Skip to main content

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
Cancel
×
×
Home
  • Home
Article
  • Cited by 27
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Sullivan, Kathleen Pantazopoulos, Harry Liebson, Elizabeth Woo, T.-U.W. Baldessarini, Ross J. Hedreen, John and Berretta, Sabina 2018. Brain Banking. Vol. 150, Issue. , p. 181.
    Tunbridge, Elizabeth M. Eastwood, Sharon L. and Harrison, Paul J. 2011. Changed Relative to What? Housekeeping Genes and Normalization Strategies in Human Brain Gene Expression Studies. Biological Psychiatry, Vol. 69, Issue. 2, p. 173.
    Papapetropoulos, Spiridon Shehadeh, Lina and McCorquodale, Donald 2007. Optimizing human post-mortem brain tissue gene expression profiling in Parkinson's disease and other neurodegenerative disorders: From target “fishing” to translational breakthroughs. Journal of Neuroscience Research, Vol. 85, Issue. 14, p. 3013.
    Papapetropoulos, Spiridon and McCorquodale, Donald 2007. Gene-expression profiling in Parkinson’s disease: discovery of valid biomarkers, molecular targets and biochemical pathways. Future Neurology, Vol. 2, Issue. 1, p. 29.
    Woulfe, John M. Hammond, Robert Richardson, Bryan Sooriabalan, Danushan Parks, William Rippstein, Peter and Munoz, David G. 2006. Reduction of Neuronal Intranuclear Rodlets Immunoreactive for Tubulin and Glucocorticoid Receptor in Alzheimer's Disease. Brain Pathology, Vol. 12, Issue. 3, p. 300.
    Ginsberg, Stephen D. Che, Shaoli Counts, Scott E. and Mufson, Elliott J. 2006. Single cell gene expression profiling in Alzheimer’s disease. NeuroRX, Vol. 3, Issue. 3, p. 302.
    Ginsberg, Stephen D. Che, Shaoli Counts, Scott E. and Mufson, Elliott J. 2006. Single cell gene expression profiling in Alzheimer’s disease. NeuroRX, Vol. 3, Issue. 3, p. 302.
    Mufson, Elliott J. Counts, Scott E. Che, Shaoli and Ginsberg, Stephen D. 2006. Functional Genomics and Proteomics in the Clinical Neurosciences. Vol. 158, Issue. , p. 197.
    Tomita, Hiroaki Vawter, Marquis P Walsh, David M Evans, Simon J Choudary, Prabhakara V Li, Jun Overman, Kevin M Atz, Mary E Myers, Richard M Jones, Edward G Watson, Stanley J Akil, Huda and Bunney, William E 2004. Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain. Biological Psychiatry, Vol. 55, Issue. 4, p. 346.
    Eastwood, S L and Harrison, P J 2003. Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis. Molecular Psychiatry, Vol. 8, Issue. 9, p. 821.
    Husseman, Jacob W. Hallows, Janice L. Bregman, David B. Leverenz, James B. Nochlin, David Jin, Lee-Way and Vincent, Inez 2001. Hyperphosphorylation of RNA Polymerase II and Reduced Neuronal RNA Levels Precede Neurofibrillary Tangles in Alzheimer Disease. Journal of Neuropathology & Experimental Neurology, Vol. 60, Issue. 12, p. 1219.
    Ginsberg, Stephen D. Hemby, Scott E. Lee, Virginia M.-Y. Eberwine, James H. and Trojanowski, John Q. 2000. Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Annals of Neurology, Vol. 48, Issue. 1, p. 77.
    Thomas, Gregory J. Harper, Clive G. and Dodd, Peter R. 1998. Expression of GABAA receptor isoform genes in the cerebral cortex of cirrhotic and alcoholic cases assessed by S1 nuclease protection assays. Neurochemistry International, Vol. 32, Issue. 4, p. 375.
    Heffernan, Josephine M. Eastwood, Sharon L. Nagy, Zsuzsanna Sanders, Maurice W. McDonald, Brendan and Harrison, Paul J. 1998. Temporal Cortex Synaptophysin mRNA Is Reduced in Alzheimer's Disease and Is Negatively Correlated with the Severity of Dementia. Experimental Neurology, Vol. 150, Issue. 2, p. 235.
    Harrison, Paul J Burnet, Philip W.J Falkai, Peter Bogerts, Bernard and Eastwood, Sharon L 1997. Gene expression and neuronal activity in schizophrenia: a study of polyadenylated mRNA in the hippocampal formation and cerebral cortex. Schizophrenia Research, Vol. 26, Issue. 2-3, p. 93.
    Amoureux, Marie-Claude Van Gool, Dominique Herrero, Maria-Trinidad Dom, René Colpaert, Francis C. and Pauwels, Petrus J. 1997. Regulation of metallothionein-III (GIF) mRNA in the brain of patients with Alzheimer disease is not impaired. Molecular and Chemical Neuropathology, Vol. 32, Issue. 1-3, p. 101.
    Fahnestock, Margaret Scott, Samuel A. Jetté, Nathalie Weingartner, Jean A. and Crutcher, Keith A. 1996. Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex. Molecular Brain Research, Vol. 42, Issue. 1, p. 175.
    Eastwood, Sharon L. McDonald, Brendan Burnet, Philip W.J. Beckwith, Jason P. Kerwin, Robert W. and Harrison, Paul J. 1995. Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluRl and GluR2 in medial temporal lobe neurons in schizophrenia. Molecular Brain Research, Vol. 29, Issue. 2, p. 211.
    Harrison, P.J. Heath, P.R. Eastwood, S.L. Burnet, P.W.J. McDonald, B. and Pearson, R.C.A. 1995. The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins. Neuroscience Letters, Vol. 200, Issue. 3, p. 151.
    Jetté, N. Cole, M.S. and Fahnestock, M. 1994. NGF mRNA is not decreased in frontal cortex from Alzheimer's Disease patients. Molecular Brain Research, Vol. 25, Issue. 3-4, p. 242.
    Download full list
    ×
  • Get access
    Add to cart USD35.00
    Check if you have access via personal or institutional login
    Log in Register Recommend to librarian

Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease

  • Paul J. Harrison (a1), Amanda J. L. Barton (a1), Abdolrahman Najlerahim (a1), Brendan McDonald (a1) and R. Carl A. Pearson...
Synopsis

Messenger RNA (mRNA) is the key intermediate in the gene expression pathway. The amount of mRNA in Alzheimer's disease (AD) brains has been determined using in situ hybridization histochemistry (ISHH) to detect the poly(A) tails of polyadenylated mRNA (poly(A) + mRNA). On a regional basis, AD cases had significantly less poly(A) + mRNA than controls in hippocampus (field CA3) and cerebellum (granule cell layer). Analysis of constituent pyramidal neurons showed mean reductions per cell within AD hippocampus (field CA3) and temporal cortex, but not in visual cortex. Similar changes were seen in a small group of non-AD dementias. The finding of reduced poly(A) + mRNA content is another indication of the altered brain gene expression occurring in AD. It is proposed that measurement of poly(A) + mRNA may be valuable in identifying functionally impaired neuronal populations. The methodology also provides a means by which changes in the quantitative distribution of individual mRNAs can be determined relative to that of poly(A) + mRNA as a whole.

Copyright
COPYRIGHT: © Cambridge University Press 1991
Corresponding author
1Address for correspondence: Dr P. J. Harrison, University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX.
References
Hide All
Arai, H., Noguchi, I., Saigi, N., Moroji, T. & Izizuka, R. (1989). A study of non-isotopic in situ hybridization histochemistry on post mortem changes in vasopressin mRNA in rat brain. Neuroscience Letters 103, 127–132.
Ball, M. J. (1978). Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study. Acta Neuropathologica (Berlin) 42, 73–80.
Ball, M. J., Hachinski, V., Fox, A., Kirshen, A. J., Fisman, M., Blume, W., Kral, V. A., Fox, H. & Merskey, H. (1985). A new definition of Alzheimer's disease: a hippocampal dementia. Lancet i, 14–16.
Barton, A. J. L. & Hardy, J. A. (1987). Stability of brain RNA post mortem: effect of Alzheimer's disease. Biochemical Society Transactions 15, 558–559.
Barton, A. J. L., Harrison, P. J., Najlerahim, A., Heffernan, J., McDonald, B., Robinson, J. R., Davies, D. C., Harrison, W. J., Mitra, P., Hardy, J. A. & Pearson, R. C. A. (1990). Increased tau messenger RNA in Alzheimer's disease hippocampus. American Journal of Pathology 137, 497–502.
Beach, T. G. & McGeer, E. G. (1988). Lamina-specific arrangement of astrocytic gliosis and senile plaques in Alzheimer disease visual cortex. Brain Research 463, 357–361.
Bernstein, P. & Ross, J. (1989). Poly(A), poly (A) binding protein and the regulation of mRNA stability. Trends in Biochemical Sciences 14, 373–377.
Braak, H., Braak, E., Bohl, J. & Lang, W. (1989). Alzheimer's disease: amyloid plaques in the cerebellum. Journal of Neurological Science 93, 277–287.
Bustany, P., Henry, J. F., Sargent, T., Zorifian, E., Cabanis, E., Collard, P. & Comar, D. (1983). Local brain protein metabolism in dementia and schizophrenia: in vivo studies with [11C]L-methionine and positron emission tomography. In Positron Emission Tomography of the Brain (ed. Heiss, W. D. and Phelps, M. E.), pp. 208–211. Springer: New York.
Chaudhari, N. & Hahn, W. E. (1983). Genetic expression in the developing brain. Science 220, 924–928.
Clark, A. W. & Parhad, I. M. (1989). Expression of neuronal mRNAs in Alzheimer type degeneration of the nervous system. Canadian Journal of the Neurological Sciences 16, 477–482.
Coleman, P. D. & Flood, D. G. (1987). Neuron numbers and dendritic extent in normal aging and Alzheimer's disease. Neurobiology of Aging 8, 521–545.
Cowburn, R. F., Hardy, J. A. & Roberts, P. J. (1989). Neurotransmitter deficits in Alzheimer's disease. In Alzheimer's Disease: Towards an Understanding of the Aetiology and Pathogenesis (ed. Davies, D. C.), pp. 9–32. John Libbey: London.
Crapper McLachlan, D. R. & Lewis, P. N. (1985). Alzheimer's disease: errors in gene expression. Canadian Journal of the Neurological Sciences 12, 1–5.
Crapper McLachlan, D. R., Lukiw, W. J., Wong, L., Bergeron, C. & Bech-Hansen, N. T. (1988). Selective messenger RNA reduction in Alzheimer's disease. Molecular Brain Research 3, 255–262.
Davies, D. C. (1989). Hippocampal pathology and memory impairment in Alzheimer's disease. In Alzheimer's Disease: Towards an Understanding of the Aetiology and Pathogenesis (ed. Davies, D. C.), pp. 89–105. John Libbey: London.
Davis, L. G., Dibner, M. D. & Batty, J. F. (1986). Basic Methods in Molecular Biology. Elsevier: New York.
Doebler, J. A., Markesbery, W. R., Anthony, A. & Rhoads, R. E. (1987). Neuronal RNA in relation to neuronal loss and neurofibrillary pathology in the hippocampus in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology 46, 28–39.
Doebler, J. A., Markesbery, W. R., Anthony, A., Scheff, S. W. & Rhoads, R. E. (1988). Astrocyte RNA in relation to neuronal RNA depletion in Alzheimer's disease. Acta Neuropathologica (Berlin) 75, 272–276.
Doebler, J. A., Rhoads, R. E., Anthony, A. & Markesbery, W. R. (1989). Neuronal RNA in Pick's and Alzheimer's diseases: comparison of disease-susceptible and disease-resistant cortical areas. Archives of Neurology, 46, 134–137.
Duvernoy, H. M. (1988). The Human Hippocampus. J. F. Bergman: Munich.
Finch, C. E. & Morgan, D. G. (1990). RNA and protein metabolism in the aging brain. Annual Review of Neuroscience 13, 75–87.
Geddes, J. W., Wong, J., Choi, B. H., Kim, R. C., Cotman, C. W. & Miller, F. D. (1990). Increased expression of the embryonic form of a developmentally-regulated mRNA in Alzheimer's disease. Neuroscience Letters 109, 54–61.
Griffin, W. S. T., Ling, C., White, C. L. & Morrison-Bogorad, M. (1990). Polyadenylated messenger RNA in paired helical filament- immunoreactive neurons in Alzheimer disease. Alzheimer Disease and Associated Disorders 4, 69–78.
Guillemette, J. G., Wong, L., Crapper McLachlan, D. R. & Lewis, P. N. (1986). Characterization of messenger RNA from the cerebral cortex of control and Alzheimer-afflicted brain. Journal of Neurochemistry 47, 987–997.
Harrison, P. J. & Pearson, R. C. A. (1989). Gene expression and mental disease. Psychological Medicine 19, 813–819.
Harrison, P. J. & Pearson, R. C. A. (1990). In situ hybridization histochemistry and the study of gene expression in the human brain. Progress in Neurobiology 34, 271–312.
Harrison, P. J., Barton, A. J. L., Najlerahim, A. & Pearson, R. C. A. (1990). Distribution of a kainate/AMPA receptor mRNA in normal and Alzheimer brain. Neuro Report 1, 149–152.
Harrison, P. J., Barton, A. J. L., Najlerahim, A., McDonald, B. & Pearson, R. C. A. (1991 a). Increased muscarinic receptor messenger RNA in Alzheimer's disease temporal cortex demonstrated by in situ hybridization histochemistry. Molecular Brain Research 9, 15–21.
Harrison, P. J., Barton, A. J. L., McDonald, B. & Pearson, R. C. A. (1991 b). Alzheimer's disease: specific increases in a G protein subunit (G,α) mRNA in hippocampal and cortical neurons. Molecular Brain Research 10, 71–81.
Harrison, P. J., Procter, A. W., Barton, A. J. L., Lowe, S. L., Najlerahim, A., Bertolucci, P. H. F., Bowen, D. M. & Pearson, R. C. A. (1991 c). Terminal coma affects messenger RNA detection in post mortem human temporal cortex. Molecular Brain Research 9, 161–164.
Hof, P. R., Bouras, C., Constantinidis, J. & Morrison, J. H. (1989). Selective dissociation of specific visual association pathways in cases of Alzheimer's disease presenting with Balint's syndrome. Journal of Neuropathology and Experimental Neurology 49, 168–184.
Jackson, R. J. & Standard, N. (1990). Do the poly(A) tail and 3′ untranslated region control mRNA translation? Cell 62, 15–24.
Joachim, C. L., Morris, J. H. & Selkoe, D. J. (1989). Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. American Journal of Pathology 135, 309–319.
Johnson, S. A., Morgan, D. G. & Finch, C. E. (1986). Extensive post-mortem stability of mRNA from rat and human brain. Journal of Neuroscience Research 16, 267–280.
Jones, L. M. & Knowler, J. T. (1989). Role of ribonuclease and ribonuclease inhibitor activities in Alzheimer's disease. Journal of Neurochemistry 53, 1341–1344.
Khachaturian, Z. S. (1985). Diagnosis of Alzheimer's disease. Archives of Neurology 42, 1097–1105.
Kosik, K. S., Crandall, J. E., Mufson, E. J. & Neve, R. L. (1989). Tau in situ hybridization in Alzheimer brain: localization in the somatodendritic compartment. Annals of Neurology 26, 352–361.
Langstrom, N. S., Anderson, J. P., Lindroos, H. G., Winblad, B. & Wallace, W. C. (1989). Alzheimer's disease-associated reduction of polysomal mRNA translation. Molecular Brain Research 5, 259–269.
Lewis, D. A., Campbell, M. J., Terry, R. D. & Morrison, J. H. (1987). Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. Journal of Neuroscience 7, 1799–1808.
Mann, D. M. A. & Sinclair, K. G. A. (1978). The quantitative assessment of lipofuscin pigment, cytoplasmic RNA and nucleolar volume in senile dementia. Neuropathology and Applied Neurobiology 4, 129–135.
Mann, D. M. A., Neary, D., Yates, P. O., Lincoln, J., Snowden, J. S. & Stanworth, P. (1981). Alterations in protein synthetic capability of nerve cells in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry 44, 97–102.
Man, D. M. A., Yates, P. O. & Marcyniuk, B. (1985). Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of the Alzheimer type and Down's syndrome in middle age. Journal of Neurological Science 69, 139–159.
Marotta, C. A., Majocha, R. E., Coughlin, J. F., Manz, H. J., Davies, P., Ventosa-Michelman, M., Chou, W.-G., Zain, S. B. & Sajdel-Sulkowska, E. M. (1986). Transcriptional and translational regulatory mechanisms during normal aging of the mammalian brain and in Alzheimer's disease. Progress in Brain Research 70, 303–320.
Maschoff, K., White, C. L. II, Jennings, L. W. & Morrison-Bogorad, M. R. (1989). Ribonuclease activities and distribution in Alzheimer's and control brains. Journal of Neurochemistry 52, 1071–1078.
May, P. C., Johnson, S. A., Poirier, J., Lampert-Etchells, M. & Finch, C. E. (1989). Altered gene expression in Alzheimer's disease brain tissue. Canadian Journal of the Neurological Sciences 16, 473–476.
Mengod, G., Charli, J.-L. & Palacios, J. M. (1990). The use of in situ hybridization histochemistry for the study of neuropeptide gene expression in the human brain. Cellular and Molecular Neurobiology 10, 113–126.
Morrison, M. R., Pardue, S., Maschoff, K., Griffin, W. S. T., White, C. L., Gilbert, J. & Roses, A. (1987). Brain messenger RNA levels and ribonuclease activity in Alzheimer's disease. Biochemical Society Transactions 15, 133–134.
Naber, D. & Dahnke, H. G. (1979). Protein and nucleic acid content in the aging human brain. Neuropathology and Applied Neurobiology 5, 17–24.
Netsky, M. G. (1968). Degenerations of the cerebellum and its pathways. In Pathology of the Nervous System, (ed. Minckler, J.), pp. 1163–1185. McGraw Hill: New York.
Neve, R. L. (1990). Genetics of the Alzheimer amyloid precursor. In Molecular Aspects of Development and Aging of the Nervous System (ed. Lauder, J. M.), pp. 291–299. Plenum Press: New York.
Pearson, R. C. A. & Powell, T. P. S. (1989). The neuroanatomy of Alzheimer's disease. Reviews in the Neurosciences 2, 101–122.
Pearson, R. C. A., Esiri, M. M., Hiorns, R. W., Wilcock, G. & Powell, T. P. S. (1985). Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer's disease. Proceedings of the National Academy of Sciences, USA 82, 4531–4535.
Perrett, C. W., Marchbanks, R. M. & Whatley, S. A. (1988). Characterisation of messenger RNA extracted post-mortem from the brains of schizophrenic, depressed and control subjects. Journal of Neurology, Neurosurgery and Psychiatry 51, 325–331.
Ross, J. (1989). The turnover of messenger RNA. Scientific American 260, 28–35.
St George Hyslop, P. H., Haines, J. L., Farrer, L. A., Polinsky, R., Van Broeckhoven, C., Goate, A., Crapper McLachlan, D. R., Orr, H., Bruni, A. C., Sorbi, S., Rainero, I., Foncin, J.-F., Pollen, D., Cantu, J.-M., Tupler, R., Voskresenskaya, N., Mayeux, R., Growdon, J., Fried, V. A., Myers, R. H., Nee, L., Backhovens, H., Martin, J.-J., Rossor, M. N., Owen, M. J., Mullan, M., Percy, M. E., Karlinsky, H., Rich, S., Heston, L., Montesi, M., Mortilla, M., Nacmias, N., Gusella, J. F. & Hardy, J. A. (1990). Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature 347, 194–197.
Sajdel-Sulkowska, E. M. & Marotta, C. A. (1984). Alzheimer's disease brain: alterations in RNA levels and in a ribonuclease-inhibitor complex. Science 225, 947–949.
Sajdel-Sulkowska, E. M., Majocha, R. A., Salim, M., Zain, S. B. & Marotta, C. A. (1988). The post mortem Alzheimer brain is a source of structurally and functionally intact astrocytic messenger RNA. Journal of Neuroscience Methods 23, 173–179.
Selkoe, D. J. (1989). Biochemistry of altered brain proteins in Alzheimer's disease. Annual Review of Neuroscience 12, 463–490.
Somerville, M. J., Percy, M. E., Bergeron, C., Yoong, L. K. K., Grima, E. A. & McLachlan, D. R. C. (1991). Localization and quantitation of 68 kDa neurofilament and superoxide dismutase-I mRNA in Alzheimer brain. Molecular Brain Research 9, 1–14.
Tabaton, M., Cammarata, S., Manetto, V., Perry, G. & Mancardi, G. (1989). Tau-reactive neurofibrillary tangles in cerebellar cortex from patients with Alzheimer's disease. Neuroscience Letters 103, 259–262.
Taylor, G. R., Carter, G. I., Crow, T. J., Johnson, J. A., Fairbairn, A. F., Perry, E. K. & Perry, R. H. (1986). Recovery and measurement of specific RNA species from postmortem brain tissue: a general reduction in Alzheimer's disease detected by molecular hybridization. Experimental and Molecular Pathology 44, 111–116.
Tomlinson, B. E. & Corsellis, J. A. N. (1984). Aging and the dementias. In Greenfield's Neuropathology, 4th edn. (ed. Adams, J. H., Corsellis, J. A. N. and Duchen, L. W.), pp. 951–1025. Butterworth: London.
Uemura, E. & Hartmann, H. (1979). Quantitative studies of neuronal RNA on the subiculum of demented old individuals. Brain Research Bulletin 4, 301–305.
Walker, D. G., Boyes, P. L. & McGeer, E. G. (1989). Strategies for the identification of novel brain specific genes affected in Alzheimer's disease. Canadian Journal of Neurological Sciences 16, 483–489.
Zhang, H., Sternberger, N. H., Rubinstein, L. J., Herman, M. M., Binder, L. I. & Sternberger, L. A. (1989). Abnormal phosphorylation of multiple proteins in Alzheimer's disease. Proceedings of the National Academy of Sciences USA 86, 8045–8049.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *

CAPTCHA *

Skip to the audio challenge
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 5 *
Loading metrics...

Abstract views

Total abstract views: 91 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 12th June 2018. This data will be updated every 24 hours.

Cancel
Confirm
×