Barbosa, PC, Strassman, RJ, da Silveira, DX, Areco, K, Hoy, R, Pommy, J, Thoma, R and Bogenschutz, M (2016) Psychological and neuropsychological assessment of regular hoasca users. Comprehensive Psychiatry 71, 95–105.
Berman, RM, Cappiello, A, Anand, A, Oren, DA, Heninger, GR, Charney, DS and Krystal, JH (2000) Antidepressant effects of ketamine in depressed patients. Biological Psychiatry 47, 351–354.
Bogenschutz, MP, Forcehimes, AA, Pommy, JA, Wilcox, CE, Barbosa, P and Strassman, RJ (2015) Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. Journal of Psychopharmacology 29, 289–299.
Bouso, JC, González, D, Fondevila, S, Cutchet, M, Fernández, X, Ribeiro Barbosa, PC, Alcázar-Córcoles, M, Araújo, WS, Barbanoj, MJ, Fábregas, JM and Riba, J (2012) Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of ayahuasca: a longitudinal study. PLoS ONE 7, e42421.
Bremner, JD, Krystal, JH, Putnam, FW, Southwick, SM, Marmar, C, Charney, DS and Mazure, CM (1998) Measurement of dissociative states with the clinician-administered dissociative states scale (CADSS). Journal of Traumatic Stress 11, 125–136.
Cai, S, Huang, S and Hao, W (2015) New hypothesis and treatment targets of depression: an integrated view of key findings. Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. Neuroscience Bulletin 31, 61–74.
Callaway, JC, McKenna, DJ, Grob, CS, Brito, GS, Raymon, LP, Poland, RE, Andrade, EONO, Andrade, EONO and Mash, DC (1999) Pharmacokinetics of Hoasca alkaloids in healthy humans. Journal of Ethnopharmacology 65, 243–256.
Carbonaro, TM and Gatch, MB (2016) Neuropharmacology of N,N-dimethyltryptamine. Brain Research Bulletin 126, 74–88.
Carhart-Harris, RL, Bolstridge, M, Rucker, J, Day, CMJ, Erritzoe, D, Kaelen, M, Bloomfield, M, Rickard, JA, Forbes, B, Feilding, A, Taylor, D, Pilling, S, Curran, VH and Nutt, DJ (2016) Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry 3, 619–627.
Carneiro, AM, Fernandes, F and Moreno, RA (2015) Hamilton depression rating scale and montgomery–asberg depression rating scale in depressed and bipolar I patients: psychometric properties in a Brazilian sample. Health and Quality of Life Outcomes 13, 42.
Conway, CR, George, MS and Sackeim, HA (2017) Toward an evidence-based, operational definition of treatment-resistant depression: when enough is enough. JAMA Psychiatry 74, 9–10.
Crippa, JAS, Sanches, RF, Hallak, JEC, Loureiro, SR and Zuardi, AW (2001) A structured interview guide increases Brief Psychiatric Rating Scale reliability in raters with low clinical experience. Acta Psychiatrica Scandinavica 103, 465–470.
Dakic, V, de Moraes Maciel, R, Drummond, H, Nascimento, JM, Trindade, P and Rehen, SK (2016) Harmine stimulates proliferation of human neural progenitors. PeerJ 4, e2727.
De Araujo, DB, Ribeiro, S, Cecchi, GA, Carvalho, FM, Sanchez, TA, Pinto, JP, de Martinis, BS, Crippa, JA, Hallak, JEC and Santos, AC (2012) Seeing with the eyes shut: neural basis of enhanced imagery following ayahuasca ingestion. Human Brain Mapping 33, 2550–2560.
Delgado, PL, Price, LH, Charney, DS and Heninger, GR (1988) Efficacy of fluvoxamine in treatment-refractory depression. Journal of Affective Disorders 15, 55–60.
Dos Santos, RG, Valle, M, Bouso, JC, Nomdedéu, JF, Rodríguez-Espinosa, J, McIlhenny, EH, Barker, SA, Barbanoj, MJ and Riba, J (2011) Autonomic, neuroendocrine, and immunological effects of ayahuasca: a comparative study with d-amphetamine. Journal of Clinical Psychopharmacology 31, 717–726.
Fortunato, JJ, Réus, GZ, Kirsch, TR, Stringari, RB, Fries, GR, Kapczinski, F, Hallak, JE, Zuardi, AW, Crippa, JA and Quevedo, J (2010 a) Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus. Journal of Neural Transmission 117, 1131–1137.
Fortunato, JJ, Réus, GZ, Kirsch, TR, Stringari, RB, Fries, GR, Kapczinski, F, Hallak, JE, Zuardi, AW, Crippa, JA and Quevedo, J (2010 b) Effects of beta-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: further evidence of antidepressant properties. Brain Research Bulletin 81, 491–496.
Frecska, E, Bokor, P and Winkelman, M (2016) The therapeutic potentials of ayahuasca: possible effects against various diseases of civilization. Frontiers in Pharmacology 7, 1–17.
Garcia-Romeu, A, Griffiths, R and Johnson, M (2015) Psilocybin-occasioned mystical experiences in the treatment of tobacco addiction. Current Drug Abuse Reviews 7, 157–164.
Griffiths, RR, Johnson, MW, Carducci, MA, Umbricht, A, Richards, WA, Richards, BD, Cosimano, MP and Klinedinst, MA (2016) Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: a randomized double-blind trial. Journal of Psychopharmacology 30, 1181–1197.
Grob, CS, Danforth, AL, Chopra, GS, Hagerty, M, McKay, CR, Halberstadt, AL and Greer, GR (2011) Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Archives of General Psychiatry 68, 71–78.
Grob, CS, McKenna, DJ, Callaway, JC, Brito, GS, Neves, ES, Oberlaender, G, Saide, OL, Labigalini, E, Tacla, C, Miranda, CT, Strassman, RJ and Boone, KB (1996) Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil. Journal of Nervous and Mental Disease 184, 86–94.
Hamilton, M (1960) Hamilton Depression Rating Scale (HAM-D) instructions for the clinician: HAM-D scoring instructions. Journal of Neurology, Neurosurgery, and Psychiatry 23, 56–62.
Hashimoto, K (2009) Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship. Central Nervous System Agents in Medicinal Chemistry 9, 197–204.
Labate, BC and Jungaberle, H (2011) The Internationalization of Ayahuasca. Zürich: Performanzen, interkulturelle Studien zu Ritual, Speil and Theater. Lit.
Lapidus, KAB, Levitch, CF, Perez, AM, Brallier, JW, Parides, MK, Soleimani, L, Feder, A, Iosifescu, DV, Charney, DS and Murrough, JW (2014) A randomized controlled trial of intranasal ketamine in major depressive disorder. Biological Psychiatry 76, 970–976.
Luna, LE (2011) Indigenous and Mestizo use of Ayahuasca. An Overview. The Ethnopharmacology of Ayahuasca. Tivandrum: Transworld Research Network.
MacLean, KA, Leoutsakos, JMS, Johnson, MW and Griffiths, RR (2012) Factor analysis of the mystical experience questionnaire: a study of experiences occasioned by the hallucinogen psilocybin. Journal for the Scientific Study of Religion 51, 721–737.
Majić, T, Schmidt, TT and Gallinat, J (2015) Peak experiences and the afterglow phenomenon: when and how do therapeutic effects of hallucinogens depend on psychedelic experiences? Journal of Psychopharmacology 29, 241–253.
McKenna, DJ, Towers, GH and Abbott, FS (1984) Monoamine oxidase inhibitors in South American hallucinogenic plants Part 2: constituents of orally-active Myristicaceous hallucinogens. Journal of Ethnopharmacology 12, 179–211.
Morales-García, JA, de la Fuente Revenga, M, Alonso-Gil, S, Rodríguez-Franco, MI, Feilding, A, Perez-Castillo, A and Riba, J (2017) The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen ayahuasca, stimulate adult neurogenesis in vitro. Scientific Reports 7, 5309.
Murrough, JW, Iosifescu, DV, Chang, LC, Al Jurdi, RK, Green, CE, Perez, AM, Iqbal, S, Pillemer, S, Foulkes, A, Shah, A, Charney, DS and Mathew, SJ (2013) Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. American Journal of Psychiatry 170, 1134–1142.
Osório, F de L, Sanches, RF, Macedo, LR, dos Santos, RG, Maia-de-Oliveira, JPJP, Wichert-Ana, L, de Araujo, DB, Riba, J, Crippa, JAJA and Hallak, JE (2015) Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Revista Brasileira de Psiquiatria 37, 13–20.
Otte, C, Gold, SM, Penninx, BW, Pariante, CM, Etkin, A, Fava, M, Mohr, DC and Schatzberg, AF (2016) Major depressive disorder. Nature Reviews. Disease Primers 2, 16065.
Palhano-Fontes, F, Alchieri, JC, Oliveira, JPM, Soares, BL, Hallak, JEC, Galvao-Coelho, N and de Araujo, DB (2014) The therapeutic potentials of ayahuasca in the treatment of depression. In: Labate, B, Cavnar, C (eds) The Therapeutic use of Ayahuasca. Berlin, Heidelberg: Springer, pp. 23–39.
Palhano-Fontes, F, Andrade, KC, Tofoli, LF, Jose, ACS, Crippa, AS, Hallak, JEC, Ribeiro, S and De Araujo, DB (2015) The psychedelic state induced by ayahuasca modulates the activity and connectivity of the Default Mode Network. PLoS ONE 10, e0118143.
Pic-Taylor, A, da Motta, LG, de Morais, JA, Junior, WM, Santos, AF, Campos, LA, Mortari, MR, von Zuben, MV and Caldas, ED (2015) Behavioural and neurotoxic effects of ayahuasca infusion (Banisteriopsis caapi and Psychotria viridis) in female Wistar rat. Behavioural Processes Processes 118, 102–110.
Riba, J, Valle, M, Urbano, G, Yritia, M, Morte, A and Barbanoj, MJ (2003) Human pharmacology of ayahuasca: subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics. Journal of Pharmacology and Experimental Therapeutics 306, 73–83.
Ripoll, LH (2013) Psychopharmacologic treatment of borderline personality disorder. Dialogues in Clinical Neuroscience 15, 213–224.
Ross, S, Bossis, A, Guss, J, Agin-Liebes, G, Malone, T, Cohen, B, Mennenga, SE, Belser, A, Kalliontzi, K, Babb, J, Su, Z, Corby, P and Schmidt, BL (2016) Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial. Journal of Psychopharmacology 30, 1165–1180.
Sanches, RF, de Lima Osório, F, dos Santos, RG, Macedo, LRH, Maia-de-Oliveira, JP, Wichert-Ana, L, de Araujo, DB, Riba, J, Crippa, JAS and Hallak, JEC (2016) Antidepressant effects of a single dose of ayahuasca in patients With recurrent depression: a SPECT study. Journal of Clinical Psychopharmacology 36, 77–81.
Segal, ZV, Bieling, P, Young, T, MacQueen, G, Cooke, R, Martin, L, Bloch, R and Levitan, RD (2010) Antidepressant monotherapy v. sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression. Archives of General Psychiatry 67, 1256–1264.
Shanon, B (2002) The Antipodes of the Mind: Charting the Phenomenology of the Ayahuasca Experience. Oxford, New York: Oxford University Press.
Sheline, YI, Barch, DM, Price, JL, Rundle, MM, Vaishnavi, SN, Snyder, AZ, Mintun, MA, Wang, S, Coalson, RS and Raichle, ME (2009) The default mode network and self-referential processes in depression. Proceedings of the National Academy of Sciences of the United States of America 106, 1942–1947.
Soler, J, Elices, M, Franquesa, A, Barker, S, Friedlander, P, Feilding, A, Pascual, JC and Riba, J (2016) Exploring the therapeutic potential of ayahuasca: acute intake increases mindfulness-related capacities. Psychopharmacology 233, 823–829.
Sonawalla, SB and Rosenbaum, JF (2002) Placebo response in depression. Dialogues in Clinical Neuroscience 4, 105–113.
Spruce, R and Wallace, AR (1908) Notes of a Botanist on the Amazon & Andes. Macmillan, London.
Strassman, RJ, Qualls, CR, Uhlenhuth, EH and Kellner, R (1994) Dose-response study of N,N-dimethyltryptamine in humans: II. Subjective effects and preliminary results of a new rating scale. Archives of General Psychiatry 51, 98–108.
Tafur, J (2017) The Fellowship of the River: A Medical Doctor's Exploration into Traditional Amazonian Plant Medicine. Espiritu, Phoenix.
Vilela, JAA, Crippa, JAS, Del-Ben, CM and Loureiro, SR (2005) Reliability and validity of a Portuguese version of the Young Mania Rating Scale. Brazilian Journal of Medical and Biological Research 38, 1429–1439.
Vollenweider, FX and Kometer, M (2010) The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nature Reviews Neuroscience 11, 642–651.
World Health Organization (2017) Depression and Other Common Mental Disorders: Global Health Estimates. Rep. CC BY-NC-SA 3.0 IGO. Geneva: World Health Organization.
Zarate, CA, Singh, JB, Carlson, PJ, Brutsche, NE, Ameli, R, Luckenbaugh, DA, Charney, DS and Manji, HK (2006) A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Archives of General Psychiatry 63, 856–864.