scholar

Sherrington, R., Brynjolfsson, H. P., Potter, M., Pudleston, K., Barraclough, B., Wasmuth, J., Dobbs, M. & Gurling, H. (1988). Localisation of a susceptibility locus for schizophrenia on chromosome 5. Nature 336, 164–167.CrossRefGoogle ScholarPubMed

St. Clair, D., Blackwood, D., Muir, W., Baillie, D., Hubbard, A., Wright, A. & Evans, H. J. (1989). No linkage of chromosome 5q 11-q13 markers to schizophrenia in Scottish families. Nature 339, 305–309.CrossRefGoogle Scholar

Sturt, E. & McGuffin, P. (1985). Can linkage and marker association resolve the genetic aetiology of psychiatric disorders? Review and argument. Psychological Medicine 15, 455–462.CrossRefGoogle ScholarPubMed

Weeks, D. E., Lehnor, T., Squires-Wheeler, E., Kaufmann, C. & Ott, J. (1990). Measuring the inflation of the lod score due to its maximation over model parameter values in human linkage analysis. Genetic Epidemiology 7, 237–243.CrossRefGoogle Scholar

World Health Organization (1978). Mental Disorders: Glossary and Guide to Their Classification in Accordance with the Ninth Revision of the International Classification of Diseases. WHO: Geneva.Google Scholar