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Separation of genetic influences on attention deficit hyperactivity disorder symptoms and reaction time performance from those on IQ

  • A. C. Wood (a1), P. Asherson (a1), J. J. van der Meere (a2) and J. Kuntsi (a1)
  • DOI: http://dx.doi.org/10.1017/S003329170999119X
  • Published online: 15 September 2009
Abstract
Background

Attention deficit hyperactivity disorder (ADHD) shows a strong phenotypic and genetic association with reaction time (RT) variability, considered to reflect lapses in attention. Yet we know little about whether this aetiological pathway is shared with other affected cognitive processes in ADHD, such as lower IQs or the generally slower responses (mean RTs). We aimed to address the question of whether a shared set of genes exist that influence RT variability, mean RT, IQ and ADHD symptom scores, or whether there is evidence of separate aetiological pathways.

Method

Multivariate structural equation modelling on cognitive tasks data (providing RT data), IQ and ADHD ratings by parents and teachers collected on general population sample of 1314 twins, at ages 7–10 years.

Results

Multivariate structural equation models indicated that the shared genetic influences underlying both ADHD symptom scores and RT variability are also shared with those underlying mean RT, with both types of RT data largely indexing the same underlying liability. By contrast, the shared genetic influences on ADHD symptom scores and RT variability (or mean RT) are largely independent of the genetic influences that ADHD symptom scores share with IQ.

Conclusions

The finding of unique aetiological pathways between IQ and RT data, but shared components between mean RT, RT variability and ADHD symptom scores, illustrates key influences in the genetic architecture of the cognitive and energetic processes that underlie the behavioural symptoms of ADHD. In addition, the multivariate genetic model fitting findings provide valuable information for future molecular genetic analyses.

Copyright
Corresponding author
*Address for correspondence: Miss A. C. Wood, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK. (Email: Lekki.Wood@Gmail.com)
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

MA Bellgrove , Z Hawi , A Kirley , M Gill , IH Robertson (2005). Dissecting the attention deficit hyperactivity disorder (ADHD) phenotype: sustained attention, response variability and spatial attentional asymmetries in relation to dopamine transporter (DAT1) genotype. Neuropsychologia 43, 18471857.

MA Bellgrove , R Hester , H Garavan (2004). The functional neuroanatomical correlates of response variability: evidence from a response inhibition task. Neuropsychologia 42, 19101916.

LC Bidwell , EG Willcutt , JC Defries , BF Pennington (2007). Testing for neuropsychological endophenotypes in siblings discordant for attention-deficit/hyperactivity disorder. Biological Psychiatry 62, 991998.

N Borger , J van der Meere (2000). Motor control and state regulation in children with ADHD: a cardiac response study. Biological Psychology 51, 247267.

FX Castellanos , R Tannock (2002). Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nature Reviews Neuroscience 3, 617628.

CK Conners , G Sitarenios , JD Parker , JN Epstein (1998 b). Revision and restandardization of the Conners' Teacher Rating Scale (CTRS-R): factor structure, reliability, and criterion validity. Journal of Abnormal Child Psychology 26, 279291.

SV Faraone , RH Perlis , AE Doyle , JW Smoller , JJ Goralnick , MA Holmgren , P Sklar (2005). Molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry 57, 13131323.

KA Johnson , SP Kelly , MA Bellgrove , E Barry , M Cox , M Gill , IH Robertson (2007). Response variability in attention deficit hyperactivity disorder: evidence for neuropsychological heterogeneity. Neuropsychologia 45, 630638.

KA Johnson , JR Wiersema , J Kuntsi (2009). What would Karl Popper say? Are current psychological theories of ADHD falsifiable? Behavioral and Brain Functions 5, 15.

C Klein , K Wendling , P Huettner , H Ruder , M Peper (2006). Intra-subject variability in attention-deficit hyperactivity disorder. Biological Psychiatry 60, 10881097.

J Kuntsi , P Andreou , J Ma , NA Borger , JJ van der Meere (2005). Testing assumptions for endophenotype studies in ADHD: reliability and validity of tasks in a general population sample. BMC Psychiatry 5, 40.

J Kuntsi , G McLoughlin , P Asherson (2006 a). Attention deficit hyperactivity disorder. Neuromolecular Medicine 8, 461484.

J Kuntsi , J Oosterlaan , J Stevenson (2001). Psychological mechanisms in hyperactivity: I. Response inhibition deficit, working memory impairment, delay aversion, or something else? Journal of Child Psychology and Psychiatry 42, 199210.

J Kuntsi , J Stevenson (2001). Psychological mechanisms in hyperactivity: II. The role of genetic factors. Journal of Child Psychology and Psychiatry 42, 211219.

C Leth-Steensen , ZK Elbaz , VI Douglas (2000). Mean response times, variability, and skew in the responding of ADHD children: a response time distributional approach. Acta Psychologica (Amsterdam) 104, 167190.

JC Loehlin (1996). The Cholesky approach: a cautionary note. Behavior Genetics 26, 6569.

SK Loo , SL Smalley (2008). Preliminary report of familial clustering of EEG measures in ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B, 107109.

M Luciano , MJ Wright , GM Geffen , LB Geffen , GA Smith , NG Martin (2004). A genetic investigation of the covariation among inspection time, choice reaction time, and IQ subtest scores. Behavior Genetics 34, 4150.

JT Nigg , LG Blaskey , JA Stawicki , J Sachek (2004). Evaluating the endophenotype model of ADHD neuropsychological deficit: results for parents and siblings of children with ADHD combined and inattentive subtypes. Journal of Abnormal Psychology 113, 614625.

RG O'Connell , MA Bellgrove , PM Dockree , A Lau , M Fitzgerald , IH Robertson (2008). Self-Alert Training: volitional modulation of autonomic arousal improves sustained attention. Neuropsychologia 46, 13791390.

TS Price , B Freeman , I Craig , SA Petrill , L Ebersole , R Plomin (2000). Infant zygosity can be assigned by parental report questionnaire data. Twin Research 3, 129133.

FV Rijsdijk , PC Sham (2002). Analytic approaches to twin data using structural equation models. Briefings in Bioinformatics 3, 119133.

NN Rommelse (2008). Endophenotypes in the genetic research of ADHD over the last decade: have they lived up to their expectations? Expert Review of Neurotherapeutics 8, 14251429.

NN Rommelse , ME Altink , J Oosterlaan , L Beem , CJ Buschgens , J Buitelaar , JA Sergeant (2008). Speed, variability, and timing of motor output in ADHD: which measures are useful for endophenotypic research? Behavior Genetics 38, 121132.

JA Sergeant (2005). Modeling attention-deficit/hyperactivity disorder: a critical appraisal of the cognitive-energetic model. Biological Psychiatry 57, 12481255.

FM Spinath , TG O'Connor (2003). A behavioral genetic study of the overlap between personality and parenting. Journal of Personality 71, 785808.

A Trouton , FM Spinath , R Plomin (2002). Twins early development study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood. Twin Research 5, 444448.

J van der Meere , N Stemerdink , B Gunning (1995). Effects of presentation rate of stimuli on response inhibition in ADHD children with and without tics. Perceptual and Motor Skills 81, 259262.

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