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Effects of childhood trauma on left inferior frontal gyrus function during response inhibition across psychotic disorders

  • Y. Quidé (a1) (a2), N. O'Reilly (a1), O. J. Watkeys (a1) (a2), V. J. Carr (a1) (a2) (a3) and M. J. Green (a1) (a2) (a4) (a5)...



Childhood trauma is a risk factor for psychosis. Deficits in response inhibition are common to psychosis and trauma-exposed populations, and associated brain functions may be affected by trauma exposure in psychotic disorders. We aimed to identify the influence of trauma-exposure on brain activation and functional connectivity during a response inhibition task.


We used functional magnetic resonance imaging to examine brain function within regions-of-interest [left and right inferior frontal gyrus (IFG), right dorsolateral prefrontal cortex, right supplementary motor area, right inferior parietal lobule and dorsal anterior cingulate cortex], during the performance of a Go/No-Go Flanker task, in 112 clinical cases with psychotic disorders and 53 healthy controls (HCs). Among the participants, 71 clinical cases and 21 HCs reported significant levels of childhood trauma exposure, while 41 clinical cases and 32 HCs did not.


In the absence of effects on response inhibition performance, childhood trauma exposure was associated with increased activation in the left IFG, and increased connectivity between the left IFG seed region and the cerebellum and calcarine sulcus, in both cases and healthy individuals. There was no main effect of psychosis, and no trauma-by-psychosis interaction for any other region-of-interest. Within the clinical sample, the effects of trauma-exposure on the left IFG activation were mediated by symptom severity.


Trauma-related increases in activation of the left IFG were not associated with performance differences, or dependent on clinical diagnostic status; increased IFG functionality may represent a compensatory (overactivation) mechanism required to exert adequate inhibitory control of the motor response.


Corresponding author

Author for correspondence: Associate Professor M. J. Green, E-mail:


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Aas, M et al. (2011) Childhood trauma and cognitive function in first-episode affective and non-affective psychosis. Schizophrenia Research 129, 1219.
Abbott, CC et al. (2013) Antipsychotic drug effects in schizophrenia: a review of longitudinal FMRI investigations and neural interpretations. Current Medicinal Chemistry 20, 428437.
Alsawy, S et al. (2015) Psychotic experiences and PTSD: exploring associations in a population survey. Psychological Medicine 45, 28492859.
Alvarez, MJ et al. (2011) Prevalence and clinical impact of childhood trauma in patients with severe mental disorders. Journal of Nervous and Mental Disease 199, 156161.
Aron, AR (2011) From reactive to proactive and selective control: developing a richer model for stopping inappropriate responses. Biological Psychiatry 69, e55e68.
Aron, AR, Robbins, TW and Poldrack, RA (2014) Inhibition and the right inferior frontal cortex: one decade on. Trends in Cognitive Sciences 18, 177185.
Berk, M et al. (2007) The bipolar depression rating scale (BDRS): its development, validation and utility. Bipolar Disorders 9, 571579.
Bernstein, DP et al. (2003) Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse and Neglect 27, 169190.
Blasi, G et al. (2006) Brain regions underlying response inhibition and interference monitoring and suppression. European Journal of Neuroscience 23, 16581664.
Boehler, CN et al. (2010) Pinning down response inhibition in the brain – conjunction analyses of the Stop-signal task. NeuroImage 52, 16211632.
Brett, M et al. (2002) Region of interest analysis using an SPM toolbox. In 8th International Conference on Functional Mapping of the Human Brain. NeuroImage: Sendai, Japan.
Cancel, A et al. (2015) Childhood neglect predicts disorganization in schizophrenia through grey matter decrease in dorsolateral prefrontal cortex. Acta Psychiatrica Scandinavica 132, 244256.
Carrion, VG et al. (2008) Posttraumatic stress symptoms and brain function during a response-inhibition task: an fMRI study in youth. Depression and Anxiety 25, 514526.
Castle, DJ et al. (2006) The diagnostic interview for psychoses (DIP): development, reliability and applications. Psychological Medicine 36, 6980.
Criaud, M and Boulinguez, P (2013) Have we been asking the right questions when assessing response inhibition in go/no-go tasks with fMRI? A meta-analysis and critical review. Neuroscience & Biobehavioral Reviews 37, 1123.
Duhig, M et al. (2015) The prevalence and correlates of childhood trauma in patients with early psychosis. Australian and New Zealand Journal of Psychiatry 49, 651659.
Faul, F et al. (2009) Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behavior Research Methods 41, 11491160.
Faul, F et al. (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods 39, 175191.
Fusar-Poli, P et al. (2013) Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies. Neuroscience & Biobehavioral Reviews 37, 16801691.
Gibson, LE, Alloy, LB and Ellman, LM (2016) Trauma and the psychosis spectrum: a review of symptom specificity and explanatory mechanisms. Clinical Psychology Review 49, 92105.
Green, MJ et al. (2014) Stress, schizophrenia and bipolar disorder. In Behavioral Neurobiology of Stress-Related Disorders (ed. Pariante, M. C., Lapiz-Bluhm, D. M.), pp. 217235. Springer Berlin Heidelberg: Berlin, Heidelberg.
Gu, X et al. (2013) Anterior insular cortex and emotional awareness. Journal of Comparative Neurology 521, 33713388.
Hardy, A et al. (2016) Psychological mechanisms mediating effects between trauma and psychotic symptoms: the role of affect regulation, intrusive trauma memory, beliefs, and depression. Schizophrenia Bulletin 42, S34S43.
Hart, H and Rubia, K (2012) Neuroimaging of child abuse: a critical review. Frontiers in Human Neuroscience 6, 52.
Hayes, AF (2013) Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach. Guilford Press, New York, USA.
Hill, SK et al. (2013) Neuropsychological impairments in schizophrenia and psychotic bipolar disorder: findings from the bipolar-schizophrenia network on intermediate phenotypes (B-SNIP) study. American Journal of Psychiatry 170, 12751284.
Ho, BC et al. (2011) Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Archives of General Psychiatry 68, 128137.
Isvoranu, AM et al. (2017) A network approach to psychosis: pathways between childhood trauma and psychotic symptoms. Schizophrenia Bulletin 43, 187196.
Ivleva, EI et al. (2012) Cognitive endophenotypes of psychosis within dimension and diagnosis. Psychiatry Research 196, 3844.
Kay, SR, Opler, LA and Lindenmayer, J-P (1989) The positive and negative syndrome scale (PANSS): rationale and standardisation. The British Journal of Psychiatry 155, 5965.
Keren-Happuch, E et al. (2014) A meta-analysis of cerebellar contributions to higher cognition from PET and fMRI studies. Human Brain Mapping 35, 593615.
Leucht, S et al. (2003) New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis. Lancet 361, 15811589.
Lim, L et al. (2015) Neural correlates of error processing in young people with a history of severe childhood abuse: an fMRI study. American Journal of Psychiatry 172, 892900.
Lim, L, Radua, J and Rubia, K (2014) Gray matter abnormalities in childhood maltreatment: a voxel-wise meta-analysis. American Journal of Psychiatry 171, 854863.
Loughland, C et al. (2010) Australian Schizophrenia Research Bank: a database of comprehensive clinical, endophenotypic and genetic data for aetiological studies of schizophrenia. Australian and New Zealand Journal of Psychiatry 44, 10291035.
Lovibond, SH and Lovibond, PF (1995) The DASS: Manual for the Depression, Anxiety Stress Scales, 2nd edn. Psychology Foundation of Australia, Sydney, NSW, Australia.
Lysaker, PH et al. (2001) Neurocognitive and symptom correlates of self-reported childhood sexual abuse in schizophrenia spectrum disorders. Annals of Clinical Psychiatry 13, 8992.
McGuffin, P and Farmer, A (1991) A polydiagnostic application of operational criteria in studies of psychotic illness: development and validation of the OPCRIT system. Archives of General Psychiatry 48, 764770.
McLaren, DG et al. (2012) A generalized form of context-dependent psychophysiological interactions (gPPI): a comparison to standard approaches. NeuroImage 61, 12771286.
Mitchell, PB et al. (2009) Characteristics of bipolar disorder in an Australian specialist outpatient clinic: comparison across large datasets. Australian and New Zealand Journal of Psychiatry 43, 10091017.
Moncrieff, J and Leo, J (2010) A systematic review of the effects of antipsychotic drugs on brain volume. Psychological Medicine 40, 14091422.
Montgomery, P and Asberg, B (1979) A new depression scale designed to be sensitive to change. The British Journal of Psychiatry 134, 382389.
Mørkved, N et al. (2017) Childhood trauma in schizophrenia spectrum disorder as compared to other mental health disorders. Psychosis 9, 4856.
Morrison, AP (2001) The interpretation of intrusions in psychosis: an integrative cognitive approach to hallucinations and delusions. Behavioural and Cognitive Psychotherapy 29, 257276.
Mueller, SC et al. (2010) Early-life stress is associated with impairment in cognitive control in adolescence: an fMRI study. Neuropsychologia 48, 30373044.
Oldfield, RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9, 97113.
Peters, ER et al. (2000) The relationship between cognitive inhibition and psychotic symptoms. Journal of Abnormal Psychology 109, 386395.
Powers, A et al. (2016) Childhood trauma, PTSD, and psychosis: findings from a highly traumatized, minority sample. Child Abuse and Neglect 58, 111118.
Quidé, Y et al. (2017) Effects of childhood trauma on working memory in affective and non-affective psychotic disorders. Brain Imaging Behavior 11, 722735.
Read, J et al. (2014) The traumagenic neurodevelopmental model of psychosis revisited. Neuropsychiatry 4, 6579.
Reichenberg, A et al. (2009) Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophrenia Bulletin 35, 10221029.
Roberts, G et al. (2013) Reduced inferior frontal gyrus activation during response inhibition to emotional stimuli in youth at high risk of bipolar disorder. Biological Psychiatry 74, 5561.
Sambataro, F et al. (2013) Altered cerebral response during cognitive control: a potential indicator of genetic liability for schizophrenia. Neuropsychopharmacology 38, 846853.
Shannon, C et al. (2011) The association between childhood trauma and memory functioning in schizophrenia. Schizophrenia Bulletin 37, 531537.
Sheehan, DV et al. (1998) The mini-international neuropsychiatric interview (MINI): the development and validation of a structured diagnostic interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 59, 2233.
Sheffield, JM et al. (2013) Reduced gray matter volume in psychotic disorder patients with a history of childhood sexual abuse. Schizophrenia Research 143, 185191.
Stoodley, CJ and Schmahmann, JD (2009) Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. NeuroImage 44, 489501.
Swick, D, Ashley, V and Turken, AU (2008) Left inferior frontal gyrus is critical for response inhibition. BMC Neuroscience 9, 102.
Teicher, MH and Samson, JA (2013) Childhood maltreatment and psychopathology: a case for ecophenotypic variants as clinically and neurobiologically distinct subtypes. American Journal of Psychiatry 170, 11141133.
Teicher, MH et al. (2016) The effects of childhood maltreatment on brain structure, function and connectivity. Nature Reviews Neuroscience 17, 652666.
Uddin, LQ (2015) Salience processing and insular cortical function and dysfunction. Nature Reviews Neuroscience 16, 5561.
van den Berg, DP et al. (2015) Prolonged exposure vs eye movement desensitization and reprocessing vs waiting list for posttraumatic stress disorder in patients with a psychotic disorder: a randomized clinical trial. JAMA Psychiatry 72, 259267.
van Haren, NE et al. (2011) Changes in cortical thickness during the course of illness in schizophrenia. Archives of General Psychiatry 68, 871880.
Varese, F et al. (2012) Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophrenia Bulletin 38, 661671.
Wechsler, D (1999) Wechsler Abbreviated Scale of Intelligence (WASI). The Psychological Corporation: New York.
Welander-Vatn, A et al. (2013) The neural correlates of cognitive control in bipolar I disorder: an fMRI study of medial frontal cortex activation during a Go/No-go task. Neuroscience Letters 549, 5156.
WHO (2008) ICD-10: International Statistical Classification of Diseases and Related Health Problems, 10th Rev. edn. World Health Organization: New York.
Woods, SW (2003) Chlorpromazine equivalent doses for the newer atypical antipsychotics. Journal of Clinical Psychiatry 64, 663667.
Young, RC et al. (1978) A rating scale for mania: reliability, validity, and sensitivity. The British Journal of Psychiatry 133, 429435.


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