Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 54
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Douven, Elles Schievink, Syenna H. J. Verhey, Frans R. J. van Oostenbrugge, Robert J. Aalten, Pauline Staals, Julie and Köhler, Sebastian 2016. The Cognition and Affect after Stroke - a Prospective Evaluation of Risks (CASPER) study: rationale and design. BMC Neurology, Vol. 16, Issue. 1,


    Ferro, José M. Caeiro, Lara and Figueira, Maria Luísa 2016. Neuropsychiatric sequelae of stroke. Nature Reviews Neurology, Vol. 12, Issue. 5, p. 269.


    Groeneweg-Koolhoven, Isis Huitema, Lotte J. de Waal, Margot W. M. Stek, Max L. Gussekloo, Jacobijn van der Mast, Roos C. and Rhebergen, Didi 2016. Latent class analysis of the Apathy Scale does not identify subtypes of apathy in general population-based older persons. International Journal of Geriatric Psychiatry, p. n/a.


    López-Dóriga Bonnardeaux, Pedro and Andrino Díaz, Nuria 2016. Apatía postictus. Revista Española de Geriatría y Gerontología, Vol. 51, Issue. 3, p. 164.


    Stanton, Biba R and Carson, Alan 2016. Apathy: a practical guide for neurologists. Practical Neurology, Vol. 16, Issue. 1, p. 42.


    Starkstein, Sergio E. Brockman, Simone Hatch, Katherine K. Bruce, David G. Almeida, Osvaldo P. Davis, Wendy A. and Robinson, Robert G. 2016. A Randomized, Placebo-Controlled, Double-Blind Efficacy Study of Nefiracetam to Treat Poststroke Apathy. Journal of Stroke and Cerebrovascular Diseases, Vol. 25, Issue. 5, p. 1119.


    McIntosh, Roger C. Rosselli, Monica Uddin, Lucina Q. and Antoni, Michael 2015. Neuropathological sequelae of Human Immunodeficiency Virus and apathy: A review of neuropsychological and neuroimaging studies. Neuroscience & Biobehavioral Reviews, Vol. 55, p. 147.


    Schievink, Syenna Douven, Elles Aalten, Pauline and Köhler, Sebastian 2015. Neuropsychiatrische syndromen na een beroerte. Tijdschrift voor Neuropsychiatrie en Gedragsneurologie, Vol. 3, Issue. 2, p. 36.


    Skidmore, Elizabeth R. Whyte, Ellen M. Butters, Meryl A. Terhorst, Lauren and Reynolds, Charles F. 2015. Strategy Training During Inpatient Rehabilitation May Prevent Apathy Symptoms After Acute Stroke. PM&R, Vol. 7, Issue. 6, p. 562.


    Tang, Wai Kwong Caeiro, Lara Lau, Chieh Grace Liang, Huajun Mok, Vincent Ungvari, Gabor S and Wong, Ka Sing 2015. Apathy and suicide-related ideation 3 months after stroke: a cross-sectional study. BMC Neurology, Vol. 15, Issue. 1,


    van Almenkerk, Suzanne Smalbrugge, Martin Depla, Marja F.I.A. Eefsting, Jan A. and Hertogh, Cees M.P.M. 2015. Apathy Among Institutionalized Stroke Patients: Prevalence and Clinical Correlates. The American Journal of Geriatric Psychiatry, Vol. 23, Issue. 2, p. 180.


    Groeneweg-Koolhoven, Isis de Waal, Margot W.M. van der Weele, Gerda M. Gussekloo, Jacobijn and van der Mast, Roos C. 2014. Quality of Life in Community-Dwelling Older Persons with Apathy. The American Journal of Geriatric Psychiatry, Vol. 22, Issue. 2, p. 186.


    Harris, Ari L. Elder, Jessica Schiff, Nicholas D. Victor, Jonathan D. and Goldfine, Andrew M. 2014. Post-Stroke Apathy and Hypersomnia Lead to Worse Outcomes from Acute Rehabilitation. Translational Stroke Research, Vol. 5, Issue. 2, p. 292.


    Obama, Satsuki Hidaka, Tsuyako and Matsuo, Miyoko 2014. The Evaluation of Apathy by Using the Scale of Clinical Assessment for Spontaneity: Characteristics of Evaluation between Families and Nurses. Journal of Japan Academy of Nursing Science, Vol. 34, Issue. 1, p. 66.


    Schievink, Syenna Douven, Elles Aalten, Pauline and Köhler, Sebastian 2014. Neuropsychiatrische syndromen na een beroerte. Neuropraxis, Vol. 18, Issue. 5, p. 151.


    Tang, Wai-Kwong Lau, Chieh Grace Mok, Vincent Ungvari, Gabor S. and Wong, Ka-Sing 2014. Apathy and Health-Related Quality of Life in Stroke. Archives of Physical Medicine and Rehabilitation, Vol. 95, Issue. 5, p. 857.


    Caeiro, Lara Ferro, José M. and Costa, João 2013. Apathy Secondary to Stroke: A Systematic Review and Meta-Analysis. Cerebrovascular Diseases, Vol. 35, Issue. 1, p. 23.


    Caeiro, Lara Ferro, José M. Pinho e Melo, Teresa Canhão, Patrícia and Figueira, M. Luísa 2013. Post-Stroke Apathy: An Exploratory Longitudinal Study. Cerebrovascular Diseases, Vol. 35, Issue. 6, p. 507.


    Mikami, Katsunaka Jorge, Ricardo E. Moser, David J. Arndt, Stephan Jang, Mijin Solodkin, Ana Small, Steven L. Fonzetti, Pasquale Hegel, Mark T. and Robinson, Robert G. 2013. Prevention of Poststroke Apathy Using Escitalopram or Problem-Solving Therapy. The American Journal of Geriatric Psychiatry, Vol. 21, Issue. 9, p. 855.


    Mikami, Katsunaka Jorge, Ricardo E. Moser, David J. Jang, Mijin and Robinson, Robert G. 2013. Incident Apathy During the First Year After Stroke and Its Effect on Physical and Cognitive Recovery. The American Journal of Geriatric Psychiatry, Vol. 21, Issue. 9, p. 848.


    ×

Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke – the Sydney Stroke Study

  • HENRY BRODATY (a1) (a2), PERMINDER S. SACHDEV (a1) (a3), ADRIENNE WITHALL (a2), ANNETTE ALTENDORF (a2), MICHAEL J. VALENZUELA (a3) and LISA LORENTZ (a3)
  • DOI: http://dx.doi.org/10.1017/S0033291705006173
  • Published online: 05 October 2005
Abstract

Background. The frequency and clinical, neuropsychological and neuroimaging correlates of apathy in patients who have had a stroke are inadequately defined.

Method. A total of 167 consecutive patients admitted to the stroke units of two university hospitals after an ischaemic stroke and 109 controls received extensive medical, psychiatric and neuropsychological assessments; a subset received a magnetic resonance imaging (MRI) scan. The groups were matched for sex and age. Patients were assessed 3–6 months after their stroke. The sample for this study comprised 135 patients and 92 controls who completed the Apathy Evaluation Scale (AES).

Results. Apathy was present in 26·7% of stroke patients compared to 5·4% of controls. Apathetic stroke patients were older, more functionally dependent and had lower Mini-Mental State Examination (MMSE) scores than those without apathy. Apathy was not associated with risk factors for cerebrovascular disease or stroke severity. There was a weak but significant correlation between apathy and self-reported depression but not with clinician-rated depression. Neuropsychologically, after correction for age, premorbid intelligence (IQ) and depression, apathy was associated with reduced attention and speed of information processing. On neuroimaging there were trends for associations of apathy with the extent of hyperintensities in the right hemisphere and right fronto-subcortical circuit, but not with total stroke volume or number of strokes.

Conclusions. Apathy is common following a cerebrovascular event. Presence of apathy may be related to older age and right fronto-subcortical pathway pathology, rather than stroke severity. It is associated with functional impairment and cognitive deficits.

Copyright
Corresponding author
Academic Department for Old Age Psychiatry, Euroa Centre, Prince of Wales Hospital, Avoca St, Randwick, NSW, 2031, Australia. (Email: h.brodaty@unsw.edu.au)
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×