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Symptoms of depression and anxiety, and change in body mass index from adolescence to adulthood: results from a British birth cohort

  • D. Gaysina (a1), M. Hotopf (a2), M. Richards (a1), I. Colman (a3), D. Kuh (a1) and R. Hardy (a1)
  • DOI:
  • Published online: 18 March 2010

Depression and anxiety have been shown to be associated with obesity and underweight, but little is known about how the relationship varies across the life course, from adolescence through adulthood. We aimed to investigate the association between adolescent- and adult-onset affective symptoms and body mass index (BMI) change from age 15 to 53 years.


We used data from a British birth cohort born in 1946 and followed up ever since. The relationship between affective symptom profiles, distinguishing adolescent-onset and adult-onset symptoms, and BMI change from adolescence to age 53 years was investigated using multilevel models.


Women with adolescent-onset symptoms had lower mean BMI at age 15 years, faster rates of increase across adulthood, and higher BMI at age 53 years than those with no symptoms. Men with adolescent-onset symptoms had lower BMI at all ages from 15 to 53 years. The BMI trajectories of men and women with adult-onset symptoms did not differ from those with absence of symptoms at all ages.


The relationship between affective symptoms and change in BMI varies by sex and age at onset of symptoms. Adolescence may be an important period for the development of the association between affective symptoms and weight gain in girls. Intervention to prevent increases in BMI across adult life in women with adolescent-onset symptoms, even if they are not overweight at this age, should be considered.

Corresponding author
*Address for correspondence: D. Gaysina, Ph.D., MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, LondonWC1B 5JU, UK. (Email:
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SE Anderson , P Cohen , EN Naumova , A Must (2006). Association of depression and anxiety disorders with weight change in a prospective community-based study of children followed up into adulthood. Archives of Pediatrics and Adolescent Medicine 160, 285291.

E Atlantis , M Baker (2008). Obesity effects on depression: systematic review of epidemiological studies. International Journal of Obesity 32, 881891.

AM Bardone , TE Moffitt , A Caspi , N Dickson , WR Stanton , PA Silva (1998). Adult physical health outcomes of adolescent girls with conduct disorder, depression, and anxiety. Journal of the American Academy of Child and Adolescent Psychiatry 37, 594601.

JC Barefoot , BL Heitmann , MJ Helms , RB Williams , RS Surwit , IC Siegler (1998). Symptoms of depression and changes in body weight from adolescence to mid-life. International Journal of Obesity and Related Metabolic Disorders 22, 688694.

T Bjorge , A Engeland , A Tverdal , GD Smith (2008). Body mass index in adolescence in relation to cause-specific mortality: a follow-up of 230,000 Norwegian adolescents. American Journal of Epidemiology 168, 3037.

B Blaine (2008). Does depression cause obesity?: a meta-analysis of longitudinal studies of depression and weight control. Journal of Health Psychology 13, 11901197.

SR Bornstein , A Schuppenies , ML Wong , J Licinio (2006). Approaching the shared biology of obesity and depression: the stress axis as the locus of gene–environment interactions. Molecular Psychiatry 11, 892902.

MO Chaiton , JE Cohen , J O'Loughlin , J Rehm (2009). A systematic review of longitudinal studies on the association between depression and smoking in adolescents. BMC Public Health 9, 356.

S Clennell , D Kuh , JM Guralnik , KV Patel , GD Mishra (2008). Characterisation of smoking behaviour across the life course and its impact on decline in lung function and all-cause mortality: evidence from a British birth cohort. Journal of Epidemiology and Community Health 62, 10511056.

I Colman , J Murray , RA Abbott , B Maughan , D Kuh , TJ Croudace , PB Jones (2009). Outcomes of conduct problems in adolescence: 40 year follow-up of national cohort. British Medical Journal 338, a2981.

I Colman , GB Ploubidis , ME Wadsworth , PB Jones , TJ Croudace (2007 a). A longitudinal typology of symptoms of depression and anxiety over the life course. Biological Psychiatry 62, 12651271.

I Colman , ME Wadsworth , TJ Croudace , PB Jones (2007 b). Forty-year psychiatric outcomes following assessment for internalizing disorder in adolescence. American Journal of Psychiatry 164, 126133.

MT Compton , GL Daumit , BG Druss (2006). Cigarette smoking and overweight/obesity among individuals with serious mental illnesses: a preventive perspective. Harvard Review of Psychiatry 14, 212222.

LM de Wit , A van Straten , M van Herten , BW Penninx , P Cuijpers (2009). Depression and body mass index, a U-shaped association. BMC Public Health 9, 14.

Diverse Populations Collaboration (2005). Weight–height relationships and body mass index: some observations from the diverse populations collaboration. American Journal of Physical Anthropology 128, 220229.

CS Duarte , A Sourander , G Nikolakaros , H Pihlajamaki , H Helenius , J Piha , K Kumpulainen , I Moilanen , T Tamminen , F Almqvist , A Must (2010). Child mental health problems and obesity in early adulthood. Journal of Pediatrics 156, 9397.

VL Forman-Hoffman , JW Yankey , SL Hillis , RB Wallace , FD Wolinsky (2007). Weight and depressive symptoms in older adults: direction of influence? Journals of Gerontology B Psychological Sciences and Social Sciences 62, S43S51.

X Ge , RD Conger , GH Elder Jr. (2001). Pubertal transition, stressful life events, and the emergence of gender differences in adolescent depressive symptoms. Developmental Psychology 37, 404417.

E Goodman , RC Whitaker (2002). A prospective study of the role of depression in the development and persistence of adolescent obesity. Pediatrics 110, 497504.

R Hardy , M Wadsworth , D Kuh (2000). The influence of childhood weight and socioeconomic status on change in adult body mass index in a British national birth cohort. International Journal of Obesity and Related Metabolic Disorders 24, 725734.

T Harris (2001). Recent developments in understanding the psychosocial aspects of depression. British Medical Bulletin 57, 1732.

G Hasler , DS Pine , DG Kleinbaum , A Gamma , D Luckenbaugh , V Ajdacic , D Eich , W Rossler , J Angst (2005). Depressive symptoms during childhood and adult obesity: the Zurich Cohort Study. Molecular Psychiatry 10, 842850.

A Haukkala , A Uutela , V Salomaa (2001). Depressive symptoms, cynical hostility, and weight change: a 3-year follow-up among middle-aged men and women. International Journal of Behavioral Medicine 8, 116133.

SR Jaffee , TE Moffitt , A Caspi , E Fombonne , R Poulton , J Martin (2002). Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Archives of General Psychiatry 59, 215222.

P Jones , B Rodgers , R Murray , M Marmot (1994). Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet 344, 13981402.

J Kaufman , A Martin , RA King , D Charney (2001). Are child-, adolescent-, and adult-onset depression one and the same disorder? Biological Psychiatry 49, 980–1001.

M Kivimaki , GD Batty , A Singh-Manoux , H Nabi , S Sabia , AG Tabak , TN Akbaraly , J Vahtera , MG Marmot , M Jokela (2009). Association between common mental disorder and obesity over the adult life course. British Journal of Psychiatry 195, 149155.

D Kuh , Y Ben Shlomo , J Lynch , J Hallqvist , C Power (2003). Life course epidemiology. Journal of Epidemiology and Community Health 57, 778783.

ET Liem , PJ Sauer , AJ Oldehinkel , RP Stolk (2008). Association between depressive symptoms in childhood and adolescence and overweight in later life: review of the recent literature. Archives of Pediatrics and Adolescent Medicine 162, 981988.

M Lindelow , R Hardy , B Rodgers (1997). Development of a scale to measure symptoms of anxiety and depression in the general UK population: The Psychiatric Symptom Frequency Scale. Journal of Epidemiology and Community Health 51, 549557.

PK Magnusson , F Rasmussen , DA Lawlor , P Tynelius , D Gunnell (2006). Association of body mass index with suicide mortality: a prospective cohort study of more than one million men. American Journal of Epidemiology 163, 18.

AA Mamun , MJ O'Callaghan , SM Cramb , JM Najman , GM Williams , W Bor (2009). Childhood behavioral problems predict young adults' BMI and obesity: evidence from a birth cohort study. Obesity 17, 761766.

B Maughan (2002). Depression and psychological distress: a life course perspective. In A Life Course Approach to Women's Health (ed. D. Kuh and R. Hardy ), pp. 161176. Oxford University Press: Oxford.

ME Moore , A Stunkard , L Srole (1997). Obesity, social class, and mental illness. 1962. Obesity Research 5, 503508.

JG Noll , MH Zeller , PK Trickett , FW Putnam (2007). Obesity risk for female victims of childhood sexual abuse: a prospective study. Pediatrics 120, e61e67.

DS Pine , P Cohen , J Brook , JD Coplan (1997). Psychiatric symptoms in adolescence as predictors of obesity in early adulthood: a longitudinal study. American Journal of Public Health 87, 13031310.

DS Pine , RB Goldstein , S Wolk , MM Weissman (2001). The association between childhood depression and adulthood body mass index. Pediatrics 107, 10491056.

LP Richardson , R Davis , R Poulton , E McCauley , TE Moffitt , A Caspi , F Connell (2003). A longitudinal evaluation of adolescent depression and adult obesity. Archives of Pediatrics and Adolescent Medicine 157, 739745.

RE Roberts , S Deleger , WJ Strawbridge , GA Kaplan (2003). Prospective association between obesity and depression: evidence from the Alameda County Study. International Journal of Obesity and Related Metabolic Disorders 27, 514521.

M Rutter (1967). A children's behaviour questionnaire for completion by teachers: preliminary findings. Journal of Child Psychology and Psychiatry 8, 111.

Y Schutz , V Woringer (2002). Obesity in Switzerland: a critical assessment of prevalence in children and adults. International Journal of Obesity and Related Metabolic Disorders 26 (Suppl. 2), S3–S11.

E Stice , K Presnell , D Spangler (2002). Risk factors for binge eating onset in adolescent girls: a 2-year prospective investigation. Health Psychology 21, 131138.

AJ Stunkard , MS Faith , KC Allison (2003). Depression and obesity. Biological Psychiatry 54, 330337.

M Tanofsky-Kraff , ML Cohen , SZ Yanovski , C Cox , KR Theim , M Keil , JC Reynolds , JA Yanovski (2006). A prospective study of psychological predictors of body fat gain among children at high risk for adult obesity. Pediatrics 117, 12031209.

MH Teicher , JA Samson , A Polcari , SL Andersen (2009). Length of time between onset of childhood sexual abuse and emergence of depression in a young adult sample: a retrospective clinical report. Journal of Clinical Psychiatry 70, 684691.

A Ternouth , D Collier , B Maughan (2009). Childhood emotional problems and self-perceptions predict weight gain in a longitudinal regression model. BMC Medicine 7, 46.

J van Os , P Jones , G Lewis , M Wadsworth , R Murray (1997). Developmental precursors of affective illness in a general population birth cohort. Archives of General Psychiatry 54, 625631.

ME Wadsworth , SL Butterworth , RJ Hardy , DJ Kuh , M Richards , C Langenberg , WS Hilder , M Connor (2003). The life course prospective design: an example of benefits and problems associated with study longevity. Social Science and Medicine 57, 21932205.

DF Williamson , TJ Thompson , RF Anda , WH Dietz , V Felitti (2002). Body weight and obesity in adults and self-reported abuse in childhood. International Journal of Obesity and Related Metabolic Disorders 26, 10751082.

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