Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 68
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Brielmaier, J. Senerth, J. M. Silverman, J. L. Matteson, P. G. Millonig, J. H. DiCicco-Bloom, E. and Crawley, J. N. 2014. Chronic desipramine treatment rescues depression-related, social and cognitive deficits inEngrailed-2knockout mice. Genes, Brain and Behavior, Vol. 13, Issue. 3, p. 286.

    Guo, M and Lu, X-Y 2014. Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates. Translational Psychiatry, Vol. 4, Issue. 12, p. e486.

    Gorwood, P. Bayle, F. Vaiva, G. Courtet, P. Corruble, E. and Llorca, P.-M. 2013. Is it worth assessing progress as early as week 2 to adapt antidepressive treatment strategy? Results from a study on agomelatine and a global meta-analysis. European Psychiatry, Vol. 28, Issue. 6, p. 362.

    Sakurai, Hitoshi Uchida, Hiroyuki Abe, Takayuki Nakajima, Shinichiro Suzuki, Takefumi Pollock, Bruce G. Sato, Yuji and Mimura, Masaru 2013. Trajectories of individual symptoms in remitters versus non-remitters with depression. Journal of Affective Disorders, Vol. 151, Issue. 2, p. 506.

    Schaffer, Ayal Kreindler, David Reis, Catherine and Levitt, Anthony J. 2013. Use of Mental Health Telemetry to Enhance Identification and Predictive Value of Early Changes During Augmentation Treatment of Major Depression. Journal of Clinical Psychopharmacology, Vol. 33, Issue. 6, p. 775.

    Douglas, K. M. Porter, R. J. Knight, R. G. and Maruff, P. 2011. Neuropsychological changes and treatment response in severe depression. The British Journal of Psychiatry, Vol. 198, Issue. 2, p. 115.

    Katz, Martin M. Berman, Nancy Bowden, Charles L. and Frazer, Alan 2011. The Componential Approach Enhances the Effectiveness of 2-Week Trials for New Antidepressants. Journal of Clinical Psychopharmacology, Vol. 31, Issue. 2, p. 253.

    Lin, Ching-Hua Lane, Hsien-Yuan Chen, Cheng-Chung Juo, Suh-Hang Hank and Yen, Cheng-Fang 2011. Early Prediction of Fluoxetine Response for Han Chinese Inpatients With Major Depressive Disorder. Journal of Clinical Psychopharmacology, Vol. 31, Issue. 2, p. 187.

    Nakajima, Shinichiro Suzuki, Takefumi Watanabe, Koichiro Kashima, Haruo and Uchida, Hiroyuki 2010. Accelerating response to antidepressant treatment in depression: A review and clinical suggestions. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 34, Issue. 2, p. 259.

    Vieira, Rodrigo Machado Baumann, Jacqueline Wheeler-Castillo, Cristina Latov, David Henter, Ioline D. Salvadore, Giacomo and Zarate Jr., Carlos A. 2010. The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments. Pharmaceuticals, Vol. 3, Issue. 1, p. 19.

    Katz, Martin M. 2009. Reply to Drs Rickels and Robinson's Comments on "Clinical Trials of Antidepressants: Time to Shift to a New Model". Journal of Clinical Psychopharmacology, Vol. 29, Issue. 2, p. 198.

    Morris, David W. Trivedi, Madhukar H. Fava, Maurizio Wisniewski, Stephen R. Balasubramani, G. K. Khan, Ahsan Y. Jain, Shailesh and Rush, A. John 2009. Diurnal mood variation in outpatients with major depressive disorder. Depression and Anxiety, Vol. 26, Issue. 9, p. 851.

    Fava, Giovanni A. and Tossani, Eliana 2007. Prodromal stage of major depression. Early Intervention in Psychiatry, Vol. 1, Issue. 1, p. 9.

    Gomeni, Roberto and Merlo-Pich, Emilio 2007. Bayesian modelling and ROC analysis to predict placebo responders using clinical score measured in the initial weeks of treatment in depression trials. British Journal of Clinical Pharmacology, Vol. 63, Issue. 5, p. 595.

    Malatynska, Ewa Pinhasov, Albert Creighton, Christopher J. Crooke, Jeffrey J. Reitz, Allen B. Brenneman, Douglas E. and Lubomirski, Mariusz S. 2007. Assessing activity onset time and efficacy for clinically effective antidepressant and antimanic drugs in animal models based on dominant–submissive relationships. Neuroscience & Biobehavioral Reviews, Vol. 31, Issue. 6, p. 904.

    Papakostas, George I. Petersen, Timothy Sklarsky, Katherine G. Nierenberg, Andrew A. Alpert, Jonathan E. and Fava, Maurizio 2007. Timing of clinical improvement and symptom resolution in the treatment of major depressive disorder. Psychiatry Research, Vol. 149, Issue. 1-3, p. 195.

    Schmidt, Heath D. and Duman, Ronald S. 2007. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behavioural Pharmacology, Vol. 18, Issue. 5-6, p. 391.

    Averill, Patricia M. and Wassef, Adel A. 2006. WHO RECEIVES ANTIDEPRESSANTS AND WHAT IMPACT DO THEY HAVE? AN ACUTE-CARE STUDY. Psychiatric Quarterly, Vol. 77, Issue. 2, p. 139.

    Papakostas, George I. Perlis, Roy H. Scalia, Margaret J. Petersen, Timothy J. and Fava, Maurizio 2006. A Meta-Analysis of Early Sustained Response Rates Between Antidepressants and Placebo for the Treatment of Major Depressive Disorder. Journal of Clinical Psychopharmacology, Vol. 26, Issue. 1, p. 56.

    Brannan, Stephen K. Mallinckrodt, Craig H. Detke, Michael J. Watkin, John G. and Tollefson, Gary D. 2005. Onset of action for duloxetine 60 mg once daily: double-blind, placebo-controlled studies. Journal of Psychiatric Research, Vol. 39, Issue. 2, p. 161.


The timing, specificity and clinical prediction of tricyclic drug effects in depression

  • M. M. Katz (a1), S. H. Koslow (a1), J. W. Maas (a1), A. Frazer (a1), C. L. Bowden (a1), R. Casper (a1), J. Croughan (a1), J. Kocsis (a1) and E. Redmond (a1)
  • DOI:
  • Published online: 01 July 2009

This research was aimed at studying the rate of action of tricyclic drugs in depressive disorders, specifying the behavioural effects associated with recovery, and predicting clinical response. The research design involved comparison of a recovered group with a group treated for the equivalent four weeks, who showed minimal to no response. The findings indicated significant differences in baseline characteristics between responders and non-responders. Further, the drugs were found to act early in the responders, within the first week of treatment. Specific changes at one week which distinguished responder and non-responder groups occurred in the disturbed affects, and in cognitive functioning. Improvements also occurred in somatic symptoms, but these latter changes were general and not associated with later recovery. At 2½ weeks, all facets of the depressed condition showed positive change in the responders. Implications of the results for assessing rate of tricyclic drug actions, their effects on the interaction of affect and neurochemistry, and the practical application of the results for the clinical situation, are discussed.

Corresponding author
* Address for correspondence: Dr Martin M. Katz, Department of Psychiatry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

M. T. Abou-Saleh & A. Coppen (1983). Classification of depression and response to anti-depressive therapies. British Journal of Psychiatry 143, 601603.

A. DiMascio , M. M. Weissman , B. A. Prusoff , C. Neu , M. Zwilling & G. L. Klerman (1979). Differential symptom reduction by drugs and psychotherapy in acute depression. Archives of General Psychiatry 36,14501456.

J. Endicott & R. K. Spitzer (1978). A diagnostic interview: the schedule for affective disorders and schizophrenia. Archives of General Psychiatry 35, 837844.

J. Endicott , R. L. Spitzer , J. L. Fleiss & J. Cohen (1976). The global assessment scale, a procedure for measuring overall severity of psychiatric disturbance. Archives of General Psychiatry 33, 766771.

A. Frazer , I. Lucki & M. Sills (1985). Alterations in monoaminecontaining neuronal function due to administration of antidepressants repeatedly to rats. Acta Pharmacologica et Toxicologica 56, (Supplement 1), 2134.

M. Hamilton (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 5662.

L. Hollister , J. E. Overall , M. Johnson , V. Pennington , G. Katz & J. Shelton (1964). Controlled comparison of amitriptyline, imipramine and placebo in hospitalized depressed patients. Journal of Nervous and Mental Diseases 139, 370375.

M. M. Katz , S. H. Koslow , N. Berman , S. Secunda , J. W. Maas , R. Casper , J. Koscis & P. Stokes (1984). Multivantaged approach to the measurement of behavioural and affect states for clinical and psychological research. Psychological Reports 55, 619671.

F. M. Quitkin , J. G. Rabkin , D. Ross & P. J. McGrath (1984). Duration of anti-depressant drug treatment. Archives of General Psychiatry 41, 238245.

R. L. Spitzer , J. Endicott & R. Robins (1978). Research diagnostic criteria. Archives of General Psychiatry 35, 713782.

M. F. Sugrue (1983). Chronic antidepressant therapy and associated changesin central monoaminergic receptor functioning. Pharmacology and Therapeutics 21, 133.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *