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The ‘well control’ artefact in case/control studies of specific psychiatric disorders

  • Sharon Schwartz (a1) and Bruce G. Link (a1)
  • DOI: http://dx.doi.org/10.1017/S0033291700024338
  • Published online: 01 July 2009
Abstract
Synopsis

An appropriate choice of controls in case/control studies of specific psychiatric disorders is crucial for valid risk-factor assessment. One suggested approach to control-group selection, the use of a well control group, is the focus of this paper. While using well controls has intuitive appeal, this paper shows that such a procedure can lead to ambiguous and biased results.

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Corresponding author
1Address for correspondence: Dr Sharon Schwartz, Social Psychiatry Research Unit, Columbia University, 100 Haven Avenue, Tower III 19E, New York, New York 10032, USA.
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

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D. L. Sackett (1979). Bias in analytic research. Journal of Chronic Diseases 32, 5163.

J. Schlesselmann (1985). Valid selection of subjects in case-control studies. Journal of Chronic Diseases 38, 549550.

S. Shapiro , E. Skinner , L. Kessler , M. VonKorff , P. German , G. Tischler , P. Leaf , L. Benham , L. Cottler & D. Regier (1984). Utilization of health and mental health services: three epidemiologic catchment area sites. Archives of General Psychiatry 41, 971978.

W. Spitzer (1985). Ideas and words: two dimensions for debates on case controlling. Journal of Chronic Diseases 38, 541542.

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Psychological Medicine
  • ISSN: 0033-2917
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