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Familial risk for distress and fear disorders and emotional reactivity in adolescence: an event-related potential investigation

  • B. D. Nelson (a1), G. Perlman (a1), G. Hajcak (a1), D. N. Klein (a1) and R. Kotov (a1)...
Abstract
Background

The late positive potential (LPP) is an event-related potential component that is sensitive to the motivational salience of stimuli. Children with a parental history of depression, an indicator of risk, have been found to exhibit an attenuated LPP to emotional stimuli. Research on depressive and anxiety disorders has organized these conditions into two empirical classes: distress and fear disorders. The present study examined whether parental history of distress and fear disorders was associated with the LPP to emotional stimuli in a large sample of adolescent girls.

Method

The sample of 550 girls (ages 13.5–15.5 years) with no lifetime history of depression completed an emotional picture-viewing task and the LPP was measured in response to neutral, pleasant and unpleasant pictures. Parental lifetime history of psychopathology was determined via a semi-structured diagnostic interview with a biological parent, and confirmatory factor analysis was used to model distress and fear dimensions.

Results

Parental distress risk was associated with an attenuated LPP to all stimuli. In contrast, parental fear risk was associated with an enhanced LPP to unpleasant pictures but was unrelated to the LPP to neutral and pleasant pictures. Furthermore, these results were independent of the adolescent girls’ current depression and anxiety symptoms and pubertal status.

Conclusions

The present study demonstrates that familial risk for distress and fear disorders may have unique profiles in terms of electrocortical measures of emotional information processing. This study is also one of the first to investigate emotional/motivational processes underlying the distress and fear disorder dimensions.

Copyright
Corresponding author
* Address for correspondence: B. D. Nelson, Department of Psychology, Stony Brook University, Stony Brook, NY 11794, USA. (Email: brady.nelson@stonybrook.edu)
References
Hide All
Bar-Haim, Y, Lamy, D, Pergamin, L, Bakermans-Kranenburg, MJ, van IJzendoorn, MH (2007). Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychological Bulletin 133, 124.
Behar, E, DiMarco, ID, Hekler, EB, Mohlman, J, Staples, AM (2009). Current theoretical models of generalized anxiety disorder (GAD): conceptual review and treatment implications. Journal of Anxiety Disorders 23, 10111023.
Bittner, A, Egger, HL, Erkanli, A, Costello, EJ, Foley, DL, Angold, A (2007). What do childhood anxiety disorders predict? Journal of Child Psychology and Psychiatry 48, 11741183.
Borkovec, TD, Inz, J (1990). The nature of worry in generalized anxiety disorder: a predominance of thought activity. Behaviour Research and Therapy 28, 153158.
Brown, TA (2006). Confirmatory Factor Analysis for Applied Research. Guilford Press: New York, NY.
Bylsma, LM, Morris, BH, Rottenberg, J (2008). A meta-analysis of emotional reactivity in major depressive disorder. Clinical Psychology Review 28, 676691.
Carthy, T, Horesh, N, Apter, A, Gross, JJ (2010). Patterns of emotional reactivity and regulation in children with anxiety disorders. Journal of Psychopathology and Behavioral Assessment 32, 2336.
Cuthbert, B, Insel, T (2010). The data of diagnosis: new approaches to psychiatric classification. Psychiatry 73, 311314.
Cuthbert, B, Schupp, H, Bradley, M, Birbaumer, N, Lang, P (2000). Brain potentials in affective picture processing: covariation with autonomic arousal and affective report. Biological Psychology 52, 95111.
Dunning, JP, Hajcak, G (2009). See no evil: directed visual attention modulates the electrocortical response to unpleasant images. Psychophysiology 46, 2833.
Eaton, NR, Krueger, RF, Markon, KE, Keyes, KM, Skodol, AE, Wall, M, Hasin, DS, Grant, BF (2013). The structure and predictive validity of the internalizing disorders. Journal of Abnormal Psychology 122, 8692.
Feeny, NC, Zoellner, LA, Fitzgibbons, LA, Foa, EB (2000). Exploring the roles of emotional numbing, depression, and dissociation in PTSD. Journal of Traumatic Stress 13, 489498.
Ferri, J, Bress, JN, Eaton, NR, Proudfit, GH (2014). The impact of puberty and social anxiety on amygdala activation to faces in adolescence. Developmental Neuroscience 36, 239249.
Ferri, J, Weinberg, A, Hajcak, G (2012). I see people: the presence of human faces impacts the processing of complex emotional stimuli. Social Neuroscience 7, 436443.
First, MB, Spitzer, RL, Gibbon, M, Williams, JBW (1996). Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version. American Psychiatric Press: Washington, DC.
Foti, D, Olvet, DM, Klein, DN, Hajcak, G (2010). Reduced electrocortical response to threatening faces in major depressive disorder. Depression and Anxiety 27, 813820.
Gao, PX, Liu, HJ, Ding, N, Guo, DJ (2010). An event-related-potential study of emotional processing in adolescence. Acta Psychologica Sinica 42, 342351.
Goodman, SH, Rouse, MH, Connell, AM, Broth, MR, Hall, CM, Heyward, D (2011). Maternal depression and child psychopathology: a meta-analytic review. Clinical Child and Family Psychology Review 14, 127.
Gratton, G, Coles, MG, Donchin, E (1983). A new method for off-line removal of ocular artifact. Electroencephalography and Clinical Neurophysiology 55, 468484.
Hajcak, G, Dennis, TA (2009). Brain potentials during affective picture processing in children. Biological Psychology 80, 333338.
Hajcak, G, Dunning, JP, Foti, D (2009). Motivated and controlled attention to emotion: time-course of the late positive potential. Clinical Neurophysiology 120, 505510.
Hajcak, G, Dunning, J, Foti, D, Weinberg, A (2014). Temporal dynamics of emotion regulation. In Handbook of Emotion Regulation, 2nd edn. (ed. Gross, J.). Guilford Publications: New York, NY.
Hajcak, G, MacNamara, A, Foti, D, Ferri, J, Keil, A (2013). The dynamic allocation of attention to emotion: simultaneous and independent evidence from the late positive potential and steady state visual evoked potentials. Biological Psychology 92, 447455.
Hajcak, G, Olvet, DM (2008). The persistence of attention to emotion: brain potentials during and after picture presentation. Emotion 8, 250255.
Hankin, BL, Abramson, LY, Moffitt, TE, Silva, PA, McGee, R, Angell, KE (1998). Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal study. Journal of Abnormal Psychology 107, 128140.
Kagan, J (2008). Behavioral inhibition as a risk factor for psychopathology. In Child and Adolescent Psychopathology (ed. Beauchaine, T. P. and Hinshaw, S. P.), pp. 157179. John Wiley & Sons Inc.: Hoboken, NJ.
Kaufman, J, Birmaher, B, Brent, D, Rao, U, Flynn, C, Moreci, P, Williamson, D, Ryan, N (1997). Schedule for Affective Disorders and Schizophrenia for School-age Children Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry 36, 980988.
Kayser, J, Bruder, G, Tenke, C, Stewart, J, Quitkin, F (2000). Event-related potentials (ERPs) to hemifield presentations of emotional stimuli: differences between depressed patients and healthy adults in P3 amplitude and asymmetry. International Journal of Psychophysiology 36, 211236.
Kendler, KS, Prescott, CA, Myers, J, Neale, MC (2003). The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Archives of General Psychiatry 60, 929937.
Kendler, KS, Walters, EE, Neale, MC, Kessler, RC, Heath, AC, Eaves, LJ (1995). The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Archives of General Psychiatry 52, 374383.
Kessel, EM, Huselid, RF, DeCicco, JM, Dennis, TA (2013). Neurophysiological processing of emotion and parenting interact to predict inhibited behavior: an affective–motivational framework. Frontiers in Human Neuroscience 7, 326.
Kessler, RC, Chiu, WT, Demler, O, Walters, EE (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry 62, 617627.
Kessler, RC, Walters, EE (1998). Epidemiology of DSM-III-R major depression and minor depression among adolescents and young adults in the National Comorbidity Survey. Depression and Anxiety 7, 314.
Keyes, KM, Eaton, NR, Krueger, RF, Skodol, AE, Wall, MM, Grant, B, Siever, LJ, Hasin, DS (2013). Thought disorder in the meta-structure of psychopathology. Psychological Medicine 43, 16731683.
Kotov, R (in press). The quantitative classification of mental illness: emerging solution to boundary problems. In Long-Term Outcomes in Psychopathology Research: Rethinking the Scientific Agenda (ed. Bromet, E.). Oxford University Press: New York, NY.
Kotov, R, Perlman, G, Gámez, W, Watson, D (2014). The structure and short-term stability of the emotional disorders: a dimensional approach. Psychological Medicine. Published online 12 December 2014. doi:10.1017/S0033291714002815.
Krueger, RF (1999). The structure of common mental disorders. Archives of General Psychiatry 56, 921926.
Krueger, RF, Markon, KE (2006). Reinterpreting comorbidity: a model-based approach to understanding and classifying psychopathology. Annual Review of Clinical Psychology 2, 111133.
Kujawa, A, Hajcak, G, Torpey, D, Kim, J, Klein, DN (2012 a). Electrocortical reactivity to emotional faces in young children and associations with maternal and paternal depression. Journal of Child Psychology and Psychiatry 53, 207215.
Kujawa, A, Klein, DN, Hajcak, G (2012 b). Electrocortical reactivity to emotional images and faces in middle childhood to early adolescence. Developmental Cognitive Neuroscience 2, 458467.
Ladouceur, CD, Dahl, RE, Birmaher, B, Axelson, DA, Ryan, ND (2006). Increased error-related negativity (ERN) in childhood anxiety disorders: ERP and source localization. Journal of Child Psychology and Psychiatry 47, 10731082.
Lang, PJ, Bradley, MM, Cuthbert, BN (2008). International Affective Picture System (IAPS): affective ratings of pictures and instruction manual. Technical Report A-8. University of Florida: Gainesville, FL.
Lewinsohn, PM, Rohde, P, Seeley, JR (1998). Major depressive disorder in older adolescents: prevalence, risk factors, and clinical implications. Clinical Psychology Review 18, 765794.
MacNamara, A, Ferri, J, Hajcak, G (2011). Working memory load reduces the late positive potential and this effect is attenuated with increasing anxiety. Cognitive, Affective and Behavioral Neuroscience 11, 321331.
MacNamara, A, Foti, D, Hajcak, G (2009). Tell me about it: neural activity elicited by emotional stimuli and preceding descriptions. Emotion 9, 531543.
MacNamara, A, Hajcak, G (2010). Distinct electrocortical and behavioral evidence for increased attention to threat in generalized anxiety disorder. Depression and Anxiety 27, 234243.
Marshall, WA, Tanner, JM (1969). Variations in pattern of pubertal changes in girls. Archives of Disease in Childhood 44, 291303.
Merikangas, KR, He, J, Burstein, M, Swanson, SA, Avenevoli, S, Cui, L, Benjet, SA, Georgiades, K, Swendsen, J (2010). Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication-Adolescent Supplement (NCS-A). Journal of the American Academy of Child and Adolescent Psychiatry 49, 980989.
Michalowski, JM, Melzig, CA, Weike, AI, Stockburger, J, Schupp, HT, Hamm, AO (2009). Brain dynamics in spider-phobic individuals exposed to phobia-relevant and other emotional stimuli. Emotion 9, 306315.
Miltner, WHR, Trippe, RH, Krieschel, S, Gutberlet, I, Hecht, H, Weiss, T (2005). Event-related brain potentials and affective responses to threat in spider/snake-phobic and non-phobic subjects. International Journal of Psychophysiology 57, 4352.
Mitchell, DGV, Richell, RA, Leonard, A, Blair, RJR (2006). Emotion at the expense of cognition: psychopathic individuals outperform controls on an operant response task. Journal of Abnormal Psychology 115, 559566.
Mogg, K, Bradley, BP (1998). A cognitive–motivational analysis of anxiety. Behaviour Research and Therapy 36, 809848.
Moser, JS, Huppert, JD, Duval, E, Simons, RF (2008). Face processing biases in social anxiety: an electrophysiological study. Biological Psychology 78, 93103.
Muthén, LK, Muthén, BO (2011). Mplus User's Guide, 6th edn. Muthén & Muthén: Los Angeles, CA.
Nelson, CA III, McCleery, JP (2008). Use of event-related potentials in the study of typical and atypical development. Journal of the American Academy of Child and Adolescent Psychiatry 47, 12521261.
Pauli, P, Dengler, W, Wiedemann, G, Montoya, P, Flor, H, Birbaumer, N, Buchkremer, G (1997). Behavioral and neurophysiological evidence for altered processing of anxiety-related words in panic disorder. Journal of Abnormal Psychology 106, 213220.
Petersen, AC, Crockett, L, Richards, M, Boxer, A (1988). A self-report measure of pubertal status: reliability, validity, and initial norms. Journal of Youth and Adolescence 17, 117133.
Pine, DS, Cohen, P, Gurley, D, Brook, J, Ma, Y (1998). The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Archives of General Psychiatry 55, 5664.
Rottenberg, J, Gross, J, Gotlib, I (2005). Emotion context insensitivity in major depressive disorder. Journal of Abnormal Psychology 114, 627639.
Ruscio, AM, Weathers, FW, King, LA, King, DW (2002). Male war-zone veterans’ perceived relationships with their children: the importance of emotional numbing. Journal of Traumatic Stress 15, 351357.
Sanislow, CA, Pine, DS, Quinn, KJ, Kozak, MJ, Garvey, MA, Heinssen, RK, Wang, PS, Cuthbert, BN (2010). Developing constructs for psychopathology research: research domain criteria. Journal of Abnormal Psychology 119, 631639.
Schmitz, A, Grillon, C, Avenevoli, S, Cui, L, Merikangas, KR (2014). Developmental investigation of fear-potentiated startle across puberty. Biological Psychology 97, 1521.
Silk, JS, Davis, S, McMakin, DL, Dahl, RE, Forbes, EE (2012). Why do anxious children become depressed teenagers? The role of social evaluative threat and reward processing. Psychological Medicine 42, 20952107.
Slade, TIM, Watson, D (2006). The structure of common DSM-IV and ICD-10 mental disorders in the Australian general population. Psychological Medicine 36, 15931600.
Sullivan, PF, Neale, MC, Kendler, KS (2000). Genetic epidemiology of major depression: review and meta-analysis. American Journal of Psychiatry 157, 15521562.
Thom, N, Knight, J, Dishman, R, Sabatinelli, D, Johnson, DC, Clementz, B (2014). Emotional scenes elicit more pronounced self-reported emotional experience and greater EPN and LPP modulation when compared to emotional faces. Cognitive, Affective and Behavioral Neuroscience 14, 849860.
Van Leijenhorst, L, Zanolie, K, Van Meel, CS, Westernberg, PM, Rombouts, SARB, Crone, EA (2010). What motivates the adolescent? Brain regions mediating reward sensitivity across adolescence. Cerebral Cortex 20, 6169.
Vollebergh, WAM, Iedema, J, Bijl, RV, de Graaf, R, Smit, F, Ormel, J (2001). The structure and stability of common mental disorders: the NEMESIS study. Archives of General Psychiatry 58, 597603.
Watson, D (2005). Rethinking the mood and anxiety disorders: a quantitative hierarchical model for DSM-V. Journal of Abnormal Psychology 114, 522536.
Watson, D, O'Hara, MW, Naragon-Gainey, K, Koffel, E, Chmielewski, M, Kotov, R, Stasik, SM, Ruggero, CJ (2012). Development and validation of new anxiety and bipolar symptom scales for an expanded version of the IDAS (the IDAS-II). Assessment 19, 399420.
Weinberg, A, Ferri, J, Hajcak, G (2013). Bottom-up and top-down contributions to emotion: Reflections from ERP research. In Handbook of Cognition and Emotion (ed. Robinson, M., Watkins, E. and Harmon-Jones, E.), pp. 3554. Guilford Publications: New York, NY.
Weinberg, A, Hajcak, G (2011 a). Electrocortical evidence for vigilance-avoidance in generalized anxiety disorder. Psychophysiology 48, 842851.
Weinberg, A, Hajcak, G (2011 b). The late positive potential predicts subsequent interference with target processing. Journal of Cognitive Neuroscience 23, 29943007.
Weinberg, A, Hilgard, J, Bartholow, B, Hajcak, G (2012). Emotional targets: evaluative categorization as a function of context and content. International Journal of Psychophysiology 84, 149154.
Wright, AGC, Krueger, RF, Hobbs, MJ, Markon, KE, Eaton, NR, Slade, T (2013). The structure of psychopathology: toward an expanded quantitative empirical model. Journal of Abnormal Psychology 122, 281294.
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