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From laboratory to life: associating brain reward processing with real-life motivated behaviour and symptoms of depression in non-help-seeking young adults

  • Jindra M. Bakker (a1) (a2), Liesbet Goossens (a1), Poornima Kumar (a3) (a4), Iris M. J. Lange (a1), Stijn Michielse (a1), Koen Schruers (a1) (a5), Jojanneke A. Bastiaansen (a6) (a7), Ritsaert Lieverse (a1), Machteld Marcelis (a1) (a8), Thérèse van Amelsvoort (a1), Jim van Os (a1) (a9) (a10), Inez Myin-Germeys (a2), Diego A. Pizzagalli (a3) (a4) and Marieke Wichers (a6)...

Abstract

Background

Depression has been associated with abnormalities in neural underpinnings of Reward Learning (RL). However, inconsistencies have emerged, possibly owing to medication effects. Additionally, it remains unclear how neural RL signals relate to real-life behaviour. The current study, therefore, examined neural RL signals in young, mildly to moderately depressed – but non-help-seeking and unmedicated – individuals and how these signals are associated with depressive symptoms and real-life motivated behaviour.

Methods

Individuals with symptoms along the depression continuum (n = 87) were recruited from the community. They performed an RL task during functional Magnetic Resonance Imaging and were assessed with the Experience Sampling Method (ESM), completing short questionnaires on emotions and behaviours up to 10 times/day for 15 days. Q-learning model-derived Reward Prediction Errors (RPEs) were examined in striatal areas, and subsequently associated with depressive symptoms and an ESM measure capturing (non-linearly) how anticipation of reward experience corresponds to actual reward experience later on.

Results

Significant RPE signals were found in the striatum, insula, amygdala, hippocampus, frontal and occipital cortices. Region-of-interest analyses revealed a significant association between RPE signals and (a) self-reported depressive symptoms in the right nucleus accumbens (b = −0.017, p = 0.006) and putamen (b = −0.013, p = .012); and (b) the quadratic ESM variable in the left (b = 0.010, p = .010) and right (b = 0.026, p = 0.011) nucleus accumbens and right putamen (b = 0.047, p < 0.001).

Conclusions

Striatal RPE signals are disrupted along the depression continuum. Moreover, they are associated with reward-related behaviour in real-life, suggesting that real-life coupling of reward anticipation and engagement in rewarding activities might be a relevant target of psychological therapies for depression.

Copyright

Corresponding author

Author for correspondence: Jindra M. Bakker, E-mail: jindra.bakker@maastrichtuniversity.nl

Footnotes

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These authors contributed equally to this work.

Footnotes

References

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