Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 5
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Hoffer, Barry J. 2016. Editorial. Journal of Neuroscience Methods,


    Fujii, Daryl E. and Ahmed, Iqbal 2014. Psychotic Disorder Caused by Traumatic Brain Injury. Psychiatric Clinics of North America, Vol. 37, Issue. 1, p. 113.


    Shih, Chun-Chuan Lee, Hsun-Hua Chen, Ta-Liang Tsai, Chin-Chuan Lane, Hsin-Long Chiu, Wen-Ta and Liao, Chien-Chang 2013. Reduced Use of Emergency Care and Hospitalization in Patients with Traumatic Brain Injury Receiving Acupuncture Treatment. Evidence-Based Complementary and Alternative Medicine, Vol. 2013, p. 1.


    Miller, Shannon C Whitehead, Casserly R Otte, Clifford N Wells, Timothy S Webb, Timothy S Gore, Russell K and Maynard, Charles 2015. Risk for broad-spectrum neuropsychiatric disorders after mild traumatic brain injury in a cohort of US Air Force personnel. Occupational and Environmental Medicine, Vol. 72, Issue. 8, p. 560.


    Lam, Carlos Lin, Mau-Roung Chu, Shu-Fen Tsai, Shin-Han Bai, Chyi-Huey and Chiu, Wen-Ta 2015. The Effect of Various Types of Motorcycle Helmets on Cervical Spine Injury in Head Injury Patients: A Multicenter Study in Taiwan. BioMed Research International, Vol. 2015, p. 1.


    ×

Increased risk of schizophrenia following traumatic brain injury: a 5-year follow-up study in Taiwan

  • Yi-Hua Chen (a1), Wen-Ta Chiu (a2), Shu-Fen Chu (a2) and Herng-Ching Lin (a3)
  • DOI: http://dx.doi.org/10.1017/S0033291710001819
  • Published online: 22 September 2010
Abstract
Background

Whether traumatic brain injury (TBI) is an independent risk factor for the subsequent development of schizophrenia has evoked considerable controversy. No evidence has been previously reported from Asia. This study estimated the risk of schizophrenia during a 5-year period following hospital admission for TBI relative to a comparison group of non-TBI patients during the same period in Taiwan.

Method

Two datasets were linked: the Traumatic Brain Injury Registry and the Taiwan National Health Insurance Research Dataset. A total of 3495 patients hospitalized with a diagnosis of TBI from 2001 to 2002 were included, together with 17 475 non-TBI patients as the comparison group, matched on sex, age, and year of TBI hospitalization. Each individual was followed for 5 years to identify any later diagnosis of schizophrenia. Cox proportional hazard regressions were performed for analysis.

Results

During the 5-year follow-up period, patients who had suffered TBI were independently associated with a 1.99-fold (95% confidence interval 1.28–3.08) increased risk of subsequent schizophrenia, after adjusting for monthly income and residential geographical location. The severity and type of TBI was not associated with the subsequent development of schizophrenia.

Conclusions

Our findings add important evidence from Asia and suggest a potential link between TBI and schizophrenia. Our study suggests that clinicians and family members should be alert to possible neuropsychiatric conditions following TBI.

Copyright
Corresponding author
*Address for correspondence: H.-C. Lin, Ph.D., School of Health Care Administration, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan. (Email: henry@tmu.edu.tw) [H.-C. Lin]
(Email: wtchiu@tmu.edu.tw) [W.-T. Chiu]
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

P AbdelMalik , J Husted , EW Chow , AS Bassett (2003). Childhood head injury and expression of schizophrenia in multiply affected families. Archives of General Psychiatry 60, 231236.

KA Achté , E Hillbom , V Aalberg (1969). Psychoses following war brain injuries. Acta Psychiatrica Scandinavica 45, 118.

AS David , M Prince (2005). Psychosis following head injury: a critical review. Journal of Neurology Neurosurgery and Psychiatry 76 (Suppl. 1), i53i60.

JR Fann , B Burington , A Leonetti , K Jaffe , WJ Katon , RS Thompson (2004). Psychiatric illness following traumatic brain injury in an adult health maintenance organization population. Archives of General Psychiatry 61, 5361.

D Fujii , I Ahmed (2002). Characteristics of psychotic disorder due to traumatic brain injury: an analysis of case studies in the literature. Journal of Neuropsychiatry and Clinical Neurosciences 14, 130140.

T Gualtieri , DR Cox (1991). The delayed neurobehavioural sequelae of traumatic brain injury. Brain Injury 5, 219232.

GL Haas , JA Sweeney (1992). Premorbid and onset features of first-episode schizophrenia. Schizophrenia Bulletin 18, 373386.

G Harrison , E Whitley , F Rasmussen , G Lewis , C Dalman , D Gunnell (2006). Risk of schizophrenia and other non-affective psychosis among individuals exposed to head injury: case control study. Schizophrenia Research 88, 119126.

MS Keshavan , R Tandon , NN Boutros , HA Nasrallah (2008). Schizophrenia, ‘just the facts’: what we know in 2008. Part 3: neurobiology. Schizophrenia Research 106, 89–107.

TK Larsen , TH McGlashan , JO Johannessen , L Vibe-Hansen (1996). First-episode schizophrenia: II. Premorbid patterns by gender. Schizophrenia Bulletin 22, 257269.

WA Lishman (1968). Brain damage in relation to psychiatric disability after head injury. British Journal of Psychiatry 114, 373410.

D Malaspina , RR Goetz , JH Friedman , CA Kaufmann , SV Faraone , M Tsuang , CR Cloninger , JI Nurnberger Jr, MC Blehar (2001). Traumatic brain injury and schizophrenia in members of schizophrenia and bipolar disorder pedigrees. American Journal of Psychiatry 158, 440446.

AS Nielsen , PB Mortensen , E O'Callaghan , O Mors , H Ewald (2002). Is head injury a risk factor for schizophrenia? Schizophrenia Research 55, 9398.

E O'Callaghan , C Larkin , O Redmond , J Stack , JT Ennis , JL Waddington (1988). ‘Early-onset schizophrenia’ after teenage head injury. A case report with magnetic resonance imaging. British Journal of Psychiatry 153, 394396.

JM Silver , R Kramer , S Greenwald , M Weissman (2001). The association between head injuries and psychiatric disorders: findings from the New Haven NIMH Epidemiologic Catchment Area Study. Brain Injury 15, 935945.

R Tandon , MS Keshavan , HA Nasrallah (2008). Schizophrenia, ‘just the facts’: what we know in 2008. 2. Epidemiology and etiology. Schizophrenia Research 102, 118.

P Tienari , LC Wynne , A Sorri , I Lahti , K Laksy , J Moring , M Naarala , P Nieminen , KE Wahlberg (2004). Genotype–environment interaction in schizophrenia-spectrum disorder. Long-term follow-up study of Finnish adoptees. British Journal of Psychiatry 184, 216222.

DS Tzeng , LC Lian , CU Chang , CY Yang , GT Lee , P Pan , FW Lung (2007). Healthcare in schizophrenia: effectiveness and progress of a redesigned care network. BMC Health Service Research 7, 129.

JA Wilcox , HA Nasrallah (1987). Childhood head trauma and psychosis. Psychiatry Research 21, 303306.

AR Yung , PD McGorry (1996). The initial prodrome in psychosis: descriptive and qualitative aspects. Australian and New Zealand Journal of Psychiatry 30, 587599.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: