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Comparison of the effects of four commercially available weight-loss programmes on lipid-based cardiovascular risk factors

  • LM Morgan (a1), BA Griffin (a1), DJ Millward (a1), A DeLooy (a2), KR Fox (a3), S Baic (a3), MP Bonham (a4), JMW Wallace (a4), I MacDonald (a5), MA Taylor (a5) and H Truby (a1)...
Abstract
AbstractObjective

To investigate the relative efficacy of four popular weight-loss programmes on plasma lipids and lipoproteins as measures of CVD risk.

Design

A multi-centred, randomised, controlled trial of four diets – Dr Atkins’ New Diet Revolution, The Slim-Fast Plan, Weight Watchers Pure Points programme and Rosemary Conley’s ‘Eat yourself Slim’ Diet and Fitness Plan – against a control diet, in parallel for 6 months.

Setting and subjects

The trial was conducted at five universities across the UK (Surrey, Nottingham, Ulster (Coleraine), Bristol and Edinburgh (Queen Margaret University College)) and involved the participation of 300 overweight and obese males and females aged 21–60 years in a community setting.

Results

Significant weight loss was achieved by all dieting groups (5–9 kg at 6 months) but no significant difference was observed between diets at 6 months. The Weight Watchers and Rosemary Conley (low-fat) diets were followed by significant reductions in plasma LDL cholesterol (both −12·2 % after 6 months, P < 0·01), whereas the Atkins (low-carbohydrate) and Weight Watchers diets were followed by marked reductions in plasma TAG (–38·2 % and –22·6 % at 6 months respectively, P < 0·01). These latter two diets were associated with an increase in LDL particle size, a change that has been linked to reduced CVD risk.

Conclusions

Overall, these results demonstrate the favourable effects of weight loss on lipid-mediated CVD risk factors that can be achieved through commercially available weight-loss programmes. No detrimental effects on lipid-based CVD risk factors were observed in participants consuming a low-carbohydrate diet.

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Copyright
Corresponding author
*Corresponding author: Email L.Morgan@surrey.ac.uk
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4.FF Samaha , N Iqbal , P Seshadri , KL Chicano , DA Daily , J McGrory , T Williams , M Williams , EJ Gracely & L Stern (2003) A low-carbohydrate diet as compared with a low-fat diet in severe obesity. N Engl J Med 348, 20742081.

5.GD Foster , HR Wyatt , JO Hill , BG McGuckin , C Brill , BS Mohammed , PO Szapary , DJ Rader , JS Edman & S Klein (2003) A randomised trial of a low-carbohydrate diet for obesity. N Engl J Med 348, 20822090.

7.BJ Brehm , RJ Seeley , SR Daniels & DA D’Alessio (2003) A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular disease risk factors in healthy women. J Clin Endocrinol Metab 88, 16171623.

8.EC Westman , WS Yancy , JS Edman , KF Tomlin & CE Perkins (2002) Effect of 6-month adherence to a very low carbohydrate diet programme. Am J Med 113, 3036.

9.MA Austin , MC King , KM Vranizan & RM Krauss (1990) Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation 82, 495506.

10.BA Griffin , DJ Freeman , GW Tait , J Thomson , MJ Caslake , CJ Packhard & J Shepherd (1994) Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions. Relative contribution of small, dense LDL subfractions to coronary heart disease risk. Atherosclerosis 106, 241253.

12.DM Dreon , HA Fernstrom , B Miller & RM Krauss (1995) Apolipoprotein E isoform phenotype and LDL subclass response to a reduced-fat diet. Arterioscler Thromb Vasc Biol 15, 105111.

14.JS Volek , MJ Sharman , AL Gomez , C DiPasquale , M Roti , A Pumerantz & WJ Kraemer (2004) Comparison of very low-carbohydrate and low-fat diets on fasting lipids, LDL subclasses, insulin resistance, and postprandial lipemic responses in young women. J Am Coll Nutr 23, 177184.

15.ML Dansinger , JA Gleason , JL Griffith , HP Selker & EJ Schaefer (2005) Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease reduction: a randomized trial. JAMA 293, 4353.

19.DR Matthews , JP Hosker , AS Rudenski , BA Naylor , DF Treacher & RC Turner (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412419.

20.IG Davies , JM Graham & BA Griffin (2003) Rapid separation of LDL subclasses by iodixanol gradient ultracentrifugation. Clin Chem 49, 18651872.

21.BA Griffin , MJ Caslake , B Yip , GW Tait , CJ Packard & J Shepherd (1990) Rapid isolation of low density lipoprotein (LDL) subfractions from plasma by density gradient ultracentrifugation. Atherosclerosis 83, 5967.

22.DJ Newman , H Thakkar , RG Edwards , M Wilkie , T White , AO Grubb & CP Price (1995) Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int 47, 312318.

23.A Poobalan , L Aucott , WCS Smith , A Avenell , R Jung , J Broom & AM Grant (2004) Effects of weight loss in overweight/obese individuals and long-term lipid outcomes – a systematic review. Obes Rev 5, 4350.

25.KJ Acheson (2004) Carbohydrate and weight control: where do we stand? Curr Opin Clin Nutr Metab Care 7, 485492.

30.MA Zulet , ME Berkenpas & JA Martinez (2005) Comparison of dietary approaches to treat obesity based on different carbohydrate/fat content: impact on weight loss and lipid profile. Curr Nutr Food Sci 1, 1321.

32.DM Dreon , HA Fernstrom , PT Williams & RM Krauss (1997) LDL subclass patterns and lipoprotein response to a low-fat, high-carbohydrate diet in women. Arterioscler Thromb Vasc Biol 17, 707714.

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Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
  • URL: /core/journals/public-health-nutrition
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