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Intergenerational effects of maternal lifetime stressor exposure on offspring telomere length in Black and White women

Published online by Cambridge University Press:  02 December 2022

Stefanie E. Mayer ,
Joanna Guan ,
Jue Lin ,
Elissa Hamlat ,
Jordan E. Parker Open the ORCID record for Jordan E. Parker [Opens in a new window] ,
Kristy Brownell ,
Candice Price ,
Mahasin Mujahid ,
A. Janet Tomiyama  and
George M. Slavich
...Show all authors
Stefanie E. Mayer*
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA 94143-0984, USA
Joanna Guan
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA 94143-0984, USA
Jue Lin
Affiliation:
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA
Elissa Hamlat
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA 94143-0984, USA
Jordan E. Parker
Affiliation:
Department of Psychology, University of California, Los Angeles, CA 90095, USA
Kristy Brownell
Affiliation:
School of Public Health, University of California Berkeley, Berkeley, CA 94720, USA
Candice Price
Affiliation:
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Mahasin Mujahid
Affiliation:
School of Public Health, University of California Berkeley, Berkeley, CA 94720, USA
A. Janet Tomiyama
Affiliation:
Department of Psychology, University of California, Los Angeles, CA 90095, USA
George M. Slavich
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
Barbara A. Laraia
Affiliation:
School of Public Health, University of California Berkeley, Berkeley, CA 94720, USA
Elissa S. Epel
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA 94143-0984, USA
*
Author for correspondence: Stefanie E. Mayer, E-mail: Stefanie.Mayer@ucsf.edu
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Abstract

Background

Although maternal stressor exposure has been associated with shorter telomere length (TL) in offspring, this literature is based largely on White samples. Furthermore, timing of maternal stressors has rarely been examined. Here, we examined how maternal stressors occurring during adolescence, pregnancy, and across the lifespan related to child TL in Black and White mothers.

Method

Mothers (112 Black; 110 White; Mage = 39) and their youngest offspring (n = 222; Mage = 8) were part of a larger prospective cohort study, wherein mothers reported their stressors during adolescence (assessed twice during adolescence for the past year), pregnancy (assessed in midlife for most recent pregnancy), and across their lifespan (assessed in midlife). Mother and child provided saliva for TL measurement. Multiple linear regression models examined the interaction of maternal stressor exposure and race in relation to child TL, controlling for maternal TL and child gender and age. Race-stratified analyses were also conducted.

Results

Neither maternal adolescence nor lifespan stressors interacted with race in relation to child TL. In contrast, greater maternal pregnancy stressors were associated with shorter child TL, but this effect was present for children of White but not Black mothers. Moreover, this effect was significant for financial but not social pregnancy stressors. Race-stratified models revealed that greater financial pregnancy stressors predicted shorter telomeres in offspring of White, but not Black mothers.

Conclusions

Race and maternal stressors interact and are related to biological aging across generations, but these effects are specific to certain races, stressors, and exposure time periods.

Keywords

Chronic stressSTRAINPregnancyCellular agingRaceIntergenerational stress
Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 13 , October 2023 , pp. 6171 - 6182
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

Co-senior authors.

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