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Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis

  • Yimin Zhao (a1) (a2), Kejian Wu (a1) (a2), Jusheng Zheng (a1) (a2), Ruiting Zuo (a1) (a2) and Duo Li (a1) (a2)...

We aimed to use the meta-analysis method to assess the relationship between coffee drinking and all-cause mortality.


Categorical and dose–response meta-analyses were conducted using random-effects models.


We systematically searched and identified eligible literature in the PubMed and Scopus databases.


Seventeen studies including 1 054 571 participants and 131 212 death events from all causes were included in the present study.


Seventeen studies were included and evaluated in the meta-analysis. A U-shaped dose–response relationship was found between coffee consumption and all-cause mortality (P for non-linearity <0·001). Compared with non/occasional coffee drinkers, the relative risks for all-cause mortality were 0·89 (95 % CI 0·85, 0·93) for 1–<3 cups/d, 0·87 (95 % CI 0·83, 0·91) for 3–<5 cups/d and 0·90 (95 % CI 0·87, 0·94) for ≥5 cups/d, and the relationship was more marked in females than in males.


The present meta-analysis of prospective cohort studies indicated that light to moderate coffee intake is associated with a reduced risk of death from all causes, particularly in women.

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1.RM Van Dam & FB Hu (2005) Coffee consumption and risk of type 2 diabetes. JAMA 294, 97104.

2.GY Lai , SJ Weinstein , D Albanes et al. (2013) The association of coffee intake with liver cancer incidence and chronic liver disease mortality in male smokers. Br J Cancer 109, 13441351.

3.M Misik , C Hoelzl , KH Wagner et al. (2010) Impact of paper filtered coffee on oxidative DNA-damage: results of a clinical trial. Mutat Res 692, 4248.

4.ND Freedman , Y Park , CC Abnet et al. (2012) Association of coffee drinking with total and cause-specific mortality. N Engl J Med 366, 18911904.

5.J Liu , X Sui , CJ Lavie et al. (2013) Association of coffee consumption with all-cause and cardiovascular disease mortality. Mayo Clin Proc 88, 10661074.

6.A Tamakoshi , Y Lin , M Kawado et al. (2011) Effect of coffee consumption on all-cause and total cancer mortality: findings from the JACC study. Eur J Epidemiol 26, 285293.

7.JH O’Keefe , SK Bhatti , HR Patil et al. (2013) Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality. J Am Coll Cardiol 62, 10431051.

8.E Lopez-Garcia , RM van Dam , TY Li et al. (2008) The relationship of coffee consumption with mortality. Ann Intern Med 148, 904914.

9.P Kleemola , P Jousilahti , P Pietinen et al. (2000) Coffee consumption and the risk of coronary heart disease and death. Arch Intern Med 160, 33933400.

10.J Wu , SC Ho , C Zhou et al. (2009) Coffee consumption and risk of coronary heart diseases: a meta-analysis of 21 prospective cohort studies. Int J Cardiol 137, 216225.

11.A Ascherio , SM Zhang , MA Hernán et al. (2001) Prospective study of caffeine consumption and risk of Parkinson’s disease in men and women. Ann Neurol 50, 5663.

12.J Higgins & SG Thompson (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21, 15391558.

13.D Jackson , IR White & SG Thompson (2010) Extending DerSimonian and Laird’s methodology to perform multivariate random effects meta-analyses. Stat Med 29, 12821297.

14.R DerSimonian & N Laird (1986) Meta-analysis in clinical trials. Control Clin Trials 7, 177188.

15.SC Larsson & N Orsini (2011) Coffee consumption and risk of stroke: a dose–response meta-analysis of prospective studies. Am J Epidemiol 174, 9931001.

16.M Egger , GD Smith , M Schneider et al. (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315, 629634.

18.FE Harrell (2001) Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis. New York: Springer.

19.N Orsini , R Li , A Wolk et al. (2012) Meta-analysis for linear and nonlinear dose–response relations: examples, an evaluation of approximations, and software. Am J Epidemiol 175, 6673.

22.HN Ahmed , EB Levitan , A Wolk et al. (2009) Coffee consumption and risk of heart failure in men: an analysis from the Cohort of Swedish Men. Am Heart J 158, 667672.

24.JM de Koning Gans , CS Uiterwaal , YT van der Schouw et al. (2010) Tea and coffee consumption and cardiovascular morbidity and mortality. Arterioscler Thromb Vasc Biol 30, 16651671.

25.H Gardener , T Rundek , CB Wright et al. (2013) Coffee and tea consumption are inversely associated with mortality in a multiethnic urban population. J Nutr 143, 12991308.

26.N Iwai , H Ohshiro , Y Kurozawa et al. (2002) Relationship between coffee and green tea consumption and all-cause mortality in a cohort of a rural Japanese population. J Epidemiol 12, 191198.

29.AL Klatsky , MA Armstrong & GD Friedman (1993) Coffee, tea, and mortality. Ann Epidemiol 3, 375381.

30.M Laaksonen , K Talala , T Martelin et al. (2008) Health behaviours as explanations for educational level differences in cardiovascular and all-cause mortality: a follow-up of 60 000 men and women over 23 years. Eur J Public Health 18, 3843.

31.A Paganini-Hill , CH Kawas & MM Corrada (2007) Non-alcoholic beverage and caffeine consumption and mortality: the Leisure World Cohort Study. Prev Med 44, 305310.

32.A Rosengren & L Wilhelmsen (1991) Coffee, coronary heart disease and mortality in middle-aged Swedish men: findings from the Primary Prevention Study. J Intern Med 230, 6771.

33.K Sugiyama , S Kuriyama , M Akhter et al. (2010) Coffee consumption and mortality due to all causes, cardiovascular disease, and cancer in Japanese women. J Nutr 140, 10071013.

36.E Mostofsky , MS Rice , EB Levitan et al. (2012) Habitual coffee consumption and risk of heart failure: a dose–response meta-analysis. Circ Heart Fail 5, 401405.

37.MA Hernan , B Takkouche , F Caamano Isorna et al. (2002) A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson’s disease. Ann Neurol 52, 276284.

38.X Yu , Z Bao , J Zou et al. (2011) Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer 11, 96102.

42.AE Mesas , LM Leon-Munoz , F Rodriguez-Artalejo et al. (2011) The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis. Am J Clin Nutr 94, 11131126.

43.SH Jee , J He , LJ Appel et al. (2001) Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol 153, 353362.

44.TA Corrêa , MM Rogero , BM Mioto et al. (2013) Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: a clinical trial. Nutrition 29, 977981.

45.Y Ye , GHA Said , Y Lin et al. (2008) Caffeinated coffee blunts the myocardial protective effects of statins against ischemia-reperfusion injury in the rat. Cardiovasc Drugs Ther 22, 275282.

46.A Gunes & M Dahl (2008) Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms. Pharmacogenomics 9, 625637.

48.EC Lowcock , M Cotterchio , LN Anderson et al. (2013) High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype. Nutr Cancer 65, 398409.

49.H Hallstrom , H Melhus , A Glynn et al. (2010) Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study. Nutr Metab (Lond) 7, 1220.

51.NH Farag , TL Whitsett , BS Mckey et al. (2010) Caffeine and blood pressure response: sex, age, and hormonal status. J Womens Health (Larchmt) 19, 11711176.

52.M Woodward & H Tunstall-Pedoe (1999) Coffee and tea consumption in the Scottish Heart Health Study follow up: conflicting relations with coronary risk factors, coronary disease, and all cause mortality. J Epidemiol Community Health 53, 481487.

53.KJ Mukamal , M Maclure , JE Muller et al. (2004) Caffeinated coffee consumption and mortality after acute myocardial infarction. Am Heart J 147, 9991004.

54.S Malerba , F Turati , C Galeone et al. (2013) A meta-analysis of prospective studies of coffee consumption and mortality for all causes, cancers and cardiovascular diseases. Eur J Epidemiol 28, 527539.

55.Y Je & E Giovannucci (2013) Coffee consumption and total mortality: a meta-analysis of twenty prospective cohort studies. Br J Nutr 111, 11621173.

57.A Muley , P Muley & M Shah (2012) Coffee to reduce risk of type 2 diabetes? A systematic review. Curr Diabetes Rev 8, 162168.

58.AK Shlonsky , AL Klatsky & MA Armstrong (2003) Traits of persons who drink decaffeinated coffee. Ann Epidemiol 13, 273279.

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Public Health Nutrition
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