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Association between betel-nut chewing and chronic kidney disease in men

  • Che-Yi Chou (a1), Shi-Yann Cheng (a2), Jiung-Hsiun Liu (a1), Wen-Chun Cheng (a3), I-Min Kang (a4), Yu-Hsiang Tseng (a3), Chuen-Ming Shih (a3) and Walter Chen (a3)
  • DOI:
  • Published online: 01 May 2009

Betel-nut use is associated with metabolic syndrome and obesity. However, the association between betel-nut chewing and risk for chronic kidney disease (CKD) is unknown. The present study was conducted to determine the association between betel-nut chewing and CKD in men.


We retrospectively reviewed health-check records of 3264 men in a hospital-based cross-sectional screening programme from 2003 to 2006. CKD was defined as estimated glomerular filtration rate less than 60 ml/min/1·73 m2 calculated by the Modification of Diet in Renal Disease formula. Risk factors for CKD including diabetes, hypertension, BMI, smoking, alcohol consumption and age were also considered.


A total of 677 (20·7 %) men were found to have CKD and 427 (13·1 %) participants reported a history of betel-nut use. The prevalence (24·8 %) of CKD in betel-nut users was significantly higher than that (11·3 %) of participants without betel-nut use (P = 0·026). In multivariate logistic regression analysis with adjustments for age, hypertension, diabetes and hyperlipidaemia, betel-nut use was independently associated with CKD (P < 0·001). The adjusted odds ratio for betel-nut use was 2·572 (95 % CI 1·917, 3·451).


Betel-nut use is associated with CKD in men. The association between betel-nut use and CKD is independent of age, BMI, smoking, alcohol consumption, hypertension, diabetes and hyperlipidaemia.

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Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
  • URL: /core/journals/public-health-nutrition
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