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The role of oestrogen replacement in the climacteric syndrome

Abstract
synopsis

Using a double-blind placebo-controlled cross-over design, the effect of equine conjugated oestrogens tablets (Premarin®) was studied in 20 women with the climacteric syndrome followed during 15 months. Sixteen women were equally improved on placebo and oestrogen. Only 2 patients had an improved sense of well-being on oestrogen and not on placebo. The psychological diagnosis was unrelated to the subjective response to oestrogen or placebo. Performance in psychological tests administered before and during treatment periods was not changed by oestrogen or placebo.

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1Address for correspondence: Dr Rudi Borth, Department of Obstetrics and Gynaecology, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8.
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H. I. Kantor , C. M. Michael & H. Shore (1973). Estrogen for older women. American Journal of Obstetrics and Gynecology 116, 115118.

H. S. Kupperman , B. B. Wetchler & M. G. Blatt (1959). Contemporary therapy of the menopausal syndrome. Journal of the American Medical Assocation 171, 16271637.

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R. A. Wilson & T. A. Wilson (1963). The fate of the non-treated post-menopausal woman: a plea for the maintenance of adequate oestrogen from puberty to the grave. Journal of the American Geriatrics Society 11, 347362.

B.J. Winer (1962). Statistical Principles in Experimental Design. McGraw-Hill: New York.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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