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Physiological and pharmacological basis for the chemotherapy of enuresis1

  • J. D. Stephenson (a1)
Synopsis
Synopsis

Enuresis is a disorder of micturition occurring in the absence of an organic urinary tract lesion. To understand its possible causation, the mechanisms controlling micturition are described together with the possible sites of action of various anti-enuretic agents, particularly imipramine. It is concluded that further research into the central control of micturition is required before the precise actions of centrally-acting anti-enuretic agents can be elucidated. Knowledge of these may give insight into the nature of the defect causing enuresis.

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2Address for correspondence: Dr J. D. Stephenson, Department of Pharmacology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.
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1

This article formed the basis of a lecture given at the Institute of Psychiatry, London, October 1977.

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Psychological Medicine
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