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Genetic influences on life events in childhood

  • Anita Thapar (a1) and Peter McGuffin (a1)
  • DOI: http://dx.doi.org/10.1017/S0033291700037831
  • Published online: 01 July 2009
Abstract
Synopsis

Until recently, life events were considered as chance occurrences. However, there is now increasing evidence that reported life events, at least in adult life are not random. Life events not only tend to cluster in families but also appear to be influenced by genetic factors. The aim of this study was to investigate whether genetic factors also influence reported life events in childhood using a systematically ascertained sample of 376 twin pairs aged 8 to 17. Overall, reported life events in this younger population were found to be heritable. However, the degree of genetic and environmental influence appeared to vary across the sexes, at least for parent-rated life events and according to whether life events were rated by the parents or the children themselves. Genetic influences appeared to be more important for self reports, suggesting that individual differences in cognition play a role in reporting life events.

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Corresponding author
1Address for correspondence: Dr Anita Thapar, Department of Child and Adolescent Psychiatry, Royal Manchester Children's Hospital, Pendlebury, Manchester M27 4HA.
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

L. Beardsall & J. Dunn (1992). Adversities in childhood: siblings' experiences, and their relations to self-esteem. Journal of Child Psychology and Psychiatry 33, 349359.

G. W. Brown , T. O. Harris & C. Hepworth (1994). Life events and endogenous depression. Archives of General Psychiatry 51, 525534.

D. J. Cohen , E. Dibble , J. M. Grawe & W. Pollin (1975). Reliably separating identical from fraternal twins. Archives of General Psychiatry 32, 13711375.

L. J. Eaves , H. J. Eysenck & N. Martin (1989). Genes, Culture and Personality. Academic: New York.

I. M. Goodyer (1990). Recent life events and psychiatric disorder in school age children. Journal of Child Psychology and Psychiatry 31, 839848.

I. M. Goodyer , I. Kolvin & S. Gatzanis (1987). The impact of recent life events in psychiatric disorders of childhood and adolescence. British Journal of Psychiatry 151, 179185.

I. M. Goodyer , P. J. Cooper , C. M. Vize & L. Ashby (1993). Depression in 11–16-year-old girls: the role of past parental psychopathology and exposure to recent life events. Journal of Child Psychology and Psychiatry 34, 11031115.

K. S. Kendler , M. Neale , R. Kessler , A. Heath & L. Eaves (1993). A twin study of recent life events and difficulties. Archives of General Psychiatry 50, 789796.

P. McGuffin & R. Katz (1993). Genes, adversity and depression. In Nature, Nurture and Psychology (ed. R. Plomin and G. E. McClearn ), pp. 217230. American Psychological Association: Washington, DC.

P. McGuffin , R. Katz , J. Aldrich & P. Bebbington (1988). The Camberwell collaborative depression study. II. Investigation of family members. British Journal of Psychiatry 152, 766774.

S. McGuire , J. M. Neiderhiser , D. Reiss , E. M. Hetherington & R. Plomin (1994). Genetic and environmental influences on perceptions of self-worth and competence in adolescence: a study of twins, full siblings and step-siblings. Child Development 65, 785799.

K. Magnus , E. Diener , F. Fujita & W. Pavot (1993). Extraversion and neuroticism as predictors of objective life events: a longitudinal analysis. Journal of Personality and Social Psychology 65, 10461053.

M. C. Neale & L. R. Cardon (1992). Methodology for Genetic Studies of Twins and Families. Kluwer Academiemic Publishers: Dordrecht.

R. Plomin , P. Litchenstein , N. L. Pedersen , G. E. McClearn & J. R. Nesselroade (1990). Genetic influences on life events during the last half of the life span. Psychology and Aging 5, 2530.

R. G. Poulton & G. Andrews (1992). Personality as a cause of adverse life events. Acta Psychiatrica Scandinavica 85, 3538.

S. Scarr & K. McCartney (1983). How people make their own environments: a theory of genotype environment effects. Child Development 54, 424435.

P. Schulman , D. Keith & M. E. Seligman (1993). Is optimism heritable? A study of twins. Behaviour Research and Therapy 31, 569574.

A. D. Simons , K. L. Angell , S. M. Monroe & M. E. Thase (1993). Cognition and life stress in depression cognitive factors and the definition, rating and generation of negative life events. Journal of Abnormal Psychology 102, 584591.

A. Thapar & P. McGuffin (1994). A twin study of depressive symptoms in childhood. British Journal of Psychiatry 165, 259265.

A. Thapar , A. Hervas & P. McGuffin (1995). Childhood hyperactivity disorder is highly heritable and shows sibling competition effects: twin study evidence. Behaviour Genetics 25, 537544.

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