Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 38
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Gilbert, Donald L. and Jankovic, Joseph 2014. Pharmacological treatment of Tourette syndrome. Journal of Obsessive-Compulsive and Related Disorders, Vol. 3, Issue. 4, p. 407.


    Mørkeberg Nilsson, Flemming 2012. Parkinson’s disease and affective disorder: The temporal relationship. Open Journal of Psychiatry, Vol. 02, Issue. 02, p. 96.


    Wichowicz, Hubert M. Sławek, Jarosław Derejko, Mirosława and Cubała, Wiesław Jerzy 2006. Factors associated with depression in Parkinson’s disease: a cross-sectional study in a Polish population. European Psychiatry, Vol. 21, Issue. 8, p. 516.


    Bassett, Susan 2005. Psychiatric Issues in Parkinson's Disease.


    Kendell, Steven F Krystal, John H and Sanacora, Gerrard 2005. GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert Opinion on Therapeutic Targets, Vol. 9, Issue. 1, p. 153.


    Kugaya, Akira and Sanacora, Gerard 2005. Beyond Monoamines: Glutamatergic Function in Mood Disorders. CNS Spectrums, Vol. 10, Issue. 10, p. 808.


    Nuti, A. Ceravolo, R. Piccinni, A. Dell'Agnello, G. Bellini, G. Gambaccini, G. Rossi, C. Logi, C. Dell'Osso, L. and Bonuccelli, U. 2004. Psychiatric comorbidity in a population of Parkinson's disease patients. European Journal of Neurology, Vol. 11, Issue. 5, p. 315.


    Nilsson, Flemming M. Kessing, Lars V. Sorensen, Tine M. Andersen, Per K. and Bolwig, Tom G. 2002. Major depressive disorder in Parkinson's disease: a register-based study. Acta Psychiatrica Scandinavica, Vol. 106, Issue. 3, p. 202.


    Caap-Ahlgren, Marianne and Dehlin, Ove 2001. Insomnia and depressive symptoms in patients with Parkinson's disease. Archives of Gerontology and Geriatrics, Vol. 32, Issue. 1, p. 23.


    Choi, Chulhee Sohn, Young H. Lee, Joon H. and Kim, Jin-Soo 2000. The effect of long-term levodopa therapy on depression level in de novo patients with Parkinson’s disease. Journal of the Neurological Sciences, Vol. 172, Issue. 1, p. 12.


    Zesiewicz, Theresa A. and Hauser, Robert A. 2000. Depression in Patients with Parkinson??s Disease. CNS Drugs, Vol. 13, Issue. 4, p. 253.


    Zesiewicz, Theresa A. Gold, Michael Chari, Ganesh and Hauser, Robert A. 1999. Current Issues in Depression in Parkinson's Disease. The American Journal of Geriatric Psychiatry, Vol. 7, Issue. 2, p. 110.


    Hoogendijk, W.J.G. Sommer, I.E.C. Tissingh, G. Deeg, D.J.H. and Wolters, E.Ch. 1998. Depression in Parkinson’s Disease: The Impact of Symptom Overlap on Prevalence. Psychosomatics, Vol. 39, Issue. 5, p. 416.


    Sandyk, Reuven 1994. A drug naive parkinsonian patient successfully treated with weak electromagnetic fields. International Journal of Neuroscience, Vol. 79, Issue. 1-2, p. 99.


    Sandyk, Reuven 1994. Improvement in Word-Fluency Performance in Parkinson's Disease by Administration of Electromagnetic Fields. International Journal of Neuroscience, Vol. 77, Issue. 1-2, p. 23.


    Hasle, Nicolas 1993. Psychiatric side effects of levodopa treatment of parkinsonism A survey. Nordic Journal of Psychiatry, Vol. 47, Issue. 5, p. 379.


    Sandyk, Reuven 1993. Delusional Depression in Parkinson's Disease. International Journal of Neuroscience, Vol. 70, Issue. 1-2, p. 69.


    Boyd, J. L. Cruickshank, C. A. Kenn, C. W. Madeley, P. Mindham, R. H. S. Oswald, A. G. Smith, R. J. and Spokes, E. G. S. 1991. Cognitive impairment and dementia in Parkinson's disease: a controlled study. Psychological Medicine, Vol. 21, Issue. 04, p. 911.


    Cummings, Jeffrey L. 1991. Behavioral Complications of Drug Treatment of Parkinson's Disease. Journal of the American Geriatrics Society, Vol. 39, Issue. 7, p. 708.


    Ebmeier, K. P. Calder, S. A. Crawford, J. R. Stewart, L. Cochrane, R. H. B. and Besson, J. A. O. 1991. Dementia in idiopathic Parkinson's disease: prevalence and relationship with symptoms and signs of Parkinsonism. Psychological Medicine, Vol. 21, Issue. 01, p. 69.


    ×

Psychiatric symptoms during L-dopa therapy for Parkinson's disease and their relationship to physical disability

  • R. H. S. Mindham (a1), C. D. Marsden (a1) and J. D. Parkes (a1)
  • DOI: http://dx.doi.org/10.1017/S0033291700007467
  • Published online: 01 July 2009
Abstract
Synopsis

Fifty patients attending a neurological outpatient clinic for Parkinson's disease were assessed by standardized methods for both physical and psychiatric symptoms. The patients then received treatment with L-dopa, L-dopa with carbidopa or anticholinergic drugs and/or amantadine. During the following six-month period the subjects were assessed at intervals, both physically and psychiatrically. Forty patients were followed up for the full six-month period. The severity of physical signs and affective symptoms was shown to be significantly related at several stages of the investigation. Initially, the patients showed a high psychiatric morbidity. During treatment, 22 patients developed a depressive disorder, 12 of which had a history of previous depressive episodes. By contrast, of the 11 patients who showed very few affective symptoms during follow-up, none had a history of depression. Of the 22 patients with a depressive disorder, only two were in the anticholinergic/amantadine group, compared with nine and 11 in the other groups. L-dopa was not an effective antidepressant agent. The probable relevance of the findings of the study to the management of patients with Parkinson's disease is outlined.

Copyright
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

B. J. Carroll (1971). Monoamine precursors in the treatment of depression. Clinical Pharmacology and Therapeutics 12, 743761.

A. R. Damásio , J. Lobo-Antunes & C. Macedo (1971). Psychiatric aspects in Parkinsonism treated with L-dopa. Journal of Neurology, Neurosurgery and Psychiatry 34, 502507.

M. R. Eastwood , R. H. S. Mindham & T. G. Tennent (1970). The physical status of psychiatric emergencies. British Journal of Psychiatry 116, 545550.

M. D. Eilenberg & P. B. Whatmore (1961). Physical disease and psychiatric emergencies. Comprehensive Psychiatry 2, 358363.

A.-K. Granerus , G. Steg & A. Sanborg (1972). Clinical analyses of factors influencing L-dopa treatment of Parkinson's syndrome. Acta Medica Scandinavica 192, 111.

J. A. Jackson , G. B. M. Free & H. V. Pike (1923). The psychic manifestations in paralysis agitans. Archives of Neurology and Psychiatry 10, 680684.

W. A. Lishman (1968). Brain damage in relation to psychiatric disability after head injury. British Journal of Psychiatry 114, 373410.

I. Maclay (1965). The ‘functional’ medical outpatient. British Journal of Psychiatry 111, 3438.

G. P. Maguire & K. L. Granville-Grossman (1968). Physical illness in psychiatric patients. British Journal of Psychiatry 114, 13651369.

R. H. S. Mindham (1970). Psychiatric symptoms in Parkinsonism. Journal of Neurology, Neurosurgery and Psychiatry 33, 188191.

H. T. Patrick & D. M. Levy (1922). Parkinson's disease: a clinical study of one hundred and forty-six cases. Archives of Neurology and Psychiatry 7, 711720.

T. A. C. Rennie (1942). Prognosis in manic-depressive psychosis. American Journal of Psychiatry 98, 801814.

R. H. Rosillo , M. L. Fogel & K. Freedman (1971). Affect levels and improvement in physical rehabilitation. Journal of Chronic Disease 24, 651660.

J. J. Schildkraut (1969). Neuropsychopharmacology and the affective disorders. New England Journal of Medicine 281, 197201, 248–255, 302–308.

D. Surridge (1969). An investigation into some psychiatric aspects of multiple sclerosis. British Journal of Psychiatry 115, 749764.

M. D. Yahr , R. C. Duvoisin , M. J. Schear , R. E. Barrett & M. M. Hoehn (1969). Treatment of Parkinsonism with levodopa. Archives of Neurology 21, 343354.

G. Zaphiropoulos & H. C. Burry (1974). Depression in rheumatoid disease. Annals of Rheumatic Diseases 33, 132135.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×