Skip to main content
×
Home
    • Aa
    • Aa

Association between serum 25-hydroxyvitamin D concentration and symptoms of respiratory tract infection in a Norwegian population: the Tromsø Study

  • Steinar Robertsen (a1), Guri Grimnes (a2) and Hasse Melbye (a1)
Abstract
Abstract Objective

Previous studies have suggested anti-infection effects of vitamin D, although the associations reported between vitamin D (serum 25-hydroxyvitamin D (25(OH)D) concentration) and respiratory tract infection (RTI) are conflicting. The main aim of the present study was to explore this association in a Norwegian population.

Design

We examined the association between serum 25(OH)D and recent RTI symptoms in 6350 middle-aged and elderly participants in the Tromsø Study 6. The main outcome measurement was self-reported RTI symptoms in the previous week.

Setting

Tromsø, Norway, 69°N.

Subjects

Six thousand three hundred and fifty middle-aged and elderly residents of Tromsø.

Results

Of the 6350 included, 791 (12·5 %) reported RTI symptoms in the previous week. We classified serum 25(OH)D concentrations into quartiles and adjusted the data for current smoking habit and month of attendance. The prevalence of RTI symptoms did not increase with decreasing serum 25(OH)D level, was highest in quartile 3 (15·0 %) followed by quartile 4 (12·4 %), and was lowest in quartiles 1 and 2 (11·1 % and 11·4 %). There was no trend for increasing duration of illness with decreasing serum 25(OH)D. The prevalence of RTI symptoms was not significantly associated with the intake of fish, n-3 capsules or vitamin and/or mineral supplements, or sun exposure. Only use of cod-liver oil or fish oil capsules daily or sometimes was significantly associated with fewer RTI symptoms during the preceding 7 d (P = 0·04).

Conclusions

Low serum 25(OH)D was not associated with increased prevalence of recent RTI symptoms. Our findings do not support the idea that vitamin D supplementation can reduce the incidence of RTI in Norway.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Association between serum 25-hydroxyvitamin D concentration and symptoms of respiratory tract infection in a Norwegian population: the Tromsø Study
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Association between serum 25-hydroxyvitamin D concentration and symptoms of respiratory tract infection in a Norwegian population: the Tromsø Study
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Association between serum 25-hydroxyvitamin D concentration and symptoms of respiratory tract infection in a Norwegian population: the Tromsø Study
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Email Steinar.robertsen@uit.no
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1. M Gulliford , R Latinovic , J Charlton et al. (2009) Selective decrease in consultations and antibiotic prescribing for acute respiratory tract infections in UK primary care up to 2006. J Public Health (Oxf) 31, 512520.

2. AA Ginde , JM Mansbach & CA Camargo Jr (2009) Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 169, 384390.

4. AM Fendrick , AS Monto , B Nightengale et al. (2003) The economic burden of non-influenza-related viral respiratory tract infection in the United States. Arch Intern Med 163, 487494.

5. TJ Bramley , D Lerner & M Sames (2002) Productivity losses related to the common cold. J Occup Environ Med 44, 822829.

6. AC Ross , JE Manson , SA Abrams et al. (2011) The 2011 Dietary Reference Intakes for Calcium and Vitamin D: what dietetics practitioners need to know. J Am Diet Assoc 111, 524527.

7. MF Holick , M Uskokovic , JW Henley et al. (1980) The photoproduction of 1α,25-dihydroxyvitamin D3 in skin: an approach to the therapy of vitamin-D-resistant syndromes. N Engl J Med 303, 349354.

8. I Laaksi , JP Ruohola , V Mattila et al. (2010) Vitamin D supplementation for the prevention of acute respiratory tract infection: a randomized, double-blinded trial among young Finnish men. J Infect Dis 202, 809814.

9. O Engelsen , M Brustad , L Aksnes et al. (2005) Daily duration of vitamin D synthesis in human skin with relation to latitude, total ozone, altitude, ground cover, aerosols and cloud thickness. Photochem Photobiol 81, 12871290.

11. M Brustad , E Alsaker , O Engelsen et al. (2004) Vitamin D status of middle-aged women at 65–71°N in relation to dietary intake and exposure to ultraviolet radiation. Public Health Nutr 7, 327335.

13. MF Holick (2007) Vitamin D deficiency. N Engl J Med 357, 266281.

14. E Giovannucci , Y Liu , BW Hollis et al. (2008) 25-Hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 168, 11741180.

15. ML Melamed , P Muntner , ED Michos et al. (2008) Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004. Arterioscler Thromb Vasc Biol 28, 11791185.

16. S Pilz , H Dobnig , JE Fischer et al. (2008) Low vitamin D levels predict stroke in patients referred to coronary angiography. Stroke 39, 26112613.

21. S Aydin , I Aslan , I Yildiz et al. (2011) Vitamin D levels in children with recurrent tonsillitis. Int J Pediatr Otorhinolaryngol 75, 364367.

22. BK Jacobsen , AE Eggen , EB Mathiesen et al. (2011) Cohort profile: the Tromso Study. Int J Epidemiol 41, 961967.

23. R Jorde , M Sneve , M Hutchinson et al. (2010) Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study. Am J Epidemiol 171, 903908.

24. H Melbye , K Amundsen , J Brox et al. (2011) The association between self-reported symptoms of recent airway infection and CRP values in a general population. The Tromso Study: Tromso 6. Inflammation 35, 10151022.

25. MR Miller , J Hankinson , V Brusasco et al. (2005) Standardisation of spirometry. Eur Respir J 26, 319338.

26. A Langhammer , R Johnsen , A Gulsvik et al. (2001) Forced spirometry reference values for Norwegian adults: the Bronchial Obstruction in Nord-Trondelag Study. Eur Respir J 18, 770779.

28. G Grimnes , B Almaas , AE Eggen et al. (2010) Effect of smoking on the serum levels of 25-hydroxyvitamin D depends on the assay employed. Eur J Endocrinol 163, 339348.

29. R Jorde , M Witham , W Janssens et al. (2012) Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized clinical trials. Scand J Infect Dis 44, 126132.

30. MF Holick (2005) Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. South Med J 98, 10241027.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
  • URL: /core/journals/public-health-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 7
Total number of PDF views: 63 *
Loading metrics...

Abstract views

Total abstract views: 160 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 21st August 2017. This data will be updated every 24 hours.