Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 28
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Perkins, Michael R. 2011. Handbook of Pragmatics.

    Koch, K. Wagner, G. Schachtzabel, C. Schultz, C. Sauer, H. and Schlosser, R. G. M. 2010. Association Between Learning Capabilities and Practice-Related Activation Changes in Schizophrenia. Schizophrenia Bulletin, Vol. 36, Issue. 3, p. 486.

    Cascella, Nicola G. Testa, S. Marc Meyer, Stephen M. Rao, Vani A. Diaz-Asper, Catherine M. Pearlson, Godfrey D. and Schretlen, David J. 2008. Neuropsychological impairment in deficit vs. non-deficit schizophrenia. Journal of Psychiatric Research, Vol. 42, Issue. 11, p. 930.

    Kebir, O. Dellagi, L. Ben Azouz, O. Rabeh, Y. Sidhom, O. and Tabbane, K. 2008. Déficits des fonctions exécutives dans la schizophrénie selon les dimensions positive, négative et de désorganisation. Annales Médico-psychologiques, revue psychiatrique, Vol. 166, Issue. 8, p. 627.

    SEVINCOK, LEVENT AKOGLU, AYBARS TOPALOGLU, BEYZA and ASLANTAS, HULYA 2004. Neurological soft signs in schizophrenic patients with obsessive-compulsive disorder. Psychiatry and Clinical Neurosciences, Vol. 58, Issue. 3, p. 274.

    Perkins, Michael R. 2003. Handbook of Pragmatics.

    Wölwer, Wolfgang and Gaebel, Wolfgang 2002. Impaired Trail-Making Test-B performance in patients with acute schizophrenia is related to inefficient sequencing of planning and acting. Journal of Psychiatric Research, Vol. 36, Issue. 6, p. 407.

    Laurent, Annie Duly, Dominique Murry, Pierre Foussard, Nicole Boccara, Sandra Mingat, Françoise Dalery, Jean and d'Amato, Thierry 2001. WCST performance and schizotypal features in the first-degree relatives of patients with schizophrenia. Psychiatry Research, Vol. 104, Issue. 2, p. 133.

    Menon, V. Anagnoson, R.T. Mathalon, D.H. Glover, G.H. and Pfefferbaum, A. 2001. Functional Neuroanatomy of Auditory Working Memory in Schizophrenia: Relation to Positive and Negative Symptoms. NeuroImage, Vol. 13, Issue. 3, p. 433.

    Sitskoorn, M.M. Appels, M.C.M. Hulshoff Pol, H.E. and Kahn, R.S. 2000. Cognition, emotion and autonomic responses: The integrative role of the prefrontal cortex and limbic structures.

    Gard, Diane Harrell, Ernest H. and Poreh, Amir 1999. Cognitive deficits in schizophrenia on the WAIS-R NI sentence arrangement subtest. Journal of Clinical Psychology, Vol. 55, Issue. 9, p. 1085.

    Laws, Keith R. 1999. A Meta-analytic Review of Wisconsin Card Sort Studies in Schizophrenia: General Intellectual Deficit in Disguise?. Cognitive Neuropsychiatry, Vol. 4, Issue. 1, p. 1.

    Galderisi, Silvana 1998. The relevance of recent neuropsychological and neurophysiological studies for social psychiatry. Epidemiologia e Psichiatria Sociale, Vol. 7, Issue. 02, p. 82.

    Mahurin, Roderick K. Velligan, Dawn I. and Miller, Alexander L. 1998. Executive-frontal lobe cognitive dysfunction in schizophrenia: A symptom subtype analysis. Psychiatry Research, Vol. 79, Issue. 2, p. 139.

    Earnst, Kelly S. and Kring, Ann M. 1997. Construct validity of negative symptoms: An empirical and conceptual review. Clinical Psychology Review, Vol. 17, Issue. 2, p. 167.

    Galletly, Cherrie A. Clark, C.Richard McFarlane, Alexander C. and Weber, Darren L. 1997. Relationships between changes in symptom ratings, neuropsychological test performance and quality of life in schizophrenic patients treated with clozapine. Psychiatry Research, Vol. 72, Issue. 3, p. 161.

    Abbruzzese, Massimo Ferri, Stefano and Scarone, Silvio 1996. Performance on the Wisconsin Card Sorting Test in schizophrenia: Perseveration in clinical subtypes. Psychiatry Research, Vol. 64, Issue. 1, p. 27.

    Daniel Ragland, J. Censits, David M. Gur, Ruben C. Glahn, David C. Gallacher, Fiona and Gur, Raquel E. 1996. Assessing declarative memory in schizophrenia using Wisconsin Card Sorting Test stimuli: the Paired Associate Recognition Test. Psychiatry Research, Vol. 60, Issue. 2-3, p. 135.

    Joyce, E. M. Collinson, S. L. and Crichton, P. 1996. Verbal fluency in schizophrenia: relationship with executive function, semantic memory and clinical alogia. Psychological Medicine, Vol. 26, Issue. 01, p. 39.

    Laws, Keith R McKenna, Peter J and McCarthy, Rosaleen A 1996. Reconsidering the Gospel According to Group Studies: A Neuropsychological Case Study Approach to Schizophrenia. Cognitive Neuropsychiatry, Vol. 1, Issue. 4, p. 319.


Frontal and non-frontal lobe neuropsychological test performance and clinical symptomatology in schizophrenia

  • S. L. Morrison-Stewart (a1), P. C. Williamson (a1), W. C. Corning (a1), S. P. Kutcher (a1), W. G. Snow (a1) and H. Merskey (a1)
  • DOI:
  • Published online: 01 July 2009

Schizophrenic subjects performed significantly worse on neuropsychological tests of frontal lobe function but not on tests of non-frontal lobe function when compared to a matched group of normal subjects. Correlations expected between frontal lobe neuropsychological test performance and negative symptoms were not found.

Corresponding author
1Address for correspondence: Dr S. L. Morrison-Stewart, EEG Department, London Psychiatric Hospital, 850 Highbury Avenue, PO Box 2532, London, Ontario, Canada N6A 4H1.
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

K. Berman , R. Zec & D. Weinberger (1986). Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention and mental effort. Archives of General Psychiatry 43, 126135.

K. Berman , B. Illowsky & D. Weinberger (1988). Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia. IV. Further evidence for regional and behavioral specificity. Archives of General Psychiatry 45, 616622.

R. A. Bornstein , H. A. Nasrallah , S. C. Olsen , J. A. Coffman , M. Torello & S. Schwarzkopf (1990). Neuropsychological deficit in schizophrenic subtypes: Paranoid, nonparanoid and schizo-affective subgroups. Psychiatry Research 31, 1524.

P. Bryden (1977). Measuring handedness with questionnaires. Neuropsychologia 15, 617624.

M. Buchsbaum & R. Haier (1987). Functional and anatomical brain imaging: impact on schizophrenia research. Schizophrenia Bulletin 13, 115132.

M. Buchsbaum , D. Ingvar , R. Kessler , R. Waters , J. Cappelletti , D. van Kammen , C. King , J. Johnson , R. Manning , R. Flynn , L. Mann , W. Bunney & L. Sokoloff (1982). Cerebral glucography with positron emission tomography: use in normal subjects and in patients with schizophrenia. Archives of General Psychiatry 39, 251259.

R. Cohen , W. Semple , M. Gross , T. Nordahl , L. DeLisi , H. Holcomb , A. King , J. Morihisa & D. Pickar (1987). Dysfunction in a prefrontal substrate of sustained attention in schizophrenia. Life Sciences 40, 20312039.

C. B. Dodrill (1981). An economical method for the evaluation of general intelligence in adults. Journal of Consulting and Clinical Psychology 49, 668673.

E. Goldberg (1985). Akinesia, tardive dysmentia and frontal lobe disorder in schizophrenia. Schizophrenia Bulletin 11, 255263.

J. Gruzelier , K. Seymour , L. Wilson , A. Jolly & S. Hirsch (1988). Impairments on neuropsychological tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Archives of General Psychiatry 45, 623629.

R. Gur , S. Resnick , R. Gur , A. Alavi , S. Caroff , M. Kushner & M. Revich (1987). Regional brain function in schizophrenia. II. Repeated evaluation with positron emission tomography. Archives of General Psychiatry 44, 126129.

M. Jones-Gotman & B. Milner , (1977). Design fluency: the invention of nonsense drawings after focal cortical lesions. Neuropsychologia 15, 635674.

J. Kear-Colwell (1973). The structure of the Wechsler Memory Scale and its relationship to ‘brain damage’. British Journal of Social and Clinical Psychology 12, 384392.

J. Keilp , J. Sweeney , P. Jacobsen , C. Solomon , L. St. Louis , M. Deck , A. Frances & J. Mann (1988). Cognitive impairment in schizophrenia: specific relations to ventricular size and negative symptomatology. Biological Psychiatry 24, 4755.

B. Kolb & I. Whishaw (1983). Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal or parietal function in neurological patients. Journal of Nervous and Mental Disease 171, 435443.

B. Milner (1963). Effects of different brain lesions on card sorting. Archives of Neurology 9, 90100.

L. Seidman (1983). Schizophrenia and brain dysfunction: an integration of recent neurodiagnostic findings. Psychological Bulletin 94, 195238.

D. Weinberger (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 44, 660669.

D. Weinberger , K. Berman & R. Zec (1986). Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Archives of General Psychiatry 43, 114124.

D. Weinberger , K. Berman & B. Illowsky (1988). Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monaminergic mechanism. Archives of General Psychiatry 45, 609615.

P. Williamson , S. Kutcher , P. Cooper , G. Snow , J. Szalai , H. Kaye , S. L. Morrison , R. Willinsky & M. Mamelak (1989). Psychological, topographic EEG, and CT scan correlates of frontal lobe function in schizophrenia. Psychiatry Research 29, 137149.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *